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王璐研究员2013年博士毕业于中国科学院动物研究所,主要利用斑马鱼开展早期胚胎发育的基础研究,尤其是造血干细胞命运决定、维持和分化等。研究工作涉及造血干细胞产生过程中内源因子、微环境以及表观遗传修饰(RNA甲基化和DNA甲基化)的调控机制,成果包括:发现m6A甲基化调控造血干细胞命运决定(Nature, 2017)以及早期胚胎发育(Cell Res, 2014);揭示DNA甲基化修饰影响左右不对称发育的机制(EMBO J,2017);转录因子Fev(Blood, 2013)调控造血干细胞产生且标识胚胎起源的白血病(Leukemia,2017);阐明炎性信号(Blood,2015)、血液流动(Blood,2011)及5羟色胺(JEM, 2017)调控造血干细胞命运决定、维持及存活的分子机制。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg科技部国家重点研发计划青年科学家项目,国家自然科学基金面上项目,国家自然科学基金青年项目
1. 刘帆, 王璐*. RNA修饰调控造血发育和白血病发生的研究进展. 中国科学: 生命科学, 2020, 50
2. Lu XY, Zhang YL, Liu F*,Wang L*. Rac2 Regulates the Migration of T Lymphoid Progenitors to the ThymusDuring Zebrafish Embryogenesis. J Immunol. 2020, May1;204(9):2447-2454.
3. Liu ZB, Tu HQ, Kang YS, Xue YY,Ma DY, Zhao CT, Li HY, Wang L*, LiuF*. Primary cilia regulate hematopoietic stem and progenitorcell specification through Notch signaling in zebrafish. Nat Commun.2019, 10(1):1839
4. Yang Y#, Wang L#, Han X#, Yang WL#,Zhang M#, Ma HL, Sun BF,Li A, Xia J, Chen J, Heng J, Wu B, Chen YS, Xu JW, Yang X, Yao H, Sun J, Lyu C,Wang HL, Huang Y, Sun YP, Zhao YL, Meng A, Ma J, Liu F, Yang YG. RNA5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by PreventingMaternal mRNA Decay. Mol Cell. 2019 Jul 16. pii:S1097-2765(19)30490-3. doi: 10.1016/j.molcel.2019.06.033.(# 共同一作)
5. Wang L, Liu ZB, Lin H, Ma DY, Tao QH, Liu F*. Epigenetic regulation of left-rightasymmetry by DNA methylation. EMBO J. 2017, 36(20):2987-97
6. Zhang CX#, Chen YS#,Sun BF#, Wang L#, Yang Y#, Ma DY, Lv JH, Heng J,Ding YY, Xue YY, Lu XY, Xiao W, Yang YG*, LiuF*. m6A modulateshaematopoietic stem and progenitor cell specification. Nature. 2017,549(7671):273-76(# 共同一作)
7. LvJH#, WangL#, Gao Y, Ding YQ, Liu F*. 5-hydroxytryptamine synthesized inthe aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cellsurvival. J Exp Med. 2017,214(2):529-545(# 共同一作)
8. Liu TH#, Tang YJ#, Huang Y#, Wang L#, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, YeQJ, Li BS, Tang JY, Ford A, Enver T, Liu F*, Chen GQ*, Hong DL*. Expressionof the fetal hematopoiesis regulator FEV indicates leukemias of prenatalorigin. Leukemia. 2017, 31(5):1079-1086(# 共同一作)
9. He QP#, Zhang CX#,Wang L#, Zhang PP, Ma DY,Lv JH, Liu F*. Inflammatory signaling regulates hematopoietic stem andprogenitor cell emergence in vertebrates. Blood. 2015, 125(7):1098-106(# 共同一作)
10. Ping XL#, Sun BF#, Wang L#, Xiao W#, Yang X,Wang WJ, Samir A, Shi Y, LvY, Chen YS, Zhao X, Li A, Yang Y, Ujwal D, Lou XM, Liu X, Huang J, Yuan WP, ZhuXF, Cheng T, Zhao YL, Wang XQ, Danielsen JMR, Liu F*, YangYG*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosinemethyltransferase. Cell Res. 24(2):177-89, (2014)(# 共同一作)
11. Wang L#,Liu TH#, Xu LJ#,Gao Y, Wei YL, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong DL, Liu F*. Fev regulates hematopoieticstem cell development via ERK signaling. Blood. 2013, 122(3):367-75
12. Ciau-Uitz A#, Wang L#, Patient R, Liu F*. ETS transcription factors inhematopoietic stem cell development. Blood Cells Mol Dis.51(4):248-55, (2013)(# 共同一作)
13. Ma DY#, Wang L#, Wang SF#, Gao Y, Wei YL, Liu F*. Foxn1 maintains thymicepithelial cells to support T-cell development via mcm2 in zebrafish. PNAS.2012, 109(51):21040-5(# 共同一作)
14. Wang L, Zhang PP, Wei YL, Gao Y, Patient R, Liu F*. A blood flow-dependent klf2a-NO signaling cascade isrequired for stabilization of hematopoietic stem cell programming in zebrafishembryos. Blood. 2011, 118(15):4102-10
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