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刘晓军，男，博士，中国医学科学院基础医学研究所研究员，博士研究生导师。主要从事2型糖尿病、非酒精性脂肪肝、肥胖等代谢性疾病分子病理机制和干预研究。通过筛选不同营养与环境条件下造成的代谢组织（如肝脏、脂肪组织）差异表达基因和lncRNA，利用分子生物学、细胞生物学等实验方法，在动物、细胞和分子水平层面上深入研究其在糖脂代谢、慢性炎症以及氧化应激中的功能和分子机制，并筛选可能的小分子药物和中药。作为负责人主持国家自然基金面上项目和青年基金，北京市自然基金面上项目，参与中国医学科学院北京协和医学院创新工程工程项目。曾作为负责人承担北京协和医学院研究生课程《分子生物学实验》的教学工作。参与研究的项目《中国人2型糖尿病易感基因生物学功能及作用机制的研究》获2008年中华医学科技奖三等奖。2011年获北京协和医学院“协和新星”称号。2011年获医科院基础所“先进科研工作者”称号。2019年7月获“国家卫生健康委直属机关优秀共产党员”称号。国家自然科学基金，北京市自然科学基金评审专家，教育部学位论文评审专家。SCI杂志Cell Proliferation, Cell & Bioscience, Oxidative Medicine and Cellular Longevity, Plos One, Cardiology Research and Practice, International Immunopharmacology等杂志审稿专家。已发表学术论文30余篇，其中以第一作者或通讯作者在J Hepatol., Sci China Life Sci., Mol Metab., iSCIENCE, J Proteome Res., J Mol Med (Berl).等杂志发表论文10余篇。
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支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpegSelectedPublications: (* Corresponding author, # Co-first author)
1. Zhao W #，*, Ruze R #, Xie X #, Yang J, Yao H, Fang F, Xu Q *, Liu X *. Protocol to knock in or out target genes in mouseepidydimal white adipose tissue by spot injecting adeno-associated viruses. STAR Protocols, 2022 Dec 16; (3):101820.
2. Zhao W #, Yang J #, Xie X, Li C, Zhang W, Chen E, Guo Y, YanL, Fang F, Yao H*, Liu X*. A MDM2inhibitor MX69 inhibits adipocytes adipogenesis and differentiation. Biochem Biophys Res Commun. 625 (2022) 9-15. https://doi.org/10.1016/j.bbrc.2022.07.115
3. Zhao W #, Xu Q #, Yang J, Xie X, Li C, Zhang W, Chen E, Guo Y, Gao M, Shi J, Zhang H, Yao H, Li M, Yan L, Fang F, Wu W*, Liu X*.Murine double minute 2 aggravates adipose tissue dysfunction throughubiquitin-mediated six-transmembrane epithelial antigen of prostate 4degradation. iScience. 2022 Jun7;25(7):104544. doi:10.1016/j.isci.2022.104544. eCollection 2022 Jul15.
4. Geng C #, Xue Y #, Yang JH #, Gao MY, Zhao W, Li CM, Xie XH, Zhang WH, Zhang HB, Fang F, Yao H*, Liu XJ*. SIRT1 Mediates Sestrin1-Induced Improvement in Hepatic Insulin Resistance. Biomed Environ Sci. 2022 Jan 20;35(1):79-83. doi: 10.3967/bes2022.011.
5. Xu M, Xiang Y, Liu X, Bai B, Chen R, Liu L, Li M. Long noncoding RNA SMRG regulatesDrosophila macrochaetes by antagonizing scute through E(spl)mβ. RNA Biol. 2019 Jan;16(1):42-53. doi: 10.1080/15476286.2018.1556148. Epub2018 Dec 17.
6. Gao M, Zhao W, Li C, Xie X, Li M, Bi Y, Fang F, Du Y*, Liu X*. Spermidineameliorates non-alcoholic fatty liver disease through regulating lipid metabolismvia AMPK. Biochem Biophys Res Commun. 2018 Oct 20;505(1):93-98.doi:10.1016/j.bbrc.2018.09.078. Epub 2018 Sep 18.
7. Geng C #, Xu H #, Zhang Y, Gao Y, Li M, Liu X, Gao M, Wang X, Liu X*, Fang F*, Chang Y*. Retinoic acid ameliorates high-fat diet-inducedliver steatosis through sirt1. Sci China Life Sci. 2017 Nov;60(11):1234-1241. doi:10.1007/s11427-016-9027-6. Epub 2017 Jun 29.
8. Yang YG #, Li MX #, Kou L, Zhou Y, Qin YW, Liu XJ*,Chen Z*. Long Noncoding RNA Expression Signatures of Abdominal Aortic Aneurysm Revealed by Microarray. Biomed Environ Sci. 2016 Oct;29(10):713-723.
9. Zhang Y, Geng C, Liu X, Li M, Gao M, Liu X*, Fang F*, Chang Y*. Celastrolameliorates liver metabolic damage caused by a high-fat diet through Sirt1. MolMetab. 2016 Nov 17;6(1):138-147. doi:10.1016/j.molmet.2016.11.002.eCollection 2017 Jan. (Highlighted by Nature Reviews Endocrinology,doi:10.1038/nrendo.2016.202)
10. Geng C, Zhang Y, Gao Y, Tao W, Zhang H, Liu X*, Fang F*, Chang Y*. Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice. Biochem Biophys Res Commun. 2016 Mar 18;471(4):444-9.doi: 10.1016/j.bbrc.2016.02.059.Epub 2016 Feb 20.
