课题组主页: http://sbm.pumc.edu.cn/article/11536

课题组成员

牛亚梅，博士，研究员、博士生导师。电子邮箱：niuym(AT)ibms.pumc.edu.cn

马春卉，博士，助理研究员。电子邮箱：machunhui(AT)ibms.pumc.edu.cn

李晴，硕士，科研助理。电子邮箱：liqing(AT)ibms.pumc.edu.cn

研究生：

博士研究生：潘文琦（2022）、陈颜（2021，直博）、许月思（2022，直博）、李一凡（2022，直博）、魏楠（2023，直博）

硕士研究生：肖灵凤（2021）、巫乔（2022）、付玉洁（2023）

联合培养研究生：刘思梦（2019，直博，中国医科大学）、沈文平（2021，博士，北京同仁医院）、叶立果（2022，博士，北京协和医院）

1. 细胞微颗粒纳米药物的细胞响应与机制研究，国家重点研发计划，2023-2028 

2. 胰腺癌精准分型研究，医科院创新工程，2021-2025

3. 内生代谢物与命运决定因子互作调控组织发育与发病过程的分子机理，国家重点研发计划，2019-2024

4. 猴发育与生殖生物学的研究，医科院创新工程，2016-2020

5. 线粒体内膜蛋白mitofilin在神经元退行性变中的作用及机制研究，国家自然科学基金，2015-2018

1. 1         Liu, S.M., Li, M., Ma, C., Liu, C., Lv, A., Li, Q., Niu, Y., Wang, P., Huang, B., and Tong, W.M. (2024). HIV encephalopathy is contributed by macrophages and microglia. Sci China Life Sci. 67, 836-838.

   2          Dong, T., Zhang, Z.Q., Sun, L.H., Zhang, W., Zhu, Z., Lin, L., Yang, L., Lv, A., Liu, C., Li, Q., Yang, R.F., Zhang, X., Niu, Y., Chen, H.Z., Liu, D.P.*, and Tong, W.M.* (2023). Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy. Brain Pathol, e13157.

   3         Zhang, Z.W.#, Teng, X.#, Zhao, F.#, Ma, C.#, Zhang, J., Xiao, L.F., Wang, Y., Chang, M., Tian, Y., Li, C., Zhang, Z., Song, S*., Tong, W.M. *, Liu, P*., and Niu, Y.* (2022). METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep 41, 111530.

   4         Wang, Z.#, Zhou, Y.#, Bao, L., Li, D., Lv, J., Wang, D., Li, S., Liu, J., Qin, C.*, Tong, W.M.*, and Huang, B.* (2022). Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages. Signal Transduct Target Ther 7, 116.

   5         Lyu, C.#, Niu, Y.#, Lai, W., Wang, Y., Wang, Y., Dai, P., Ma, C., Chen, S., Li, Y., Jiang, G., Liang, Z., Ma, W., Gao, Z.*, Tong, W.M.*, and Wang, H.* (2022). Rare and misincorporated DNA N(6)-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells. Cell Discov 8, 39.

   6         Gao, C.C.#, Li, M.#, Deng, W.#, Ma, C.H., Chen, Y.S., Sun, Y.Q., Du, T., Liu, Q.L., Li, W.J., Zhang, B., Sun, L., Liu, S.M., Li, F., Qi, F., Qu, Y., Ge, X., Liu, J., Wang, P., Niu, Y., Liang, Z., Zhao, Y.L., Huang, B., Peng, X.Z., Yang, Y.*, Qin, C.*, Tong, W.M.*, and Yang, Y.G.* (2022). Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques. Protein Cell 13, 920-939.

   7         Wu, S.L.#, Zhang, X.#, Chang, M., Huang, C., Qian, J., Li, Q., Yuan, F., Sun, L., Yu, X., Cui, X., Jiang, J., Cui, M., Liu, Y., Wu, H.W., Liang, Z.Y., Wang, X., Niu, Y.*, Tong, W.M.*, and Jin, F.* (2021). Genome-wide 5-Hydroxymethylcytosine profiling analysis identifies MAP7D1 as a novel regulator of lymph node metastasis in breast cancer. Genomics Proteomics Bioinformatics 19, 64-79.

   8         Ma, C.#, Chang, M.#, Lv, H.#, Zhang, Z.W., Zhang, W., He, X., Wu, G., Zhao, S., Zhang, Y., Wang, D., Teng, X., Liu, C., Li, Q., Klungland, A., Niu, Y.*, Song, S.*, and Tong, W.M.* (2018). RNA m(6)A methylation participates in regulation of postnatal development of the mouse cerebellum. Genome Biol 19, 68.

   9         Chang, M.#, Lv, H.#, Zhang, W., Ma, C., He, X., Zhao, S., Zhang, Z.W., Zeng, Y.X., Song, S., Niu, Y.*, and Tong, W.M.* (2017). Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain. Open Biol 7.

   10       Yang, H., Liu, P., Zhang, J., Peng, X., Lu, Z., Yu, S., Meng, Y., Tong, W.M.*, and Chen, J.* (2016). Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated bymiR-193b. Oncogene 35,3647-3657.

   11       Li, R., Yang, Y.G., Gao, Y., Wang, Z.Q., and Tong, W.M.* (2012). A distinct response to endogenous DNA damage in the development ofNbs1-deficient cortical neurons. Cell Res 22, 859-872.

   12       Guan, J.#, Tong, W.M.#, Ding, W.#, Du, S., Xiao, Z., Han, Q., Zhu, Z., Bao, X., Shi, X., Wu, C., Cao, J., Yang, Y., Ma, W., Li, G., Yao, Y., Gao, J., Wei, J., Dai, J.*, and Wang, R.* (2012). Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model. Biomaterials 33,1386-1395.

        本课题组是中国医学科学院基础医学研究所特聘教授兼协和学者佟伟民教授于2007年回国成立的科研团队。研究兴趣与方向主要有以下两方面：

1、研究表观转录标记RNAm6A 甲基化修饰在神经发育中的功能与作用机制；同时与临床紧密结合，探索RNA m6A甲基化参与介导的脑肿瘤与神经系统疾病的发病机制，为寻找新的疾病早期诊断或治疗靶标提供理论依据。

2、利用不同类型的基因工程修饰小鼠，探讨蛋白磷酸酶在神经发育与神经退行性病变过程中的作用与机制，同时构建相应的疾病模型用于筛选神经退行性病的药物。

神经发育、神经退行性病、脑肿瘤……

表观遗传修饰、蛋白质磷酸化、DNA损伤修复……

未知的机制，可能的改变，如同浩瀚宇宙中的繁星，等待着我们去发现。

庄子曰：吾生也有涯，而知也无涯 。以有涯随无涯，殆已；已而为知者，殆而已矣。

希望在“随无涯”的路上，有更多勇于探索、勤于思考、敢于承担、敏于实践、善于分享、乐于互助的伙伴，加入我们团队，一起开拓，共同追寻。