团队依托中国医学科学院肿瘤免疫生物材料及纳米技术重点实验室（培育），主要成员包括2名研究员、4名副研究员、1名助理研究员，在学研究生15名，形成了以肿瘤免疫生物材料及纳米技术为研究特色的研究团队。

        近年来作为项目负责人先后主持了国家自然科学基金面上项目、国家自然科学基金青年基金、国家外国专家局高校重点引智项目、人社部留学归国人员择优资助项目、教育部博士点新教师基金、天津市自然科学基金面上项目、协和新教师基金、协和青年基金、中央级公益性科研院所基本科研业务费项目等十多项科研项目。

中国医学科学院中央级公益性科研院所基本科研业务费项目（2019PT320028），纳米生物材料介导肿瘤免疫治疗（2019.12-2022.12），300万元，项目负责人

国家自然科学基金面上项目（81671806），智能靶向多功能磷脂-聚合物杂化纳米粒克服MDR及用于肿瘤化疗-光热诊疗的研究 （2017.1-2020.12），58万元，项目负责人

中国医学科学院医学与健康科技创新工程协同创新团队项目（2017-I2M-3-020），高分辨力生物医学结构与功能成像关键技术与仪器研发 (2017.1-2020.12)，160万元，岗位负责人

人社部留学人员科技活动择优资助项目，多重环境响应性磷脂-聚合物杂化纳米药物递送系统的构建及其抗肿瘤效果研究（2016.1-2018.12），3万元，项目负责人

国家外国专家局高校重点引智项目，新型中枢神经系统再生可注射型水凝胶（2017.1-2017.12），3万元，项目负责人

国家外国专家局高校重点引智项目，新型生物医用材料与药物递送系统（2016.1-2016.12），4.5万元，项目负责人

北京协和医学院小规模特色办学经费，协和教师培养项目（2014.5-2017.4），10万元，项目负责人

国家自然科学基金青年科学基金（81100100），TFPI基因修饰内皮祖细胞靶向多途径防治血管再狭窄的实验研究（2012.1-2014.12），23万元，项目负责人

天津市自然科学基金面上项目（10JCYBJC10600），VEGF强化内皮祖细胞促进工程化组织血管化的初步研究（2010.4-2013.3），10万元，项目负责人

教育部新教师基金（20091106120048），VEGF基因修饰内皮祖细胞促进工程化组织血管化的基础研究（2010.1-2012.12），3.6万元，项目负责人

协和青年科研基金,TFPI基因修饰血管内皮祖细胞防治血管再狭窄的研究（2010.1-2010.12），10万元，项目负责人

1.  Xinyu Yang, Chenlu Huang, Hanyong Wang, Kaiyue Yang, Mingyang Huang, Weijia Zhang, Qingyu Yu, Hai Wang, Linhua Zhang*, Yanli Zhao*, Dunwan Zhu*. Multifunctional Nanoparticle Loaded Injectable Alginate Hydrogels with Deep Tumor Penetration for Enhanced Chemo-Immunotherapy of Cancer. ACS Nano, 2024, 18(28): 18604–18621. (SCI 一区, IF 15.8)

2. Chenlu Huang, Hanyong Wang, Xinyu Yang, Qingyu Yu, Hai Wang, Linhua Zhang*, Yanli Zhao*, Dunwan Zhu*. Cascade Carrier-Free Nanoparticles Forming In Situ Nanovaccines for Synergistic Photothermal-Immunotherapy of Cancer. Advanced Functional Materials, 2024, 34(29): 2401489. (SCI 一区, IF 19)

3.  Yu Qin#, Mingyang Huang#,Chenlu Huang, Hannah L. Perry, Linhua Zhang*, Dunwan Zhu*. O2-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024,35(7): 109171. (SCI 一区, IF 9.1)

4.   Chenlu Huang, Xinyu Yang, Qingyu Yu, Linhua Zhang*, Dunwan Zhu*. Gas-generating polymersomes-based amplified photo immunotherapy for abscopal effect and tumor metastasis inhibition. Chinese Chemical Letters, 2024, 35(6): 109680. (SCI 一区, IF 9.1)

