导师风采
高磊
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  • 研究员
  • 导师类别:博士生导师
  • 性别:
  • 学历:博士研究生
  • 学位:博士

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  • 所属院系:病原生物学研究所
  • 所属专业: 流行病与卫生统计学
  • 邮箱 : gaolei@ipbcams.ac.cn
  • 工作电话 : 010-67855003

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高磊,中国医学科学院病原生物学研究所研究员,博士生导师,主要从事传染病流行病学研究。承担了国家传染病科技重大专项、国家自然科学基金、中国医学科学院医学与健康科技创新工程和国际合作等多项课题。作为第一作者或通讯作者在Lancet Infectious Diseases,EuropeanRespiratory Journal等国际学术期刊发表SCI论文50余篇。入选教育部新世纪优秀人才、北京市科技新星、协和新星等。获得中华预防医学会科学技术一等奖、中国防痨协会科学技术一等奖、中华医学科学技术二等奖、中国医学科学院“杰出贡献奖”、中国医学科学院-法国梅里埃研究院“青年科学家奖”等。兼任国家传染病标准专业委员会委员、中国防痨协会结核潜伏感染防治专业分会副主任委员、中国防痨协会标准化专业分会秘书长、第一批国家健康科普专家库成员,以及中华结核和呼吸杂志、中国防痨杂志、BMC Infectious Diseases、PLOS Global Public Health、Chronic Diseases and Translational Medicine等期刊编委。


  • 研究方向Research Directions
传染病流行病学和干预研究
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
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科研项目

项目来源

项目名称

项目时间

分工

中国医学科学院医学与健康科技创新工程

农村中老年人群结核潜伏感染流行病学调查和干预研究队列

2019-2020

负责人

传染病防治科技重大项目

既往肺结核患者潜伏感染干预技术研究

2017-2020

负责人

中国医学科学院医学与健康科技创新工程

农村中老年人群结核分枝杆菌感染进程的前瞻性研究

2016-2018

任务负责人

传染病防治科技重大项目

结核分枝杆菌感染的流行病学调查和队列研究

2013-2015

负责人

传染病防治科技重大项目

结核分枝杆菌潜伏感染人群的干预研究

2014-2016

负责人

教育部新世纪优秀人才支持计划项目

初治涂阳肺结核患者治疗转归的分子流行病学研究

2011-2013

负责人

北京市科技新星

北京市男性人群人乳头瘤病毒(HPV)感染状况及疫苗接受度调查

2012-2015

负责人

国家自然科学基金青年基金项目

男男性行为人群HIV/HPV合并感染的分子流行病学研究

2011-2013

负责人



研究成果

近五年原创论文(累计IF=140.69,平均IF=7.03)

1.        Gao L, LiX, Liu J, Wang X, Lu W, Bai L, Xin H, Zhang H, Li H, Zhang Z, Ma Y, Li M, FengB, Du J, Sui H, Zhao R, Su H, Pan S, Guan L, Shen F, He J, Yang S, Si H, ChengX, Xu Z, Tan Y, Chen T, Xu W, Peng H, Wang Z, Zhu T, Chen X, Zhou X, Guan X,Jin Q*; LATENTTB-NSTM study team. Incidence of active tuberculosis among individualswith latent tuberculosis infection in rural China: follow-up results of apopulation-based multicenter prospective cohort study. Lancet Infect Dis.2017;17(10):1053-61 .(共同第一作者, IF=25.071)

2.        Gao L*,Zhang H, Xin H, Liu J, Pan S, Li X, Guan L, Shen F, Liu Z, Wang D, Guan X, YanJ, Li H, Feng B, Cao X, Chen Y, Cui W, Zhang Z, Ma Y, Chen X, Zhou X, Jin Q*;LATENTTB-NSTM study team. Short-course regimens of rifapentineplus isoniazid to treat latent tuberculosisinfection in older Chinese: a randomisedcontrolled study. Eur Respir J. 2018;52(6):1801470. (共同第一作者, 共同通讯作者,IF=16.671)

