个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
向志光,副研究员,医学博士,本科毕业于山东大学生物系。2005年于协和医科大学基础医学院免疫学系获硕士学位,2010年在北京协和医学院获得博士学位。从事实验动物质量保障研究,并以实验动物为模型研究炎症的比较免疫学研究。研究工作获十三五重大专项、十四五重点研发计划以及院校创新团队、协和青年基金等科研项目支持。
本实验室从事实验动物质量保障及医学比较免疫学研究。
目前团队有研究员2人,副研究员1人,副主任技师1人。专业北京包括病毒学、微生物学、免疫学、动物学等。
开展实验动物微生物、寄生虫、遗传以及动物设施环境研究。
开展动物感染炎症疾病的研究。
实验室是国家级从事实验动物质量检测工作的实验室,经CNAS和CMA认证认可。
重大专项:2017ZX10304402-001-009
重点研发计划:2016YFD0501003
上传附件
支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg上传附件
支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg上传附件
支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg重大专项传染病动物模型平台的工作中感染研究用动物的特殊病原控制。
研究实验动物常见病原感染动物后动物的机体免疫应答及体内粘膜微生物环境的改变;
研究实验动物在呼吸道感染中固有免疫的应答及炎症控制。
获得国家发明专利8项;
参与编制实验动物国家标准1项;
主持制定中国实验动物学会团体标准3项,参与制定4项。
发表文章:
[1]Qi Kong,Zhiguang Xiang,Yue Wu,Yu Gu,Jianguo Guo,Fei Geng. Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection[J]. Molecular Cancer,2020,19(1).
[2]Jianguo Guo,Yi Xiong,Taisheng Kang,Zhiguang Xiang,Chuan Qin. Bacterial community analysis of floor dust and HEPA filters in air purifiers used in office rooms in ILAS, Beijing[J]. Scientific Reports,2020,10(1).
[3]Pin Yu,Feifei Qi,Yanfeng Xu,Fengdi Li,Peipei Liu,Jiayi Liu,Linlin Bao,Wei Deng,Hong Gao,Zhiguang Xiang,Chong Xiao,Qi Lv,Shuran Gong,Jiangning Liu,Zhiqi Song,Yajin Qu,Jing Xue,Qiang Wei,Mingya Liu,Guanpeng Wang,Shunyi Wang,Haisheng Yu,Xing Liu,Baoying Huang,Wenling Wang,Li Zhao,Huijuan Wang,Fei Ye,Weimin Zhou,Wei Zhen,Jun Han,Guizhen Wu,Qi Jin,Jianwei Wang,Wenjie Tan,Chuan Qin. Age‐related rhesus macaque models of COVID‐19[J]. Animal Models and Experimental Medicine,2020,3(1).
[4]Hongxiao Li,Meixiu Sun,Zhiguang Xiang,Ling Lin,Chuan Qin,Yingxin Li. Identification of blood species based on diffuse reflectance and transmission joint spectra with machine learning method[J]. Infrared Physics and Technology,2018,88.
[5]Zhiguang Xiang,Shengnan Tian,Wei Tong,Hui Chang,Jingfen Su,Lifang Zhang,Xianju Liu,Yuhan Li,Qiang Wei,Yunbo Liu. MNV primarily surveillance by a recombination VP1-derived ELISA in Beijing area in China[J]. Journal of Immunological Methods,2014,408.
[6]Lili Xu,Linlin Bao,Wei Deng,Hua Zhu,Ting Chen,Qi Lv,Fengdi Li,Jing Yuan,Zhiguang Xiang,Kai Gao,Yanfeng Xu,Lan Huang,Yanhong Li,Jiangning Liu,Yanfeng Yao,Pin Yu,Weidong Yong,Qiang Wei,Lianfeng Zhang,Chuan Qin. The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus[J]. BioMed Central,2013,10(1).
[7]Zhiguang Xiang,Wei Tong,Yuhan Li,Chuan Qin,Qiang Wei. Three unique Sendai virus antigenic peptides screened from nucleocapsid protein by overlapping peptide array[J]. Journal of Virological Methods,2013,193(2).
