本团队由我、卢善发研究员（博导），王梅珍副研究员以及5名在读研究生组成，主要从事药用活性成分生物合成与调控的分子机制研究。以丹参、夏枯草、北马兜铃和连翘等药用植物为研究对象，通过全基因组测序，转录组、代谢组和小RNA组分析以及基因功能鉴定，揭示药用活性成分生物合成与调控的分子机制，探讨用合成生物学手段生产药效物质。

1. 中国医学科学院医学与健康科技创新工程项目“本草基因组协同创新团队”-基于本草基因组的药材品质形成机制研究

2. 国家自然科学基金青年基金项目-SmMYB3，SmMYB6和SmMYB109在丹参生物活性化合物生物合成中的调控作用研究

3. 北京协和医学院协和青年基金项目-SmMYB3参与丹酚酸生物合成调控的分子机制

Caili Li,Dongqiao Li, Hong Zhou, Jiang Li, Shanfa Lu. Analysis of the laccase genefamily and miR397-/miR408-mediated posttranscriptional regulation in Salvia miltiorrhiza. PeerJ, 2019, 7:e7605.

Hong Zhou, Caili Li, Xiaoxiao Qiu, Shanfa Lu.Systematic analysisof alkaline/neutral invertase genes revealsthe involvement of Smi-miR399 in regulation of SmNINV3 and SmNINV4 in Salvia miltiorrhiza.Plants (Basel), 2019, 8(11): 490.

Yuxing Deng, Caili Li, Heqin Li, Shanfa Lu. Identification and characterizationof flavonoid biosynthetic enzyme genes in Salviamiltiorrhiza (Lamiaceae). Molecules, 2018, 23(6): 1467.

HeqinLi, Caili Li, Yuxing Deng, XuwenJiang, Shanfa Lu. The pentatricopeptide repeat gene family in Salvia miltiorrhiza: Genome-wide characterizationand expression analysis. Molecules, 2018, 23(6): 1364.

Jiang Li, Caili Li, Shanfa Lu. Systematicanalysis of DEMETER-like DNA glycosylase genes shows lineage-specificSmi-miR7972 involved in SmDML1 regulation in Salvia miltiorrhiza. Scientific Reports, 2018, 8: 7143.

Jiang Li, Caili Li, Shanfa Lu. Identification andcharacterization of the cytosine-5 DNA methyltransferase gene family in Salvia miltiorrhiza. PeerJ, 2018, 6:e4461.

MeizhenWang, Caili Li, Shanfa Lu. Originand evolution of MIR1444 genes in Salicaceae. Scientific Reports, 2017, 7: 39740.

Caili Li, Dongqiao Li, Jiang Li, Fenjuan Shao, ShanfaLu. Characterization of the polyphenol oxidase gene family reveals a novelmicroRNA involved in posttranscriptional regulation of PPOs in Salvia miltiorrhiza.Scientific Reports, 2017, 7: 44622.

Qing Du, Caili Li, Dongqiao Li, Shanfa Lu.Genome-wide analysis, molecular cloning and expression profiling revealtissue-specifically expressed, feedback-regulated, stress-responsive andalternatively spliced novel genes involved in gibberellin metabolism in Salvia miltiorrhiza. BMC Genomics. 2015,16(1): 1087.

Caili Li, Dongqiao Li, Fenjuan Shao, Shanfa Lu. Molecularcloning and expression analysis of WRKY transcription factor genes in Salvia miltiorrhiza. BMCGenomics, 2015, 16: 200.

Caili Li, Shanfa Lu. Molecularcharacterization of the SPL genefamily in Populus trichocarpa. BMC Plant Biology, 2014, 14: 131.

Caili Li, Shanfa Lu. Genome-wide characterization andcomparative analysis of R2R3-MYB transcription factors show the complexity of MYB-associated regulatory networks in Salviamiltiorrhiza. BMC Genomics, 2014, 15: 277.

Linsu Zhang, Bin Wu,Degang Zhao, Caili Li, Fenjuan Shao,Shanfa Lu. Genome-wide analysis and molecular dissection of the SPL gene family in Salvia miltiorrhiza. Journal of Integrative Plant Biology, 2014,56(1): 38-50.

代表性论文论著

论著：

《The Salvia miltiorrhiza genome. Compendium of Plant Genomes》. Springer, Cham, Switzerland. 2019, 参编

《药用植物品质生物学》，科学出版社，北京，2019，参编.