国自然基金委“优青”基金、面上项目、科技部重点研发计划等项目资助。

代表性文章 :

1.  Zika NS1–induced ERremodeling is essential for viral replication. Yali Ci, ZhongYu Liu, NaNa Zhang, Yuqiang Niu, Yang Yang, Caimin Xu, WeiYang#, ChengFeng Qin#, and Lei Shi#.            J. Cell Biol.  2020, 219 (2): e201903062.

2.  Zika virus NS3 is acanonical RNA helicase stimulated by NS5 RNA polymerase.  Shan Xu, Yali Ci, Leijie Wang, Yang Yang,Leiliang Zhang , Caimin Xu Chengfeng Qin and Lei Shi#.           NucleicAcids Research.  2019, Vol. 47, No. 16 8693–8707.

3. Electrostatic Interaction Between NS1 and Negatively Charged Lipids Contributes to Flavivirus Replication Organelles Formation. Ci Y, Yang Y, Xu C, Qin CF, Lei Shi#.                Front Microbiol. 2021 May 6;12:641059.

3.  Zika NS2B is a crucialfactor recruiting NS3 to the ER and activating its protease activity. HuaipengXing, Shan Xu, Fangfei Jia, Yang Yang, Caimin Xu, Chengfeng Qin#，Lei Shi#.         VirusResearch.  275 (2020) 197793.

4.  Vesicular stomatitis virus G proteintransmembrane region is crucial for the hemi-fusion to full fusion transition.  Yali Ci, Yang Yang, Caimin Xu, Lei Shi#.              Sci Rep.  2018 Jul13;8(1):10669.

5.  ROSinhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53in selenite-treated NB4 cells. Ci Y, Shi K, An J, Yang Y, Hui K, Wu P, Shi L#, Xu C#.               CellDeath Dis.  2014 Nov27;5:e1542.

6.  SNARE Proteins: One to Fuse and Threeto Keep the Nascent Fusion Pore Open.                                                                        ShiL, Shen QT, Alexander Kiel, WangJ, Wang HW, Melia TJ, Rothman JE, Frédéric Pincet.        Science.  2012 Mar 16, 355:1355-1359.(由美国《科学家》杂志（TheScientist）报道，并被Faculty 1000推荐)

7.  Preparation and characterization ofSNARE-containing nanodiscs and direct study of cargo release through fusionpores.          Shi L*, Kevin Howan*, Qing-tao Shen, Yong Jian Wang, James E. Rothman,Frédéric Pincet.      NatureProtocols.  2013May;8(5):935-48. ( * these authors contribute equally).

8.  Dual roles of Munc18-1 rely ondistinct binding modes of the central cavity with Stx1A and SNARE complex.                                 Shi L, Kümmel D, Coleman J, Melia TJ, Giraudo CG.           Mol Biol Cell.  2011 Nov;22(21):4150-60.