1.  国家自然科学基金面上项目，主持，双靶向降解HSP90AB1/PGK1的楤木皂苷PROTAC分子的构建及抗动脉粥样硬化活性研究

2.  国家自然科学基金青年项目，主持，基于新型小分子探针技术寻找民族药露兜簕中咖啡酰奎宁酸类天然产物降脂作用靶标的基础研究

3.  北京市自然科学基金面上项目，主持，金盏花苷E新型化学小分子探针的构建及其心肌保护作用靶标的钓取及确认

4.  北京市自然科学基金青年项目，主持，齐墩果酸-3-O-β-D-吡喃葡萄醛酸苷小分子探针寻心肌保护作用靶标研究

5.  国家重点研发计划项目，项目骨干，闽产高品质道地中药材灵芝、太子参规范化种植及精准扶贫示范研究

6.  中国医学科学院医学与健康科技创新工程项目，岗位负责人，中药资源可持续利用关键技术和新药开发

7.  中国医学科学院医学与健康科技创新工程项目，项目骨干，防治新冠肺炎重要中药材品质保障关键技术研究

近期发表论文：

1. Yi Jia, Haiyan Xiao, Xiaolin Wang, Ying Liu, JiaxinWang, Haochen Xie, Hai Shang, Guibo Sun*, YuTian*. Design, synthesis, and evaluation of n-butylphthalide andligustrazine hybrids as potent neuroprotective agents for the treatment ofischemic stroke in vitro and in vivo. Bioorg Chem, 2024, 142, 106961.

2. Yan Li, Guangyu Li, Chenwei Zuo, Xiaolin Wang, Fang Han, Yi Jia, Hai Shang*, Yu Tian*. Discovery of ganoderic acid A PROTACs as MDM2 protein degraders for the treatment of breast cancer. EurJ Med Chem, 2024, 270, 116367.

3. Yan Li, Yi Jia, Xiao-Lin Wang, Hai Shang*, Yu Tian*. Protein-Targeted Degradation Agents Based on Natural Products. Pharmaceuticals, 2023, 16, 46.

4. Yi Jia, Yan Li, Hai Shang, Yun Luo, Yu Tian*. Ganoderic Acid A and Its Amide Derivatives as Potential Anti-Cancer Agents by Regulating the p53-MDM2 Pathway: Synthesis and Biological Evaluation. Molecules, 2023, 28, 2374.

5. Yi Jia, Yan Li, Xu-Dong Xu, Yu Tian*, Hai Shang*. Design and Development of Autotaxin Inhibitors. Pharmaceuticals, 2021,14, 1203.

6. Shan Lu, Yu Tian(co-first author), Yun Luo, Xudong Xu,Wenxiu Ge, Guibo Sun* and Xiaobo Sun*, Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia–reperfusion injury. Journal of Advanced Research, 2021, 29, 83–94.

7. Xi Zhang, Dong-yun Liu, Hai Shang, Yi Jia, Xu-Dong Xu, Yu Tian * and Peng Guo*. Aminoacid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemicagents: synthesis and biological evaluation. RSC Adv., 2021, 11, 1654.

8. Yu Tian, Shan Wang, Hai Shang, Wen-Qian Wang, Bao-Qi Wang, Xi Zhang, XuDong Xu*, Gui-Bo Sun* and Xiao-Bo Sun*. The clickable activity-basedprobe of anti-apoptotic calenduloside E. PharmBiol. 2019, 57, 133–139.

9. Yu Tian, Xiao-Xue Cao,Hai Shang, Chong-Ming Wu, Xi Zhang, Peng Guo*, Xiao-Po Zhang* and Xu-Dong Xu*. Synthesis and in vitro evaluation of caffeoylquinicacid derivatives as potential hypolipidemic agents. Molecules. 2019, 24, 964.

10. Wu Chongming*, Tian Yu(co-first author), Yu Jiaqi, Zhang Rong, Zhang Xiaopo, Guo Peng*. The pandanustectorius fruit extract (PTF) modulates the gut microbiota and exertsanti-hyperlipidaemic effects. Phytomedicine. 2019, 58, 152863.

11. Xiaoxue Cao, ChongmingWu, Yu Tian*, Peng Guo*. The caffeic acid moiety plays an essential role inattenuating lipid accumulation by chlorogenic acid and its analogues. RSCAdv., 2019, 9, 12247.

