先后承担了国家自然科学基金、国家高技术研究发展计划（863计划）、卫生部行业科研专项、国家“十一五”、“十二五”、“十三五”重大新药创制科技重大专项、北京市重大创新药物专项、美国克林顿基金会艾滋病防治药物研究项目等三十多项基础性和应用性的研究项目。承担企业新药研发及技术开发项目近50项。

发表论文

1.    Xia, Jie; Wang, Zhenyi; Huan, Yi; Xue, Wenjie; Wang, Xing; Wang, Yu-Xi; Liu, Zhen-ming; Hsieh, Jui-Hua; Zhang, Liang-Ren; Wu, Song; Shen, Zhu-fang; Zhang, Hongmin; Wang, Xiang， Pose Filter-based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists，J. Chem. Inf. Model. 2020, 60, 1202−1214.

2.    Wenjie Xue , Xueyao Li a, Guixing Ma , Hongmin Zhang , Ya Chen , Johannes Kirchmair , Jie Xia , Song Wu ,N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification，European Journal of Medicinal Chemistry 188 (2020) 112022.

3.           Jie Xia#, Shan Li#, Yu Ding, Song Wu*, Xiang Simon Wang*, MUBD-DecoyMaker 2.0: A Python GUI application to generate maximal unbiased benchmarking data sets for virtual drug screening, Molecular Informatics, 2019, 2020, 39, 1900151.

4.    Tianlei L.#, Jishun L#., Zihao Z., Weidong P., Song W.*. Cobalt(II)-catalyzed benzylic oxidations with potassium persulfate in TFA/TFAA, RSC advance, 2019, 9, 20879-20883.

5.    Hongna Wu, Jun Wu, Wenxuan Zhang, Zhongwen Li, Jinhui Fang, Xu Lian, Tong Qin, Hao Jie, Qi Zhou, Song Wu，Discovery and structure-activity relationship study of phthalimidephenylpyridine conjugate as inhibitor of Wnt pathway，Bioorganic & Medicinal Chemistry Letters，2019，29：870–872.

6.    Wenjie Xue, Jinlong Tian, Xiang Simon Wang, Jie Xia*, Song Wu*，Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives，Bioorganic Chemistry ，2019，86, 224-234.

7.    Tianlei Li 1, Gang Wen 1, Jishun Li, Wenxuan Zhang , and Song Wu* ,A Useful Synthesis of 2-Acylamino-1,3,4-oxadiazoles from Acylthiosemicarbazides Using Potassium Iodate and the Discovery of New Antibacterial Compounds，Molecules 2019, 24, 1490.

8.    Dongmei Wang#, Min Hu#, Xinpeng Li, Dan Zhang, Chengjuan Chen, Junmin Fu, Shuai Shao, Gaona Shi, Yu Zhou, Song Wu*, Tiantai Zhang*,Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease, European Journal of Medicinal Chemistry, 2019, 168, 207-220.

9.    Jian Xin, Min Hu, Qian Liu, Tian Tai Zhang, Dong Mei Wang，Song Wu.Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists, Journal of Enzyme Inhibition and Medicinal Chemistry, 2018，33（1）, 1545-1553, DOI: 10.1080/14756366.2018.1509212.

10.  Wenxuan Zhang, Wenjie Xue, Yuqing Jia, Gang Wen, Xu Lian, Jing Shen, Ailin Liu and Song Wu* A concise synthesis of (±)-7-O-galloyltricetiflavan, RSC Adv., 2018, 8, 14389-14392. Impact factor: 3.108.

11.  Jie Xia*, Huabin Hu, Wenjie Xue, Xiang Simon Wang and Song Wu*, The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay. Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33, (1), 525-535.

12.  Wen, Gang; Liu, Qian; Hu, Huabin; Wang, Dongmei* ; Wu, Song*  Design, synthesis, biological evaluation, and molecular docking of novel flavones as H3R inhibitors, Chemical Biology & Drug Design, 2017.10, 90(4): 580~589.

