研究团队现有助理研究员2名，直博生5名，联合培养博士生2名。

已毕业研究生风采

课题组合影-2019教师节                                                              课题组合影-2021年春

国家科技重大专项重大新药创制项目：

2018.01- 2020.12  天然药物与肠道菌群相互作用研究的关键技术（No. 2018ZX09711001-002-002）

国家高技术研究发展计划 (863计划) :

2014.01- 2016.12 结直肠癌早期诊断关键技术研究 (No. SS2014AA020803)

国家科技重大专项项目：

2014.04 -2015.12 香青兰总黄酮有效部位药代动力学研究

2014.01-2016.12 W1302质量控制及临床前药代动力学研究（No. GTZK201310）

2013.01-至今 ZZH107非临床药代动力学研究

国家自然科学基金面上项目： 

2020.01- 2023.12 基于“多组学-多通路”的天然药物J06改善高尿酸血症的药效及分子机制（No. 81973290）

2020.01- 2023.12 过敏性鼻炎患者代谢组学研究 (No.81971515)

2016.01- 2019.12 肠道菌引起的口服异喹啉生物碱药物的代谢转化及分子基础 (No. 81573493)

2012.01- 2015.12 人参皂苷Rg1及代谢产物透过血脑屏障的机制研究

2011.01- 2013.12 苗药头花蓼代谢特征研究 (No. 81072611)

2009.01- 2011.12 藏药花锚活性Xanthones系列衍生物代谢特性研究（No.30873115）

北京市自然科学基金重点项目：

2018. 01- 2021.12 新型多肽TCP-1用于结直肠癌早期诊断的靶向机制及分子基础 (No. 7181007）

中国医学科学院医学与健康科技创新工程项目：

2016.09 - 2020.12 肠道菌与天然药物的相互作用及药理学意义 (No. 2016-I2M-3-011)

2016医科院基本科研业务费“炎症相关疾病国际合作”项目:

2016.11 - 2017.11 天然药物作用肠道菌产生抗炎产物丁酸及药理学意义（No. 2016GH320002）

创新药物非临床药物代谢及药代/药效研究北京市重点实验室项目:

2014.07 - 2015.08 创新药物非临床药物代谢及药代/药效研究北京市重点实验室项目（No. Z141102004414062）

天然药物活性物质与功能国家重点实验室开放课题: 

2014.01 - 2015.12 吉玛烷倍半萜新化合物的代谢立体选择性研究 (No. GTZK201310)

北京市科委“十病十药”研发项目:

2013.07- 2014.08 芍药内酯苷临床前药代动力学及制剂研究试验

“重大新药创制”科技重大专项课题:

2013.01- 2015.12 新型哌嗪基香豆素衍生物IMMLG-5645抗痴呆作用的研究 (No. 2012ZX09103101-006）

“十二五”重大专项临床前品种:

2012.01- 2015.12 新型N6-取代腺苷类镇静催眠候选药物YZG-331研究 (No. 2012ZX09103101-001)

“十二五”重大新药创制科技重大专项: 

2013.01- 2015.12 早期成药性评价关键技术

“十二五”重大专项:

2012.01- 2015.12  药物分析质控平台

“十一五重大专项”综合大平台:

2009.01- 2010.12  重大新药创制—药代平台

2009.01- 2010.12  重大新药创制—质控平台

2009.01- 2010.12  重大新药创制—筛选平台

“十一五重大专项”：

2009.01- 2011.12 左黄皮酰胺—一种新型的抗老年痴呆药物

国家科技支撑计划:

2009.01- 2010.12 临床使用量大面广药品杂质检测技术和安全控制指标

科技部创新方法工作专项:

2012.01- 2012.12 药品安全急需的高效分析测试新技术新方法研究

科技部科技基础性工作专项：

2008.01-2009.05  道地中药材及主要成分的标准物质研制与分析方法研究

2000年科技部重点项目:

2000.04 - 2002.12 桂枝、丹皮、天冬的质量研究

国家食品药品监督管理局项目:

2002.07 - 2004.12 鹿茸精注射液指纹图谱研究

北京市科委项目:

2002.01- 2010.11 北京市科技新星计划

2002 - 2003 抗肾衰新药——XLF-III-43硝克柳胺

药物所基本科研业务费:

2008.02 - 2010.02 藏药花锚活性成分及其代谢物对大鼠肺动脉高压作用机理研究

       迄今，牵头或负责国家“863 ”计划、 “十三五”新药创制重大专项（子课题）、中国医学科学院医学与健康科技创新工程-创新团队（首席专家）、国家自然科学基金面上及青年项目、人事部、北京市自然基金重点项目、北京市科委项目等50 余项。

1.     Wang Y*, Tong Q, Ma SR, Zhao ZX, Pan LB, Cong L,Han P, Peng R, Yu H, Lin Y, Gao TL, Shou JW, Li XY, Zhang XF, Zhang ZW, Fu J,Wen BY, Yu JB, Cao XT*, Jiang JD*. Oral berberine improves brain dopa/dopamine levels to ameliorateParkinson’s disease by regulating gut microbiota. Signal Transduct Target Ther.2021 Feb 24;6(1):1-20.

