1. 在中国中医科学院中药研究所陈士林研究员的指导下，开展大麻素合成调控的分子机制研究。

2. 与湖北省农业科学院中药材研究所林先明研究员、何美军副研究员、郭杰副研究员等合作，开展葛属植物富硒分子机制、林药间作提高贝母品质的分子机制等研究。

主持或参与国家科技部新药创制重大专项、国家自然科学基金、北京市自然科学基金等课题10余项。

主持或参与国家科技部新药创制重大专项、国家自然科学基金、北京市自然科学基金等课题10余项。

主要以甘草、野葛、人参等作为试材，通过分析转录组、小RNA组、降解组等组学数据并结合实验验证，重点关注了基因转录后调控的分子机制，包括可变剪接和RNA编辑；挖掘出了甘草酸、野葛异黄酮、人参皂苷等成分合成相关的结构基因及调控基因，调控基因关注了转录因子和非编码RNA中的长链非编码RNA（lncRNA）、微小RNA（miRNA）和环状RNA（CircRNA）。

近年来发表论文：

1. Yanni Li, Caixia Chen, Zhenzhen Xie, Jing Xu, Bin Wu*, Wenquan Wang*. Integrated analysis of mRNA and microRNA elucidates the regulation of glycyrrhizic acid biosynthesis in Glycyrrhiza uralensis Fisch. International Journal of Molecular Sciences, 2020, 21(9):3101.

2. Kunyuan Guo, Yiwei Yao, Meng Yang, Yanni Li, Bin Wu*, Xianming Lin*. Transcriptome sequencing and analysis reveals the molecular response to selenium stimuli in Pueraria lobata (willd.) Ohwi. PeerJ, 2020, 8: e8768.

3. Hongwu Shi#, Meng Yang#, Changming Mo, Wenjuan Xie ,Chang Liu, Bin Wu*, Xiaojun Ma*. Complete chloroplast genomes of two Siraitia Merrill species: Comparative analysis, positive selection and novel molecular marker development. PLoS One,2019, 14(12): e0226865.

4. Junjie Shao, Liqiang Wang, Xinyue Liu, Meng Yang, Haimei Chen, Bin Wu*, Chang Liu*. Identification and characterization of circular RNAs in Ganoderma lucidum. Scientific Reports, 2019, 9:16522.

5. Meijun He, Yiwei Yao, Yanni Li, Meng Yang, Yu Li, Bin Wu*, Dazhao Yu*. Comprehensive transcriptome analysis reveals genes potentially involved in isoflavone biosynthesis in Pueraria thomsonii Benth. PLoS One, 2019, 14(6): e0217593.

6. Luying Li, Xiaoyan Zhang, Xiangmei Tan, Bingda Sun, Bin Wu*, Meng Yu, Tao Zhang, Yonggang Zhang*, Gang Ding*. Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis. Molecules, 2019, 24(7): 1405.

7. Bin Wu#, Haimei Chen#, Junjie Shao, Hui Zhang, Kai Wu, Chang Liu. Identification of Symmetrical RNA Editing Events in the Mitochondria of Salvia miltiorrhiza by Strand specific RNA Sequencing. Scientific Reports, 2017, 10(7):42250.

8. Jia Tian, Bin Zeng, Shuping Luo, Xiugen Li, Bin Wu*, Jiang Li*. Cloning, Localization and Expression Analysis of Two fw2.2-like Genes in Small- and Large-Fruited Pear Species. Journal of Integrative Agriculture, 2016, 15(2):282-294.

9. Bin Wu#, Qiliang Long#, Yuan Gao, Zi Wang, Tianwei Shao, Yanan Liu, Yong Li, Wanlong Ding. Comprehensive characterization of a time-course transcriptional response induced by autotoxins in Panax ginseng using RNA-Seq. BMC Genomics, 2015, 16:1010.

10. Bin Wu, Fengmei Suo, Wanjun Lei, Lianfeng Gu. Comprehensive Analysis of Alternative Splicing in Digitalis purpurea by Strand-specific RNA-Seq. PLoS One, 2014, 7(9): e106001.

11. Jianqin Li#, Bin Wu#, Jiang Xu, Chang Liu. Genome-wide identification and characterization of long intergenic non-coding RNAs in Ganoderma lucidum. PLoS One, 2014,7(9):e44385.

12. Haimei Chen#, Bin Wu#, David Nelson, Kai Wu, Chang Liu. Computational Identification and Systematic Classification of novel Cytochrome P450 genes in Salvia miltiorrhiza. PLoS One, 2014, 9(12):e99442.

13. Bin Wu#, Baocai Zhang#, Yan Dai#, Lei Zhang, Keke Shang-Guan, Yenggang Peng, Y.ihua Zhou, Zhen Zhu. Brittle Culm15 encodes a membrane-associated chitinase-like protein required for cellulose biosynthesis in rice. Plant Physiology, 2012,159(4):1440-1452.

14. Bin Wu, Ying Li, Haixia Yan, Yimian Ma, Hongmei Luo, Licai Yuan, Shilin Chen, Shanfa Lu. Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea. BMC Genomics, 2012, 13:15.

15. Bin Wu#, Mei Wang#, Yimian Ma, Licai Yuan, Shanfa Lu. High-throughput sequencing and characterization of the small RNA transcriptome reveal features of novel and conserved microRNAs in Panax ginseng. PLoS One, 2012,7(9):e44385.

16. Yuan Gao, Xiaoli He, Bin Wu, Qiliang Long, Tianwei Shao, Zi Wang, Jianhe Wei, Yong Li, Wanlong Ding. Time-course Transcriptome Analysis Reveals Resistance Genes of Panax ginseng Induced by Cylindrocarpon destructans Infection using RNA-Seq. PLoS One, 2016, 11(2):e0149408.

17. Meizhen Wang, Bin Wu, Chao Chen and Shanfa Lu. Identification of Panax ginseng mRNA-like non-coding RNAs and validation of a mighty one regulating multiple metabolic pathways. Journal of Integrative Plant Biology, 2015, 57(3):256-270.

18. Linshu Zhang, Bin Wu, Degang Zhao, Caili Li, Fenjuan Shao, Shanfa Lu. Genome-wide analysis and molecular dissection of the SPL gene family in Salvia miltiorrhiza. Journal of Integrative Plant Biology, 2014, 56 (1): 38-50.

19. Yimian Ma, Licai Yuan, Bin Wu, Xian’en Li, Shilin Chen, Shafa Lu. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. Journal of Experimental Botany, 2012, 63(7):2809-2823.

20. 姚怡玮，徐静，杨萌，李燕呢，何美军，郭坤元，吴斌*. 基于生物信息学方法预测野葛中的miRNA及其靶基因.中国现代中药, 2019,21(4):429-437.

21. 姚怡玮，何美军，杨萌，徐静，郭坤元，吴斌*．药食两用植物富硒研究进展. 湖北农业科学, 2019,58(15):5-8.