路娟，女，副研究员。2010年从清华大学博士毕业后进入中国医学科学院药用植物研究所博士后流动站，2012年出站后留所工作至今，主要研究方向为中药成分分析及新药研发。作为课题负责人主持协和青年基金1 项，作为课题骨干，参与国家重大新药创制项目1项，国家自然科学基金面上基金2项，创新工程项目1项，以第一作者或通讯作者发表学术论文16篇，其中11篇SCI。    

1. 国家自然科学基金面上项目，81673667，生脉注射液对脓毒症肠黏膜屏障的保护及调控肠上皮紧密连接的分子机制研究，60万元，2017.01-2020.12；

2. 国家科技重大专项，2014ZX09201022-006，双黄连注射液过敏标志物及预警体系的研究，330.74万元，2014.1-2016.12；

3. 国家自然科学基金面上项目，81173645，利用敏感生物活性指标研究中药在Caco-2细胞模型中的转运特征与机制，57万元，2012.1-2015.12；

4.云南省科学技术厅, 云南省景洪市傣医药产业科技特派团, 200万元，2024.01-2026.12

5. 中国工程院院地合作项目，2020-GD-05，“粤港澳大湾区药用植物健康产业发展战略研究”项目下子课题“粤港澳大湾区药用植物健康产业基准及现状研究”，45万，2021.4-2022.12；

6. 云南省科技厅，云南省王金辉专家工作站，90万，2020.1-2022.12；

7. 柬龙制药有限公司，龙血竭系列产品研发，30万，2022.1-2024.1；

8. 神威药业股份有限公司，古代经典名方《温经汤》颗粒剂的开发研究，190万，2017.09-2027.09；

9. 虎眼万年青成药性及配方颗粒开发研究，北京济世康源医疗科技有限公司，80万，2018.12-2025.12；

10. 白芨面膜精华素研发，湖北神农本草药业有限公司，15万，2018.5-2019；

11. 宁波珐菲亚食品股份有限公司，珐菲亚酒产品研发及检测，8万，2017.9-2018. 9；

12. 宁波珐菲亚食品股份有限公司，珐菲亚（巴西人参）女士洗液产品开发，20万，2016.12-2018.12；

13. 宁波珐菲亚食品股份有限公司，珐菲亚提高精子质量新产品开发，39.26万，2017.1-2018.12；

14. 北京国兴信联技术开发有限公司，含天然植物的化妆品研究开发，90万，2014.9-2019.9；

15. 纯懿生物科技有限公司，云草卿系列化妆品产品研发，24万，2016.11-2017.5。

一、发表的主要论文（第一或通讯）

 [1] Niantong Xia#, Zimian Ding#, Mingran Dong, Shuyang Li，Jia Liu, Hongwei Xue, Zhigang Wang, Juan Lu*, Xi Chen*. Protective Effects of Lycium ruthenicum Murray against Acute Alcoholic Liver Disease in Mice via the Nrf2/HO-1/NF-κB Signaling Pathway[J]. Pharmaceuticals, 2024, 17: 497.

[2] Mingran Dong#, Juan Lu#, Hongwei Xue, Yang Lou, Shuyang Li, Tao Liu, Zimian Ding*, Xi Chen*. Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1/Nrf2 Signaling Pathway[J]. Pharmaceuticals, 2024, 17:322.

[3] Xiao Mi#, Yang Lou#, Yutian Wang, Mingran Dong, Hongwei Xue, Shuyang Li, Juan Lu * and Xi Chen *. Glycyrrhetinic Acid Receptor-Mediated Zeolitic Imidazolate Framework-8 Loaded Doxorubicin as a Nanotherapeutic System for Liver Cancer Treatment[J]. Molecules, 2023, 28:8131. 

[4] Xinyue Chang, Mingran Dong, Xiao Mi, Meigeng Hu, Juan Lu*, Xi Chen*. The Protective Effect of Trichilia catigua A. Juss. on DEHP-Induced Reproductive System Damage in Male Mice[J]. Frontiers in pharmacology, 2022, 13:832789.

[5] Xiao Mi#, Juan Lu#, Mingran Dong , Yang Lou, Xia Zhan*, Xi Chen*. Pro-Apoptotic Effect of Zeolitic Imidazolate Framework-8 (ZIF-8)-Loaded Dihydromyricetin on HepG2 Cells[J]. Molecules, 2022, 27:5484.