11. Liu X #, *,Gao Y #, Li M #, Geng C, Xu H, Yang Y, Guo Y, Jiao T,Fang F*, Chang Y*. Sirt1 mediates the effect of the heme oxygenase inducer,cobalt protoporphyrin, on ameliorating liver metabolic damage caused by ahigh-fat diet. J Hepatol. 2015 Sep;63(3):713-21.doi:10.1016/j.jhep.2015.05.018. Epub 2015 May 27.
12. Liu X, Fang F. Type 2 diabetes caused by reductive redox potential? Sci China Life Sci. 2014 Jul;57(7):729-30. (Insight)
13. Liu X #, *,Cui Y #, Li M, Xu H, Zuo J, Fang F*, Chang Y*. Cobalt protoporphyrininduces HO-1 expression mediated partially by FOXO1 and reduces mitochondria-derivedreactive oxygen species production. PLoS One. 2013 Nov 8;8(11):e80521. doi:10.1371/journal.pone.0080521.eCollection 2013.
14. Li M, Wen S, Guo X, Bai B, Gong Z, Liu X, Wang Y, Zhou Y, Chen X, Liu L,Chen R. The novel long non-coding RNA CRG regulates Drosophila locomotorbehavior. Nucleic Acids Res. 2012 Dec 1;40(22):11714-11727. Epub2012 Oct 15.
15. Qiao A, Liang J, Ke Y, Li C, Cui Y, Shen L, Zhang H, Cui A, Liu X, Liu C, Chen Y, Zhu Y, Guan Y, Fang F, Chang Y. Mouse PNPLA3 influences systemic lipid and glucose homeostasis. Hepatology. 2011 Aug;54(2):509-21.
16. Liu X #, Qiao A #, Ke Y, Kong X, Liang J, Wang R, Ouyang X, Zuo J, Chang Y, Fang F. FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoterin HepG2 cells. FEBS Lett. 2010 Oct 22;584(20):4330-4. doi:10.1016/j.febslet.2010.09.027. Epub 2010 Sep 23.
17. Zhu L, Ke Y, Shao D, Cui Y, Qiao A, Liu X, Fang F, Chang Y. PPARγ co-activator-1α co-activatessteroidogenic factor 1 to stimulate the synthesis of luteinizinghormone and aldosterone. Biochem J. 2010 Nov 25;432(3):473-83.
18. Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y. Sirtuin 3, a new target ofPGC-1alpha, plays an important role in the suppression of ROS and mitochondrialbiogenesis. PLoS One. 2010 Jul 22;5(7):e11707.
19. Wang R, Kong X, Cui A, Liu X, Xiang R,Yang Y, Guan Y, Fang F, Chang Y. Sterol-regulatory-element-bindingprotein 1c mediates the effect of insulin on the expression ofCidea in mouse hepatocytes. Biochem J. 2010 Sep 1;430(2):245-54.
20. Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, Qiao A, Kong X, Liu Y, Chen Q, Gupta N, Fang F, Chang Y. PGC-1 beta-regulated mitochondrial biogenesis and function inmyotubes is mediated by NRF-1 and ERR alpha. Mitochondrion. 2010Aug;10(5):516-27.
21. Zhu LL, Liu Y, Cui AF, Shao D, Liang JC, LiuXJ, Chen Y, Gupta N, Fang FD, Chang YS. PGC-1alpha coactivates estrogen-related receptor-alpha to induce the expression of glucokinase. Am J Physiol Endocrinol Metab. 2010Jun;298(6):E1210-8.
22. Yang YL, Xiang RL, Yang C, Liu XJ, Shen WJ, Zuo J, Chang YS, Fang FD. Gene expression profile of human skeletal muscle and adipose tissue of Chinese Han patients with type 2 diabetes mellitus. Biomed Environ Sci. 2009 Oct;22(5):359-68.
23. Kong X, Fan H, Liu X, Wang R, Liang J,Gupta N, Chen Y, Fang F, Chang Y. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridinephosphorylase. Mol Pharmacol. 2009 Oct;76(4):854-60.
24. Liu X #, Feng Q #, Chen Y, Zuo J, Gupta N, Chang Y, Fang F. Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. J Proteome Res. 2009 Mar;8(3):1255-62. doi: 10.1021/pr800850a.
25. Liu XJ #, Yang C #, Gupta N, Zuo J, Chang YS, Fang FD. Protein kinase C-zeta regulation of GLUT4 translocation through actin remodeling in CHO cells. J Mol Med (Berl). 2007 Aug;85(8):851-61. Epub 2007 Jul 10.
26. Yang C, Yang Y, Gupta N, Liu X, He A, Liu L, Zuo J, Chang Y, Fang F. Pentaspanmembrane glycoprotein, prominin-1, is involved in glucose metabolism andcytoskeleton alteration. Biochemistry (Mosc). 2007 Aug;72(8):854-62.
27. He A, Liu X, Liu L, Chang Y, Fang F. How many signals impinge on GLUT4activation by insulin? Cell Signal. 2007 Jan;19(1):1-7.Epub 2006 Jun 2. (Review)
28. Liu XJ, He AB, Chang YS, Fang FD. Atypical Protein Kinase C in Glucose Metabolism. Cell Signal. 18 (2006) 2071–2076. (Review)
29. Liu LZ, He AB, Liu XJ, Li Y, Chang YS, Fang FD. Protein kinase Czeta and glucose uptake. Biochemistry (Mosc).2006 Jul;71(7):701-6. (Review)
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