1. 国家自然科学基金青年基金项目，81502917，基于代谢性质和毒性改善的新型噁唑烷酮类化合物的设计、合成及抗结核活性研究

2. 中国医学科学院医学与健康科技创新工程，2016-I2M-1-013，感染性疾病（结核病等）诊治新策略研究

3. “重大新药创制”科技重大专项，2015ZX09102007-013，新型噁唑烷酮类抗耐药结核候选药物的研究

4. 中央公益性科研院所基本科研业务费，2014CX15，新型噁唑烷酮类化合物的设计、合成及抗结核活性研究

5. “重大新药创制”科技重大专项，2014ZX09507003-001，抗老年痴呆及轻度认知障碍新药sGC-1061的临床前研究

6. 北京市科技计划课题-创新品种临床前研究，Z131100002713006，抗耐药结核新药TBI-166 的临床前研究

7. 中国医学科学院药物研究所与Global Alliance for TB Drug Development 国际合作项目，Discovery of a New Generation of Oxazolidinones for Shortening TB Therapy

8. 中国医学科学院药物研究所与Global Alliance for TB Drug Development 国际合作项目，Discovery and Development of the

Riminophenazine Class for Shortening TB Therapy and Treatment of MDR-TB

代表性论文

1. Hongyi Zhao,# Shengnan Li,#Shihao Cheng, Ziyun Lin, Dongfeng Zhang* and Haihong Huang*, A mild andmetal-free synthesis of chiral 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazines, Tetrahedron,2021, 10.1016/j.tet.2021.132304 (IF=2.233)

2. Xiao Wang,# Wenting Zhao,# Bin Wang, Wei Ding, Hao Guo, Hongyi Zhao, Jianzhou Meng, Sihan Liu, Yu Lu, Yishuang Liu*, Dongfeng Zhang*. Identification of inhibitors targetingpolyketide synthase 13 of Mycobacterium tuberculosis as antituberculosisdrug leads. Bioorganic Chemistry, 2021, 114, 105110 (IF=4.831)

3. DongfengZhang,# Peng Li,# Yongxin Gao, Yaoyao Song, Yaqin Zhu,Hong Su, Beibei Yang, Li Li, Gang Li, Ningbo Gong, Yang Lu, Huanjie Shao,*Chunrong Yu,* and Haihong Huang*. Discovery of a Candidate Containing an (S)‑3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro‑1H‑indenScaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including theT315I Resistant Mutant for the Treatment of Chronic Myeloid Leukemia. Journal ofMedicinal Chemistry, 2021, 64(11), 7434−7452 (IF=6.205)

4.  Yongqi Wu, Bin Wang, Haijia Lu, Hongyi Zhao, Beibei Yang,Li Li, Yu Lu, Dongfeng Zhang*, Ning Sun*, Haihong Huang*.Identification of novel tricyclic benzo[1,3]oxazinyloxazolidinones as potentantibacterial agents with excellent pharmacokinetic profiles againstdrug-resistant pathogens. Journal of Medicinal Chemistry, 2021, 64(6), 3234−3248(IF=6.205)

5. Hongyi Zhao, Bin Wang, Lei Fu, Gang Li, Haijia Lu, YukeLiu, Li Sheng, Yan Li, Baoxi Zhang, Yang Lu, Chen Ma, Haihong Huang*, DongfengZhang*, and Yu Lu*. Discovery of a conformationally constrainedoxazolidinone with improved safety and efficacy profiles for the treatment ofmultidrug-resistant tuberculosis. Journal ofMedicinal Chemistry, 2020, 63(17), 9316-9339 (IF=6.205)

6.  Hongyi Zhao, Wenting Zhao, Shihao Cheng, Haijia Lu, DongfengZhang*, and Haihong Huang*, Efficient and stereoselective one-pot synthesisof benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones, RSCAdvances, 2020, 10, 24037-24044 (IF=3.049)

7.  Wenting Zhao, Bin Wang, Yuke Liu, Lei Fu, Li Sheng,Hongyi Zhao, Yu Lu, Dongfeng Zhang*, Design, synthesis, andbiological evaluation of novel 4H-chromen-4-one derivatives asantituberculosis agents against multidrug-resistant tuberculosis. EuropeanJournal of Medicinal Chemistry, 2020, 189, 112075 (IF=5.572)

8.  Yong-Qi Wu, Hai-Jia Lu, Wen-Ting Zhao, Hong-Yi Zhao,Zi-Yun Lin, Dong-Feng Zhang*, and Hai-Hong Huang*, A convenient andefficient H2SO4-promoted regioselective monobrominationof phenol derivatives using N-bromosuccinimide, SyntheticCommunications, 2020, 50(6), 813-822 (IF=1.796)

9. Keli Cui, Meng Gao, Hongyi Zhao, Dongfeng Zhang*,Hong Yan* and Haihong Huang*. An Efficient Synthesis of Aryl-SubstitutedPyrroles by the Suzuki–Miyaura Coupling Reaction of SEM-Protected Pyrroles. Molecules, 2019,24(8), 1594 (IF=3.098)

10. Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao,Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huang*, Yongjun Lu*, YuLu*. Docking- and pharmacophore-based virtual screening for the identificationof novel Mycobacterium tuberculosis protein tyrosinephosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold. BioorganicChemistry, 2019, 85, 229-239 (IF=4.831)

11. Meng Gao, Wenting Zhao, Hongyi Zhao,Ziyun Lin, Dongfeng Zhang* and Haihong Huang*. An efficient andfacile access to highly functionalized pyrrole derivatives. Beilstein Journalof Organic Chemistry, 2018, 14, 884-890 (IF=2.597)

12. Hongyi Zhao, Yu Lu, Li Sheng, ZishuoYuan, Bin Wang, Weiping Wang, Yan Li, Chen Ma, Xiaoliang Wang, DongfengZhang*, and Haihong Huang*. Discovery of fluorine-containingbenzoxazinyl-oxazolidinones for the treatment of multidrug resistanttuberculosis. ACS Medicinal Chemistry Letters, 2017,8 (5), 533-537(IF=3.407)

13. Dongfeng Zhang, Peng Li, Ziyun Lin, Haihong Huang*.An improved synthesis of (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane. ChineseChemical Letters, 2014, 45(3), 479-481 (IF=1.822)

14. Dongfeng Zhang, Peng Li, Ziyun Lin, Haihong Huang*. Anefficient and convenient protocol for synthesis of 1,1-difluoro-6-nitro-2,3-dihydro-1H-indenederivatives. Synthesis, 2014, 46(5), 613-620 (IF=2.664)

15. Dongfeng Zhang, Yang Liu, Chunlin Zhang, Hao Zhang,Bin Wang, Jian Xu, Lei Fu, Dali Yin, Christopher B. Cooper, Zhenkun Ma*, YuLu*, and Haihong Huang*. Synthesis and biological evaluation of novel2-methoxypyridylamino-substituted riminophenazine derivatives asantituberculosis agents. Molecules, 2014,19(4), 4380-4394 (IF=2.581)

16. Dongfeng Zhang#, Yu Lu#,Kai Liu, Binna Liu, Jingbin Wang, Gang Zhang, Hao Zhang, Yang Liu, Bin Wang,Meiqin Zheng, Lei Fu, Yanyan Hou, Ningbo Gong, Yang Lv, Chun Li, Christopher B.Cooper, Anna M. Upton, Dali Yin, Zhenkun Ma*, and HaihongHuang*. Identificationof less lipophilic riminophenazine derivatives for the treatment of drug-resistanttuberculosis. Journal of Medicinal Chemistry, 2012, 55(19), 8409-8417 (IF=5.765)

17.  鲁海嘉, 张东峰*, 黄海洪，抗革兰氏阴性菌药物的研究进展，药学学报，2019, 54(9), 1554-1563

18.  丁威, 赵文婷, 张东峰*，结核分枝杆菌聚酮合成酶13抑制剂的研究进展，药学学报, 2020, 55(8), 1768-1773 

授权专利

1. 刘凯、克里斯多佛. B. 库珀、黄海洪、李春、刘彬娜、刘洋、马振坤、王经斌、尹大力、张东峰、张刚、张昊，具有2-(杂芳基)氨基取代基的氯苯吩嗪及其抗微生物活性，ZL201180032107.9

2. 黄海洪、申竹芳、林紫云、金宏山、王燕、刘泉、孙素娟、陈跃腾、张东峰、马慧勇，吲唑及四氢吲唑类化合物及其制法和其药物组合物与用途，ZL200710303688.0

3. Kai Liu, Christopher B. Cooper, Haihong Huang, Chun Li, Binna Liu, Yang Liu,Zhenkun Ma, Jingbin Wang, Dali Yin, Dongfeng Zhang, Gang Zhang, Hao Zhang. Riminophenazines with 2-(heteroaryl)amino substituents and their anti-microbial activity. US8716292

4. Liya Zhu, Wenjie Wang, Haihong Huang, Ziyun Lin, Liyuan Mou, Zhengui Nie, YuHe, Xueyu Ouyang, Shanying Peng, Dongfeng Zhang, Jun Wei. Arylamine ketones, their preparation methods, thepharmaceutical composition containing them and their use. CA2576830

5. Liya Zhu, Wenjie Wang, Haihong Huang, Ziyun Lin,Liyuan Mou, Zhengui Nie, Yu He, Xueyu Ouyang, Shanying Peng, Dongfeng Zhang, Jun Wei. Arylamine ketones, theirpreparation methods, the pharmaceutical composition containing them and theiruse, US8524744

6. 朱莉亚、王文杰、黄海洪、林紫云、牟丽媛、聂珍贵、何瑜、欧阳雪宇、彭珊英、张东峰、魏峻，芳胺酮类化合物、其合成方法、含有其的药物组合物及用途，授权号：第I 368614号（中国台湾）

7. Chunrong Yu, Haihong Huang, Dongfeng Zhang, Peng Li. Protein kinase inhibitors, US9174996

8. 黄海洪、余春荣、张东峰、李鹏，蛋白激酶抑制剂，CN104470934

1999年9月 - 2003年6月  沈阳药科大学    制药工程  学士

2005年9月 - 2010年6月  北京协和医学院  药物化学  博士