化学生物学和创新药物发现。

（1）利用化学蛋白质组学技术，阐明活性分子的蛋白靶标和作用机制，开展机制指导的先导化合物发现。

（2）设计、合成小分子荧光探针，用于先导化合物的发现。

国家科技重大专项-重大新药创制

中国医学科学院医学与健康科技创新工程协同创新团队青年项目

(1) Chen, L.; Wang, H.; Ji, T.-F.*; Zhang, C.-J.*“Chemoproteomics-based target profiling of sinomenine reveals multiple proteinregulators of inflammation”. Chem. Commun.,2021, 57, 5981-5984.

(2) Zhao, C.; Liu, T.; Xu, M.; Lin, H.; Zhang,C.-J.* “A fundamental study on the fluorescence-quenching effect of nitrogroups in tetraphenylethene AIE dyes with electron-withdrawing groups”. Chin. Chem. Lett. 2021, 32, 1925-1928.

(3) Wei, C.; Zhao, C.; Liu, S.; Zhao, J.; Ye, Z;Wang, H.*; Yu, S.*; Zhang, C.-J.* “Activity-based protein profilingreveals thatsecondary-carbon-centered radicals of synthetic 1,2,4-trioxolanesare predominately responsible for modification of protein targets in malariaparasites”. Chem. Commun., 2019, 55, 9535.

(4)  Lin, H.;Yang, W.-Q; Ye, Z; Zhang, C.-J*. “Identification of Potent Caspase-8Inhibitors from a Library of Fluorescent Natural Products Screened by anAIEgen-based Light-up Probe.” ChemBioChem,2019, 20, 1292 – 1296. (Invited paper in the special issue of youngChemBio Talent).

(5) Lin, H.; Yang, H.; Huang, S.; Wang, F.; Wang,D.-M.; Liu, B*.; Tang, Y.-D*.; Zhang, C.-J*., Caspase‑1 SpecificLight-Up Probe with Aggregation-Induced Emission Characteristics for InhibitorScreening of Coumarin-Originated Natural Products. ACS Appl. Mater. Interfaces. 2018,10, 12173−12180.

(6) Feng, G.; Liu, J.; Zhang, C.-J*.; Liu,B*. Artemisinin and AIEgen Conjugate for Mitochondria-Targeted and Image-GuidedChemo- and Photodynamic Cancer Cell Ablation. ACS Appl. Mater. Interfaces. 2018,10, 11546−11553.

(7) Yang, H.#; Wang, F.#; Zheng, J.; Lin, H.; Liu,B*.; Tang, Y.-D*.; Zhang, C.-J*. Super-quenched Molecular Probe Based onAggregation-Induced Emission and Photoinduced Electron Transfer Mechanisms forFormaldehyde Detection in Human Serum. ChemAsian J. 2018, 13, 1432-1437.

(8) Zhang, C.-J.#; Wang, J.#*; Zhang, J.; Lee, Y. M.; Feng, G.; Lim, T. K.; Shen,H.; Lin, Q.; Liu, B*. Mechanism-Guided Designand Synthesis of Mitochondria-targeting Artemisinin Analogue with EnhancedAnticancer Activity. Angew. Chem. Int. Ed., 2016, 55, 13770-13774.

(9) Zhang, C.-J.; Feng, G.; Xu. S.; Zhu, Z.;Lu. X.; Wu. J.; Liu, B*.Structure-dependent cis/trans Isomerization for TetraphenyletheneDerivatives:Consequences for Aggregation-Induced Emission. Angew.Chem. Int. Ed., 2016, 55, 6192-6196. (Selected as Very Important Paper).

(10) Zhang, C.-J.#; Hu, Q.#; Feng, G.; Zhang,R.; Yuan, Y.; Liu, B*. Image-Guided CombinationChemotherapy and Photodynamic Therapy Using a Mitochondria-Targeted MolecularProbe with Aggregation-Induced Emission Characteristics. Chem. Sci., 2015, 6, 4580-4586.

(11) Wang, J. *#; Zhang, C.-J.#; Chia, W. N.; Loh, C. C. Y.;Li, Z.; Lee, Y. Q.; Lee, Y. M.; He, Y.; Yuan, L.; Liu, M.; Liew, C. X.; Zhang,J.; Lim, T. K.;  Lim, C. K.; Shen, H. M.;Tan, K. S. W. *; Lin, Q. S*.Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun, 2015, 6, 10111.

(12) Zhang, C.-J.;Tan, C. Y. J.; Ge, J.; Na, Z.; Chen, G. Y. J.; Uttamchandani, M.; Sun, H.; Yao,S. Q*. Preparation of Small-Molecule Microarrays by trans-Cyclooctene TetrazineLigation and Their Application in the High-Throughput Screening ofProtein–Protein Interaction Inhibitors of Bromodomains. Angew. Chem. Int. Ed., 2013,52, 14060-14064. (Selected as HotPaper).

(13) Yuan, Y.#; Zhang, C.-J.#; Kwok, R. T. K.; Xu, S.; Zhang, R.; Wu, J.; Tang, B.Z.; Liu, B*. Light-up Probe for Targeted and Activatable Photodynamic Therapywith Real-time In-situ Reporting of Sensitizer Activation and TherapeuticResponses. Adv. Funct. Mater, 2015, 25, 6586-6595.

(14) Yuan, Y.#; Zhang, C.-J.#; Liu, B*. APhotoactivatable AIE Polymer for Light-Controlled Gene Delivery: ConcurrentEndo/Lysosomal Escape and DNA Unpacking. Angew.Chem. Int. Ed., 2015, 54, 11419-11423.

(15) Yuan, Y.#; Zhang, C.-J.#; Gao, M.;Zhang, R.; Tang, B. Z.; Liu, B*. Specific Light-Up Bioprobe withAggregation-Induced Emission and Activatable Photoactivity for the Targeted andImage-Guided Photodynamic Ablation of Cancer Cells. Angew. Chem. Int. Ed., 2015,54, 1780-1786.

*corresponding author； # equal contribution

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