2.      Han P, Gu JQ, Li LS, Wang XY, Wang HT, Wang Y*, Chang C*, Sun JL*. TheAssociation between Intestinal Bacteria and Allergic Diseases—Cause orConsequence? Front Cell Infect Microbiol. 2021 Apr 15;11:650893.

3.      HanP, Li LS, Wang ZX, Xi L, Yu H, Cong L, Zhang ZW, Fu J, Peng R, Pan LB, Ma SR. WangXY, Wang HT*, Wang Y*, Sun JL*, Jiang JD*. Multi-OmicsAnalysis Provides Insight into the Possible Molecular Mechanism of Hay FeverBased on Gut Microbiota. Engineering. 2021 May 1.

4.     Ma SR, Yu JB, Fu J,Pan LB, Yu H, Han P, Zhang ZW, Peng R, Xu H, Wang, Y*. Determination and Application ofNineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan,and Glutamic Acid Metabolic Pathways. Molecules.2021, 26, 1377.

5.     ShangJ, Ma S, Zang CX, Bao XQ*, Wang Y*, Zhang D*. Gutmicrobiota mediates the absorption of FLZ, a new drug for Parkinson’s diseasetreatment. Acta Pharm Sin B. 2021 May;11(5):1213-1226.

6.     ZhangZW, Cong L, Peng R, Han P, Ma SR, Pan LB, Fu J, Yu H, Wang Y*, Jiang JD*. Transformation of Berberine to ItsDemethylated Metabolites by the CYP51 Enzyme in the Gut Microbiota. J.Pharm. Anal. 2020 Oct 14. https://doi.org/10.1016/j.jpha.2020.10.001.

7.     张正威, 赵朕雄, 王琰*, 蒋建东*. 药物基于“肠-脑”通路的研究进展. 药学学报, 2021, 56(3): 643-653.

8.     解笑瑜，甄雪燕，于航，张正威，王嗣岑*，王琰*，马双成*. 2018年度药物分析技术研究进展. 药物分析杂志, 2020, 40(05):8-25.

9.     Pan L, Han P, Ma S, Peng R,Wang C, Kong W, Cong L, Fu J, Zhang Z, Yu H, Wang Y*, Jiang J.D*. Abnormal metabolism of gut microbiota revealsthe possible molecular mechanism of nephropathy induced by hyperuricemia. ActaPharm Sin B. 2020 Feb; 10(2):249-261.

10.  Peng R, Ma SR, Fu J, Han P, PanLB, Zhang ZW, Yu H, Wang Y*.Transforming of Triptolide into Characteristic Metabolites by the GutMicrobiota. Molecules. 2020 Jan 30;25(3):606..

11.  Wang C, Wang Y, Ma SR, Zuo ZY, Wu YB, Kong WJ*, Wang AP*, Jiang JD*.  Berberine inhibits adipocyte differentiation,proliferation and adiposity through down-regulating galectin-3. SciRep. 2019 Sep 16; 9(1):13415.

12.  Ma SR, Tong Q, Zhao ZX, Cong L,Yu JB, Fu J, Han P, Pan LB, Gu R, Peng R, Zhang ZW, Wang Y*, Jiang JD*. Determination of berberine-upregulatedendogenous short-chain fatty acids through derivatization by2-bromoacetophenone. Anal Bioanal Chem. 2019May;411(14):3191-3207.  

13.  Yu JB, Zhao ZX, Peng R, Pan LB,Fu J, Ma SR, Han P, Cong L, Zhang ZW, Sun LX, Jiang JD*, Wang Y*. Gut Microbiota-Based Pharmacokinetics and theAntidepressant Mechanism of Paeoniflorin. Front Pharmacol. 2019 Mar 20;10:268.

14.  Li C, Chen H, Lan Z, He S, ChenR, Wang F, Liu Z, Li K, Cheng L, Liu Y, Sun K, Wan X, Chen X, Peng H, Li L,Zhang Y, Jing Y, Huang M, Wang Y, Wang Y,Jiang J, Zha X, Chen L*, Zhang H*. mTOR-dependent upregulation of xCT blocksmelanin synthesis and promotes tumorigenesis. Cell Death Differ. 2019Feb 13. doi: 10.1038/s41418-019-0274-0.

15.  Zhen-Xiong Zhao, Jie Fu,Shu-Rong Ma, Ran Peng, Jin-Bo Yu, Lin Cong, Li-Bin Pan, Zuo-Guang Zhang, HuiTian, Chun-Tao Che, Yan Wang*,Jian-Dong Jiang*. Gut-brain axis metabolic pathway regulates antidepressantefficacy of albiflorin. Theranostics. 2018 Nov 13;8(21):5945-5959.

16.  王琰, 蒋建东*. 肠道菌介导的PK-PD 新模式: 小檗碱药代动力学引发的思考. 药学学报, 2018, 53 (5): 659−666.

17.  Li CH, Tang SC, Wong CH, Wang Y*, Jiang JD*, Chen Y*. Berberineinduces miR-373 expression in hepatocytes to inactivate hepatic steatosisassociated AKT-S6 kinase pathway. Eur J Pharmacol. 2018 Apr 15;825:107-118.

