郭庆兰：博士，副研究员

朱承根：硕士，助理研究员

徐成博：博士，助理研究员

在研项目信息：

1、“重大新药创制”科技重大专项“十三五”重大新药创制项目，2018ZX09711001-001，天然有效／活性小分子高效获取鉴定的技术集成体系构建及应用，2018/01-2020/12，5802.95万，在研，主持。

2、国家自然科学基金重点项目，81630094，天然药物新型微量活性成分的发现与功能研究，2017/01-2021/12，直接经费275万，在研，主持。

3、中国医学科学院医学与健康科技创新工程协同创新团队项目，2017-I2M-3-010，具有显著活性的新型天然产物结构与功能研究，2017/01月-2020/12，330万元/年，在研，主持。

 先后参加和负责多项国家和地方重点项目。取得成果有：1）相关技术体系获得国家科学技术进步二等奖1项和北京市科学技术奖一等奖等各1项，其他省部级二等奖2项；2）1个新药进入临床IIa期试验，1个候选物进入临床前评价，3个先导结构进入成药性研究，16个与传统药物药效一致的先导化合物；4）获得授权专利15项，主编书籍1部，参编书籍11部，发表论文200余篇。

1.       QinglanGuo, Dawei Li, Chengbo Xu, Chenggen Zhu, Ying Guo, Haibo Yu, Xiaoliang Wang,Jiangong Shi. Indole alkaloid glycosides with a 10-(phenyl)ethyl unit from Isatisindigotica leaves. Acta Pharm. Sin. B2020, 10(5): 895-902.

2.       ChengboXu, Yijing Xin, Minghua Chen, Mingyu Ba, Qinglan Guo, Chenggen Zhu, Ying Guo*,Jiangong Shi*. Eur. J. Med. Chem. 2020, 189:112071.

3.       YuzhuoWu#, Shuai Shao#, Qinglan Guo, Chengbo Xu, Huan Xia,Tiantai Zhang*, Jiangong Shi*. Aconicatisulfonines A and B, analgesiczwitterionic C20-diterpenoid alkaloids with a rearranged atisaneskeleton from Aconitum carmichaelii. Org Lett. 2019, 21(17):6850-6854.

4.       YueWang, Qing-Lan Guo, Ruo-Fei Li , Cheng-Bo Xu , Cheng-Gen Zhu , Jian-Gong Shi .Two folate-derived analogues from an aqueous decoction of Uncariarhynchophylla. Chin. J. Nat. Med. 2019,17(12):928-934.

5.       Cheng-BoXu, Qing-Lan Guo, Ya-Nan Wang, Sheng Lin, Cheng-Gen Zhu, Jian-Gong Shi. GastrodinDerivatives from Gastrodia elata, Nat. Prod. Bioprospect. 2019, 9,393-404.

6.       QinglanGuo#, Huan Xia#, Gaona Shi, Tiantai Zhang*, and Jiangong Shi*. AconicarmisulfonineA, a sulfonated C20-diterpenoid alkaloid from the lateral roots of Aconitumcarmichaelii, Org. Lett. 2018, 20:816-819.

7.       QinglanGuo#, Huan Xia#, Xianhua Meng, Gaona Shi, Chengbo Xu,Chenggen Zhu, Tiantai Zhang*, Jiangong Shi*. C19-Diterpenoidalkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and theiranalgesic activities. Acta Pharm. Sin. B2018, 8(3): 409-419.

8.       QinglanGuo, Chengbo Xu, Minghua Chen, Sheng Lin, Yuhuan Li, Chenggen Zhu, JiandongJiang, Yongchun Yang, and Jiangong Shi. Sulfur-enriched alkaloids from the rootof Isatis indigotica. Acta Pharm. Sin. B 2018, 8(6):933-943.

9.       Ling-JieMeng, Qing-Lan Guo, Ming-Hua Chen, Jian-Dong Jiang, Yu-Huan Li, Jian-Gong Shi. IsatindolignanosideA, a glucosidic indole-lignan conjugate with a novel carbon skeleton from anaqueous extract of “ban lan gen”. Chin.Chem. Lett. 2018, 29(8):1257-1260.

10.   Ling-JieMeng，Qing-LanGuo，Cheng-GenZhu，Cheng-BoXu，Jian-GongShi. Isatindigodiphindoside, an alkaloid glycoside with a newdiphenylpropylindole skeleton from the root of Isatis indigotica. Chin.Chem. Lett. 2018, 29(1):119-122.

11.   Xue Zhou, Qing-Lan Guo,Cheng-Gen Zhu, Cheng-Bo Xu, Ya-Nan Wang, Jian-Gong Shi. Gastradefurphenol,a minor 9,9′-neolignan with a new carbon skeleton substituted by two p-hydroxybenzyls from an aqueous extractof “tian ma”,Chin. Chem. Lett. 2017, 28,1185–1189.

12.   Xian-Hua Meng, Zhi-BoJiang, Qing-Lan Guo, Jian-Gong Shi.Unprecedented C19-diterpenoid alkaloidglycosides from an aqueous extract of “fu zi”: Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls, Chin.Chem. Lett.2017, 28,1705–1710.

13.   Xian-Hua Meng, Zhi-BoJiang, Qing-Lan Guo, Jian-Gong Shi.A minor arcutine-type C20-diterpenoidalkaloid iminium constituent of “fu zi”, Chin. Chem. Lett. 2017, 28,588–592.

14.   Ling-JieMeng, Qing-Lan Guo, Cheng-Bo Xu, Cheng-Gen Zhu, Yu-Feng Liu, Ming-Hua Chen,Sheng Lin, Yu-Huan Li, Jian-Dong Jiang and Jian-Gong Shi. Diglycosidicindole alkaloid derivatives from an aqueous extract of Isatis indigotica roots, J.Asian Nat. Prod. Res.2017, 19(6), 529–540.

15.   LingjieMeng, Qinglan Guo, Yufeng Liu. Jiangong Shi. 8,4′-Oxyneolignaneglucosides from an aqueous extract of “ban langen” (Isatis indigotica root) and their absolute configurations, Acta Pharm. Sin. B 2017, 7(6), 638–646.

16.   Lingjie Meng, QinglanGuo, Yufeng Liu, Minghua Chen, Yuhuan Li, Jiandong Jiang, Jiangong Shi. Indolealkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity, Acta Pharm. Sin. B 2017, 7(3), 334–341.

17.   YufengLiu, Minghua Chen, Qinglan Guo, Yuhuan Li, Jiandong Jiang, Jiangong Shi.Aromatic compounds from an aqueous extract of “ban langen” and their antiviral activities,ActaPharm. Sin. B 2017, 7(2), 179–184.