[6] Juan Lu, Yue Yu, Xiaojing Wang, Ruiping Chai, Xinkai Lyu, Minghui Deng, Meigeng Hu, Yun Qi, Xi Chen*. Mechanism of Shengmai Injection on Anti-Sepsis and Protective Activities of Intestinal Mucosal Barrier in Mice[J]. Chin J Integr Med. 2022, 28(9):817-822.

[7] Xiao Mi, Meigeng Hu, Mingran Dong, Zhihong Yang, Xia Zhan, Xinyue Chang, Juan Lu*, Xi Chen*. Folic Acid Decorated Zeolitic Imidazolate Framework (ZIF-8) Loaded with Baicalin as a Nano-Drug Delivery System for Breast Cancer Therapy[J]. International Journal of Nanomedicine, 2021, 16:8337-8352.

[8] Yue Yu#, Juan Lu#, Le Sun, Xinkai Lyu, Xin-yue Chang, Xiao Mi, Mei-geng Hu, Chongming Wu*, Xi Chen*. Akkermansia muciniphila: a potential novel mechanism of nuciferine to improve hyperlipidemia [J]. Biomedicine & Pharmacotherapy, 2021, 133:111014.

[9] Meigeng Hu, Dan Zhao, Xudong Xu, Guoxu Ma, Haifeng Wu*, Xi Chen*. Actaticas A−G, Cycloartane Triterpenes from Actaea asiatica with Their Antiproliferative Activity[J]. Frontiers In Chemistry, 2021, 9:695456

[10] Haowen Li, Yijing Li, Hui Ao, Jingxin Fu, Yifei Guo, Meihua Han, XueyingYan, Xi Chen*, Xiangtao Wang*. A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods[J]. Drug Delivery, 2020, 27(1): 1176-1187.

[11] Juan Lu, Xinkai Lyu, Ruiping Chai, Yue Yu, Minghui Deng, Xia Zhan, Zhengqi Dong*, Xi Chen*. Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches[J]. Evidence-Based Complementary and Alternative Medicine, 2020, 2020: 4956329.

[12] Yihang Li, Guoxu Ma, Yana Lv, Jing Su, *Guang Li, *Xi Chen. Efficacy of Obcordata A from Aspidopterys obcordata on Kidney Stones by Inhibiting NOX4 Expression[J]. Molecules, 2019, 24:1957.

[13] Ge Li, Ning Zhang, Fang Geng, Guoliang Liu, Bin Liu, Xia Lei, Guang Li, Xi Chen*. High-throughput metabolomics and ingenuity pathway approach reveals the pharmacological effect and targets of Ginsenoside Rg1 in Alzheimer's disease mice[J]. Scientific Reports, 2019, 9(1):7040.

[14] Yan Zhang, Lihong Zhang, Xi Chen*, Ning Zhang, Guang Li. Piceatannol attenuates behavioral disorder and neurological deficits in aging mice via activating the Nrf2 pathway[J]. Food & Function, 2018, 9:371.

[15] Xi Chen, Ting Gu, Jinghua Wang, Hui Xiong, Yeqiu Wang, Guoliang Liu, Yan Qu, Ning Zhang. Effects of wogonin on the mechanism of melanin synthesis in A375 cells[J]. Experimental and Therapeutic Medicine, 2017, 14(5):4547-4553.

[16] Yusheng Shi, Yan Zhang, Wenzhong Hu, Xi Chen*, Xin Fu, Xia Lv, Lihong Zhang, Ning Zhang, Guang Li. Anti-Inflammatory Triterpene Glycosides from the Roots of Ilex dunniana Levl[J]. Molecules, 2017, 22:1206.

[17] Yan Zhang, Bin Liu, Xi Chen*, Ning Zhang, Guang Li, Lihong Zhang, Liyan Tan. Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway[J]. Rejuvenation research, 2017, 20(6):462-472.

[18] Yu-Sheng Shi, Yan Zhang, Wen-Zhong Hu, Li-Hong Zhang, Xi Chen*, Ning Zhang, Guang Li, Li-Yan Tan. Cytotoxic diterpenoids from Pteris ensiformis[J]. Journal of Asian Natural Products Research, 2017, 19(2):188-193.

[19] Juan Lu, YiHang Li, Xia Zhan, Guang Li, Zhe Chen, Xi Chen*. The protective effect of qiancao naomaitong mixture on neuronal damage and cerebral ischemia/reperfusion injury[J]. Pharmaceutical biology, 2016, 54(10): 2304-2311.  