13.  Lu-Lu Wang, Chen-Lin Feng, Wen-Sheng Zheng, Shuai Huang, Wen-Xuan Zhang, Hong-Na Wu, Yun Zhan, Yan-Xing Han*, Song Wu*, Jian-Dong Jiang*, Tumor-selective lipopolyplex encapsulated small active RNA hampers colorectal cancer growth in vitro and in orthotopic murine， Biomaterials 2017，141，13-28.

14.  Gang Wen, Wen-Xuan Zhang * and Song Wu *, A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct _-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine，Molecules 2017, 22, 1102.

15.  Wenxuan Zhang , Jun Wu , Bo Li a, Xu Lian , Jie Xia a, Qi Zhou b, Song Wu *, Design and synthesis of conformationally constrained salinomycin derivatives，European Journal of Medicinal Chemistry，2017，138，353-356.

16.  Xiaocong Pang , Hui Fu , Shilun Yang , Lin Wang , Ai-Lin Liu *, Song Wu * and Guan-Hua Du* Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR, and Molecular Docking Approaches，Molecules 2017, 22, 1254.

17.  Bo Feng#, Xinpeng Li#, Jie Xia*, Song Wu*, Discovery of Novel Isoflavone Derivatives as Ache/Buche Dual-Targeted Inhibitors: Synthesis, Biological Evaluation and Molecular Modeling, Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32 (1): 968-977.

18.  Jie Xia , Bo Feng , Qianhang Shao , Yuhe Yuan , Xiang Simon Wang , Naihong Chen  and Song Wu*, Virtual Screening against Phosphoglycerate Kinase 1 in Quest of Novel Apoptosis Inhibitors，Molecules 2017, 22, 1029.

19.  Xia, Jie; Hsieh, Jui-Hua; Hu, Huabin; Wu, Song*; Wang, Xiang， The Development of Target-Specific Pose Filter Ensembles to Boost Ligand Enrichment for Structure-Based Virtual Screening，J. Chem. Inf.  Model 2017，57(6):1414-1425.

20.  Bo Li, Jun Wub Wenxuan Zhang, Zhongwen Li, Gang Chen, Qi Zhou, Song Wu*，Synthesis and biological activity of salinomycin-hydroxamic acid conjugates，Bioorganic & Medicinal Chemistry Letters 27 (2017) 1624–1626.

21.  Dongmei Wang, Bo Feng, Hui Fu, Ailin Liu, Lin Wang, Guanhua Du, Song Wu*, Design, synthesis, and biological evaluation of a new series of biphenyl/bibenzyl derivatives functioning as dual inhibitors of acetylcholinesterase and butyrylcholinesterase，Molecules, 2017,22，172.

22.  Huabin Hu †, Jie Xia †, Dongmei Wang, Xiang Simon Wang and Song Wu*, A Thoroughly Validated Virtual Screening Strategy for Discovery of Novel HDAC3 Inhibitors，Int. J. Mol. Sci. 2017, 18, 137.

23.  Wenxuan Zhang,a   Jun Wu,b   Bo Li,a   Jie Xia,a   Hongna Wu,a  Liu Wang,b   Jie Hao,b   Qi Zhoub and   Song Wu*，a  Synthesis and biological activity evaluation of 20-epi-salinomycin and its 20-O-acyl derivatives， RSC Adv., 2016,6, 41885-41890.

24.  Yan Yang, Hui-Min Wang, Yuan-Feng Tong, Min-Zhi Liu, Ke-Di Cheng, Song Wu* and Wei Wang*, Systems metabolic engineering of Escherichia coli to enhance the production of flavonoid glucuronides, RSC Adv., 2016, 6, 33622–33630.

25.  Wenxuan Zhang, Jun Wu, Bo Li, Hongna Wu, Liu Wang, Jie Hao, Song Wu* and Qi Zhou*. Structure–activity & structure–toxicity relationship study of salinomycin diastereoisomers and their  benzoylated derivatives . Organic & Biomolecular Chemistry, 2016, 14, 2840 - 2845.