3.        Gao L*, BaiL, Liu J, Lu W, Wang X, Li X, Du J, Chen X, Zhang H, Xin H, Sui H, Li H, Su H,He J, Pan S, Peng H, Xu Z, Catanzaro A, Evans TG, Zhang Z, Ma Y, Li M, Feng B,Li Z, Guan L, Shen F, Wang Z, Zhu T, Yang S, Si H, Wang Y, Tan Y, Chen T, ChenC, Xia Y, Cheng S, Xu W, Jin Q*; LATENTTB-NSTM study team. Annual risk oftuberculosis infection in rural China: a population-based prospective study.Eur Respir J. 2016;48(1):168-78. (共同第一作者, 共同通讯作者,IF=16.671)

4.        Xin H, Zhang H, Yang S, Liu J, Lu Wei, Bai L, Cao X,Feng B, Jin Q, Gao L*. 5-year follow-up of active tuberculosis development fromlatent infection in rural China. Clin Infect Dis. 2020;70(5):947-50.(通讯作者, IF=9.079)

5.        Xin H, Cao X, Zhang H, Liu J, Pan S, Li X, Guan L,Shen F, Liu Z, Wang D, Guan X, Yan J, Li H, Feng B, Zhang M, Yang Q, Jin Q, GaoL*; LATENTTB-NSTM study team. Dynamicchanges of interferon-gamma Release Assay results along with latenttuberculosis infection treatment. Clin Microbiol Infect. 2020;26(11):p1555.e1-7.(通讯作者, IF=8.067)

6.        Xin H, Zhang H, Liu J, Pan S, Li X, Cao X, Feng B,Guan L, Shen F, Liu Z, Wang D, Yan J, Zhang M, Yang Q, Jin Q, Gao L*. Tuberculosis infection amongthe elderly in 20,486 rural residents aged 50-70 years old in Zhongmu County,China. Clin Microbiol Infect. 2019;25(9):1120-6. (通讯作者, IF=8.067)

7.        Zhang H, Xin H, Wang D, Pan S, Liu Z, Cao X, Wang J,Li X, Feng B, Li M, Yang Q, Zhang M, Jin Q, Gao L*. Serial testing of mycobacteriumtuberculosis infection in Chinese village doctors by QuantiFERON-TB Gold Plus,QuantiFERON-TB Gold In-Tube and T-SPOT.TB. J Infect. 2019;78(4):305-10. (通讯作者, IF=6.072)

8.        Xin H, Zhang H, Cao X, Li X, Li M, Feng B, Jin Q, Gao L*. Serum level of IL-8 is associated with reversion ofQuantiFERON-TB gold in-tube tests. J Infect. 2019;78(4):292-8. (通讯作者, IF=6.072)

9.        Zhang H, Xin H, Li X, Li H, Li M, Feng B, Gao L*. Reversion of QuantiFERON-TB Gold In-Tube test inindividuals with and without prophylactic treatment for latent tuberculosisinfection: A systematic review and meta-analysis. J Infect. 2018;77(4):276-82. (通讯作者, IF=6.072)

10.    Li H, Xin H, Qian S, Li X, Zhang H, Li M, Feng B, JinQ, Gao L*. The testing of tuberculosisinfection among the adolescents born after booster Bacillus Calmette-Guérin vaccination was terminatedin China: Subgroup analysis of a population-based cross-sectional study. FrontMed. 2017;11(4):528-535. (通讯作者, IF=4.592)

11.     Li X, Cao X, Li Z, Yang Y, Li M,Feng B, Xin H, Zhang H, Gao L*. Human Papillomavirus awareness and vaccine acceptability amongmen who have sex with men from mainland China. Sci Rep.2019;9(1):8763. (通讯作者, IF=4.379)