[20] Yana Lv, Yumei Que, Qiao Su, Qiang Li, Xi Chen*, Haitao Lu*. Bioinformatics facilitating the use of microarrays to delineate potential miRNA biomarkers in aristolochic acid nephropathy[J]. Oncotarget, 2016, 7(32): 52270.

[21] Yihang Li, Guang Li, Meifang Song, Xuelan Li, Xia Zhan, Juan Lu*, Xi Chen*. Acute toxicity study of Aspidopterys obcordata aqueous extract in Sprague-Dawley rats[J]. Journal of Traditional Chinese Medicine, 2016, 36(3): 377-381.

[22] Wennan Nie, Yana Lv, Leyu Yan, Tianbing Guan, Qiang Li, Xiaojuan Guo, Wenhu Liu, Mengpei Feng, Guang Xu, Xi Chen*, Haitao Lv*. Discovery and characterization of functional modules and pathogenic genes associated with the risk of coronary artery disease[J]. RSC Advances, 2015, 5: 26443-26451.

[23] Yuan Gao, Chuanjie Zong, Fen Liu, Runlan Cai, Yun Qi*, Xi Chen*, Evaluation of the Intestinal Transport of a Phenylethanoid Glycoside-Rich Extract from Cistanche deserticola across the Caco-2 Cell Monolayer Model[J]. PLos One, 2015, 10(2):e0116490.

[24] Wenna Nie, Yana Lv, Leyu Yan, Xi Chen*, Haitao Lv. Prediction and Characterisation of the System Effects of Aristolochic Acid: A Novel Joint Network Analysis towards Therapeutic and Toxicological Mechanisms [J]. Scientific reports, 2015, 5: 17646.

[25] Xi Chen, Chuanjie Zong, Yuan Gao, Runran Cai, Lei Fang, Fen Liu, Yun Qi. Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264.7 cells[J]. European Journal of Pharmacology, 2014, 723: 339-345.  

[26] Haitao Lv,Lian Liu,Gustavo Palaciosa, Xi Chen*. Metabolomic analysis characterizes tissue specific indomethacin-induced metabolic perturbations of rats.Analyst, 2011, 136, 2260-2269.

[27] Xi Chen*. Protective effects of quercetin on liver injury induced by ethanol[J]. Pharmacognosy Magazine, 2010, 6:135-141.

[28] Haitao Lv, Lian Liu, Yingzhi Zhang, Ting Song, Juan Lu, Xi Chen*. Ingenuity pathways analysis of urine metabonomics phenotypes toxicity of gentamicin in multiple organs[J]. Molecular BioSystems, 2010, 6:2056-2067.

[29] Xi Chen*, Lian Liu, Gustavo Palacios, Jie Gao, Ning Zhang, Guang Li, Juan Lu, Ting Song,Yingzhi Zhang, Haitao Lv .Plasma metabolomics reveals biomarkers of the atherosclerosis[J]. Journal of Separaction Science, 2010, 33: 2776-2783.

二、专利

[1] 陈曦；李宜航；李光；吕亚娜；宋美芳；一种黑色素抑制剂、护肤组合物及其应用，2019.09.06，授权号：CN105663595B；

[2] 李光；李宜航；陈曦；李学兰；里二；苏晶；吕亚娜；张丽霞；罗云；马国需；砂仁健胃中药组合物、砂仁健胃酒及其制备方法，2021.08.06，CN109395011B.

[3] 陈曦；路娟；常馨月；胡美赓；米晓；董明然；楝科植物巴西海木提取物在提高生殖系统兴奋性和修复生殖系统损伤中的应用，2022.04.05，CN114272286A；

[4] 陈曦；李丹；路娟；侯金才；川芎饮片的炮制方法、温经汤及其制备方法，2022.06.28，CN114668785A；

[5] 陈曦；齐云；路娟；蔡润兰；高源；吕欣锴；一种中药萃取物在制备治疗脂肪肝的药物中的应用，2019.11.05，CN110403981A；

[6] 李光；李宜航；陈曦；李学兰；里二；苏晶；吕亚娜；张丽霞；一种砂仁的预处理方法、砂仁粉及砂仁酒，2019.02.15，CN109331139A；

[7] 李宜航；李光；陈曦；李学兰；里二；苏晶；吕亚娜；张丽霞；罗云；陈德力；砂仁中药组合物、砂仁补肾药酒及其制备方法，2019.02.15，CN109331137A；