1.      中国医学科学院医学与健康科技创新工程，2017-I2M-3-015，衰老过程中组织干细胞变迁关键调控节点与疾病发生，2017/1-2020/12，主持，在研。

2.      国家自然科学基金，31501001，大鼠miR-29a与肝再生的关系及其作用机制研究，2016/1-2018/12，主持，已结题。

3.      协和新星项目，2017/1-2018/12，主持，已结题。

4.      国家科技支撑计划项目，2014BAI02B01，基因工程大鼠模型的研发与示范，2014/7-2017/6，子项目主持，已结题。

5.      协和青年基金滚动项目，33320140014，gp130基因缺失对大鼠神经干细胞的增殖和分化的影响，2014/7-2015/6，主持，已结题。

6.      中央级公益性科研院所基本科研业务费, CRISPR/Cas9技术在基因工程敲除大鼠中的应用研究，2013/7-2014/6，主持，已结题。

1.      中国医学科学院医学与健康科技创新工程，2017-I2M-3-015，衰老过程中组织干细胞变迁关键调控节点与疾病发生，2017/1-2020/12，主持

2.      国家自然科学基金，31501001，大鼠miR-29a与肝再生的关系及其作用机制研究，2016/1-2018/12，主持。

3.      协和新星项目，2017/1-2018/12，主持。

4.      国家科技支撑计划项目，2014BAI02B01，基因工程大鼠模型的研发与示范，2014/7-2017/6，子项目主持。

5.      协和青年基金滚动项目，33320140014，gp130基因缺失对大鼠神经干细胞的增殖和分化的影响，2014/7-2015/6，主持。

6.      中央级公益性科研院所基本科研业务费, CRISPR/Cas9技术在基因工程敲除大鼠中的应用研究，2013/7-2014/6，主持。

[1] Lei Tan, Xiaolong Qi, Weining Kong, Jiachuan Jin, Dan Lu,Xu Zhang, Yue Wang, Siting Wang, Wei Dong, Xudong Shi, Wei Chen, Jianying Wang,Keru Li, Yuan Xie, Lijuan Gao, Feifei Guan, Kai Gao, Chaojun Li, Cheng Wang,Zhibin Hu, Lianfeng Zhang, Xuejiang Guo, Bin Shen#, Yuanwu Ma#. A conditional knockout rat resource ofmitochondrial protein-coding genes via a DdCBE-induced premature stop codon. ScienceAdvance. 2023 (in press).

[2]  Xiaolong Qi*, LeiTan*, Xu Zhang*, Jiachuan Jin*, Weining Kong*, Wei Chen*, Jianying Wang, WeiDong, Lijuan Gao, Lijun Luo, Dan Lu, Jianan Gong, Feifei Guan, Wenjie Shu,Xingxu Huang, Lianfeng Zhang, Shengqi Wang, Bin Shen#, and Yuanwu Ma#. ExpandingDdCBE-mediated targeting scope to aC motif preference in rat. MolecularTherapy Nucleic Acids. 2023, 32: 1-12.

[3] Xie Z, Li D,Cheng X, Pei Q, Gu H, Tao T, Huang M, Shang C, Geng D, Zhao M, Liu A, Zhang C,Zhang F#, Ma Y#, Cao P#. A brain-to-spinal sensorimotor loop forrepetitive self-grooming. Neuron.  2022 Mar 2;110(5):874-890.e7.doi: 10.1016/j.neuron.2021.11.028. Epub 2021 Dec 20.

[4] Yang L, Sun J, Chen Z, Liu L, Sun Y, Lin J, Hu X, Zhao M,Ma Y, Lu D, Li Y, Guo Y, DongE. The LMNA p.R541C mutation causes dilated cardiomyopathy in human and mice. Int JCardiol. 2022 Sep 15; 363:149-158.

[5] Zhang L, Dong W, MaY, Bai L, Zhang X, Sun C, Li J, Zhang L. Pon1 Deficiency Promotes Trem2Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatoryCytokines Release In Vitro and In Vivo. Mol Neurobiol. 2022Jul;59(7):4612-4629.

