1. 以活性导向为基础的新疆特有民间药用植物-天山假狼毒中瑞香烷二萜靶向抗胃癌活性物质基础研究-国家自然科学基金（2019.01-2022.12）；

2. 外源污染物对中药质量及安全性影响的综合评价研究-中国医学科学院医学与健康科技创新工程重大协同创新项目子任务（2017.1-2020.12）；

3. 以计算机虚拟筛选为导向的黎药红葱醌类抗菌活性成分研究-人才共建项目（2018.06-2019.06）；

4.马尾杉中石杉碱甲提取富集工艺研究-北京三联国际投资有限责任公司（2018.03-2019.03）；

5. 天然植物消杀产品的研发-三角山(北京)生物科技有限公司（2018.01-2019.01）；

6. 中药样品委托检测服务-中国中药公司项目（2018.04-2019.04）；

7. 苏木和喙荚云实种子中丁烯酸内酯类卡山烷型二萜的抗疟作用靶点及构效关系研究-国家自然科学基金青年基金项目（2016.1-2018.12）；

8. 苏木种子中新型氧桥卡山烷型二萜成分抗疟活性及构效关系研究-协和青年科研基金（2015.06-2016.06）；

9. 黄芩药材9种成份的含量测定-中国中药公司项目（2015.06-2015.12）。

发表论文：

[1]    Deli Chen, Zhaocui Sun, Yangyang Liu, Zongyang Li, HanqiaoLiang, Lei Chen, Xudong Xu, Junshan Yang, GuoxuMa,* and Xiaowei Huo*. Eleucanainones A and B: Two Dimeric Structures fromthe Bulbs of Eleutherine americana with Anti-MRSA Activity. Organic Letters.,2020, 22, 3449-3453.

[2]  Yue-Xian Jin,Lei-LingShi,Da-Peng Zhang,Hong-Yan Wei,Yuan Si,Guoxu Ma*,JingZhang.A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies .Molecules,2019,24:1842.

[2] Haifeng Wu,GuoxuMa1,Qinwen Yang,Yindi Zhu,Li Huang,Yu Tian,Xiaoming Yang,MenghanZhang,Chin-ho Chen,Susan L. Morris-Natschke,Meihua Yang,Xudong Xu,Kuo-HsiungLee.Discovery and synthesis of novel beesioside I derivatives with potentanti-HIV activity.European Journalof Medicinal Chemistry,2019,166:159-166.

[3] Deli Chen,Jing Qiao, Zhaocui Sun,Yangyang Liu, Zhonghao Sun,Nailiang Zhu,Xudong Xu,Junshan Yang,Guoxu Ma1.New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective effffect on the injury of humanumbilical vein endothelial cells.Fitoterapia,2019,132:46-52.

[4] YuexianJin,Xiaolei Zhou,Junshan Yang,Xudong Xu,Jing Zhang,Guoxu Ma1.Bioactive triterpenoid saponins from the tubers of Hemsleya amabilis Diels.Fitoterapia,2019,139:104404.

[5] De-Li Chen,Xu-Dong Xu,Rong-Tao Li,Bo-Wen Wang,MengYu,Yang-Yang Liu ,Guoxu Ma1.Five New Cucurbitane-TypeTriterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities.Molecules,2019,24:2937.

[6] Zhaocui Sun,Xudong Xu , Hanqiao Liang,XinyiXia  , Guoxu Ma1,Leiling Shi. Five NewMeroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with CytotoxicActivity.Molecules,2019,24:4015.

[7] WenZhang,Nailiang Zhu, Meigeng Hu,Shichun Yu, Zhonghao Sun,Haifeng Wu , PengfeiLi,Junshan Yang,GuoxuMa1,XudongXu.Congmujingnosides B-G, triterpenesaponins from the stem of Aralia chinensis and their protective effects against H2O2-inducedmyocardial cell injury.Natural Product Research,2019,33(4):500-505.

[8] ZhaocuiSun, Nailiang Zhu, Man Zhou,Xiaowei Huo,Haifeng Wu,Yu Tian, Junshan Yang,Guoxu Ma1,Yan-Long Yang,Xudong Xu.Clavipines A–C, antiproliferativemeroterpenoids with a fused azepine skeleton from the basidiomycete Clitocybe clavipes.Org. Chem. Front, 2019,6:3759–3765.

