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2006年毕业于山东大学药学院,随后进入北京协和医学院基础学院药理学系攻读博士学位。2011年博士研究生毕业后留校工作,围绕小分子化合物羧胺三唑的抗炎抗癌机理展开研究,逐渐揭示其对肿瘤细胞能量代谢及微环境表型的影响。2018年赴美国弗吉尼亚大学医学院生物化学与分子遗传学系学习一年,探索蛋白质凝聚分相的特征及其影响。目前围绕羧胺三唑治疗胶质母细胞瘤的疗效和机理展开研究,探索肿瘤细胞及其微环境免疫代谢特征。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1. 国家自然科学基金委员会,面上项目,81672966,羧胺三唑抑制肿瘤细胞线粒体氧化磷酸化的作用机理及基于此作用的药效优化研究,2017-01至2020-12,51万元,在研,主持。
2. 国家自然科学基金委员会,面上项目,81872897,基于Ca2+-calcineurin-NFAT2和IDO-Kyn-AhR双重信号抑制的小分子组合药物抗肿瘤疗效及肿瘤免疫机制研究,2019-01至2022-12,57万元,在研,参加。
3. 国家自然科学基金委员会,青年基金,81201728,羧胺三唑联合糖酵解抑制剂对肿瘤相关巨噬细胞中炎性细胞因子表达的作用及其机制研究,2013-01至2015-12,23万元,已结题,主持。
4. 教育部博士点基金,新教师类,20121106120019, 肿瘤相关巨噬细胞中有氧糖酵解代谢及其对肿瘤炎性微环境的调控研究,2013-01至2016-12,4万元,已结题,主持。
5. 北京协和医学院“协和青年基金”,3332015168,靶向Tet2蛋白的新型抗炎药物探索及其作用机制研究,2015-09至2016-09,25万元,已结题,参加。
1. Rui Ju, Kailun Fei, Siang Li, Chen Chen, Lei Zhu, Juan Li, Dechang Zhang, Lei Guo, Caiying Ye. Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression After Chemotherapy. J Pharmacol Exp Ther. 2018
2. Rui Ju , Lei Guo, Juan Li, Lei Zhu, Xiaoli Yu, Chen Chen, Wei Chen, Caiying Ye, Dechang Zhang. Carboxyamidotriazole Inhibits Oxidative Phosphorylation in Cancer Cells and Exerts Synergistic Anti-Cancer Effect With Glycolysis Inhibition. Cancer Lett. 2016
3. Rui Ju, Danwei Wu, Lei Guo, Juan Li, Caiying Ye, Dechang Zhang. Inhibition of Pro-Inflammatory Cytokines in Tumour Associated Macrophages Is a Potential Anti-Cancer Mechanism of Carboxyamidotriazole. Eur J Cancer. 2012
4. Jing Shi, Chen Chen, Rui Ju, Qingzhu Wang, Juan Li, Lei Guo, Caiying Ye, Dechang Zhang. Carboxyamidotriazole Combined With IDO1-Kyn-AhR pathway Inhibitors Profoundly Enhances Cancer immunotherapy. J Immunother Cancer. 2019
5. Chen Chen, Rui Ju, Jing Shi, Wei Chen, Fangrui Sun, Lei Zhu, Juan Li, Dechang Zhang, Caiying Ye, Lei Guo. Carboxyamidotriazole Synergizes With Sorafenib to Combat Non-Small Cell Lung Cancer Through Inhibition of NANOG and Aggravation of Apoptosis. J Pharmacol Exp Ther. 2017
6. Chen Chen, Rui Ju, Lei Zhu, Juan Li, Wei Chen, De-Chang Zhang, Cai-Ying Ye, Lei Guo. Carboxyamidotriazole Alleviates Muscle Atrophy in Tumor-Bearing Mice by Inhibiting NF-κB and Activating SIRT1. Naunyn Schmiedebergs Arch Pharmacol. 2017
7. Lei Guo, Lifeng Luo, Rui Ju, Chen Chen, Lei Zhu, Juan Li, Xiaoli Yu, Caiying Ye, Dechang Zhang. Carboxyamidotriazole: A Novel Inhibitor of Both cAMP-phosphodiesterases and cGMP-phosphodiesterases. Eur J Pharmacol. 2015
8.Lei Guo, Caiying Ye, Xiaojian Hao, Ru Zheng, Rui Ju, Danwei Wu, Lifeng Luo, Conghui Wang, Juan Li, Xiaoli Yu, Lei Zhu, Dechang Zhang. Carboxyamidotriazole Ameliorates Experimental Colitis by Inhibition of Cytokine Production, Nuclear factor-κB Activation, and Colonic Fibrosis. J Pharmacol Exp Ther. 2012
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