[6] Ling Y, Yang X, Zhang X, Guan F, Qi X, Dong W, Liu M, MaJ, Jiang X, Gao K, Li J, Chen W, Gao S, Gao X, Pan S, Wang J, Ma Y, Lu D, Zhang L. Myocardium-specificIsca1 knockout causes iron metabolism disorder and myocardial oncosis in rat. LifeSci. 2022 May 15; 297:120485.

[7] Li Z*, Qi X*, Zhang X, Yu L, Gao L, Kong W, Chen Wei,Dong Wei, Luo L, Lu D, Zhang L, Ma Y. TRDMT1 exhibitedprotective effects against LPS-induced inflammation in rats throughTLR4-NF-κB/MAPK-TNF-α pathway. AnimalModel Exp Med. 2022 Apr;5(2):172-182. doi: 10.1002/ame2.12221.

[8] Ling Y, Ma J,Qi X, Zhang X, Kong Q, Guan F, Dong W, Chen W, Gao S, Gao X, Pan S, Ma Y,Lu D, Zhang L. Novel rat model of multiple mitochondrialdysfunction syndromes (MMDS) complicated with cardiomyopathy. AnimalModel Exp Med. 2021 Dec 6;4(4):381-390.doi: 10.1002/ame2.12193.eCollection 2021 Dec.

[9] Jiang XY, Guan FF,Ma JX, Dong W, Qi XL, Zhang X, Chen W, Gao S, Gao X, Pan S, Wang JZ,Ma YW, Zhang LF, Lu D. Cardiac-specificTrim44 knockout in rat attenuates isoproterenol-induced cardiac remodeling viainhibition of AKT/mTOR pathway. Dis Model Mech. 2023 May 1;16(5): dmm049444.

[10] Li M, Qiu C,Bian Y, Shi D, Wang B, Ma Q, Wang X, Shi J, Zhang L, Ma Y, Zhu P,Cheng T, Chu Y, Yuan W. SETD5 modulates homeostasis of hematopoietic stem cellsby mediating RNA Polymerase II pausing in cooperation with HCF-1. Leukemia. 2021 Dec 1. doi: 10.1038/s41375-021-01481-1.

[11] Xu J, Wang P,Li Z, Li Z, Han D, Wen M, Zhao Q, Zhang L, Ma Y, Liu W, Jiang M,Zhang X, Cao X. IRF3-binding lncRNA-ISIR strengthens interferon production inviral infection and autoinflammation. Cell Rep. 2021 Nov 2;37(5):109926. doi: 10.1016/j.celrep.2021.109926.

[12] Hou D, Fu H, Zheng Y, Lu D, MaY, Yin Y, Zhang L, Bao D. Uncoupling protein 1 knockout aggravatesisoproterenol-induced acute myocardial ischemia via AMPK/mTOR/PPARα pathways inrats. Transgenic Res. 2022 Feb;31(1):107-118.doi:10.1007/s11248-021-00289-0.

[13] Qi X, Chen X, Guo J, Zhang X, Sun H, Wang J, Qian X, Li B,Tan L, Yu L, Chen W, Zhang L, Ma Y#, Shen B#. Precisionmodeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing. Cell Discov. 2021 Oct 19;7(1):95. doi:10.1038/s41421-021-00325-7.

[14] Liu S, Liu J, Yang X, Jiang M, Wang Q, Zhang L, Ma Y,Shen Z, Tian Z, Cao X. Cis-actinglnc-Cxcl2 restrains neutrophil-mediated lung inflammation by inhibitingepithelial cell CXCL2 expression in virus infection. Proc Natl Acad Sci US A. 2021 Oct 12;118(41):e2108276118. doi: 10.1073/pnas.2108276118.