26.  Xiaolin Zhang, Jinying Tian, Juan Li, Liwei Huang, Song Wu*, Wei Liang, Liangwei Zhong, Jianping Ye and Fei Ye* ,A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance, Brit. J. Pharmacol., 2016, 173(12) ,1939–1949.

27.  Hongkun Yang, Yuan Feng Tong, Wu Song* .A novel and efficient strategy involving a CuI catalyzed cascade reaction to synthesize acenaphtho[1,2-b]quinolone derivatives. Chinese Chemical Letters, 2016, 27(3):349-352.

28.  Wen-Xuan Zhang, Hong-Na Wu, Bo Li, Hong-Lin Wu, Dong-Mei Wang, Song Wu *，The Synthesis of the Metabolites of 2′,3′,5′-Tri-O-acetyl-N6-(3-hydroxyphenyl) Adenosine (WS070117) Molecules, 2016, 21(1), 8.

专利

1． 吴松，周琪，张文轩，吴骏，李波，王柳，郝捷，盐霉素肟及肟醚生物以及制备方法和抗肿瘤用途，专利号ZL201610347806.7。

2． 中国医学科学院药物研究所，计算机软件著作权登记证书：面向药物发现的最大无偏好性基准数据集计算软件，登记号：2019SR1278580。

3． 杜冠华、吴松、黄中麟、白晓宇、郝玲花，一种腺苷化合物在制备防治应激障碍药物中的用途，专利号ZL201310204455.0。

4． 王伟、吴松、杨燕、童元峰、王慧敏、林霖、唐亮、陈成娟、刘忞之、程克棣、孔建强，用于生物催化黄酮类化合物葡萄糖苷化的基因工程菌ZL201410185256.4。

5． 王伟、吴松、杨燕、童元峰、王慧敏、林霖、唐亮、陈成娟、刘忞之、程克棣、孔建强，用于生物催化黄酮类化合物葡萄糖醛酸苷化的基因工程菌，专利号ZL201410184995.1

6． 杜冠华、吴松、刘艾林、周丹、王冬梅、冯章英、李莉（筛选）、刘前，一个异黄酮衍生物的多靶点作用及其改善学习记忆用途专利号ZL201310113150.9 。

7． 吴松、朱海波、陈帅、渠凯、郝玲花、杨庆云、戚燕、童元峰。溴化N-邻甲氧羰基苄基四氢小檗碱及其治疗高血脂症的用途。专利号ZL200910235772.2。

8． 吴松,杜冠华,戚燕,高梅,杨庆云,光红梅,李薇,王月华,童元峰，松属素环糊精或环糊精衍生物包合物，专利号ZL 200810084682.3。

9． Wu Song, Du Guanhua, Qi Yan，et al,，Inclusion complexes of pinosembrin with cyclodextrin or its derivatives, EP2359861,欧洲34国。

10．      朱海波，吴松，郝玲花,渠凯，朱平，王欣，李薇，三乙酰基苯基腺苷及其调血脂的用途，ZL 200810223649.4。Zhu Haibo, Wu Song，Hao Linhua，et al，Triacetyl-3-hydroxyphenyladenosine and its use for regulating blood fat,EP2407474B1。

11．      吴松,杜冠华, 原悦， 杨庆云,高梅，戚燕, 童元峰,王月华，松属素外消旋体的拆分方法,专利号ZL200710177016.X。

12．      杜冠华, 吕杨，吴松,王珂，常颖， 杨志宏, 童元峰,高梅，生松素化合物两种晶型和制备方法及其在治疗疾病中的应用，ZL 200710099312.2。

