中国医学科学院&北京协和医学院药物研究所 杨敏课题组，主要从事肿瘤生物标志物、肿瘤及心血管药理学、肿瘤生物信息学的研究。课题组系药理室生物分析中心，实验室面积约434平方米，下设病理平台、分子影像平台、蛋白分子平台、同位素实验室，配备大型仪器39台，价值共计约4238万元，是天然药物活性物质与功能国家重点实验室的组成部分。课题组现有职工11名，其中博士5名，硕士2名，均具有专业领域多年的科研经历及新技术、新方法开发的丰富经验，在读硕士研究生3名。本课题组迄今主持5项国家自然科学基金、4项北京市自然科学基金及1项院校级课题，并且负责北京协和医学院研究生课程《实验病理学技术》的教学工作。

本课题组迄今主持5项国家自然科学基金、4项北京市自然科学基金及1项院校级课题。

（1）肿瘤生物标志物研究

        基于肿瘤公共数据库、组学数据与临床数据的多层面、多水平整合与挖掘，探寻肿瘤基因、免疫应答、信号通路富集变化、分子网络、分子分型与肿瘤临床表型等关系，通过分子标记物筛选、临床预后疗效等预测模型建立、组织芯片免疫组化检测及临床随访参数的关联分析，并探究肿瘤发生发展的分子机制，实现肿瘤生物标志物的发现验证、免疫诊疗及临床诊疗的转化。

（2）肿瘤发展转移的药物靶点研究

        利用转录组测序、单细胞测序、代谢组学数据，通过生物信息手段进行差异基因表达、节点基因、分子网络、代谢通路及临床表型关联分析，挖掘潜在药物靶点。进一步采用原位肿瘤及肿瘤转移动物模型、细胞模型，利用病理学、多模态分子影像技术、分子细胞生物学、基因修饰等技术手段，研究肿瘤预后、复发和转移相关的基因功能及机制。

（3）心血管重塑的分子靶点研究

        基于组学数据和遗传修饰模式动物，采用病理学、药理学、多模态分子影像技术与分子细胞生物学、基因修饰等技术手段，以免疫炎症反应为靶点，应用于高血压心脏损伤模型、阿霉素心肌损伤模型、动脉粥样硬化模型和细胞模型进行机制研究和药效评价。

发表论文

[1] Silin Lv, Zifan Zeng, Wenqiang Gan, Weiqi Wang, Tiegang Li, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang*. Lp-PLA2 inhibition prevents Ang II–induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation. Acta Pharmacologica Sinica; 2021. DOI: 10.1038/s41401-021-00703-7 (一区, IF: 6.15)

[2] Yufang Hou#, Weiqi Wang#, Zifan Zeng#, Wenqiang Gan, Silin Lv, Tiegang Li, Zheng Yan, Rixin Zhang, Min Yang*. High SEMA4C expression promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal carcinoma. Aging-US; 2020. 12(21): 21992-22018. (二区, 5-Year IF: 5.682)

[3] Rixin Zhang, Tiegang Li, Weiqi Wang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Zheng Yan, Min Yang*. Indoleamine 2, 3-dioxygenase 1 (IDO1) and CD8 expression profiling revealed an immunological subtype of colon cancer with a poor prognosis. Frontiers in Oncology; 2020. 12. doi: 10.3389 (二区, IF: 6.244)

[4] Weiqi Wang, Silin Lv, Wenqiang Gan, Zifan Zeng, Min Yang*. A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019. Annals of Translational Medicine; 2020. 8(21): 1403 (二区, IF: 3.932)

[5] Yufang Hou, Tiegang Li, Wenqiang Gan, Silin Lv, Zifan Zeng, Zheng Yan, Weiqi Wang, Min Yang*. Prognostic significance of mutant-allele tumor heterogeneity in uterine corpus endometrial carcinoma. Annals of Translational Medicine; 2020. 8(6):339 (二区, IF: 3.932)

[6] Wenqiang Gan#, Jingyuan Ren#, Tiegang Li, Silin Lv, Chenghe Li, Ziliang Liu, Min Yang*. The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. Biochimica et Biophysica Acta-Molecular Basis of Disease; 2018. 1864(1):1-10. (一区, 5-Year IF: 5.540)

[7] Wenqiang Gan#, Tiegang Li#, Jingyuan Ren, Chenghe Li, Ziliang Liu, Min Yang*. Serum-glucocorticoid-regulated kinase 1 contributes to mechanical stretch-induced inflammatory responses in cardiac fibroblasts. Molecular and Cellular Biochemistry; 2018. 445(1-2): 67-78 (5-Year IF: 2.731)

[8] Min Yang, Bo Ma, Hanshuang Shao, Amanda M. Clark, Alan Wells*. Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC Cancer; 2016. 16: 419. doi: 10.1186/s12885-016-2411-1 (5-Year IF: 3.645)

[9] Min Yang#, Jingwei Liu#, Chunmei Piao, Jianghua Shao, Jie Du*. ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis. Cell Death & Disease; 2015. 6: e1780. (一区, 5-Year IF: 5.497)

[10] Min Yang, Jianghua Shao, Yanju Miao, Wei Cui, Yongfen Qi, Jiahuai Han, Xin Lin, Jie Du*. Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization. Cell Death & Differentiation; 2014. 21(8):1290-1302. (一区, 5-Year IF:8.461)

[11] Min Yang#, Jingwei Liu#, Jianghua Shao, Yanwen Qin, Qunsheng Ji, Xiaolin Zhang, Jie Du*. Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization. Molecular Cancer; 2014. 13:43. doi:10.1186/1476-4598-13-43. (一区, 5-Year IF: 5.220)

[12] Jiao Zheng#, Min Yang# (Co-first author), Jianghua Shao, Yanju Miao, Jiahuai Han, Jie Du*. Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis. Molecular Cancer; 2013. 12(1):141. doi: 10.1186/1476-4598-12-141. (一区, 5-Year IF:5.236)

[13] Min Yang, Jiao Zheng, Yanjv Miao, Ying Wang, Wei Cui, Jun Guo, Shulan Qiu, Yalei Han, Lixin Jia, Huihua Li, Jizhong Cheng, Jie Du*. Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arteriosclerosis Thrombosis & Vascular Biology. 2012; 32:1675-1686. (一区, 5-Year IF:6.607)

[14] Min Yang, Sheng-di Hu, Bin Wu, Yan-ying Miao, Hui Pan, Shi-gong Zhu*. Ghrelin inhibits apoptosis signal-regulating kinase 1 activity via upregulating heat shock protein 70. Biochemical and Biophysical Research Communications. 2007; 359:373-378. (5-Year IF:2.985)