中国医学科学院医学与健康科技创新工程，主持，500万元，在研

区域创新发展联合基金重点支持项目，参与，258万元，在研

国家自然科学基金面上项目，参与，60万元，已结题

代表性文章：

• · Sun H#, Lu Z, Singh A, Zhou Y, Zheng E, Zhou M, Wang J, Wu X, Hu Z, Gu Z, Campbell JL,Zheng L*, Shen B*. Error-prone, stress-induced 3'flap-based Okazaki fragment maturation supports cell survival. Science, 2021; 374(6572):1252-1258.

• · Sun H#, Ma L, Tsai YF, Abeywardana T, Shen B*, Zheng L*. Okazakifragment maturation: DNA flap dynamics for cell proliferation and survival. Trends Cell Biol., 2023; 33(3):221-234.

1. · Sun H#, Zhang J, Xin S, Jiang M, Zhang J, Li Z, Cao Q*, Lou H*.Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatidcohesion through regulation of cohesin acetyltransferase Esco2. PLoS Genet., 2019;15(2):e1007685
2. · Ma L#, Sun H#, Abeywardana T, Zheng L*, Shen B*.Structure-specific nucleases: role in Okazaki fragment maturation. Trends Genet., 2022; 38(8):793-796.
3. · Zheng L, Dai H, Sun H, Zhou M, Zheng E, Qiu R, Lu Q, Wei C, Shen B. JMJD1B mediates H4R3me2s reprogramming tomaintain DNA demethylation status in neural progenitor cells during embryonicdevelopment. Cell insight, 2023; 2(4), 100114.
4. · Zhang J, Li L,Miao Y, Liu X, Sun H, Jiang M, Li X, Li Z, Liu C, Liu B, Xu X, Cao Q,Hou W, Chen C, Lou H. Symmetric control of sister chromatid cohesionestablishment. Nucleic Acids Res., 2023; 51(10):4760-4773.

     *corresponding author； # equal contribution

专利：

1. 楼慧强, 曹勤红, 张晶晶, 孙海涛. Cul4蛋白的应用. 2016. 7, 中国, ZL201610547977.4

2. 楼慧强, 曹勤红, 张晶晶, 孙海涛. Ddb1蛋白的应用, 2016. 7, 中国, ZL201610547976.X

3. Li Zheng, Binghui Shen, Haitao Sun, Mian Zhou. 3flap Okazaki Fragments and uses thereof. 2021. 12, USA, 20230175072

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