•        
•        王婧课题组主要从事心肺血管重塑疾病 (肺动脉高压，动脉粥样硬化，高血压，腹主动脉瘤，心力衰竭)的病理机制，分子诊断和治疗方法的研究。
  
• 力图从分子和细胞水平阐述炎症在心肺血管相关疾病的发生发展过程中的作用，寻找抗炎治疗的新靶点。与美国哈佛医学院、罗切斯特大学密切合作，
• 联合培养学生博士后。团队现有副研究员2名、副教授1名、博士后3名、科研助理2名、博士生4名、硕士生1名及联合培养硕士数名。

• 招生要求：对呼吸、循环系统疾病的临床和基础研究感兴趣的有志青年较好的英文阅读和写作能力。
  
• 推荐免试或者统招，基础医学、生物学、临床医学、公共卫生与预防医学,免疫学、细胞生物学、
  
• 生物化学与分子生物学、生物信息学、流行病与卫生统计学相关专业的同学优先考虑。
  

主持国家自然科学基金优秀青年项目（动脉粥样硬化的炎症反应机制，2017-2019）

主持国家自然科学基金面上项目（免疫球蛋白E及其受体在腹主动脉瘤发病过程中的作用，2015-2018）

主持国家自然科学基金重大培育项目（过敏介导的高IgE促进肥大细胞和血管平滑肌功能紊乱导致腹主动脉瘤形成的病理机制，2018-2020）

主持霍英东教育基金 （IgE刺激肥大细胞活化的miR与动脉粥样硬化，2016-2017）

主持国家级青年人才项目 2015-2017

担任中国医学科学院创新工程项目首席（高血压的发病机制与干预研究，2016-2020）

参加国家重点研发计划 （跨器官通讯调控造血稳态的代谢机制研究，2019-2024）

1. Wang M, Zhang Z, Liu J, Song M, Zhang T, Chen Y, Hu H, Yang P, Li B, Song X,Pang J, Xing Y, Cao Z, Guo W, Yang H, Wang J#, Yang J, Wang C. Gefitinib andfostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics studywith drug exploration. Signal Transduct Target Ther. 2022 May 13;7(1):157. doi:10.1038/s41392-022-00959-3.（SCI影响因子18.19）

2. Li Z, Feng Y, Liu H, Yang H, Li J, Zhou Y, Pang J, Yang P, Zhao H, Wang J#.Single-cell transcriptomics of mouse lung reveal inflammatory memory neutrophilsin allergic asthma. Allergy. 2022 Mar 21. doi: 10.1111/all.15286. （SCI影响因子13.15）

3. Ge W*, Guo X*, Song X,Pang J, Zou X,Liu Y, Niu Y, Li Z,Gao R#, Zhao H#, Wang J#. The role of immunoglobulin E and mast cells in hypertension. Cardiovasc Res. 2022 Jan 20:cvac010. doi: 10.1093/cvr/cvac010. （SCI影响因子10.79）

4. Fan T*, Hou Y*, Ge W,Fan TH,Guo W,Song X,Gao R#,Wang J#. Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction. Commun Biol. 2022 Jan 20;5(1):81. doi:10.1038/s42003-022-03029-0. （SCI影响因子6.27）

5. Zhao H*, Yang H*,Geng C*, Chen Y, Pang J, Shu T, Zhao M, Tang Y, Li B,Li Z, Hou C, Song X, Wu A, Guo X,Chen S,Liu B, Yan C#, and Wang J#,Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction. Circulation., 2021. Mar 9;143(10):1014-1030.doi: 10.1161/CIRCULATIONAHA.120.047852. （SCI影响因子29.69）

6. Feng Y*, Song X*, Huang Y*, Deng W, Li M, Guo X, Qin C, Tong W, Liu J#, Wang J#. SARS-CoV-2 leads to myocardial injury in rhesus macaque. Signal Transduct Target Ther. 2021 Sep 6;6(1):338. doi: 10.1038/s41392-021-00747-5.（SCI影响因子18.19）

7. Song X*, Zou X*, Ge W, Hou C, Cao Z, Zhao H, Zhang T, Jin L, Fu Y, Kong W, Yan C, Cai J, Wang J#. Blocking FcγRIIB in smooth muscle cells reduces hypertension.Circ. Res.. 2021, May 13.doi:10.1161/CIRCRESAHA.120.318447, （SCI影响因子17.38）

8. Zhao H*, Yang H*,Geng C*, Chen Y, Tang Y,Li Z, Pang J, Shu T, Nie Y, Liu Y, Jia K, Wang J#. Elevated IgE promotes cardiac fibrosis by suppressing miR-486-5p.Theranostics., 2021, Jun 5; 11(15):7600-7615. doi: 10.7150/thno.47845.（SCI影响因子11.56）