12.     Li X,Yang Q, Feng B, Xin H, Zhang M, Deng Q, Deng G, Shan W, Yue J, Zhang H, Li M,Li H, Jin Q, Chen X*, Gao L*. Tuberculosis infection inrural labor migrants in Shenzhen, China: Emerging challenge to tuberculosiscontrol during urbanization. Sci Rep. 2017;7(1):4457. (共同通讯作者, IF=4.379)

13.     Zhang H, Li X, Xin H, Li H,Li M, Lu W, Bai L, Wang X, Liu J, Jin Q*, GaoL*. Association of body mass index with the tuberculosis infection: a population-basedstudy among 17796 adults in rural China. Sci Rep. 2017;7:41933. (共同通讯作者, IF=4.379)

14.     Li X,Li M, Yang Y, Zhong X, Feng B, Xin H, Li Z, Jin Q*, Gao L*. Anal HPV/HIV co-infection among Men Who Have Sex with Men:a cross-sectional survey from three cities in China. Sci Rep. 2016;6:21368. (共同通讯作者, IF=4.379)

15.    Zhang H, Xin H, Li X, Li H, Li M, Lu W, Bai L, Wang X, Liu J, Jin Q, GaoL*. Adose-response relationship of smoking with tuberculosis infection: across-sectional study among 21008 rural residents in China. PloS One.2017;12(4):e0175183. (通讯作者, IF=3.240)

16.    Xin H, Yang Y, Liu J, Li X, Li M, Feng B, Li Z, ZhangH, Li H, Shen F, Guan L, Gao L*.Association between tuberculosis and circulating microRNA hsa-let-7b andhsa-miR-30b: A pilot study in a Chinese population. Tuberculosis (Edinb).2016;99:63-9. (通讯作者, IF=3.131)

17.    Zhang H, Cao X, Xin H, Liu J, Pan S, Guan L, Shen F,Liu Z, Wang D, Guan X, Yan J, Feng B, Li N, Jin Q, Gao L*. Serumlevel of IL-1ra was associated with the treatment of latent tuberculosisinfection in a Chinese population. BMC Infect Dis.2020;20(1):330. (通讯作者, IF=3.091)

18.    Xin H, Li H, Li Z, Li X, Li M, Zhang H, Feng B, Lun W,Yan H, Long J, Gao L*. Genital HPVinfection among heterosexual and homosexual male attendees of sexually transmitteddiseases clinic in Beijing, China. Epidemiol Infect. 2017;145(13):2838-47. (通讯作者, IF=2.451)

19.    Xin H, Li X, Zhang L, Li Z, Zhang H, Yang Y, Li M,Feng B, Li H, Gao L*. Tuberculosisinfection testing in HIV-positive men who have sex with men from Xi'an China.Epidemiol Infect. 2017;145(3):498-502. (通讯作者, IF=2.451)

20.    Zhang H, Cao X, Wang D, Xin H, Liu Z, Yan J, FengB, Quan Z, Du Y, Liu J, Guan L, Shen F, Guan X, Jin Q, Pan S, Gao L*. Theacquisition of Mycobacterium tuberculosis infection in village doctors inChina: aprospective study. Int J Tuberc Lung Dis. 2020;24(12):1241-6. (通讯作者, IF=2.373)


五年前原创论文(累计IF=175.81,平均IF=6.28)

21.     Gao L, Lu W, Bai L, Wang X, Xu J, Catanzaro A, Cárdenas V, Li X, Yang Y, Du J,Sui H, Xia Y, Li M, Feng B, Li Z, Xin H, Zhao R, Liu J, Pan S, Shen F, He J,Yang S, Si H, Wang Y, Xu Z, Tan Y, Chen T, Xu W, Peng H, Wang Z, Zhu T, Zhou F,Liu H, Zhao Y, Cheng S, Jin Q*; LATENTTB-NSTM study team. Latent tuberculosisinfection in rural China: baseline results of a population-based, multicentre,prospective cohort study. Lancet Infect Dis. 2015;15(3):310-9. (共同第一作者, IF=25.071)

