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2005/9 - 2010/7 北京协和医学院,药物化学,博士
2001/9 - 2005/7 河北医科大学,药学,学士
2010/7 - 2014/5 中国医学科学院,医学实验动物研究所,助理研究员
2014/5 - 至今 中国医学科学院,药物研究所,副研究员
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1 药物筛选
2 新药先导化合物的发现与优化
3 活性天然产物的结构改造
1. Zhao WX, Li Y, Cheng HZ, Wang MY, Zhang ZS, CaiML, Zhao C, Xi XM, Zhao XJ, Zhao WL*, Yang YJ*, Shao RG*. Myofibrillogenesis Regulator-1 Regulates the UbiquitinLysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin-ProteinLigase Itchy Homolog in the Metastasis of Non-Small Cell Lung Cancer. Adv Sci, 2024, 11(15):2306472.
2. Wan YC1, Yang YJ1, Pang S, Kong ZL*. A novel derivative of evodiamineimproves cognitive impairment and synaptic integrity in AD mice. Biomed Pharmacother, 2024, 177(8):117103.
3. Pang S, Li SY, Cheng HZ, Luo ZH, Qi XL, Guan FF,Dong W, Gao S, Liu N, Gao X, Pan S, Zhang X, Zhang L, Yang YJ*, Zhang LF*.Discovery of an evodiamine derivative for PI3K/AKT/GSK3β pathway activation andAD pathology improvement in mouse models. Front Mol Neurosci, 2023, 15:1025066.
4. Yang YJ, Yan DA,Cheng HZ, Nan GL, Hou XX, Ren L, Yang Y, Li XC, Tian JY, Ye F*,Xiao ZY*. Discovery of novel 1,2,4-triazolederivatives as xanthine oxidoreductase inhibitors with hypouricemic effects. Bioorg Chem, 2022, 129:106162.
5. Luo ZH, Wang YC, Pang S, Gao S, Liu N, Gao X,Zhang L, Qi XL, Yang YJ*,Zhang LF*. Synthesis and BioactivityEvaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice. Drug Des Dev Ther, 2022, 16:3285-3296.
6. Yang YJ, Wang K, Wu B, Yang Y,Lai FF, Chen XG, Xiao ZY*. Design, synthesis and biological evaluation of triarylcompounds as novel 20S proteasome inhibitors. Bioorg Med Chem Lett, 2020, 30(21):127508.
7. Pang S, Sun CX, Gao S, Yang YJ*, Pan XD*, Zhan LF*. Evodiamine derivatives improve cognitive abilitiesin APPswe/ PS1ΔE9 transgenic mouse models of Alzheimer's disease. Anim Model Exp Med, 2020, 3(3):193-199.
8. Yang YJ, Zhu CJ, Zhang M, Huang SJ, Lin JJ, Pan XD*, Su WP*, Condensation of anthranilic acids with pyridines to furnishpyridoquinazolones via pyridinedearomatization. Chem Comm, 2016, 52(87):12869-12872.
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