9. Song M, Wang J, Sun Y, Pang J, Li X, Liu Y, Zhou Y, Yang P, Fan T, Liu Y, Li Z, Qi X, Li B, Zhang X#, Wang J#, Wang C#. Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis. Acta Pharm. Sin. B, 2021 In press. doi: 10.1016/j.apsb.2021.10.006.（SCI影响因子11.41）

10. Zhang C*, Zhao H*, Cai Y, Xiong J, Army Mohan,Lou D,Shi H, Zhang Y, Long X,Wang J#,Yan C#, Cyclic Phosphodiesterase 1C contributes to Abdominal Aortic Aneurysm. Proc Natl Acad Sci U S A. 2021 Aug 3;118(31): e2107898118 .doi:10.1073/pnas.2107898118.（SCI影响因子11.21）

11. Tang Y, Li Z, Feng Y,Yang H, Hou C, Geng C, Yang P, Zhao H#, Wang J#. MK2206 attenuates atherosclerosis by inhibiting lipid accumulation, cell migration, proliferation, and inflammation. Acta Pharmacol. Sin. 2021. Jun,27 Accepted.（SCI影响因子6.15）

12. Song M, Wang J, Sun Y, Han Z, Zhou Y, Liu Y, Fan T, Li Z, Qi X, Luo Y, Yang P, Li B, Zhang X#, Wang J#, Wang C. Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages. Acta Pharmacol. Sin., 2021 Aug 20. doi: 10.1038/s41401-021-00693-6.（SCI影响因子6.15）

13. Cao ZJ, Liu Y, Zhang Z, Yang PR, Li ZG, Song MY, Qi XM, Han ZF, Pang JL, Li BC, Zhang XR, Dai HP, Wang J#, Wang C. Pirfenidone ameliorates silica-induced lung inflammation and fibrosis in mice by inhibiting the secretion of interleukin-17A. Acta Pharmacol Sin. 2021 Jul 27. doi: 10.1038/s41401-021-00706-4. （SCI影响因子6.15）

14. Shu T, Xing Y#, Wang J#. Autoimmunity in pulmonary arterial hypertension: evidences for local immunoglobulins production. Front Cardiovasc Med. 2021, Sep 21;8:680109. doi: 10.3389/fcvm.2021.680109. eCollection 2021.（SCI影响因子6.05）

15. Li BL, Song X, Guo W, Hou Y, Ge W, Fan T, Yang P, Gao R#, Zhao H#, Wang J#. Single-cell transcriptome profiles reveal fibrocytes as potential targets of cell therapies for abdominal aortic aneurysm. Front. Cardiovasc. Med. 2021(In press)（SCI影响因子6.05）

16. Li Z, Zhao H, Wang J#. Metabolism and Chronic Inflammation: The Links Between Chronic Heart Failure and Comorbidities. Front Cardiovasc Med. 2021 May 5;8:650278. doi: 10.3389/fcvm.2021.650278.（SCI影响因子6.05）

17. Hou Y, Guo W, Fan T, Li B, Ge W, Gao R#, Wang J#. Advanced Research of Abdominal Aortic Aneurysms on Metabolism. Front Cardiovasc Med. 2021 Feb 5;8: 630269.doi: 10.3389/fcvm.2021.630269.（SCI影响因子6.05）

18. Ge W*,Hou C*, Zhang W,Guo X,Gao P, Song X,Gao R,Liu Y,Guo W,Li BL, Zhao H#, Wang J#. Mep1a Contribute to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis, and inflammation. J Mol Cell Cardiol.2021 Mar;152:52-68. doi: 10.1016/j.yjmcc.2020.11.015.  （SCI影响因子17.367）（SCI影响因子 5）

19. Liu J, Yang C, Liu T, Deng Z, Fang W, Zhang X, Li J, Huang Q, Liu C, Wang Y,Yang D, Sukhova GK, Lindholt JS, Diederichsen A, Rasmussen LM, Li D, Newton G,Luscinskas FW, Liu L, Libby P, Wang J#, Guo J#, Shi GP#. Eosinophils improvecardiac function after myocardial infarction. Nat Commun. 2020 Dec16;11(1):6396. doi: 10.1038/s41467-020-19297-5. （SCI影响因子14.92）                        

20. Pang JL, Qi XM, Luo Y, Li XN, Shu T, Li BC, Song MY, Liu Y, Wei D, Wang J#, Chen Jingyu #, Chen Wang#. Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2. Theranostics., 2021; 11(5): 2381-2394. doi: 10.7150/thno.47627. （SCI影响因子11.56）

21. Gao R*, Liu D*, Guo W, Ge W, Fan T, Li B, Gao P, Liu B, Zheng Y#, Wang J#. Mep1A enhances TNF-alpha secretion by mast cells and aggravates abdominal aortic aneurysms. Br J Pharmacol. 2020 Jun; 177(12): 2872-2885.（SCI影响因子8.74）

