目前团队成员包括研究员（博导2人）、副研究员（硕导1人）、青年博士骨干（2人）、副主任技师（3人）、在读研究生（7人）。

目前承担的在研项目有国家自然科学基金项目1项、重大新药创制任务课题2项、中国医学科学院医学与健康科技创新工程重大项目1项。项目主要研究内容为抗耐药菌和抗病毒药物研究。

团队正在开展的研究项目还包括：认知性障碍性疾病治疗靶点与药物、肝癌及肝病治疗药物、抗肿瘤ADC药物、基于NK细胞激活机制的抗肿瘤和抗病毒、抗结核药物等。研究目标重点集中在针对临床重大难治性疾病的药物发现。

主持完成重大新药创制“化学药临床前研究”；主持国家自然科学基金面上项目（7项）、“863“课题（1项）、重大新药创制品种项目（2项）。

目前主持在研项目有国家自然科学基金面上项目（1项）、重大新药创制品种任务课题（1个）、中国医学科学院医学与健康科技创新工程重大项目（1项），等。

代表性论文：

1.      Dai-Jie Chen,1,* A-Long Cui,2,*Jia-Rong Chen,3 Ping Yang,1 Jie Jin,2 LeiShao,4 and Zhuo-Rong Li2. The Low-Alkalinity PolymyxinDerivative, AL-6, Shows High Activity Against Multidrug-Resistant Acinetobacterbaumannii Clinical Isolates In Vitro and A. baumannii ATCC 19606 In Vivo: PreliminaryAnalysis of the Antibacterial Mechanism. MicrobialDrug Resistance, Volume 00, Number 00, 2021. DOI: 10.1089/mdr.2019.0474.

2.      Si-tuXue1, Ke Li1, Yang Gao, Lu-yao Zhao, Yan Gao, Hong Yi,Jian-dong Jiang*, and Zhuo-rong Li*. The role of the keyautophagy kinase ULK1 in hepatocellular carcinoma and its validation as atreatment target. Autophagy, 2020, 16:10, 1823-1837.

3.      Xinbei Jiang, Jiali Tan, YixuanWang, Jinhua Chen, Jianrui Li,Zhi Jiang, Yanni Quan, Jie Jin, Yuhuan Li, ShanCen, Yanping Li*, Zonggen Peng*,ZhuorongLi*.2-((4-Arylpiperazin-1-yl)methyl)benzonitrile Derivativesas OrallyAvailable Inhibitors of Hepatitis C Virus with a Novel Mechanism ofAction. Journal ofMedicinal Chemistry. 2020; 63(11):5972-5989.

4.      Xing-yueJi, Zhuorong Li. Medicinal chemistry strategies toward host targeting antiviralagents. Medicinal Research Reviews, DOI: 10.1002/med.21664 (2020）.

5.      Si-tu Xue 1, Lei Zhang 1, Zhuo-songXie, Jie Jin, Hui-Fang Guo, Hong Yi, Zong-ying Liu**, Zhuo-rong Li*.Substituted benzothiophene and benzofuran derivatives as a novel class of bonemorphogenetic Protein-2 upregulators: Synthesis, antiosteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. European Journal of Medicinal Chemistry, 200(2020)112465.

6.      JingGeng, Yuhong Wang, Lei Zhang, Co Li, Weijin Sheng*, Zhuorong Li*,Min Jiang1. The Cajanine Derivative LJ101019C Regulates the Proliferation andEnhances the Activity of NK Cells via Kv1.3 Channel-Driven Activation of theAKT/mTOR Pathway. Phytomedicine, 66(2020) 153113.

7.      Linlin Wang, LiZeng, Hailun Jiang, Zhuorong Li *, Rui Liu *. MicroarrayProfile of Long Noncoding RNA and Messenger RNA Expression in a Model ofAlzheimer’s Disease.  Life  2020, 10, 64; doi:10.3390/life10050064

8.      Shuo Zhang†, Xiaodan Qiu†, RanWang, Lianqi Sun, Zhiling Zhu, Guangzhi Shan*, Zhuorong Li**.Discovery of indolyl-containingpeptides as novel antibacterial agents targeting on tryptophanyl-tRNAsynthetase, FututreMedicinal Chemistry，(2020) 12 (10): 877-896.

