本团队由我、齐云研究员（博导）及1位技术系列的副主任技师组成，主要从事中药与天然药物的抗炎免疫研究。抗炎涉及感染性炎症及代谢性炎症；免疫涉及I型过敏反应及自身免疫性疾病。加上在读研究生，是一个规模为12人的中型团队。我们以严谨、高效为目标，并努力营造一个适宜于辛勤工作的舒心环境(人际关系的和谐)。我们均拒绝与排斥恃强凌弱与弄虚作假(不诚实)这两种恶质，欢迎志趣相投者加入！

目前团队正致力于以下几个方向的研究：

1、中药及天然药物（含成分）对抗细菌或病毒活化TLRs的炎症风暴作用与机制研究；

2、中药及天然药物（含成分）抗变态反应及中药注射剂速发性超敏反应的分子机制研究；

3、中药及天然药物（含成分）抗肥胖型脂肪肝的创制新药研究；

4、中药及其制剂的生物质控研究。

以第一作者或通讯作者发表英文文章如下：

1.   Scutellarein suppresses the production of ROS and inflammatory mediators of LPS-activated bronchial epithelial cells and attenuates acute lung injury in mice. Antioxidants. 2024, 13(6): 710.

2. Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes. Int J Mol Sci. 2023, 24(1): 320.

3.   Bupleurum chinense exerts a mild antipyretic effect on LPS-induced pyrexia rats involving inhibition of peripheral TNF-α production. J Ethnopharmacology, 2023 (310): 116375.

4. Edible O. fragrans ffower ameliorates LPS-induced inffammatory responses through suppressing NF-κB and AP-1 pathways. J Functional Foods. 2023 (104): 105505.

5. Comparing the effects of three decoctions for coronavirus disease 2019 on severe acute respiratory syndrome coronavirus 2-related toll-like receptors-mediated inflammations. J Tradit Chin Med. 2023, 43(1):51-59.

6.   Resibufogenin, one of bufadienolides in toad venom, suppresses LPS-induced inflammation via inhibiting NF-κB and AP-1 pathways. Int Immunopharmacol. 2022, 113(Pt A):109312.

7.   Oral administration of Forsythiasides-rich extract from Forsythiae fructus decreases the IgE production through suppressing Th2 response in shrimp protein-sensitized BALB/c mice. Phytomedicine Plus. 2022, 2(4): 100358.

8.   A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristics. Sci Rep. 2022, 12:17058.

9.   Anti-oxidative and anti-inflammatory activities of the ethanol extract of edible flower from Chimonanthus praecox. Front Pharmacol. 2022, 13:1004520.

10.   MAPKs/AP-1, not NF-κB, is responsible for MCP-1 production in TNF-α-activated adipocytes. Adipocyte. 2022 ,11(1):477-486.

11.   Aloe-emodin, a naturally occurring anthraquinone, is a highly potent mast cell stabilizer through activating mitochondrial calcium uniporter. Biochem Pharmacol. 2021, 186:114476.

12.   Forsythiasides-rich extract from Forsythiae Fructus inhibits mast cell degranulation by enhancing mitochondrial Ca2+ uptake. Front Pharmacol. 2021, 12: 696729.

13.  Potentilla discolor ameliorates LPS-induced inflammatory responses through suppressing NF-κB and AP-1 pathways. Biomed Pharmacother. 2021,144:112345.

14.  Compound Kushen Injection Induces Immediate Hypersensitivity Reaction Through Promoting the Production of Platelet-Activating Factor via de Novo Pathway. Front Pharmacol. 2021,12:768643.

15.  Qing-Kai-Ling Injection Induces Immediate Hypersensitivity Reaction via the Activation of Anaphylatoxin C3. Front Pharmacol. 2020, 10:1524.

16. Ethanol extract of Elephantopusscaber Linn. Attenuates inflammatory response via the inhibition of NF-κB signaling by dampening p65-DNA binding activity in lipopolysaccharide-activated macrophages. J Ethnopharmacol. 2020, 250:112499.

17. Penicillin causes non‑allergic anaphylaxis by activating the contact system. Sci Rep. 2020, 10:14160.

18.  Canscora lucidissima, a Chinese folk medicine, exerts anti-inflammatory activities by inhibiting the phosphorylation of ERK1/2 in LPS-activated macrophages. BMC Complement Altern Med. 2019, 19(1):371.

19.  Shuang-Huang-Lian Attenuates Airway Hyperresponsiveness and Inflammation in a Shrimp Protein-Induced Murine Asthma Model. Evid Based Complement Alternat Med. 2019, 2019:4827342.

20. Shuang-Huang-Lian injection induces an immediate hypersensitivity reactionvia C5a but not IgE. Sci Rep. 2018, 8(1):3572.

21.  Obacunonecauses sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF. J Cell Biochem. 2018, 119(1):837-849.

22.  The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter. Sci Rep. 2017, 7:38736.

23.  Highly specific and sensitive immunoassay for the measurement of prostaglandin E2 in biological fluids. Bioanalysis. 2015, 7(19):2597-2607.

24.  Evaluation of the intestinal transport of phenylethanoid glycosides-rich extract from Cistanche deserticola across the Caco-2 cell monolayer model. Plos one. 2015, 10(2):e011649.

25.  Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages. Free Radic Biol Med. 2014, 72: 104-112.

26.  Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages. Plos one. 2014, 9(5): e96741.

27.  Suppressive effects of irisflorentin on LPS-induced inflammatory responses in RAW 264.7 macrophages. Exp Biol Med. 2014, 239(8):1018-1024.

28.  Comparison of the endothelial toxicity induced by short-term amiodarone and diazepam exposure in a human umbilical vein endothelial cell line (EVC304). Pharm Biol. 2014, 52(10):1256-1261.

29.  Shuang Huang Lian exerts antiinflammatory and antioxidative activities in lipopolysaccharide stimulated murine alveolar macrophages. Phytomedicine 2014, 21: 461-469.

30.  Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264.7 cells. Eur J Pharmacol. 2014, 723:339-345.

31.  Preparation of highly specific anti-zearalenone antibodies by using the cationic protein conjugate and development of an indirect competitive enzyme-linked immunosorbent assay. Analyst 2012, 137:229-236.

32.  Pharmacological basis for the medicinal use of muskmelon base (Pedicellus Melo.) for abdominal distention and constipation. J Ethnopharmacol. 2012, 142:129-135.

理性的选择不仅需要你有一双慧眼，还需要你对自己有充分的了解。未来的3年对你而言是一个极其重要的人生节点，愿你跟随本心，在充分比较的前提下做出一个无怨无悔的选择。我们期待与你相遇，欢迎你的加入！