22. Cao ZJ, Song MY, Liu Y, Pang JL, Li ZG, Qi XM, Shu T, Li BC, Wei D, Chen J, Li BL,Wang J#, Wang C#. A novel pathophysiological classification of silicosis modelsprovides some new insights into the progression of the disease. Ecotoxicol Environ Saf. 2020 Oct 1; 202:110834. doi: 10.1016/j.ecoenv.2020.110834. Epub 2020Jul 1.（SCI影响因子6.3）

23. Zhou Y, Huang Y, Song X, Guo X, Pang J, Wang J#, Zhang S, Wang C. Single-cell transcriptional profile of ACE2 in healthy and failing human hearts. Sci China Life Sci. 2020 Sep 1:1–4. doi: 10.1007/s11427-020-1787-5. Epub ahead of print. （SCI影响因子6.04）

24. Guo W, Gao R, Zhang W, Ge W, Ren M, Li B, Zhao H, Wang J#. IgE Aggravates the Senescence of Smooth Muscle Cells in Abdominal Aortic Aneurysm by Upregulating LincRNA-p21. Aging Dis. 2019 Aug 1;10(4):699-710. doi: 10.14336/AD.2018.1128.（SCI影响因子6.75）

25. Song X, Li B, Wang H, Zou X, Gao R, Zhang W, Shu T, Zhao H, Liu B, Wang J#. Asthma alleviates obesity in males through regulating metabolism and energy expenditure.Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):350-359. doi: 10.1016/j.bbadis.2018.10.001. Epub 2018 Oct 2.（SCI影响因子5.19）

26. Shu T, Song X, Cui X, Ge W, Gao R, Wang J#. Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis. Int J Mol Sci. 2018 Sep 26;19(10):2932. doi: 10.3390/ijms19102932.（SCI影响因子5.92）

27. Xu Z, Wang T, Guo X, Li Y, Hu Y, Ma C, Wang J#. The Relationship of Serum.Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases. Int J Med Sci. 2018 Jul 1;15(11):1098-1104. doi: 10.7150/ijms.25857. （SCI影响因子5.92）

28. Zhao H, Song X, Yan L, Ren M, Cui X, Li Y, Gao R, Zhang W, Liu M, Liu B, Hu Y, Wang J#. IgE induces hypotension in asthma mice by down-regulating vascular NCX1 expression through activating MiR-212-5p. Biophys Acta Mol Basis Dis 2018 Jan;1864(1):189-196. doi: 10.1016/j.bbadis.2017.10.011. Epub 2017 Oct 6. （SCI影响因子5.19）

29. Wang ZQ, Ni L, Wang J#, Lu CR, Ren M, Han W, Liu CW#. The protective effect of melatonin on smoke-induced vascular injury in rats and humans: a randomized controlled trial. J Pineal Res. 2016 Mar;60(2):217-27. doi: 10.1111/jpi.12305. Epub 2016 Jan 13.（SCI影响因子 13）

30. Guo X, Yuan S, Liu Y, Zeng Y, Xie H, Liu Z, Zhang S, Fang Q, Wang J#, Shen Z#. Serum IgE levels are associated with coronary artery disease severity. Atherosclerosis. 2016 Aug; 251:355-360. doi: 10.1016/j.atherosclerosis.2016.05.020. Epub 2016 May 12. （SCI影响因子5.17）

31. Wang J*, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015 Jul;21(7):820-6. doi: 10.1038/nm.3890. Epub 2015 Jun 22. （SCI影响因子53.44）

32. Wang J*, Lindholt JS, Sukhova GK, Shi MA, Xia M, Chen H, Xiang M, He A, Wang Y, Xiong N, Libby P, Wang JA, Shi GP. IgE actions on CD4+ T cells, mast cells,and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. EMBO Mol Med. 2014 Jul;6(7):952-69. doi: 10.15252/emmm.201303811. （SCI影响因子12.14）

33. Wang J*, Sjöberg S, Tang TT, Oörni K, Wu W, Liu C, Secco B, Tia V, Sukhova GK, Fernandes C, Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biophys Acta Mol Basis Dis. 2014 Nov;1842(11):2174-83doi: 10.1016/j.bbadis.2014.07.026. Epub 2014 Aug 1.（SCI影响因子5.19）

34. Pang J, Xu X, Wang X, Majumder S, Wang J, Korshunov VA, Berk BC. G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration. Arterioscler Thromb Vasc Biol. 2013 May;33(5): 999-1005.doi: 10.1161/ATVBAHA.112.300966. Epub 2013 Feb 21. （SCI影响因子 8.31）