[15] Zhao F, Zhao H, Fan J, WangR, Han Z, Tao Z, Zheng Y, Yan F, Huang Y, Yu L, Zhang X, Qi X, Zhang L, Luo Y#,Ma Y#. MiR-29a Knockout Aggravates Neurological Damage byPre-polarizing M1 Microglia in Experimental Rat Models of Acute Stroke. Front Genet. 2021 Mar 15;12:642079.doi: 10.3389/fgene.2021.642079. eCollection 2021.

[16] Ma Y*, Lu D*,Bao L*, Qu Y*, Liu J, Qi X, Yu L, Zhang X, Qi F, Lv Q, Liu Y, Shi X, Sun C, LiJ, Wang J, Han Y, Gao K, Dong W, Liu N, Gao S, Xue J, Wei Q, Pan S, Gao H,Zhang L, Qin C. SARS-CoV-2 infection aggravates chronic comorbidities ofcardiovascular diseases and diabetes in mice. Animal Model Exp Med.2021 Mar 6;4(1):2-15. doi: 10.1002/ame2.12155. eCollection 2021 Mar.

[17] Bai L, Lyu Y, Shi G, Li K,Huang Y, Ma Y, Cong YS, Zhang L, Qin C. Polymerase I andtranscript release factor transgenic mice show impaired function ofhematopoietic stem cells. Aging(Albany NY). 2020 Oct 21;12(20):20152-20162. doi: 10.18632/aging.103729.

[18] Dong W, Zhang L, Sun C, Gao X, Guan F, Li J, Chen W, MaY, Zhang L. Knock in of a hexanucleotide repeat expansion in theC9orf72 gene induces ALS in rats. Animal Model Exp Med. 2020 Aug7;3(3):237-244. doi: 10.1002/ame2.12129. eCollection 2020 Sep.

[19] Liu W, Wang Z, Liu L, Yang Z, Liu S, Ma Z, Liu Y, Ma Y,Zhang L, Zhang X, Jiang M, Cao X. LncRNA Malat1 inhibition of TDP43 cleavagesuppresses IRF3-initiated antiviral innate immunity. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23695-23706. doi:10.1073/pnas.2003932117.

[20] Dong W, Ma Y, Guan F, Zhang X, Chen W, Zhang L,Zhang L. Ablation ofC9orf72 together with excitotoxicity induces ALS in rats. FEBS J.2021 Mar;288(5):1712-1723. doi: 10.1111/febs.15501. Epub 2020 Aug 24.

[21] LiZ*, Ma Y*, Wang G, Wang H, Dai Y, Zhu Y, Chen S, Zheng X#,Sun F#. Overexpression of human-derived DNMT3A induced intergenerationalinheritance of DNA methylation and gene expression variations in rat brain andtestis. Epigenetics. 2020 Oct;15(10):1107-1120. doi:10.1080/15592294.2020.1749962. Epub 2020 Apr 26.

[22] WuT, Ma Y, Zhang X,Dong W, Gao S, Wang J, Zhang L, Lu D. Myocardial tissue-specific Dnmt1 knockoutin rats protects against pathological injury induced by Adriamycin. LabInvest. 2020 Jul;100(7):974-985. doi: 10.1038/s41374-020-0402-y.

[23] Xu H, Jiang Y, Xu X, Su X, Liu Y, Ma Y, Zhao Y,Shen Z, Huang B, Cao X. Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediatedactivation of innate immune responses by stabilizing Stat1 mRNA. Nat Immunol. 2019Dec;20(12):1621-1630. doi: 10.1038/s41590-019-0542-7.

[24] Zhou Y,Li M, Xue Y, Li Z, Wen W, Liu X, Ma Y,Zhang L, Shen Z, Cao X. Interferon-inducible cytoplasmic lncLrrc55-AS promotesantiviral innate responses by strengthening IRF3 phosphorylation. CellRes. 2019 Aug;29(8):641-654.

[25] Lin H, Jiang M, Liu L, Yang Z, Ma Z, Liu S, Ma Y, Zhang L, Cao X. The longnoncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innateimmune response. Nat Immunol. 2019 Jul;20(7):812-823.

