国家自然科学基金     MicroRNA-451通过心肌自噬调控心肌重构的功能和机制研究

中国医学科学院中央级公益性科研院所基本科研业务费青年医学人才奖励项目     心肌肥厚的可变剪切调控

北京协和医学院协和青年科研项目     LncRNA TCONS_00027539在心肌重构中的调控作用及机制

北京市自然科学基金    CARP对心脏成纤维细胞生长、转化和分泌功能的影响

国家自然科学基金       利用基因敲除小鼠模型研究CARP基因在心肌重构中的作用

第一作者及通讯作者文章

1.Liu J#, Wu G#, Zhang C, Ruan J, Wang D, Zhang M, Wang L, Yang Y, Li X, Wang Y, Hui R, Zou Y, Kang L*, Wang J*, Song L*. Improvement in sudden cardiac death risk prediction by the enhanced ACC/AHA strategy in Chinese patients with hypertrophic cardiomyopathy. Heart Rhythm. 2020; S1547-5271(20)30349-0.   

2.Qin F#, Liu K#, Zhang C#, Sun X, Zhang Y, Wu Y, Ma W, Wang W, Wu X, Qin Y, Zou Y, Zhou X, Jiang X, Wu H, Hui R, Wang J*, Zhang H*, Song L*. Steroid metabolism gene variants and their genotype-phenotype correlations in Chinese early-onset hypertension patients. Hypertens Res, 2019, 42(10):1536-1543. 

3.Cui H#, Song L#, Zhu C, Zhang C, Tang B, Wang S, Wu G, Zou Y, Huang X, Hui R, Wang S*, Wang J*. mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models? Orphanet J Rare Dis, 2019,14(1):252

4.Lu D#,Wang J#,Li J, Guan F, Zhang X, Dong W, Liu N, GaoS, Zhang L*. Meox1 accelerates myocardial hypertrophic decompensationthrough Gata4. Cardiovasc Res,2018, 114(2):300-311.

5.Su M#,Wang J#,Wang C#,Wang X, Dong W, Qiu W,Wang Y, Zhao X, Zou Y,Song L, Zhang L*, Hui R*,MicroRNA-221 inhibits autophagy and promotes heart failure by modulating thep27/CDK2/mTORaxis. Cell Death Differ, 2015,22(6): 986-999.

6.Su M#，ChenZ#，WangC，SongL，ZouY，ZhangL，HuiR*，WangJ*，Cardiac-SpecificOverexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice.Cell Physiol Biochem,2016, 39(4):1503~1511.

7.WangJ#,Wang Y#,ZouY#, SunK, Wang Z, Ding H, Yuan J, Wei W, HouQ, Wang H, Liu X, Zhang H, JiY, Zhou X, Sharma RK, Wang D, Ahmad F, HuiR*, Song L*, Malignant effects of multiple rare variants in sarcomere genes onthe prognosis of patients with hypertrophic cardiomyopathy. Eur J Heart Fail,2014, 16(9): 950-957.

8.Zhu L#, ZouY#,Wang Y, Luo X,Sun K, Wang H, Jia L,Liu Y, Zou J,Yuan Z, Hui R,Kang L, Song L*, Wang J*. Prognostic Significance of Plasma High-SensitivityC-Reactive Protein in Patients With Hypertrophic Cardiomyopathy. J Am Heart Assoc,2017, 6(2). pii:e004529.

9.ZhangC#,Zhang H#,Wu G, Luo X,Zhang C, Zou Y,Wang H, Hui R,Wang J*,Song L*.Titin-TruncatingVariants Increase the Risk of Cardiovascular Death in Patients WithHypertrophic Cardiomyopathy. CanJ Cardiol,2017, 33(10):1292-1297.

10.Zhu L#,Wang J#,Wang Y, Jia L,Sun K, Wang H, Zou Y, TianT, Liu Y, Zou J, HuiR, Yuan Z*, Song L*, Plasma uric acid as prognostic marker in patients withhypertrophic cardiomyopathy.Can J Cardiol,2015, 31(10): 1252-1258.

11.SongL#, SuM#,Wang S#,ZouY, Wang X, Wang Y, Cui H, Zhao P, HuiR, Wang J*, MiR-451 is decreased in hypertrophic cardiomyopathy and regulatesautophagy by targeting TSC1.J Cell Mol Med,2014, 18(11): 2266-2274. 

12.BaoJ#,Wang J#,Yao Y*, Wang Y, Fan X, Sun K, He DS, Marcus FI, Zhang S, HuiR, Song L*, Correlation of ventricular arrhythmias with genotype in arrhythmogenicright ventricular cardiomyopathy. Circ Cardiovasc Genet,2013, 6(6): 552-556.

13.Su M#*,Wang S#,QiuWei, Li J, Hui R,Song L, Jia M,Wang H, Wang J*.miR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetingc-Jun. Biosci Rep,2018, 38(2). pii:BSR20171430.

14.WangX#,Wang J#,Su M, Wang C, Chen J, Wang H, Song L, ZouY, Zhang L, Zhang Y, Hui R*,TNNI3K, a cardiac-specific kinase, promotes physiological cardiac hypertrophyin transgenic mice, PLoS One,2013, 8(3): e58570.

15.ZouY#,Wang J#,Liu X#,Wang Y, Chen Y, Sun K, Gao S,Zhang C, Wang Z, Zhang Y, FengX, Song Y, Wu Y, Zhang H, JiaL, Wang H, Wang D, Yan C, Lu M, Zhou X, Song L*, HuiR*, Multiple gene mutations, not the type of mutation, are the modifier of leftventricle hypertrophy in patients with hypertrophic cardiomyopathy, Mol Biol Rep,2013, 40(6): 3969-3976.

16.Lu X#,Wang W#,Zhu L, Wang Y, Sun K, Zou Y, TianT, Hui R,Wang J*,Kang L*,Song L*.Prognostic Significance of Fragmented QRS in Patients with HypertrophicCardiomyopathy. Cardiology,2017, 138(1):26-33.

17.Cui H#,Wang J#,Zhang C, Wu G, Zhu C, Tang B, ZouY, Huang X, Hui R,Song L*, Wang S*. Mutation profile of FLNC gene and its prognostic relevance inpatients with hypertrophic cardiomyopathy. Mol Genet Genomic Med.2018 Nov 8. doi:10.1002/mgg3.488.

获奖情况

1.2009年北京市科学技术奖三等奖；《国人心肌疾病基因突变谱及发病机制研究与治疗》；惠汝太，宋雷，王虎，邹玉宝，孙凯，王继征。

2.2006年中华医学会科技进步奖三等奖；《中国人新的心脑血管疾病危险因素及其防治》；惠汝太、王曙霞、王继征、汪一波、周宪梁、张伟丽、石毅、孙凯、陈敬洲、王晓建。