1.  国自然面上项目，81772986，RYBP下调Cyclin D1表达的分子机制及其在肿瘤治疗中的作用，2018-01至2021-12，57万元，在研，主持。

2.  国自然面上项目，81272229，RYBP：一个新的抑癌基因在肝癌发生与治疗中的作用及其分子机制，2013-01至2016-12，75万元，已结题，主持。 

3.  医科院创新工程项目，2017-I2M-3-004，在研，分任务负责人。

1.     Zhang S, Zhang X, Guan X, Ma X, Chen H, Huang B, ChenD*. YAF2 exerts anti-apoptotic effect in human tumor cells in a FANK1- and phosphorylation-dependent manner. Biochem Biophys Res Commun. 2021, 554:99-106.

2.     Zhao W, Zhang S, Wang X, Ma X, Huang B, Chen H, ChenD*. ETS1 targets RYBP transcription to inhibit tumor cell proliferation. Biochem Biophys Res Commun.2019, 509(3):810-816.

3.     Li M, Zhang S, Zhao W, Hou C, Ma X, Li X, Huang B, Chen H, Chen D*. RYBP modulates stability and function of Ring1B through targeting UBE3A. FASEB J. 2019, 33(1):683-695.

4.     Zhao Q#, Cai W#, Zhang X, Tian S, Zhang J, Li H, Hou C, Ma X,Chen H, Huang B*, Chen D*. RYBP expression is regulated by KLF4 and Sp1 and is related to hepatocellular carcinoma prognosis. J Biol Chem. 2017, 292(6):2143-2158.

5.     Tan K#, Zhang X#, Cong X, Huang B, Chen H*, Chen D*. Tumor suppressor RYBP harbors three nuclear localization signals and its cytoplasm-located mutant exerts more potent anti-cancer activities than corresponding wild type. Cell Signal. 2017, 29(1):127-137.

6.     Ma W#, Zhang X#, Li M, Ma X,Huang B, Chen H*, Chen D*. Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway. Cell Signal. 2016,28(8):779-87.

7.     Tian S, Hui X, Fan Z, Li Q, Zhang J, Yang X, Ma X, Huang BR*, Chen D*,Chen H*. Suppression of hepatocellular carcinoma proliferation and hepatitis B surface antigen secretion with interferon-l1 and PEG-interferon-l1.FASEB J. 2014, 28(8):3528-39.

8.     Zhang J, Ma W, Tian S, Fan Z, Ma X, Yang X, Zhao Q, Tan K, Chen H*, Chen D*,Huang BR*. RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI.Cell Signal. 2014, 26(1): 162–172.

9.     Chen D, Wang W, Qin JJ, WangMH, Murugesan S, Nadkarni DH, Velu Sadanandan E, Wang H, Zhang R*.Identification of the ZAK-MKK4-JNK-TGFβ Signaling Pathway as a Molecular Target for Novel Synthetic Iminoquinone Anticancer Compound BA-TPQ. Curr Cancer Drug Targets. 2013, 13(6):651-660.

10. Chen D, Zhang J, Li M, Rayburn E R, Wang H, Zhang R*. RYBP stabilizes p53 by modulating MDM2. EMBO R. 2009,10(2): 166-72.

11. Chen D#, Zhang Z#,Li M, Wang W, Li Y, Rayburn E R, Hill D L, Wang H* and Zhang R*. Ribosomal protein S7 as a novel modulator of p53–MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007, 26(35):5029-37.

12. Chen Deng, Zhang Jun-Wu*, Zhang Zhen-Xin, Wu Ya-Ning, Qu Qiu-Ming. Association of a2-macroglobulin polymorphisms and Alzheimer disease in Mainland Chinese. J Neurol Sci, 2004，217(1):13-15.

13. Li Xiao-Qing#, Chen Deng#, Zhang Zhen-Xin, Qu Qiu-Ming, Zhang Jun-Wu*. Genetic Association between Cathepsin D Polymorphism and Alzheimer’s Disease inChinese Han Population. Dement Geriatr Cogn Disord. 2004，18(2):115-119.

(Note: #, co-first author; *, corresponding author.)