近五年主持的科研项目：

1.      国家自然科学基金（课题编号：31570344）：基于体内代谢及谱效表征的肉苁蓉增力有效成分群及其相互作用研究（2016-2019），主持人。

2.      国家自然科学基金（课题编号：81274054）：半夏泻心汤治疗伊立替康肠毒性药效物质基础及作用机理研究（2013-2016），主持人。

3.      北京市自然科学基金（课题编号：7142109）：基于谱效关系的生姜泻心汤治疗伊立替康肠毒性药效物质基础研究（2014-2016），主持人。

4.       国家食品药品监督管理总局项目：化妆品中10种植物组分检测方法研究（2017-2019），主持人。

5.       国家食品药品监督管理总局项目：苦参实毒性成分研究（2016-2018），主持人。

6.       国家食品药品监督管理总局项目：化妆品禁用、限用、准用组分技术要求制定（2016-2017），主持人。

7.      国家食品药品监督管理总局项目：植物类化妆品原料管理相关研究（2015-2016），主持人。

近五年发表的主要学术论文：

1.       XiaomingWang, Xiaoyao Chang, Xiaomei Luo, Meifeng Su, Rong Xu, Jun Chen, Yi Ding, Yue Shi*. AnIntegrated Approach to Characterize Intestinal Metabolites of FourPhenylethanoid Glycosides and Intestinal Microbe-Mediated Antioxidant ActivityEvaluation In Vitro Using UHPLC-Q-Exactive High-Resolution Mass Spectrometryand a 1,1-Diphenyl-2-picrylhydrazyl-Based Assay. Frontiers in Pharmacology,2019, 10: 826 (SCI: 3.845, 医学Q2)

2.      HuanyuGuan, Xiaomei Luo, Xiaoyan Chang, Meifeng Su, Zhuangzhuang Li, Pengfei Li,Xiaoming Wang and Yue Shi*.Identification of the Chemical Constituents of an Anti-Arthritic ChineseMedicineWen Luo Yin by Liquid Chromatography Coupled with Mass Spectrometry. Molecules,2019, 24, 233, doi:10.3390/molecules 24020233 (SCI 3.060, Q3)

3.      XiaomingWang, Jinfang Wang, Huanyu Guan, Rong Xu, Xiaomei Luo, Meifeng Su, XiaoyanChang. Wenting Tan, Jun Chen, Yue Shi*.Comparison of the Chemical Profiles and Antioxidant Activities of DifferentParts of Cultivated Cistanche deserticola Using Ultra Performance LiquidChromatography- Quadrupole Time-of-Flight Mass Spectrometry and a1,1-Diphenyl-2-picrylhydrazyl-Based Assay. Molecules, 2017, 22, 2011,doi:10.3390/molecules 22112011 (SCI 2.861, Q3)

4.      Huan-yuGuan, Peng-fei Li, Xiao-ming Wang, Jia-jing Yue, Yang He, Xiao-mei Luo,Mei-feng Su, Shang-gao Liao, Yue Shi*.Shengjiang Xiexin Decoction Alters Pharmacokinetics of Irinotecan by RegulatingMetabolic Enzymes and Transporters: A Multi-Target Therapy for Alleviating theGastrointestinal Toxicity. Frontiers in Pharmacology, 2017, 8:769, doi:10.3389/fphar.2017.00769 (SCI 4.400, 医学Q2)

5.      HuanyuGuan,Kaitong Li, Xiaoming Wang, Xiaomei Luo, Meifeng Su, Xiaoyan Chang, Yue Shi*. Identification of Metabolitesof the Cardioprotective Alkaloid Dehydrocorydaline in Rat Plasma and Bile byLiquid Chromatography Coupled with Triple Quadrupole Linear Ion Trap MassSpectrometry. Molecules, 2017, 22: 1686, doi:10.3390/molecules22101686 (SCI 2.861, Q3)

6.      HuanyuGuan, Xiaoming Wang, Shiping Wang, Yang He, Jiajing Yue, Shanggao Liao, YuandaHuang, Yue Shi*. Comparativeintestinal bacteria-associated pharmacokinetics of 16 components of ShengjiangXiexin decoction between normal rats and rats with irinotecan hydrochloride(CPT-11)-induced gastrointestinal toxicity in vitro using salting-out samplepreparation and LC-MS/MS. RSC Advances, 2017, 7: 43621, doi: 10.1039/c7ra03521g(SCI 3.108, Q3)

7.      QiuyueLi, Huanyu Guan, Xiaoming Wang, Yang He, Hong Sun, Wenting Tan, Xiaomei Luo,Meifeng Su, Yue Shi*. Fingerprint–efficacystudy of the quaternary alkaloids in Corydalis yanhusuo. Journal ofEthnopharmacology, 2017, 207: 108, doi: 10.1016/j.jep.2017.06.036 (SCI 2.981, 植物科学Q2)

8.      Gang Peng, Huanyu Guan, Xiaoming Wang, Yue Shi*. Simultaneous determination of 14active constituents of Shengjiang Xiexin decoction using ultrafast liquidchromatography coupled with electrospray ionization tandem mass spectrometry. Acta Pharmaceutica Sinica B, 2017,7:193-201(SCI5808, 医学Q1)