18.  Feng R, Zhao ZX, Ma SR, Guo F, Wang Y*, Jiang JD*. Gutmicrobiota-regulated pharmacokinetics of berberine and active metabolites inbeagle dogs after oral administration. Front Pharmacol. 2018 Mar 21; 9:214.

19.  Yan Wang*, Qian Tong, Jia-Wen Shou, Zhen-Xiong Zhao,Xiao-Yang Li, Xian-Feng Zhang, Shu-Rong Ma, Chi-Yu He, Bao-Ying Wen, Fang Guo,Jie Fu, Jian-Dong Jiang*. Gutmicrobiota mediated personalized medicine in berberine treatment. Theranostics. 2017, 7(9):2443-2451.

20.  Chi-Yu He, Jie Fu, Jia-WenShou, Zhen-Xiong Zhao, Long Ren, YanWang* and Jian-Dong Jiang*. In vitrostudy of the metabolic characteristics of eight isoquinoline alkaloids fromnatural plants in rat gut microbiota. Molecules, 2017, 22: 932.

21.  Yan Wang*, Jia-Wen Shou, Xiao-Yang Li, Zhen-XiongZhao, Jie Fu, Chi-Yu He, Ru Feng, Chao Ma, Bao-Ying Wen, Fang Guo, Xin-Yi Yang,Yan-Xing Han, Lu-Lu Wang, Qian Tong, Xue-Fu You, Yuan Lin, Wei-Jia Kong, Shu-YiSi, Jian-Dong Jiang*. Berberine-induced bioactive metabolites of gut microbiotaimproves energy metabolism. Metabolism, 2017, 70:72–84.

22.  潘利斌, 范辉政, 蒋建东, 王琰*. 微量元素硒的体内过程及生物学效应研究进展. 药学学报, 2017, 52 (12): 1849 −1858.

23.  Jian-Li Zhang, Yi-Nong Zhang, Yan Wang*. Validated quantificationmethod for five ephedrines in dietary supplements using LC–MS/MS: Applicationto 503 cases. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 15;1039:1-7.

24.  Jianli Zhang, Jianghai Lu*, YunWu, Xiao-Bing Wang, You-Xuan Xu, Yi-Nong Zhang, Yan Wang*. New potential biomarker for methasterone misuse in humanurine by liquid chromatography quadruple time of flight mass spectrometry. IntJ Mol Sci. 2016, 17: 4486-4492.

25.  Shi-Feng Chu, Shao-Lin Liu,Wen-Zhen Duan, Yong Cheng, Xue-Ying Jiang, Chuan-Jiang Zhu, Kang Tang,Run-Sheng Wang, Lin Xu, Xiao-YingWang, Xiao-Ming Yu, Ke-mei Wu, Yan Wang, Mu-Zou Wang, Hui-Yong Huang,Jun-Tian Zhang. The anti-dementia drug candidate, (−)-clausenamide, improvesmemory impairment through its multi-target effect. Pharmacology & Therapeutics, 2016, 162: 179-187.

26.  Jing-Yi Ma, Xuelin Zhou, JieFu, Chi-Yu He, Ru Feng, Min Huang, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li,Luye Zhang, Yang-Chao Chen, Yan Wang*.In vivo metabolite profiling of apurified ellagitannin isolated fromPolygonum capitatum in Rats. Molecules, 2016, 21: 1110.

27.  Ru Feng, Xiang-Shan Tan,Bao-YingWen, Jia-Wen Shou, Jie Fu, Chi-Yu He, Zhen-Xiong Zhao, Xiao-Yang Li,Hui-Xin Zhu, Ping Zhu, Jian-Gong Shi, Chun-Tao Che, John H.K. Yeung, Xian-FengZhang*, Yan Wang*. Interactioneffects on cytochrome P450 both in vitroand in vivo studies by two majorbioactive xanthones from Haleniaelliptica D. Don. Biomedical Chromatography. 2016, 30:1953-1962.

28.  Chi-Yu He, Ru Feng, Yu-PengSun, Shi-Feng Chu, Ji Chen, Chao Ma, Jie Fu, Zhen-Xiong Zhao, Min Huang,Jia-Wen Shou, Xiao-Yang Li, Yu-Zhu Wang, Jin- Feng Hu, Yan Wang*, Jun-Tian Zhang*. Simultaneous quantification ofginsenoside Rg1 and its metabolites by high performance liquidchromatography–tandem mass spectrometry: Rg1 excretion in rat bile, urine, andfeces. Acta Pharm Sin B. 2016 Nov;6(6):593-599..

1.      《小檗碱》，2018年，科学出版社，参加第八章、十一章编写。

2.      《The Chemistry and Biological Activities of(-)-Clasenamide》, 2014年，化学工业出版社，副主编；

3.      《中草药现代研究》, 2010年，中国协和医科大学出版社, 参加“莪术”和“黄皮”两章的编写；

4.      《常用中草药高效液相色谱分析》，1999年, 科学出版社，参加部分编写。