[26] Yang X, Lu D, Zhang X, Chen W, Gao S, Dong W, Ma Y,Zhang L. Knockout of ISCA1 causes early embryonic death in rats. Animal Model Exp Med. 2019 Mar12;2(1):18-24. doi: 10.1002/ame2.12059. eCollection 2019 Mar.  

[27] Ma Y,Zhang L, Qin C. The first genetically gene-edited babies: It's"irresponsible and too early". Animal Model Exp Med. 2019 Jan11;2(1):1-4.

[28] Zhang Y, Wang X, Zhang X, Wang J, Ma Y, Zhang L, Cao X. RNA-binding protein YTHDF3 suppressesinterferon-dependent antiviral responses by promoting FOXO3 translation. ProcNatl Acad Sci U S A. 2019 Jan 15;116(3):976-981.

[29] Bai L, Shi G, MaY, Zhang L, Guan F, Zhang X, Xu Y, Chen H, Zhang L. Paraoxonase 1knockout rats have impaired T cell development at the CD4/CD8 double-negativeto double-positive transition stage. Sci Rep. 2018 Sep 27;8(1):14457.

[30] Ma Y,Yu L, Zhang X, Xin C, Huang S, Bai L, Chen W, Gao R, Li J, Pan S, Qi X, huangX*, Zhang L*. Highly efficient and precise base editing by engineered dCas9-guidetRNA adenosine deaminase in rats. Cell Discov. 2018 Jul 17;4:39. doi:10.1038/s41421-018-0047-9.

[31] Liu N, Liu Q, Yang X, Zhang F, Li X, Ma Y, Guan F, Zhao X, Li Z,Zhang L, Ye X. Hepatitis B virus-upregulated lnc-HUR1 promotes cellproliferation and tumorigenesis by blocking p53 activity. Hepatology. 2018 May 23.doi: 10.1002/hep.30098.

[32] Jiang M, Zhang S, Yang Z, Lin H, Zhu J, Liu L, Wang W,Liu S, Liu W, Ma Y, Zhang L,Cao X. Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback RestrictsInnate Immune Response. Cell. 2018 May 3;173(4):906-919.e13.doi: 10.1016/j.cell.2018.03.064. Epub 2018 Apr 26.

[33] Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, Fan J, ZhouW, Qiu S, Zhang Y, Dong T, Li N, Jiang Z, Zhu H, Zhang Q, Ma Y, Zhang L, Wang Q, Yu Y, Li N, Cao X. Tumor-InducedGeneration of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell.2018 Apr 19;173(3):634-648.e12. doi: 10.1016/j.cell.2018.02.061. Epub 2018 Mar29.

[34] Zheng X, Li Z, Wang G, Li Z, Liang A, Wang H, Dai Y,Huang X, Chen X, Ma Y#, Sun F#.Overexpression of Human-Derived DNMT3A Induced Intergenerational Inheritance ofActive DNA Methylation Changes in Rat Sperm. Front Genet. 2017Dec 12;8:207. doi: 10.3389/fgene.2017.00207. eCollection 2017.

[35]  Ma Y#, Zhang L, Huang X#.Building Cre Knockin Rat Lines Using CRISPR/Cas9. Methods Mol Biol. 2017;1642:37-52.doi: 10.1007/978-1-4939-7169-5_3.

[36]  Ma Y, Yu L, Pan S, Gao S, ChenW, Zhang X, Dong W, Li J, Zhou R, Huang L, Han Y, Bai L, Zhang L, Zhang L.CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter ratstrains for monitoring Cre-loxP-mediated lineage tracing. FEBS J. 2017Oct;284(19):3262-3277. doi: 10.1111/febs.14188.

[37]  Xu J, Xu X, WangB, Ma Y, Zhang L, Xu H, Hu Y,Wu J, Cao X. Nuclear carbonic anhydrase 6B associates with PRMT5 toepigenetically promote IL-12 expression in innate response. Proc Natl Acad SciU S A. 2017 Aug 8;114(32):8620-8625. doi: 10.1073/pnas.1700917114.