[9] Zhaocui Sun,Meigeng Hu,NailiangZhu,XiaoweiHuo,XiaoleiZhou, Zhonghao Sun, JunshanYang,Guoxu Ma1,XudongXu.Polyhydroxycucurbitane triterpenes from Hemsleya penxianensistubers.Scientific Reports,2019,9:11835.

[10] Yihang Li,Guoxu Ma1,YanaLv,Jing Su,Guang Li,and Xi Chen.Effiffifficacy of Obcordata Afrom Aspidopterysobcordata onKidney Stones by Inhibiting NOX4 Expression.Molecules,2019,24:1957.

[11] NailiangZhu, Zhonghao Sun, Meigeng Hu, Yedan Li, Dawei Zhang , Haifeng Wu, Yu Tian,Pengfei Li, Junshan Yang, Guoxu Ma *, Xudong Xu*. Cucurbitane-type triterpenesfrom the tubers of Hemsleya penxianensis and their bioactive activity. Phytochemistry2018, 147, 49-56.

[12] JingQiao, Jiushi Liu, Jingjing Liao, Zuliang Luo, Xiaojun Ma*, Guoxu Ma*. Identificationof Key Amino Acid Residues Determining Product Specificity of 2,3-OxidosqualeneCyclase in Siraitia grosvenorii.Catalysts, 2018, 81 (20):1-28.

[13] MeigengHu, Yihang Li, Zhaocui Sun, Xiaowei Huo, Nailiang Zhu, Zhonghao Sun, YangyangLiu, Haifeng Wu, Xudong Xu, Guoxu Ma*, Guang Li*. New polyoxypregnaneglycosides from Aspidopterys obcordata vines with antitumor activity. Fitoterapia,2018, 10, 203-209.

[14] XiaoyanXing, Zhonghao Sun, Meihua Yang, Nailiang Zhu, Junshan Yang, Guoxu Ma*, XudongXu*. Quantitative Evaluation of Twelve Major Components of Sulfur-FumigatedAstragali Radix with Different Durations by UPLC-MS. molecules, 2018, 23 (10):1-12.

[15] ZhaocuiSun, Meigeng Hu, Zhonghao Sun, Nailiang Zhu, Junshan Yang, Guoxu Ma*, Xudong Xu*.Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with TheirBioactive Activities. molecules, 2018, 23 (5):1-7.

[16] De-LiChen, Mei-Geng Hu, Yang-Yang Liu, Rong-Tao Li, Meng Yu, Xu-Dong Xu, Guo-Xu Ma*.New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury ofHUVECs. molecules, 2018, 23 (9):1-9.

[17] NailiangZhu, Haifeng Wu, Ziqian Xu, Chenqi Liu, Yu Tian, Meigeng Hu, Zhonghao Sun, PengfeiLi, Guoxu Ma*, Xudong Xu*. New alkaloids with unusual spermidine moieties fromthe seeds of and their cytoprotective properties. RSC Adv., 2017, 7, 41495–41498.

[18] HuaWei, Li-Ping Dai, Li-Hua Yan, Fang-Fang Xiang, Jun-Shan Yang, Guo-Xu Ma*. NewCassane Diterpenes from the seeds of Caesalpiniadecapetala. Magn. Reson. Chem. 2017, 55, 157-160.

[19] PengfeiLi, Nailiang Zhu, Meigeng Hu, Haifeng Wu, Tian Yu, Tongyu Wu, Dawei Zhang, ZhonghaoSun, Junshan Yang, Guoxu Ma*, Xudong Xu*. New cucurbitane triterpenoids withcytotoxic activities from Hemsleya penxianensis.Fitoterapia,2017, 120, 158–163.

[20] Nai-LiangZhu, Zhong-Hao Sun, Mei-Geng Hu, Tong-Yu Wu, Jing-Quan Yuan, Hai-Feng Wu, YuTian, Peng-Fei Li, Jun-Shan Yang, Guo-Xu Ma*, and Xu-Dong Xu*. New CassaneDiterpenoids from Caesalpinia sappan andTheir Antiplasmodial Activity. Molecules 2017, 22, 1751.

[21] Nai-LiangZhua, Xu-Dong Xu, Mei-Geng Hu, Zhong-Hao Sun, Tong-Yu Wu, Jing-Quan Yuan,Hai-Feng Wu, Yu Tian, Peng-Fei Li, Jun-Shan Yang, Guo-Xu Ma*. Bioactive cassanediterpenoids from the seeds of Caesalpiniasappan. Phytochem. Lett. 2017, 22, 113-116.