13．      吴松，郝玲花，杜冠华，李薇，杨庆云，戚燕，童元峰，一种腺苷衍生物及其制备方法和应用，专利号ZL200910081639.6 。

14．    吴松、刘前、杨庆云、戚燕、童元峰，一种安全合成脱氢松香酸降解胺的制备方法，专利号ZL200910237449.9。

15．      吴松，叶菲，童元峰，张裴，田金英，张晓琳，韩静,取代的氨甲酰基环己甲酸类化合物及其制法和用途,专利号ZL201010185934.9。

16．      吴松，叶菲，郝玲花，童元峰，陈锋，张裴，田金英，陶荣亚，贺伊博；烷氧基取代芳环的氨甲酰基类芳酸化合物及其制法和用途；专利号ZL201010139761.7。

17．      戚燕、高虎、童元峰、杨庆云、王冬梅、吴松 。一种盐酸昂丹司琼有关物质B的合成方法。专利号ZL201110140268.1。

18．      王冬梅，郑焱，胡彪，田卫学，吴松，一种炔雌醇原料药杂质及其制法和作为标准品的用途，专利号ZL 201110140159.x。

19．      侯琦、玄玲玲、朱海波、吴松、白金叶、袁绍鹏、王冬梅虫草素衍生物治疗炎症疾病的用途，专利号ZL201310466756.0。

20．      朱海波、吴松、王冬梅、王瑶、李瑾，5＇-磷酸-N6-(3-羟基苯基）腺苷的制备及医药用途，专利号ZL201310206895.X。

新药证书

1.国家级二类新药奥美拉唑及其制剂的研制，已获新药证书并转让江苏常州制药四厂投产上市；

 2．国家级二类新药盐酸曲马多及其制剂的研制，已获新药证书并转让辽宁锦州黑龙制药厂投产上市；

 3．国家级二类新药盐酸恩丹西酮及其制剂的研制，已获新药证书并转让山东齐鲁制药厂投产上市；

 4．国家级二类新药鬼臼毒素及其制剂的研制，已获新药证书并转让福建顺顺药业有限公司投产上市；

 5．国家级二类新药盐酸西布曲明及其制剂的研制，已获新药证书并转让海南海得隆集团公司投产上市；

 6．国家级四类新药马来酸氨氯地平及其制剂的研制，已获新药证书并转让陕西超群科技股份有限公司投产上市；

 7．国家级四类新药布洛芬混悬液的研制，已获新药证书并转让武汉人福科技股份有限公司投产上市；

 8．国家级三类新药阿米三嗪及其制剂的研制，已获新药证书并转让江苏常州制药三厂投产上市；

 9．国家级二类新药依西美坦及其制剂的研制，已获新药证书并转让北京清华紫光药业（集团）股份有限公司投产上市；

 10．国家级二类新药盐酸丙哌维林及其制剂的研制，已获临床批文并转让广东康美药业股份有限公司；

 11．国家级二类新药盐酸塞利洛尔及其制剂的研制，已获临床批文并转让浙江海正药业股份有限公司； 

12．国家级二类新药巴柳氮及其制剂的研制，已获临床批文并转让福建博福制药有限公司；

 13．国家级四类新药美洛昔康及其制剂的研制，已获新药证书并转让四川康兮制药有限公司投产上市；

14．国家级四类新药盐酸乙哌立松及其制剂的研制，已获新药证书并转让青岛宜利药业有限公司投产上市；

 15．国家级四类新药顺铂氯化钠注射液的研制，已获新药证书并转让贵州汉方制药股份有限公司投产上市；

16．国家级二类新药奈达铂及其制剂的研制，已获新药证书并转让南京东捷药业有限公司投产上市；

 17．国家级四类新药多巴酚丁胺葡萄糖注射液的研制，已获新药证书并转让江苏黄海药业有限公司投产上市；

 18．国家级一类新药萘哌地尔及其制剂的研制，已获新药证书并转让安徽丰原药业股份有限公司投产上市；

 19．国家级四类新药盐酸阿替卡因及其制剂的研制，已获新药证书并转让安徽丰原药业股份有限公司投产上市；