5.   Shupei Sheng#, Limin Jin#, Yan Zhang, Weiting Sun, LinMei, DunwanZhu*, Xia Dong*,Feng Lv*. A Twindrive Precise Delivery System of Platelet-Neutrophil Hybrid Membrane Regulates Macrophage Combined with CD47 Blocking for Postoperative Immunotherapy. ACS Nano, 2024, 18(6): 4981-4992. (SCI 一区, IF 17.1)

6.   Qingyu Yu, Hong Sun, Linhua Zhang, Lijie Jiang, Lei Liang, Chaojie Yu, Xiaoru Dong, Bingyan Guo, Yuwei Qiu, Jingwu Li, Hong Zhang, Fanglian Yao*, Dunwan Zhu*, Junjie Li*. A Zwitterionic Hydrogel with Anti-Oxidative and Anti-Inflammatory Properties forthe Prevention of Peritoneal Adhesion by Inhibiting Mesothelial-Mesenchymal Transition. Advanced Healthcare Materials, 2023, 12(30): e2301696. (SCI 一区, IF 11.092)

7.   Yunfei Yi#, Mian Yu#, Wen Li, Dunwan Zhu*, Lin Mei*, Meitong Ou*. Vaccine-like nanomedicine for cancer immunotherapy. Journal of Controlled Release, 2023,355: 760-778. (SCI 一区, IF 11.467)

8.   Nannan Wang#, Yueyue Zuo#, Shengjie Wu, Chenlu Huang, Linhua Zhang*, Dunwan Zhu*. Spatio-temporal delivery of both intra- and extracellular toll-like receptor agonists for enhancing antigen-specific immune responses. Acta Pharmaceutica Sinica B, 2022, 12(12):4486-4500. (SCI 一区, IF 14.903)

9.  Hongjun Wu#, Chenlu Huang#,Liwei Wang, Qinghua Li, Yuejie Li*, Linhua Zhang*, Dunwan Zhu*. Folate-targeted co-delivery polymersomes for efficient photo-chemo-antiangiogenic therapy against breast cancer and in vivo evaluation via OCTA/NIRF dual-modal imaging. Chinese Chemical Letters, 2022, 33(12): 5035-5041. (SCI 一区, IF 8.455)

10.   Hanyong Wang#, Xinyu Yang#, Chunyan Hu, Chenlu Huang, Hai Wang, Dunwan Zhu*, Linhua Zhang*. Programmed polymersomes with spatio-temporal delivery of antigen and dual-adjuvants for efficient dendritic cells-based cancer immunotherapy. Chinese Chemical Letters,2022, 33(9): 4179-4184. (SCI 一区, IF 8.455)

11.  Yan Lu, Yonghua Gong, Xianghui Zhu, Xia Dong*, Dunwan Zhu*, Guilei Ma*. Design of Light-Activated Nanoplatform through Boosting "Eat Me" Signals for Improved CD47-Blocking Immunotherapy. Advanced Healthcare Materials, 2022, 11(10): e2102712. (SCI 一区,IF 11.092)

12.  Qianqian Li, Zhaoqing Shi, Fan Zhang, Weiwei Zeng, Dunwan Zhu*, Lin Mei*. Symphony of nanomaterials and immunotherapy based on thecancer‒immunity cycle. Acta Pharmaceutica Sinica B, 2022, 12(1): 107-134. (SCI 一区,IF 14.903)

13.  Chenlu Huang, Li Zhang, Qing Guo, Yueyue Zuo, Nannan Wang, Hai Wang, DelingKong*, Dunwan Zhu*, Linhua Zhang*. Robust Nanovaccine Based on Polydopamine-Coated Mesoporous Silica Nanoparticles for Effective Photothermal-Immunotherapy Against Melanoma. Advanced Functional Materials, 2021, 31(18): 2010637. (SCI 一区,IF 19.924)

14.  Zhiming Zhang#, Chenlu Huang#, Li Zhang, Qing Guo, Yu Qin, Fan Fan, BoxuanLi, Bao Xiao, Dunwan Zhu*, Linhua Zhang*. pH-Sensitive and Bubble-Generating Mesoporous Silica-Based Nanoparticles for Enhanced Tumor Combination Therapy. Acta Pharmaceutica Sinica B, 2021, 11(2): 520-533. (SCI 一区,IF 14.903)

