1.    PARP抑制剂的设计、合成和抗肿瘤活性研究

2.    FBPase抑制剂的设计、合成和抗糖尿病药物研究

3.    Pin1小分子抑制剂的设计、合成及生物功能研究

4.    靶向钾离子通道Kv2.1选择性阻断剂的设计、合成及生物功能研究

1.Lifei Du, Xiaoyu Wang, Guonan Cui, Bailing Xu* Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors, Bioorganic & Medicinal Chemistry, 2021, 29: 115878

2.Jie Zhou#, Jianbo Bie#, Xiaoyu Wang#, Quan Liu, Rongcui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu*, Zhufang Shen*, Bailing Xu*Discovery of N-arylsulfonyl-indole-2-carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors― Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis, Journal of Medicinal Chemistry, 2020,10307-10329

3.Cui Guonan#, Lai Fangfang#, Wang Xiaoyu, Chen Xiaoguang*, Xu Bailing* Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors, European Journal of Medicinal Chemistry, 2020,188: 111985

4.Zhou jie#, Ji Ming#, Yao Haiping, Cao Ran, Zhao Hailong, Wang Xiaoyu, Chen Xiaoguang*, Xu Bailing* Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP1/2 inhibitors: design,synthesis and their antitumor activity, Organic & Biomolecilar Chemistry, 2018, 16(17):3189-3202

5.Cui Guonan#, Jin Jing#, Chen Hualong, Cao Ran, Chen Xiaoguang*, Xu Bailing* Synthesis and biological evaluation of pyrimidine derivatives as novel Pin1 inhibitors, Bioorganic & Medicinal Chemistry, 2018, 26(8): 2186-2197.

6.Zhou jie#, Ji Ming#, Zhu Zhixiang, Cao Ran, Chen Xiaoguang*, Xu Bailing* Discovery of 2-substituted 1H-benzo[d]imidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity, European Journal of Medicinal Chemistry, 2017,132: 26-41.

7. Hailong Zhao#, Ming Ji#, Guonan Cui, Jie zhou, Fangfang Lai, Xiaoguang Chen*, Bailing Xu* Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors, Bioorgnic Medicinal Chemistry 2017, 25(15): 4045-4054.

8.Hailong Zhao#, Guonan Cui#, Jing Jin, Xiaoguang Chen*, Bailing Xu*, Synthesis and Pin1 inhibitory activity of thiazole derivatives, Bioorgnic Medicinal Chemistry 2016, 24, 5911-5920.

9.Haiping Yao#, Ming Ji# , Zhixiang Zhu, Jie zhou, Ran Cao, Xiaoguang Chen*, Bailing Xu* Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors, Bioorgnic Medicinal Chemistry 2015, 23, 681-693.

10.Jianbo Bie#, Shuainan Liu# , Zhanmei Li, Yongzhao Mu, Bailing Xu* , Zhufang Shen*, Discovery of novel indole derivatives as allosteric inhibitors of fructose-1, 6-bisphosphatase, European Journal of Medicinal Chemistry, 2015, 90, 394-405.

11.Jianbo Bie, Shuainan Liu, Jie Zhou, Bailing Xu*, Zhufang Shen*, Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase, Bioorgnic Medicinal Chemistry 2014, 22, 1850-1862.

12.Jie Zhou,# Mingyu Ba#, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao, Bailing Xu*, Ying Guo*, Synthesis and biological evaluation of novel quinoxalinone-based HIV-1 reverse transcriptase inhibitors, Med. Chem. Commun., 2014, 5, 441-444

13.Jie Zhou#, Jing Jin# , Yi Zhang, Yuwen, Yin, Xiaoguang Chen*, Bailing Xu*, Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4, European Journal of Medicinal Chemistry, 2013, 68, 222-232.

14.Chang Liu#, Jing Jin#, Liang Chen, Jie Zhou, Xiaoguang Chen*, Decai, Fu, Hongrui Song, Bailing Xu*. Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorg. Med. Chem. 2012, 20, 2992-2999.