主持完成“十二五”国家科技重大专项-候选药物研究项目1项、国家自然科学基金委面上项目2项、教育部留学回国人员启动基金1项，承担多项“十一五”国家科技重大专项子课题及科技部科技基础性工作专项重点项目子课题等，参加科技部、教育部、卫生部、国家自然科学基金委、北京市科委等10余项重大、重点项目的研究工作，正在承担国家自然科学基金委面上项目1项、“十三五”国家科技重大专项-临床前研究任务1项、中国医学科学院医学与健康科技创新工程项目任务1项。

参与完成4项国家1类新药的临床前研究。发表论文120余篇，授权专利12项。副主编专著1部，参编著作17部；获得北京市科学技术二等奖、中华医学科技二等奖及中华医学科技三等奖等多项科研荣誉。

发表论文

1.      Yan yu, Zhang Zhi-hui, ChenYu-cai, Hou Bi-yu, Liu Kang, Qin Hai-lin, FangLian-hua*, Du Guan-hua*. Coptisine alleviates pristane-induced lupus-likedisease and associated kidney and cardiovascular complications in mice. FrontPharmacol, 2020, 11: 00929.

2.      Wang Shou-bao, Zhao Yan,Song Jun-ke, Wang Rong-rong, Gao Li, Zhang Li, Fang Lian-hua*, Lu Yang*, Du Guan-hua*. Total flavonoids fromAnchusa italica Retz improve cardiac function and attenuate cardiac remodelingpost myocardial infarction in mice. J Ethnopharmacol, 2020, 257: 112887.

3.      Chen Yu-cai, Chen Di, LiuSi-jia, Yuan Tian-yi, Guo Jian*, FangLian-hua*, Du Guan-hua*. Systematic elucidation of the mechanism ofgenistein against pulmonary hypertension via network pharmacology approach. IntJ Mol Sci, 2019, 20(22): E5569.

4.      Yuan Tian-yi, ZhangHui-fang, Chen Di, Chen Yu-cai, Lyu Yang,Fang Lian-hua*, Du Guan-hua*. Puerarin protects pulmonary arteries fromhypoxic injury through the BMPRII and PPARγ signaling pathways in endothelialcells. Pharmacol Rep, 2019, 71(5): 855-861.

5.      Yuan Tian-Yi, Chen Di, ChenYu-Cai, Zhang Hui-Fang, Niu Zi-Ran, Jiao Xiao-Zhen, Xie Ping, Fang Lian-Hua*, Du Guan-Hua*. A novelhypertensive crisis rat model established by excessive norepinephrine infusionand the potential therapeutic effects of Rho-kinase inhibitors on it. BiomedPharmacother, 2019, 109:1867-1875.

6.      Li Xu-Guang, Yuan Tian-Yi,Chen Di, Chen Yu-Cai, Sun Shu-Chan, Wang Dan-Shu, Fang Lian-Hua*, Yang Lu, Du Guan-Hua*. Cardioprotective effects ofPuerarin-V on isoproterenol-induced myocardial infarction mice is associatedwith regulation of PPAR-γ/NF-κB pathway. Molecules, 2018, 23(12), 3322.

7.      Yuan Tian-Yi, Niu Zi-Ran,Chen-Di, Chen Yu-Cai, Zhang Hui-Fang, FangLian-hua*, Du Guan-hua*. Vasorelaxant effect of quercetin on cerebralbasilar artery in vitro and the underlying mechanisms study. J Asian Nat ProdRes, 2018, 20(5): 477-487.

8.      Chen Yu-Cai, Yuan Tian-Yi,Zhang Hui-Fang, Yan Yu, Wang Dan-Shu, FangLian-Hua*, Lu Yang, Du Guan-Hua*. Activation of Nrf2 attenuates pulmonaryvascular remodeling via inhibiting endothelial-to-mesenchymal transition: Aninsight from a plant polyphenol. Int J Biol Sci, 2017, 13(8): 1067-1081.

9.      Yuan Tian-Yi, Chen Yu-Cai,Zhang Hui-Fang, Fang Lian-hua*, DuGuan-hua*. Salvianolic acid A, a component of Salvia Miltiorrhiza, attenuatesendothelial- mesenchymal transition of HPAECs induced by hypoxia. Am J ChinMed, 2017, 45(6): 1185-1200.

10.    Yuan Tian-Yi, ZhangHui-Fang, Chen Yu-Cai, Jiao Xiao-Zhen, Xie Ping, Fang Lian-hua*, Du Guan-hua*. The Protective Effect of DL0805derivatives on pulmonary artery cells and the underlying mechanisms study.Current Vasc Pharmacol. 2017, 15(5): 469-476.

11.    Yan Yu, Zhang Hui-Fang,Zhang Zhi-Hui, Song Jun-Ke, Chen Yu-Cai, Wang Xiao-Bo, He Yang-Yang, QinHai-Llin, Fang Lian-Hua*, DuGuan-Hua*. Pharmacokinetics and tissue distribution of coptisine in rats afteroral administration by liquid chromatography-mass spectrometry. BiomedChromatogr. 2017, 31(7): e3918.

12.    Lin Yi-Huang, Yan Yu, ZhangHui-Fang, Chen Yu-Cai, He Yang-Yang Wang Shou-Bao, Fang Lian-Hua*, Lu Yang, Du Guan-Hua*. Salvianolic acid Aalleviates renal injury against the systemic lupus erythematosus induced bypristane in BALB/c mice. Acta Pharm Sin B. 2017, 7(2): 159-166.

13.    Chen Yu-cai, Yuan Tian-yi,Zhang Hui-fang, Wang Dan-shu, Niu Zi-ran, Li Li, Fang Lian-hua*, Du Guan-hua*. Fasudil evokes vasodilatation of ratmesenteric vascular bed via Ca2+ channels and Rho/ROCK pathway. EurJ Pharmacol. 2016, 788: 226-233.

14.    Chen Yu-cai, Yuan Tian-yi,Zhang Hui-fang, Wang Dan-shu, Yan Yu, Niu Zi-ran, Lin Yi-huang, Fang Lian-hua*, Du Guan-hua*.Salvianolic acid A attenuates vascular remodeling in a pulmonary arterialhypertension rat model. Acta Pharmacol Sin. 2016, 37(6): 772-782.

15.    Yuan Tian-yi, Chen Yu-cai,Zhang Hui-fang, Li Li, Jiao Xiao-zhen, Xie Ping, Fang Lian-hua*, Du Guan-hua*. DL0805-2, a novel indazolederivative, relaxes Angiotensin II-induced contractions of rat aortic rings byinhibiting Rho kinase and calcium fluxes. Acta Pharmacol Sin. 2016, 37(5):604-616.

16.    Yan Yu, Chen Yu-cai, LinYi-huang, Guo Jing, Niu Zi-ran, Li Li, Wang Shou-bao, Fang Lian-hua*, Du Guan-hua*. Brazilin isolated from the heartwoodof Caesalpinia sappan L induces endothelium-dependent and independentrelaxation of rat aortic rings. Acta Pharmacol Sin. 2015, 36(11): 1318-1326.