35. Chen H*, Wang J*, Sjoberg S, Libby P, Shi GP. E64d Deteriorates Post-Myocardial Infarction Left Ventricular Remodeling by Inhibiting Cathepsin S-Mediated Fibroblast Trans-Differentiation. Cardiovasc Res. 2013 Oct 1;100(1):84-94 doi: 10.1093/cvr/cvt158. Epub 2013 Jun 14.（SCI影响因子10.79）

36. Wang J*, Sun J, Sjöberg S, Tia V, Secco B, Chen H, Shi GP. Pharmaceutical stabilization of mast cells attenuate experimental atherogenesis in low-density lipoprotein receptor-deficient mice Atherosclerosis, 2013, Aug;229(2):304-9. doi: 10.1016/j.atherosclerosis.2013.05.025. Epub 2013 Jun 7. （SCI影响因子5.17）

37. Lv BJ, Lindholt JS, Wang J, Cheng X, Shi GP. Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study. Atherosclerosis. 2013 Sep;230(1):100-5. doi: 10.1016/j.atherosclerosis.2013.05.018. Epub 2013 Jul 14. （SCI影响因子5.17）

38. Liao YH, Xia N, Zhou SF, Tang TT, Yan XX, Lv BJ, Nie SF, Wang J, Iwakura Y, Xiao H, Yuan J, Jevallee H, Wei F, Shi GP, Cheng X. Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. Journal of the American College of Cardiology, 2012 Jan 24;59(4):420-9. doi: 10.1016/j.jacc.2011.10.863. （SCI影响因子 24.1）

39. Cheng X*, Wang J*, Xia N, Yan XX, Tang TT, Chen H, Zhang HJ, Liu J, Kong W, Sjöberg S, Folco E, Libby P, Liao YH, Shi GP.  A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med., 2012, Oct;4(10):1112-25 doi: 10.1002/emmm.201201272.（SCI影响因子12.14）

40. Wang J*, Cheng X, Xiang M, Kinnunen M, Wang J, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjoberg S , Sukhova G, Liao YH, Conrad D, Yu LY, Kawakami T, Kovanen P, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice. J Clin Invest., 2011 Sep;121(9):3564-77 doi: 10.1172/JCI46028. Epub 2011 Aug 8.（SCI影响因子14.8）

41. Wang J*, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC Phosphorylation of G Protein-Coupled Receptor Kinase 2-Interacting Protein 1 Tyrosine 392 Is Required for Phospholipase C-{gamma} Activation and Podosome Formation in Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol., 2010 Oct;30(10):1976-82. doi: 10.1161/ATVBAHA.110.212415. Epub 2010 Aug 5.（SCI影响因子8.31）

42. Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC. G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation, 2009 Mar 24;119(11):1524-32. doi: 10.1161/CIRCULATIONAHA.108.823997. Epub 2009 Mar 9. （SCI影响因子29.69）

43. Wang J*, Taba Y, Pang J, Yin G, Yan C, Berk BC. GIT1 mediates VEGF-induced endothelial cell podosome formation-critic role for PLCγ. Arterioscler Thromb Vasc Biol., 2009 Feb;29(2):202-8. doi: 10.1161/ATVBAHA.108.174391. Epub 2008 Nov 20. （SCI影响因子8.31）

44. Wang J*, Pan S, Berk BC. Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arterioscler Thromb Vasc Biol., 2007 Jun;27(6):1283-8. doi: 10.1161/ATVBAHA.107.144659. Epub 2007 Apr 12.（SCI影响因子8.31）

党委书记，中国医学科学院基础医学研究所，2022-至今

副所长，中国医学科学院基础医学研究所，2021-至今

主任，北京协和医学院教师发展中心，2020-至今

副主任，中国医学科学院基础医学研究所病理生理学系，2014-至今

研究员，中国医学科学院基础医学研究所，2014-至今

研究助理教授，哈佛医学院，2013-2014

讲师，哈佛医学院，2012-2013

博士后，哈佛医学院，2009-2012

王婧课题组主要开展肺动脉高压、动脉粥样硬化、腹主动脉瘤、高血压、心脏衰竭等重大心肺血管疾病的分子诊断、病理生理机制和干预治疗研究。重点关注炎症、代谢等关键机制在疾病发生发展中的重要作用，解决临床表象下潜在的科学问题：

1、通过大规模对临床样本的筛查分析，发现重大心血管疾病新的生物诊断标志物，为高异质性的重大心血管疾病精细分型提供新诊断分子；

2、基于小动物模型和原代细胞模型，利用多组学手段和系统生物学方法，筛选并阐明关键靶点的新分子机制；

3、针对不同类型的心血管疾病建立标准的疾病动物模型，建立稳定的体内药效评价系统，开发重大心肺血管疾病新的靶向治疗药物。