1.  主持

1.1 基于药酶和转运蛋白调控的中药复方生脉散的配伍机制研究 （批准号81202990），国家自然科学基金

1.2 新结构类型调血脂化合物WS0 70117 临床前研究（批准号2012ZX09102101-020），药代动力学子课题负责人，国家科技重大专项-重大新药创制

1.3 人源化药物转运蛋白P-gp和BCRP高表达体系的建立和应用（批准号33320140072），北京协和医学院协和青年基金

1.4 临床前药物-药物相互作用体外研究体系的建立及应用（批准号2010CHX05），中央级公益性科研院所基本科研业务费

2.  主要参与

2.1 药物代谢技术研究，十二五科技重大专项

2.2 天然药物天然药物与肠道菌群相互作用研究的关键技术，十三五科技重大专项

2.3 抗糖尿病创新中药-桑枝总生物碱有效部位体内吸收代谢特征及机制研究，国家重点实验室自主课题

2.4 中药五味子化学-药代-药效指纹图谱及相关药代动力学研究（批准号81070696），国家自然科学基金

2.5 抗HIV化合物F18与药物代谢酶的相互作用与生物学效应（批准号2011CHX12），中央级公益性科研院所基本科研业务费

近年来，完成多项Ⅰ类创新药物临床前药代动力学研究和相关委托研究项目，发表多篇研究论文。

代表性研究论文：

1.  Fen Yang1, Baolian Wang1,Zhihao Liu, Xuejun Xia, Weijun Wang, Dali Yin, Li Sheng, Yan Li. Prediction ofa therapeutic dose for Buagafuran, a potent anxiolytic agent by physiologicallybased pharmacokinetic/pharmacodynamic modeling starting from pharmacokineticsin rats and human.[J] Frontiers in Pharmacology, 2017, 8:683. doi:10.3389/fphar.2017.00683.

2.  Shuang Yang, Jiaqi Mi, Zhihao Liu, Baolian Wang*, Xuejun Xia, Renyun Wang, Yuling Liu, Yan Li. Pharmacokinetics,tissue distribution and elimination of three active alkaloids in rats afteroral administration of the effective fraction of alkaloids from Ramulus Mori,an innovative hypoglycemic agent[J]. Molecules, 2017, 22(10), 1616;doi:10.3390/molecules22101616

3.  Baolian Wang, Zhihao Liu, Dan Li, ShuangYang, Jinping Hu, Hui Chen, Li Sheng, Yan Li. Application of physiologicallybased pharmacokinetic modeling in the prediction of pharmacokinetics ofbicyclol controlled-release formulation in human[J]. European Journal ofPharmaceutical Sciences, 2015, 77: 265-272.

4.  Baolian Wang, Shuang Yang, Li Sheng, Yan Li.Simultaneous quantification of curdione, furanodiene and germacrone in rabbitplasma using liquid chromatography–tandem mass spectrometry and its applicationto a pharmacokinetic study[J]. Biomedical Chromatography, 2015,29（9）:1393-1398.

5.  Baolian Wang, Li Sheng, Yan Li. Simultaneousdetermination of telmisartan and amlodipine in dog plasma by LC-MS-MS[J].Journal of Chromatographyic Science，2015,53（10）：1708-1713.

6.  Baolian Wang, ShuangYang, JinpingHu, YanLi.Multifaceted interaction of the traditional Chinese medicinal herb Schisandrachinensis with cytochrome P450-mediated drug metabolism in rats[J]. Journal ofEthnopharmacology, 2014, 155: 1473–1482.

7.  Wei Tan1, Baolian Wang 1,Jinping Hu, Li Sheng, Yan Li. Establishment of a liquid chromatography/massspectrometry for determination of bicyclol in rat single-pass intestinalperfusion[J]. Biomedical Chromatography, 2009, 23(10)：1059-1063.

8.  Baolian Wang, Jinping Hu, Wei Tan, LiSheng, Hui Chen, Yan Li. Simultaneous quantification of four active schisandralignans from a traditional Chinese medicine Schisandra chinensis(Wuweizi) inrat plasma using liquid chromatography/mass spectrometry[J]. Journal of Chromatography B,2008, 865(1-2):114–120.

9.  Yufei Jia, BaolianWang, Xiangmeng Wu, Sheng Li, Jinping Hu, Dongmei Wang，Haibo Zhu, Yan Li.Simultaneous quantification of 2,3,5-tri-O-acetyl-N6-(3-hydroxylaniline)adenosine and its principal metabolites in hamsterblood by LC–MS/MS and its applicationin pharmacokinetics study[J]. Journal of Chromatography B-AnalyticalTechnologies in the Biomedical and Life Sciences, 2016, 1022：46-53.

10.  Shuang Yang, Baolian Wang, Xuejun Xia, Xue Li,Renyun Wang, Li Sheng, Dan Li, Yuling Liu, Yan Li. Simultaneous quantificationof three active alkaloids from atraditional Chinese medicine Ramulus Mori(Sangzhi) in rat plasma using liquid chromatography-tandem massspectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis，2015, 109：177-183.

11.  Xiaomin Yao, Baolian Wang, Yu Gu, Yan Li. Effectsof bicyclol on the activity and expression of CYP450 enzymes of rats afterpartial hepatectomy[J]. Acta Pharmaceutica Sinica, 2011,46(6):656-663

12.  Xiaomin Yao, Baolian Wang, Hong-Yan Yu, Yan Li.Effects of bicyclol on the activity and expression of cytochrome P450 afterhepatic warm ischemia/reperfusion in rats[J]. Journal of Asian Natural ProductsResearch, 2011, 13(7):634-644.

13.  Hongyan Yu, Baolian Wang, Jing Zhao, Xiaomin Yao,Yu Gu, Yan Li. Protective effect of bicyclol on tetracycline induced fattyliver in mice[J]. Toxicology, 2009, 261:112-118.

14.  Wei Tan, Baolian Wang, Jing Zhao, Li Sheng,Jinping Hu, Yan Li. Pharmacokinetics of Bicyclol in Acute Hepatic Failure Rats[J]. Xenobiotica,2008, 38(11):1399-1409.

15.  Baolian Wang, Jinping Hu, Li Sheng, YanLi. Chemical-Pharmacokinetic(PK)- Pharmacodynamic(PD) Fingerprints Study ofSchisandra chinensis Alcoholic Extract[J]. ActaPharmaceutica Sinica. 2013,48(5):734-740.

16. 王宝莲，扈金萍，盛莉，陈晖，李燕. HPLC-MS/MS法定量研究比格犬灌胃替诺福韦酯后替诺福韦血浆药代动力学.[J].药学学报，2013，48(3):390-394.

17. 王宝莲，扈金萍，盛莉，陈晖，李燕. HPLC-MS/MS法定量研究比格犬口服氨氯地平后的血浆药代动力学[J]. 解放军药学学报, 2013, 29(2): 97-100.

18. 王宝莲，扈金萍，盛莉，李燕。混合探针底物法测定五味子成分对大鼠肝脏细胞色素P450同工酶的影响，药学学报，2011，46（8）：922~927

19.  王宝莲，李燕。《植物药-化学药药代动力学相互作用及机制研究进展》,《中国药理学与毒理学杂志》，2008，22（3）：237-240.