9.      WangLinlin#, Liu Jianghong#, Wang Qian, Jiang Hailun, ZengLi, Li Zhuorong*, Liu Rui*. MicroRNA-200a-3p mediatesneuroprotection in Alzheimer-related deficits and attenuates amyloid-betaoverproduction and tau hyperphosphorylation via coregulating BACE1 and PRKACB. Front Pharmacol, 2019,10:806.

10.  Xin-yue Hu‡, Rong Wang‡, JieJin, Xiu-jun Liu, A-long Cui, Lian-qi Sun, Yan-ping Li, YiLi, Yu-cheng Wang, Yong-su Zhen, Qing-fang Miao*, Zhuo-rong Li*.An EGFR-Targeting Antibody-Drug Conjugate LR004-VC-MMAE: Potential inEsophageal Squamous Cell Carcinoma and Other Malignancies. Molecular oncology. 2019; 13(2):246-263.

11.  A-LongCui‡, Xin-Xin Hu‡, Yan Gao, Jie Jin, Hong Yi, Xiu-KunWang, Tong-Ying Nie, Yang Chen, Qi-Yang He, Hui-Fang Guo, Jian-Dong Jiang,Xue-Fu You*, Zhuo-Rong Li*. The Synthesis and BioactivityInvestigation of the Individual Components of Cyclic Lipopeptide Antibiotics. Journal of Medicinal Chemistry, 2018,61, 1845-1857.

12.  Xing-Yue Ji‡, Jin-Hua Chen‡, Guang-Hui Zheng, Meng-Hao Huang, Lei Zhang, Hong Yi, Jie Jin, Jian-Dong Jiang, Zong-Gen Peng*, Zhuo-Rong Li*. Designand Synthesis of Cajanine Analogues against Hepatitis C Virus throughDown-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1. Journal of Medicinal Chemistry, 2016 Nov23;59(22):10268-10284.

13.  Lin-tao Wu1, Zhi Jiang1,  Jia-jia Shen,  Hong Yi, Yue-chen Zhan, Ming-quan Sha, Zhen Wang, Si-tu Xue*, Zhuorong Li*.Design, synthesis and biological evaluation of novelbenzimidazole-2-substituted phenyl or pyridine propyl ketene derivatives asantitumour agents. Eur J Med Chem.2016 May 23;114:328-36.

14.   Zong-Gen Peng#,Zhi-Yun Zhao#, Yan-Ping Li#, Yu-Ping Wang,; Lan-Hu Hao,Bo Fan, Yu-Huan Li, Yue-Ming Wang, Yong-Qiang Shan, Yan-Xing Han, Yan-Ping Zhu,Jian-Rui Li, Xue-Fu You, Zhuo-Rong Li*,Jian-Dong Jiang*. Host Apolipoprotein B Messenger RNA-EditingEnzyme Catalytic Polypeptide-Like 3G Is an Innate Defensive Factor and Drug TargetAgainst Hepatitis C Virus, Hepatology, 2011, 53:1080-1089.    

15.   Hui-fang Guo#,Hua-yi Shao#, Zhao-yong Yang#, Si-tu Xue, Xue Li,Zong-ying Liu, Xiao-bo He, Jian-dong Jiang, Yue-qin Zhang, Shu-yi Si*, Zhuo-rong Li*. SubstitutedBenzothiophene or Benzofuran Derivatives as a Novel Class of Bone MorphogeneticProtein-2 Up-Regulators: Synthesis, Structure-Activity Relationships, andPreventive Bone Loss Efficacies in Senescence Accelerated Mice (SAMP6) andOvariectomized Rats, Journal of Medicinal Chemistry, 2010, 53:1819-1829.