[38]  Wang Y, Shi J,Yan J, Xiao Z, Hou X, Lu P, Hou S, Mao T, Liu W, Ma Y, Zhang L, Yang X, and Qi H. Germinal center developmentof memory B cells driven by Interleukin-9 from follicular T helper cells. NatureImmunology, 2017 Aug;18(8):921-930.

[39]  Chen S, Yang M,Du J, Li D, Li Z, Cai C, Ma Y,Zhang L, Tian Z, Dong Z. The Self-Specific Activation Receptor SLAM Family IsCritical for NK Cell Education. Immunity. 2016 Aug 16;45(2):292-304.

[40]  Wang W, Jiang M,Liu S, Zhang S, Liu W, Ma Y,Zhang L, Zhang J, Cao X. RNF122 suppresses antiviral type I interferonproduction by targeting RIG-I CARDs to mediate RIG-I degradation. ProcNatl Acad Sci U S A. 2016 Aug 23; 113 (34):9581-6.

[41]  Ma Y, Chen W, Zhang X, Yu L,Dong W, Pan S, Gao S, Huang X, Zhang L. Increasing the efficiency ofCRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ andusing Cas9 protein. RNA Biol. 2016, Jul 2;13(7):605-12.

[42]  Bao D, Ma Y, Zhang X, Guan F, Chen W,Gao K, Qin C, Zhang L. Preliminary Characterization of a Leptin ReceptorKnockout Rat Created by CRISPR/Cas9 System. Sci Rep. 2015 (5): 15942

[43]   Ma Y, Zhang X, Shen B, et al.Generating rats with conditional alleles using CRISPR/Cas9. Cell Res, 2014, 24(1): 122-125.

[44]  Ma Y, Zhang L, and Huang X. Genomemodification by CRISPR/Cas9. FEBS J, 2014, 281(23): 5186-5193.

[45]  Ma Y, Ma J, Zhang X, et al.Generation of eGFP and Cre knockin rats by CRISPR/Cas9. FEBS J, 2014, 281(17):3779-3790.

[46]  Ma Y, Shen B, Zhang X, et al.Heritable multiplex genetic engineering in rats using CRISPR/Cas9. PLoSOne, 2014, 9(3): e89413.

[47]  Bai L, Shi G,Zhang L, Guan F, Ma Y, Li Q,Cong YS, Zhang L. Cav-1 deletion impaired hematopoietic stem cell function[J]. CellDeath Dis. 2014, 27(5): e1140.

[48]  Lu D#, Ma Y#, Zhang W, Bao D,Dong W, Lian H, Huang L, Zhang L. Knockdown of cytochrome P450 2E1 inhibitsoxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathytransgenic mice[J]. Hypertension,2012, 60(1):81-89. (Co-first author)

[49]  Chu C, Wang Y,Zhang X, Ni X, Cao J, Xu W, Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. SAP-regulated T Cell-APC adhesionand ligation-dependent and -independent Ly108-CD3ζ interactions[J]. J Immunol.2014, 15;193(8):3860-71.

[50]  Lian H, Ma Y, Feng J, Dong W, Yang Q, LuD, Zhang L. Heparin-binding EGF-like growth factor induces heart interstitialfibrosis via an Akt/mTor/p70s6k pathway[J], PLoS One. 2012, 7 (9): e44946.

[1]  “人类重大传染病动物模型体系的建立及应用”获得2019年国家科技进步奖二等奖。

[2]  “基于CRISPR-Cas9的大鼠精确基因编辑技术体系的建立及应用”获2018年中国实验动物学会科学技术奖一等奖。

[3]  “基于CRISPR-Cas9的大鼠精确基因编辑技术体系的建立及应用”获2018年北京市科技奖三等奖。

[4] 协和新星（2016年）。

[5]  “APP,PS-1,α-synuclein 等基因相关神经退行性疾病动物模型的建立及应用.” 2015年中华医学科技奖三等奖。

[6]  2016年日本实验动物协会国际青年奖，获奖题目“Precise genetic modification using CRISPR/Cas9 in rats”。