科研项目

        作为项目负责人承担过国家十一五“重大新药创制”科技重大专项1项、国家自然科学基金面上项目5项、以及北京市自然科学基金面上项目和北京市科委科技计划专项各1项等， 参与十二五、十三五国家“重大新药创制”科技重大专项、科技部国际科技合作，中国医学科学院医学与健康科技创新工程协同创新团队等多项科研项目。

代表性论文

1.   Shao S, Chen CJ, Shi GN, Zhou Y, Wei YZ, Fan NY, Yang Y, Wu L, Zhang TT*. Therapeutic potential of the target on NLRP3 inflammasomein multiple sclerosis. Pharmacol Ther.  2021, 227: 107880.doi:10.1016/j.pharmthera.2021.107880.

2. Shao S¹, Xu CB¹,Chen CJ, SHI GN, Guo QL, Zhou Y, Wu L, Wei YZ, Shi JG*, Zhang TT*. Divanillylsulfone suppresses NLRP3 inflammasome activation via inducingmitophagy to ameliorate chronic neuropathic pain in mice. J Neuroinflammation. 2021, 18:142. doi:10.1186/s12974-021-02178-z.

3. Liu JK¹, Chen CJ¹, Wang DM, Zhang J^*, Zhang TT^**. Emerging small-moleculeinhibitors of the Bruton’s Tyrosine Kinase (BTK): current development. Eur J Med Chem. 2021, 217: 113329. doi:10.1016/j.ejmech.2021.113329.

4. Shi GN, Hu M, Chen CJ, Fu JM, Shao S, Zhou Y, Wu L, Zhang TT^*. Methotrexate enhances antigenpresentation and maturation of tumor antigens loaded DCs through NLRP3inflammasome activation and with potentials for DC-based cancer vaccine. Ther Adv Med Oncol. 2021, 13: 1758835920987056.doi: 10.1177/1758835920987056.

5. Fu JM, Zang YD, Zhou Y, Chen CJ, Shao S, Hu M, Shi GN, Wu L, Zhang DM, Zhang TT*. A novel triptolidederivative ZT01 exerts anti-inflammatory effects by targeting TAK1 to prevent macrophagepolarization into pro-inflammatory phenotype. Biomed Pharmacother. 2020, 126: 110084. doi: 10.1016/j.biopha.2020.110084.

6. Guo QL†, Xia H†, Wu YZ, Shao S, Xu CB, Zhang TT*, Jiangong Shi*. Structure, property, biogenesis, andactivity of diterpenoid alkaloids containing a sulfonic acid group fromAconitum carmichaelii. Acta PharmaceutSin B, 2020, 10(10):1954-1965. doi: 10.1016/j.apsb.2020.01.013.

7. Shao S, Xia H, Hu M, Chen CJ, Fu JM, Shi GN, Guo QL, Zhou Y, Wang WJ, Shi JG* and Zhang TT*. Isotalatizidine, aC19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulatingERK/CREB signaling pathway mediated microglial dynorphin A expression. J Neuroinflammation.  2020, 17: 13. doi:10.1186/s12974-019-1696-9.

8.  Shu L1,Chen CJ1, Huan XT, Huang H, Wang MM, Zhang JQ, Yan YL, Liu JM, Zhang TT*, Zhang DY*. Design,synthesis, and pharmacological evaluation of 4- or 6-phenyl-pyrimidinederivatives as novel and selective Janus kinase 3 inhibitors. Eur J Med Chem, 2020, 191:112148.doi: 10.1016/j.ejmech.2020.112148.

9.  Yin Y, Chen CJ,Yu RN, Shu L, Wang ZJ, Zhang TT*, Zhang DY*. Novel 1H-pyrazolo[3,4-d]pyrimidin-6-amino derivatives as potent selective Januskinase 3 (JAK3) inhibitors. Evaluation of their improved effect for thetreatment of Rheumatoid arthritis. Bioorg Chem. 2020, 98: 103720. doi:10.1016/j.bioorg.2020.103720.

10. Wu YZ†, Shao S†, Guo QL, Xu CB, XiaH, Zhang TT*, Shi JG*. Aconicarmisulfonines A and B, analgesic zwitterionicC20-Diterpenoid alkaloids with a rearranged atisane skeletonfrom Aconitum carmichaelii. Org lett, 2019, 21 (17):6850-6854. doi: 10.1021/acs.orglett.9b02479.

11.  Hu M†, Xu CB†,Yang C, Zuo HL, Chen CJ, Zhang D, Shi GN, Wang WJ, Shi JG, Zhang TT*. Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinaseinhibitor of JAK2V617F against myeloproliferative neoplasms. J Exp Clin Cancer Res, 2019, 38(2): 49. doi:  10.1186/s13.46-019-1062-x.

12.   Wang DM†, Hu M†,Li XP, Zhang D, Chen CJ, Fu JM, Shao S, Shi GN, Zhou Y, Wu S*, Zhang TT*. Design, synthesis, and evaluation of novel isoflavone derivatives asmultifunctional agents for the treatment of Alzheimer‘s disease. Eur J Med Chem, 2019, 168: 207-220. doi: 10.1016/j.ejmech.2019.02.053.

13. Li JZ†, Ma XW†, Wang Y, ChenCJ, Hu M, Wang LL, Fu JM, Shi GN, Zhang DM, Zhang TT*. Methylsalicylate lactoside protects neurons ameliorating congnitive disorder throughinhibiting neuroinflammatory response. Front. Aging Neurosci. 2018,10: 85. doi: 10.3389/fnagi.2018.00085.

14. Guo QL†, Xia H†, ShiGN, Zhang TT*, and Shi JG*. Aconicarmisulfonine A, a SulfonatedC20-Diterpenoid Alkaloid Inner Salt with Skeleton and Analgesic Activity froman Aqueous Extract of the Lateral Roots of Aconitum carmichaelii. Org lett, 2018, 20:816-819. doi: 10.1021/acs.orglett.7b03956.

15. Guo QL†, Xia H†,  Meng XH,  Shi GN,  Xu CB,  Zhu CG,  Zhang TT*,  Shi JG*. C19-Diterpenoidalkaloid arabinosides from an aqueous extract of the lateral root of Aconitumcarmichaelii and their analgesic activities. Acta Pharmaceut Sin B, 2018, 8(3): 409-419. doi:10.1016/j.apsb.2018.03.009.

申请发明专利

        获得国内授权发明专利5项，申请国内发明专利15项、PCT专利1项。