12. Shan Wang, Yu Tian (co-firstauthor), Shan Lu, Ruiying Wang, Hai Shang, Xuelian Zhang, Chenyang Zhang, GuiboSun,* Xudong Xu,* Xiaobo Sun.* Design and synthesis of acetaminophen probeAPAP-P1 for identification of the toxicity targets thioredoxin reductase-1 inHepaRG cells. RSC Adv., 2019, 9, 15224.

13. Yu Tian, Zhonghao Sun,Wenqian Wang, Hai Shang, Baoqi Wang, Di Deng, Guoxu Ma, Haifeng Wu, NailiangZhu, Xudong Xu*, Guibo Sun* and Xiaobo Sun*. Semisynthesis and BiologicalEvaluation of Oleanolic Acid 3-O-β-D-Glucuronopyranoside Derivatives forProtecting H9c2 Cardiomyoblasts against H2O2-InducedInjury. Molecules, 2018, 23, 44.

14. Shan Wang, Yu Tian(co-first author), Jing-Yi Zhang, Hui-Bo Xu, Ping Zhou, Min Wang, Sen-Bao Lu,Yun Luo, Min Wang, Gui-Bo Sun*, Xu-Dong Xu* and Xiao-Bo Sun*. Targets Fishingand Identification of Calenduloside E as Hsp90AB1: Design, Synthesis, and Evaluationof Clickable Activity-Based Probe. FrontPharmacol. 2018, 9, 532.

15. Yu Tian, Yu-yang Du,Hai Shang, Min Wang, Zhong-hao Sun, Bao-qi Wang, Di Deng, Shan Wang, Xu-dongXu*, Gui-bo Sun*, Xiao-bo Sun*. Calenduloside E Analogues Protecting H9c2Cardiomyocytes against H2O2-induced poptosis: Design,Synthesis and Biological evaluation. FrontPharmacol. 2017, 8, 862.

16. Yu Tian, Shan Wang,Hai Shang, Min Wang, Guibo Sun*, Xudong Xu*, and Xiaobo Sun*. The proteomicprofiling of Calenduloside E targets in HUVEC: Design, synthesis andapplication of biotinylated probe BCEA. RSCAdv. 2017, 7, 6259–6265.

17. Min Wang, Yu Tian (co-first author), Yu-yang Du, Gui-bo Sun*,Xu-dong Xu, Hai Jiang, Hui-bo Xu, Xiang-bao Meng, Jing-yi Zhang, Shi-lan Ding,Miao-di Zhang, Ming-hua Yang, Xiao-bo Sun*, Protective effects of Araloside Cagainst myocardial ischaemia/reperfusion injury: potential involvement of heatshock protein 90. J. Cell. Mol. Med. 2017,21, 1870–1880.

近期申请/授权专利

1. 田瑜, 许旭东, 孙桂波, 孙晓波, 尚海. 楤木皂苷衍生物及其制备方法和用途. 申请号：201910223031.6.（授权）

2. 田瑜, 王义, 尚海, 许旭东. 莪术醇衍生物及其制备方法和应用. 专利号: ZL201611207773.2（授权）

3. 田瑜, 许旭东, 孙晓波, 孙桂波, 尚海. 辽东楤木单体皂苷衍生物及其制备方法和用途. 申请号：201910223032.0（授权）

4. 许旭东, 田瑜, 孙桂波, 孙晓波, 王敏. 3-单糖醛酸氧苷齐墩果烷型和乌苏烷型三萜皂苷衍生物及其制备方法和应用. 专利号：ZL201510472522.6（授权）

5. 吴海峰, 许旭东, 杨美华, 马国需, 田瑜, 杨沁文. 具有式I所示结构的三萜衍生物及其制备方法和应用. 专利号：ZL201811640954.3（授权）

6. 孙晓波, 许旭东, 田瑜, 孙桂波, 王敏. D-三七素的制备方法及其用途. 申请号: 201510921063.5

7. 田瑜, 许旭东, 郭鹏, 吴崇明, 尚海. 一种咖啡酰奎宁酸类衍生物及其制备方法和用途. 专利号：ZL201910022953.0 （授权）

8. 田瑜, 罗云, 贾怡, 孙晓波. 一种灵芝酸A衍生物的制备及其应用，CN202011572509.5. (已授权)

9. 田瑜, 罗云, 贾怡, 尚海, 孙晓波. 一类具有抗纤维化功能的三萜类化合物及其制备方法, CN202011561227.5(已授权)

研究领域：天然药物化学，合成药物化学，化学生物学

1、基于结构的活性天然产物的合理设计改造、生物活性评价及作用机制研究

2、基于化学生物学、蛋白质组学及分子探针技术确认天然产物/药物的功能靶标/毒性靶标研究