15.  Yu Qin#, Qing Guo#, Shengjie Wu, Chenlu Huang, Zhiming Zhang, Li Zhang, LinhuaZhang*, Dunwan Zhu*. LHRH/TAT dual peptides-conjugated polymeric vesicles for PTT enhanced chemotherapy toovercome hepatocellular carcinoma. Chinese Chemical Letters, 2020, 31(12):3121-3126. (SCI 一区, IF 8.455)

16.  Li Zhang, Zhiming Zhang, Wenshou Wang, Anthony Tabet, Samuel Hanson, LinhuaZhang, Dunwan Zhu*, Chun Wang*. Polymer-Based Dual-Responsive Self-Emulsifying Nanodropletsas Potential Carriers for Poorly Soluble Drugs. ACS Applied Bio Materials, 2021,4(5): 4441-4449. (IF 4.7)

17.  Zhiming Zhang#, Li Zhang#, Chenlu Huang, Qin Guo, Yueyue Zuo, Nannan Wang, Xu Jin*, Linhua Zhang*, Dunwan Zhu*. Gas-generating mesoporous silica nanoparticles with rapid localized drug release for enhanced chemo-photothermal tumor therapy. Biomaterials Science, 2020, 8(23): 6754-6763. (SCI 二区,IF 7.590)

18.  Linhua Zhang, Shengjie Wu, Yu Qin, Fan Fan, Zhiming Zhang, Chenlu Huang, WeihangJi, Lu Lu, Chun Wang, Hongfan Sun, Xigang Leng, Deling Kong, Dunwan Zhu*. Targeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy. Nano Letters, 2019, 19(7): 4237-4249. (SCI 一区, IF 12.262, 副封面论文)

19.  Dunwan Zhu, Chunyan Hu, Fan Fan, Yu Qin,Chenlu Huang, Zhiming Zhang, Lu Lu, Hai Wang, Hongfan Sun, Xigang Leng, Chun Wang, Deling Kong, Linhua Zhang*. Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination. Biomaterials, 2019, 206: 25-40. (SCI 一区, IF 15.304)

20.  Chenlu Huang#, Zhiming Zhang#, Qin Guo, Li Zhang,Fan Fan, Yu Qin, Hai Wang, Sheng Zhou, Wenbin Ou-Yang, Hongfan Sun, Xigang Leng, Xiangbin Pan, Deling Kong, Linhua Zhang*, Dunwan Zhu*. A Dual-Model Imaging Theragnostic System Based on Mesoporous Silica Nanoparticles for Enhanced Cancer Phototherapy. Advanced Healthcare Materials, 2019,8(19): e1900840. (SCI 一区, IF 11.092)

21.  Jingang Li, ShuwenLi, Xiaohui Wang, Fan Fan, Kongyin Zhao*, Junfu Wei, Linhua Zhang, Dunwan Zhu*. Biologically inspired silk fibroin grafted polyacrylonitrile filtration membrane prepared in ZnCl2 aqueous solution. Chinese Chemical Letters, 2019, 30(1): 239-242. (SCI 一区, IF 8.455)

22.  Linhua Zhang#, Yu Qin#, Zhiming Zhang, Fan Fan, Chenlu Huang, Li Lu, Hai Wang, Xu Jin, Hanxue Zhao, Deling Kong, Chun Wang, Hongfan Sun, Xigang Leng, Dunwan Zhu*. Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination. Acta Biomaterialia, 2018, 75: 371-385. (SCI 一区, IF 10.633)

23.  Dunwan Zhu#, Fan Fan#, Chenlu Huang, Zhiming Zhang, Yu Qin, Li Lu, Hai Wang, Xu Jin, Hanxue Zhao, HuYang, Chao Zhang, Jun Yang, Zhipeng Liu, Hongfan Sun, Xigang Leng, Deling Kong, Linhua Zhang*. Bubble-generating Polymersomes Loaded with both Indocyanine Green and Doxorubicin for Effective Chemotherapy Combined with Photothermal Therapy. Acta Biomaterialia, 2018, 75: 386-397. (SCI 一区, IF 10.633)