[22] Lei-Ling Shi1, Guo-Xu Ma1, Hua-Chun Gao,Quan-Cheng Chen, Jun-Shan Yang,Xiao-Guang Jia & Jing Zhang.Diarylpentanolconstituents from the aerial part of Stelleropsis tianschanica.Journal of AsianNatural Products Research.2016,18:885-890.

[23] De-LiChen1, Guo-Xu Ma1,Min-Jun He, Yang-Yang Liu, Xiao-Bing Wang*, and Xin-Quan Yang*.Anti-inflammatory Activity of Two New Indole Alkaloids from the StemsofNauclea officinalis.Helv. Chim. Acta.2016, 99:742-746.

[24] Hai Jiang1, Guo-Xu Ma1, Liu Yang, Xu-Dong Xing, Mei-Ling Yan,Yan-Yan Zhang, Qiu-Hong Wang, Hai-Xue Kuang, Xu-Dong Xu*.Rearrangedent-kauranoid glycosides from the fruits of Xanthiumstrumarium and theirantiproliferative activity. Phytochemistry Letters. 2016, 18:192-196.

[25] Ye-DanLi, Si-Rong Yi, Xiao-Bo Sun, Xing-Yang Zhou, Hong-Yang ZhangYun-Qing Wang,Jun-Shan Yang, Xu-Dong Xu*, Guo-Xu Ma*. Bioactive cucurbitane triterpenoids from the tubers of Hemsleyapenxianensis. Phytochem.Lett.2016, 18, 5-9.

[26] Guo-Xu Ma, Ping Chen, Zhong-Hao Sun, Nai-LiangZhu,Peng-Fei Li, Jun-Shan Yang, De-Li Chen, Hua Wei. Novel cassane diterpenesfrom the seeds of  Caesalpinia decapetala andtheir antiproliferative activity. Phytochem.Lett. 2016, 16: 52-55.

[27] Guo-Xu Ma, Wei Feng, Zhong-Hao Sun, Peng-Fei Li,Nai-Liang Zhu, Jun-ShanYang, Xu-Dong Xu & Hai-Feng Wu. New stigmastane typeof steroidal glycosides fromthe roots of Vernoniacumingiana. J. Carbohyd. Chem. 2016, 35 (3): 172-179.

[28] Guo-Xu Ma, Xiao-Yan Huang, Hua-Nian Dai, Xiao-QingZhong, Yan-Lin Zhou, Zuo-Lin Su, Ying-Zi He, Jun-Shan Yang, Jing-Quan Yuan, andXu-Dong Xu. Two New Triterpenoid Glycosides from the Roots of Rosa cymosa TRATT. Helv. Chim. Acta2016, 99,1-5.

[29] XudongXu, Jingquan Yuan,XingyangZhou,WeipingLi,NailiangZhu,HaifengWu,PengfeiLi,Zhonghao Sun,JunshanYang, Guoxu Ma*. Cassane diterpenes with oxygen bridge fromthe seeds ofCaesalpinia sappan. Fitoterapia,2016, 112: 205-210.

[30] HuaWei, Hai Jiang, Zhu-Xiang Liu, Gui Li, Hua Long, Jian-Wu He, Gong-XiChen,Jun-Shan Yang &Guo-Xu Ma*. The new steroidal glycosides from the aerialpartsof Lepidogrammitis drymoglossoides.J. Asian. Nat. Prod Res. 2016, 18(9): 878-884.

申请专利：

[1]     马国需、杨美华、邢小燕、许旭东. 一种黄芪甲苷硫酸酯及其制备方法和应用,No.201910423590.1;

[2]     马国需、杨美华、邢小燕、许旭东,一种毛蕊异黄酮苷亚硫酸酯及其制备方法和应用,No.201910423589.9

[3]     马国需、霍小位、李宗阳、许旭东、孙照翠,含氮杂环混源萜类物质的制备及应用,No.201910827674.1

参编著作：

[1]     杨美华，骆骄阳，马国需，郭一飞等.中药质量控制与分析. 中国协和医科大学出版社.2020. 890千字

[2]     杨峻山，马国需.碳-13核磁共振波谱分析. 化学工业出版社. 2016. 1587千字

[3]     杨峻山，马国需等.天然有机化合物核磁共振碳谱集. 化学工业出版社.2011. 4359千字