[8]Wei Yuan,Na Dong,Lifang Zhang,Jiangning Liu,Shuzhu Lin,Zhiguang Xiang,Hongwei Qiao,Wei Tong,Chuan Qin. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine expressing a fusion protein of Ag85B-Esat6-HspX in mice[J]. Vaccine,2012,30(14).
[9]Haiping Zhao,Dan Lv,Wei Zhang,Wei Dong,Juan Feng,Zhiguang Xiang,Lan Huang,Chuan Qin,Lianfeng Zhang. Ginsenoside-Rb1 Attenuates Dilated Cardiomyopathy in cTnTR141W Transgenic Mouse[J]. The Japanese Pharmacological Society,2010,112(2).
[10]Zhiguang Xiang,Wei Chen,Steven Ravary,Wei Dong,Wei Zhang,Rong Mu,Zhanguo Li,Lianfeng Zhang. Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice.[J]. Immunology letters,2010,131(2).
[11]Zhiguang Xiang,Wei Tong,Zhi Guo, Yanfeng Xu, Jianguo Guo,Yanshuo Ruan and Peng Zhao.Rat H1 parvovirus infection leads to alterations in gutmicrobiota[J]. Pathogens and Disease, 77, 2019, ftz058
[12]Deng W, Bao L, Liu J, Xiao C, Liu J, Xue J, Lv Q, Qi F, Gao H,Yu P, Xu Y, Qu Y, Li F, Xiang Z, Yu H, Gong S, Liu M, Wang G, Wang S, Song Z,Liu Y, Zhao W, Han Y, Zhao L, Liu X, Wei Q, Qin C. Primary exposure toSARS-CoV-2 protects against reinfection in rhesus macaques. Science. 2020 Aug14;369(6505):818-823. doi: 10.1126/science.abc5343. Epub 2020 Jul 2. PMID:32616673; PMCID: PMC7402625.
[13]Deng W, Bao L, Gao H, Xiang Z, Qu Y, Song Z, Gong S,Liu J, Liu J, Yu P, Qi F, Xu Y, Li F, Xiao C, Lv Q, Xue J, Wei Q, Liu M, WangG, Wang S, Yu H, Chen T, Liu X, Zhao W, Han Y, Qin C. Ocular conjunctivalinoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques. NatCommun. 2020 Sep 2;11(1):4400. doi: 10.1038/s41467-020-18149-6. PMID: 32879306;PMCID: PMC7467924.
[14]Bao L, Gao H, Deng W, Lv Q, Yu H, Liu M, Yu P, Liu J,Qu Y, Gong S, Lin K, Qi F, Xu Y, Li F, Xiao C, Xue J, Song Z, Xiang Z, Wang G,Wang S, Liu X, Zhao W, Han Y, Wei Q, Qin C. Transmission of Severe AcuteRespiratory Syndrome Coronavirus 2 via Close Contact and Respiratory DropletsAmong Human Angiotensin-Converting Enzyme 2 Mice. J Infect Dis. 2020 Jul23;222(4):551-555. doi: 10.1093/infdis/jiaa281. PMID: 32444876; PMCID:PMC7313959.
[15]Xiang Z, Zhu H, Yang B, Fan H, Guo J, Liu J, Kong Q, Teng Q,Shang H, Su L, Qin C. A glance at the gut microbiota of five experimentalanimal species through fecal samples. Sci Rep. 2020 Oct 6;10(1):16628. doi:10.1038/s41598-020-73985-2. PMID: 33024229; PMCID: PMC7538948.
[16]Guo J, Tang J, Kang T, Xiong Y, Xiang Z, Qin C.Different immunization methods lead to altered gut flora and varied responsesto Mycobacterium tuberculosis infection in mice. J Infect Dev Ctries. 2020 Oct31;14(10):1170-1177. doi: 10.3855/jidc.12697. PMID: 33175713.
北京协和医学院研究生院招生办公室
360eol提供技术支持
文件上传中...