国家自然科学基金面上项目

国家自然科学基金青年项目

“十三五”重大新药创制平台建设-天然产物合成

中国医学科学院医学与健康科技创新工程重大协同创新项目

2006年至今一直从事药物化学领域研究工作，主要涉及活性天然产物的全合成、结构修饰、成药性及新合成方法学研究。目前累计发表研究论文近40篇，包括以第一或通讯作者发表在本领域主流期刊Chemical Science、Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry、Chemical Communiaction等研究论文20篇，申请发明专利12项，获得授权专利7项，其中1项国际专利分别获得美国和欧盟授权。先后获得国家自然基金青年项目、国家自然基金面上项目、中国医学科学院医学与健康科技创新工程重大协同创新项目、十三五”重大新药创制等基金支持，并参加多项国家自然科学基金重点项目。

近期发表论文

1. Rubing Wang#, Shuanggang Ma#*, Cooper S. Jamieson#, Rongmei Gao, Yunbao Liu, Yong Li, Xiaojing Wang, Yuhuan Li, Kendall N. Houk*, Jing Qu*, Shishan Yu*. Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. Chem. Sci. 2021, 12: 7003-7011.

2. Jinyao Yong#, Wenrui Li#, Xiaojing Wang, Guozhu Su, Mi Li, Jianpei Zhang, Hongli Jia, Yuhuan Li, Rubing Wang*, Maoluo Gan*,  Shuanggang Ma*. Illihenin A, an antiviral sesquiterpenoid with a cage-like tricyclo[6.2.2.01,5]dodecane skeleton from Illicium henryi. J. Org. Chem. 2021, 86: 2017-2022.

3. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. A role for isatin azomethine imines as a dipolarophile in cycloaddition reactions. Org. Lett. 2020, 22: 7358-7362.

4. Rubing Wang#, Xiaodong Ren#, Jie He, Shanshan Zhu, Huiru Xie, Guozhu Su, Shuanggang Ma, Shishan Yu*. Burchellin and its stereoisomers: total synthesis, structural elucidation and antiviral activity. Org. Biomol. Chem. 2020,18: 9081-9087.

5.  Qingyun Fang,Haishan Jin, Rubing Wang*, LimingZhao*. DABCO-mediated [3+3] cycloaddition of azomethine imines with in situgenerated nitrile oxides from hydroximoyl chlorides. Chemical Communications.2019, 55: 10587-10591

6  Jingru Zhang, Haishan Jin, Rubing Wang*, Liming Zhao*. Synthesisof 2,4-Diaryl-1,3 -benzoxazines via FeCl3-Catalyzed annulation ofortho-hydroxyphenyl-substituted para- quinone methides with imidates. Advanced Synthesis & Catalysis.2019, 361(20): 4811-4816.

7.  Yanan Wang, Fei Liu, Yong Li, Shuanggang Ma,Jing Qu, Yunbao Liu, Chongshan Niu, Zhonghai Tang, Yuhuan Li, Rubing Wang*, Shishan Yu*. Newglycosides from the twigs and leaves of Rhododendron latoucheae. J Asian Nat Prod Res. 2019, 21(4):299-307.

8.  Xiaojing Wang#, Qi Zhang#,Yuru Peng, Li Li; Jing Qu; Yunbao Liu, Song Xu, Shuanggang Ma, Yong Li, ZouZhongmei, Rubing Wang*, Shishan Yu*.Two azafluoranthene alkaloids and a phytoecdysone from the stems of Cyclea barbata. J. Asian Nat. Prod. Res., 2019, 21(3): 217-226.

9.  Rubing Wang, Haining Lv, Shanshan Zhu, Xiaodong Ren, Song Xu, Shuanggang Ma, YunbaoLiu, Jing Qu*, Shishan Yu*. A novel and practical synthesis of CAT3: aphenanthroindolizidine alkaloid with potential in treating glioblastoma. RSC Adv. 2018, 8: 29301-29308.

10.  Shuanggang Ma#, Rubing Wang#, Wenrui Li, Yunbao Liu, Jing Qu, Yong Li,Song Xu, Xiaojing Wang, Shishan Yu*. New C-2 diastereomers of flavanoneglycosides conjugated with 3-hydroxy-3- methylglutaric acid from the pericarpof Citrus grandis (L.) Osbeck. Bioorg. Chem. 2018, 80: 519-524.

11.  Rubing Wang, Xiaojie Zhang, Chengsheng Chen, GuanglinChen,Cristian Sarabia, Qiang Zhang, Shilong Zheng, Guangdi Wang, QiaoHongChen*. Structure-activity relationship studies of1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings inprostate epithelial cell models. Eur. J.Med. Chem. 2017, 133: 208-226.

12.  Jiehuan Zhang#, Rubing Wang#, Defeng Li, Liming Zhao*. Green method topreparing oxindole-fused spirotetrahydrofuran scaffolds through methanesulfonicacid-catalyzed cyclization reactions of 3-allyl-3-hydroxy-2-oxindole in water. ACS Omega 2017, 2(10): 7022-7028.

13.  Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Guanglin Chen, QiangZhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Synthesis and evaluation of1,7- diheteroarylhepta-1,4,6-trien-2-ones as promising anticancer agents. Eur. J. Med. Chem. 2016, 110: 164-180.

14. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Changde Zhang, Guanglin Chen, QiangZhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Structure-activityrelationship and pharmacokinetic studies of1,5-diheteroarylpenta-1,4-dien-3-ones: A class of curcumin-based anticanceragents. J. Med. Chem. 2015, 58(11):4713-4726.

申请专利

1.  庾石山，陈晓光，王汝冰，吕海宁，徐嵩，季鸣，李燕，扈金平，马辰，张婷婷，马双刚，刘云宝(13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶A型，中国发明专利，申请号 201810117140.5

2.  庾石山，陈晓光，王汝冰，吕海宁，徐嵩，季鸣，李燕，扈金平，马辰，张婷婷，马双刚，刘云宝(13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶B型，2018.02.05，中国发明专利，申请号 201810117139.2

3.  庾石山，王汝冰，吕海宁，徐嵩，马双刚，刘云宝 光学纯(S)-3-新戊酰氧基-6,7-二甲氧基-菲并吲哚里西啶的制备方法，中国发明专利，申请号 201810235803.3

4.  刘玉玲 王洪亮 汪仁芸 夏学军 庾石山 陈晓光 李燕 王汝冰 季鸣 金晶 扈金萍 菲并吲哚里西定生物碱衍生物纳米自乳化组合物及其制备方法，申请号：201910673840.7

5.  刘玉玲 王洪亮 汪仁芸 夏学军 李琳庾石山 陈晓光 李燕 扈金萍 高丽丽王汝冰 菲并吲哚里西定生物碱衍生物固体脂质纳米粒组合物， 中国发明专利，申请号：201911195675.5