24.  Chunyan Hu#, Fan Fan#,Yu Qin, Chenlu Huang, Zhiming Zhang, Qing Guo, Li Zhang, Xiangbin Pang, Wenbin Ou-Yang,Kongyin Zhao, Dunwan Zhu*, Linhua Zhang*. Redox-Sensitive Folate-Conjugated Polymeric Nanoparticles for Combined Chemotherapy and Photothermal Therapy Against Breast Cancer. Journal of Biomedical Nanotechnology, 2018, 14(12): 2018-2030. (SCI 二区, IF 5.068)

25.  Yu Qin, Zhiming Zhang,Chenlu Huang, Fan Fan, Li Lu, Hai Wang, Zhipeng Liu, Jun Yang, Chun Wang, HongfanSun, Xigang Leng, Deling Kong, Linhua Zhang*, Dunwan Zhu*. Folate targeted redox-responsive polymersomes loaded with chemotherapeutic drugs and tariquidar to overcome drug resistance. Journal of Biomedical Nanotechnology, 2018, 14(10): 1705-1718. (SCI 二区, IF 5.068)

26.  Yunmei Peng, JunpengNie, Wei Cheng, Gan Liu, Dunwan Zhu*, Linhua Zhang, Chaoyu Liang, Lin Mei, Laiqiang Huang*, Xiaowei Zeng*. A multifunctional nanoplatform for cancer chemo-photothermal synergistic therapy and overcoming multidrug resistance. Biomaterials Science, 2018, 6(5): 1084-1098. (SCI 二区, IF 7.590)

27.  Dunwan Zhu, Shengjie Wu, Chunyan Hu, Zhuo Chen, Hai Wang, FanFan, Yu Qin, Chun Wang, Hongfan Sun, Xigang Leng, Deling Kong, Linhua Zhang*. Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma. Acta Biomaterialia,2017, 58: 399-412. (SCI 一区, IF 10.633)

28.  Chunyan Hu#, ZhuoChen#, Shengjie Wu, Yanfeng Han, Hai Wang, Hongfan Sun, Deling Kong, Xigang Leng,Chun Wang, Linhua Zhang*, DunwanZhu*. Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems. Chinese Chemical Letters, 2017, 28(9):1905-1909. (SCI 一区, IF 8.455)

29.  DunwanZhu, Wei Tao, Hongling Zhang, Gan Liu, Teng Wang, Linhua Zhang, Xiaowei Zeng*, Lin Mei*. Docetaxel(DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer. Acta Biomaterialia, 2016,30: 144-154. (SCI 一区, IF 10.633)

30.  Linhua Zhang, Zhuo Chen, Hai Wang, Shengjie Wu, Kongyin Zhao, Hongfan Sun, Deling Kong, Chun Wang, Xigang Leng, Dunwan Zhu*. Preparation and evaluation of PCL–PEG–PCL polymeric nanoparticles for doxorubicin delivery against breast cancer. RSC Advances, 2016, 6(60): 54727-54737. (SCI 三区, IF 3.119)

31.  Dunwan Zhu, Zhuo Chen, Kongyin Zhao*, Bohong Kan, Hui Li, Xinxin Zhang, Beibei Lin, Linhua Zhang. Adsorption and sustained release of haemoglobin imprinted polysiloxane using a calcium alginate film as a matrix. RSC Advances, 2015, 5(34): 26977-26984. (SCI 三区, IF 3.119)

32.  Teng Wang#, Dunwan Zhu#, Gan Liu, Wei Tao, Wei Cao, Linhua Zhang, Lijun Wang, Hongbo Chen, Lin Mei, Laiqiang Huang*, Xiaowei Zeng*. DTX-loaded star-shaped TAPP-PLA-b-TPGS nanoparticles for cancer chemicaland photodynamic combination therapy. RSC Advances, 2015, 5(62): 50617-50627. (SCI 三区, IF 3.119)

33.  Dunwan Zhu, Zhuo Chen, Kongyin Zhao, Bohong Kan, Lanxia Liu, Xia Dong, Hai Wang, Chao Zhang, Xigang Leng, Linhua Zhang*. Polypropylene non-woven supported fibronectin molecular imprinted calcium alginate/polyacrylamide hydrogel filmfor cell adhesion. Chinese Chemical Letters, 2015, 26(6): 807-810. (SCI 一区, IF 8.455)