22.     Gao L, Weck MN, Michel A,Pawlita M, Brenner H*. Association between chronic atrophic gastritis and serumantibodies to 15 Helicobacter pylori proteins measured by multiplex serology.Cancer Res. 2009;69(7):2973-80. (第一作者, IF=12.701)

23.     Gao L, Michel A, Weck MN, ArndtV, Pawlita M, Brenner H*. Helicobacter pylori infection and gastric cancerrisk: evaluation of 15 H. pylori proteins determined by novel multiplexserology. Cancer Res. 2009;69(15):6164-70. (第一作者, IF=12.701)

24.     Gao L, Weck MN, Nieters A,Brenner H*. Association between a pro-inflammatory genetic profile and the riskof chronic atrophic gastritis among older adults from Germany. Eur J Cancer.2009;45(3):428-34. (第一作者, IF=9.162)

25.     Gao L, Weck MN, Nieters A,Brenner H*. Inverse association between a pro-inflammatory genetic profile andHelicobacter pylori seropositivity among patients with chronic atrophicgastritis: enhanced elimination of the infection during disease progression?Eur J Cancer. 2009;45(16):2860-6. (第一作者, IF=9.162)

26.    Li X, Gao C, Yang Y, Zhou F, Li M, Jin Q*, Gao L*. Systematic review withmeta-analysis: the association between human papillomavirus infection andoesophageal cancer. Aliment Pharmacol Ther. 2014;39(3):270-81. (共同通讯作者, IF=8.171)

27.     Gao L*, Weck MN, Rothenbacher D,Brenner H. Body mass index, chronic atrophic gastritis and heartburn: apopulation-based study among 8936 older adults from Germany. Aliment PharmacolTher. 2010;32(2):296-302. (第一作者,通讯作者, IF=8.171)

28.     Gao L, Nieters A, Brenner H*.Meta-analysis: tumour invasion-related genetic polymorphisms and gastric cancersusceptibility. Aliment Pharmacol Ther. 2008;28(5):565-73. (第一作者, IF=8.171)

29.     Gao L, Weck MN, Stegmaier C,Rothenbacher D, Brenner H*. Alcohol consumption and chronic atrophic gastritis:population-based study among 9,444 older adults from Germany. Int J Cancer.2009;125(12):2918-22. (第一作者, IF=7.396)

30.     Gao L, Weck MN, Raum E,Stegmaier C, Rothenbacher D, Brenner H*. Sibship size, Helicobacter pyloriinfection and chronic atrophic gastritis: a population-based study among 9444older adults from Germany. Int J Epidemiol. 2010;39(1):129-34. (第一作者, IF=7.196)

31.     Peng J, Gao L, Guo J, Wang T, Wang L, Yao Q,Zhu H, Jin Q*. Type-specific detection of 30 oncogenic human papillomavirusesby genotyping both E6 and L1 genes. J Clin Microbiol. 2013;51(2):402-8. (共同第一作者, IF=5.948)

32.    Li X, Gao L,Li H, Gao J, Yang Y, Zhou F, Gao C, Li M, Jin Q*. Human papillomavirusinfection and laryngeal cancer risk: a systematic review and meta-analysis. JInfect Dis. 2013;207(3):479-88. (共同第一作者, IF=5.226)

33.     Gao L*, Weck MN, Nieters A,Brenner H. Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacterpylori infection, and chronic atrophic gastritis among older adults fromGermany. Mol Carcinog. 2010;49(10):869-73.(第一作者,通讯作者, IF=4.784)

34.    Li X, Yang Y, Liu J, Zhou F, Cui W, Guan L, Shen F,Gao C, Li M, Jin Q*, Gao L*.Treatment outcomes of pulmonary tuberculosis in the past decade in the mainlandof China: a meta-analysis. Front Med. 2013;7(3):354-66. (共同通讯作者, IF=4.592)

