1、国家自然科学基金青年基金，81101543，血管内皮生长因子基因多态性与肝细胞肝癌遗传易感性的关系及其功能研究，2012/01-2014/12，22万元，已结题，主持。

1. Du Y, Liu X, Zhu X, Liu Y, Wang X, Wu X*. Activating transcription factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice. Int J Neurosci. 2020 Jan 21:1-9. doi: 10.1080/00207454.2020.1715977. Online ahead of print. (通讯作者)

2. Jiang DK*, Wu X*, Qian J*, Ma XP, Yang J, Li Z, Wang R, Sun L, Liu F, Zhang P, Zhu X, Wu J, Chen K, Conran C, Zheng SL, Lu D, Yu L, Liu Y, Xu J. Genetic variation in STAT4 predicts response to interferon-α therapy for hepatitis B e antigen-positive chronic hepatitis B. Hepatology. 2016;63(4):1102-11. (*并列第一作者)

3. Wu X, Xin Z, Zhang W, Zheng S, Wu J, Chen K, Wang H, Zhu X, Li Z, Duan Z, Li H, Liu Y. A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level. Int J Cancer. 2014;135(1):61-8.

4. Wu X, Xin Z, Zhang W, Wu J, Chen K, Wang H, Zhu X, Pan L, Li Z, Li H, Liu Y. Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity. Int J Cancer. 2013; 133(5):1085-93.

5. Wu X*, Shi W*, Wu J, Zhu X, Chen K, Zheng S, Li Z, Duan Z, Li H, Liu Y. A Functional Polymorphism in ADAR1 Gene Affects HBsAg Seroclearance both Spontaneously and Interferon Induced. Liver Int. 2014;34(10):1560-5. (*并列第一作者)

6. Li Y, Si L, Zhai Y, Hu Y, Hu Z, Bei JX, Xie B, Ren Q, Cao P, Yang F, Song Q, Bao Z, Zhang H, Han Y, Wang Z, Chen X, Xia X, Yan H, Wang R, Zhang Y, Gao C, Meng J, Tu X, Liang X, Cui Y, Liu Y, Wu X, Li Z, Wang H, Li Z, Hu B, He M, Gao Z, Xu X, Ji H, Yu C, Sun Y, Xing B, Yang X, Zhang H, Tan A, Wu C, Jia W, Li S, Zeng YX, Shen H, He F, Mo Z, Zhang H, Zhou G. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Nat Commun. 2016;7:11664.

7. Jiang DK, Ma XP, Yu H, Cao G, Ding DL, Chen H, Huang HX, Gao YZ, Wu XP, Long XD, Zhang H, Zhang Y, Gao Y, Chen TY, Ren WH, Zhang P, Shi Z, Jiang W, Wan B, Saiyin H, Yin J, Zhou YF, Zhai Y, Lu PX, Zhang H, Gu X, Tan A, Wang JB, Zuo XB, Sun LD, Liu JO, Yi Q, Mo Z, Zhou G, Liu Y, Sun J, Shugart YY, Zheng SL, Zhang XJ, Xu J, Yu L. Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. Hepatology. 2015;62(1):118-28.

8. Jiang DK, Ma XP, Wu X, Peng L, Yin J, Dan Y, Huang HX, Ding DL, Zhang LY, Shi Z, Zhang P, Yu H, Sun J, Lilly Zheng S, Deng G, Xu J, Liu Y, Guo J, Cao G, Yu L.Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis. Sci Rep. 2015;5:16278.

9. Pan L, Zhang L, Zhang W, Wu X, Li Y, Yan B, Zhu X, Liu X, Yang C, Xu J, Zhou G, Xu A, Li H, Liu Y. A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations. Hum Mol Genet. 2014;23(8):2210-9.

10. Wu X, Xin Z, Zhu X, Pan L, Li Z, Li H, Liu Y. Evaluation of susceptibility locus for response to interferon-α based therapy in chronic hepatitis B patients in Chinese. Antiviral Res. 2012, 93(2): 297-300

11. Wu X, Xin Z, Zhu X, Pan L, Li Z, Li H, Liu Y. Polymorphisms in ADAR1 gene affect response to interferon alpha based therapy for chronic hepatitis B in Han Chinese. Antiviral Res. 2012; 94(3): 272-5

12. Wu X, Wu J, Xin Z, Wang H, Zhu X, Pan L, Li Z, Li H, Liu Y. A 3' UTR SNP in COL18A1 is associated with susceptibility to HBV related hepatocellular carcinoma in Chinese: three independent case-control studies. PLoS One. 2012;7(3):e33855.

13. Wu Xiaopan, Zhu Xilin, Zhu Shuying, Li Jingyun, Ma Juan, Li Zhuo, Li Hui and Liu Ying. A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients. Antiviral Res. 2009; 83(3):252-6.

14. Li Wang*, Xiaopan Wu*, Wei Zhang, Ying Wang,Yanping Li, Yao Tian,Zhuo L, Xinlin Zhu, Junhong Li, Jun Cai, Dahai Zhu, Xiaoping Miao, Ying Liu, Hui Li. Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: two Independent Case-Control Studies. PLoS One 2011; 6(3): e17608. (*并列第一作者)

15. Zhu X*, Du T*, Wu X*, Guo X, Niu N, Pan L, Xin Z, Wang L, Li Z, Li H and Liu Y. Human leukocyte antigen class I and class II genes polymorphisms might be associated with interferon α therapy efficiency of chronic hepatitis B. Antiviral Res 2011; 89(3): 189-192. (*并列第一作者)