35.     Zhou F, Li M, Li X, Yang Y,Gao C, Jin Q*, Gao L*.Seroprevalence of Entamoeba histolytica infection among Chinese men who havesex with men. PLoS Negl Trop Dis. 2013;7(5):e2232. (共同通讯作者, IF=4.411)

36.     Gao L, Nieters A, Brenner H*.Cell proliferation-related genetic polymorphisms and gastric cancer risk:systematic review and meta-analysis. Eur J Hum Genet. 2009;17(12):1658-67. (第一作者, IF=4.246)

37.     Gao L*, Weck MN, Stegmaier C,Rothenbacher D, Brenner H. Alcohol consumption, serumgamma-glutamyltransferase, and helicobacter pylori infection in apopulation-based study among 9733 older adults. Ann Epidemiol.2010;20(2):122-8. (第一作者,通讯作者, IF=3.797)

38.     Gao L, Zhang L, Jin Q*.Meta-analysis: prevalence of HIV infection and syphilis among MSM in China. SexTransm Infect. 2009;85(5):354-8. (第一作者, IF=3.519)

39.    Li Z, Zhang H, Li X, Yang Y, Xin H, Li M, Feng B, Gao L*. Anal human papillomavirus genotypingamong HIV-positive men who have sex with men in Xi'an, China. PLoS One.2015;10(4):e0125120. (通讯作者, IF=3.240)

40.     Ma F, Yang Y, Li X, Zhou F,Gao C, Li M, Gao L*. The associationof sport performance with ACE and ACTN3 genetic polymorphisms: a systematicreview and meta-analysis. PLoS One. 2013;8(1):e54685. (通讯作者, IF=3.240)

41.     Yang Y, Li X, Zhang Z, QianHZ, Ruan Y, Zhou F, Gao C, Li M, Jin Q*,Gao L*. Association of human papillomavirus infection and abnormal analcytology among HIV-infected MSM in Beijing, China. PLoS One. 2012;7(4):e35983. (共同通讯作者, IF=3.240)

42.     Zhou F, Gao L, Li S, Li D, Zhang L, Fan W, YangX, Yu M, Xiao D, Yan L, Zhang Z, Shi W, Luo F, Ruan Y, Jin Q*. Willingness toaccept HIV pre-exposure prophylaxis among Chinese men who have sex with men.PLoS One. 2012;7(3):e32329. (共同第一作者, IF=3.240)

43.     Li X, Yang Y, Zhou F, ZhangY, Lu H, Jin Q*, Gao L*. SLC11A1(NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematicreview and meta-analysis. PLoS One. 2011;6(1):e15831. (共同通讯作者, IF=3.240)

44.     Gao L*, Zhou F, Li X, Jin Q*.HIV/TB co-infection in mainland China: a meta-analysis. PLoS One. 2010;5(5):e10736. (第一作者,共同通讯作者, IF=3.240)

45.     Yang Y, Li X, Zhou F, Jin Q*,Gao L*. Prevalence of drug-resistanttuberculosis in mainland China: systematic review and meta-analysis. PLoS One.2011;6(6):e20343. (共同通讯作者, IF=3.240)

46.     Gao L*, Zhou F, Li X, Yang Y,Ruan Y, Jin Q*. Anal HPV infection in HIV-positive men who have sex with menfrom China. PLoS One. 2010;5(12):e15256.(第一作者,共同通讯作者, IF=3.240)

47.     YangY, Li X, Cui W, Guan L, Shen F, Xu J, Zhou F, Li M, Gao C, Jin Q, Liu J*, Gao L*. Potential association of pulmonary tuberculosis withgenetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinesepopulation. BMC Infect Dis. 2013;13:511. (共同通讯作者, IF=3.091)

48.     Gao L, Tao Y, Zhang L, Jin Q*.Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematicreview and meta-analysis. Int J Tuberc Lung Dis. 2010;14(1):15-23. (第一作者, IF=2.373)


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