1、团队工作人员：

        迟晓静（副研究员）、刘秀英（副主任技师）

2、在校生：

       潘胜男（直博生 2019级）、段花蕊（直博生 2020级）、杨雪花（博士生 2021级）

        张心慧（博士生 2022级）、陈文芳（硕士生 2019级）、张芳媛（硕士生2021级）

        高培翔（硕士生 2022级）

3、曾经团队成员和毕业生：

        司有辉、程敏、牛玉强、杨洋、龚巧玲、李响、赵瑾、李端、凡静静、赵霞、周佳、徐花、谢利豹、周亮、林田莉

主持承担了国家“863计划”、“973计划”、“重大传染病防治科技重大专项”和“国家自然科学基金”等多项国家级科研项目，是中国医学科学院医学与健康科技创新工程协同创新团队项目负责人。作为第一完成人获教育部自然科学二等奖。

代表性论文

1.Yang X, Duan H, Liu X, Zhang X, Pan S, Zhang F, Gao P, Liu B, Yang J, Chi X, Yang W. Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening. J Virol. 2023 Jul 27;97(7). 

2.Chi X, Zhang X, Pan S, Yu Y,Shi Y, Lin T, Duan H, Liu X, Chen W, Yang X, Chen L, Dong X, Ren L, Ding Q,Wang J, Yang W. An ultrapotent RBD-targeted biparatopic nanobodyneutralizes broad SARS-CoV-2 variants. Signal Transduct Target Ther.2022 Feb 9;7(1):44.

3.Lin T, Chi X, Liu X, Pan S,Chen W, Duan H, Zhang X, Yang W. Recombinant Full-Length Hepatitis CVirus E1E2 Dimer Elicits Pangenotypic Neutralizing Antibodies. Front Immunol.2022 Jun 28;13:831285.

4.Zhou L, Zhou J, Chen T, Chi X,Liu X, Pan S, Chen W, Wu T, Lin T, Zhang X, Li YP, Yang W. Identification of Ascomycin against Zika virus infection through screening ofnatural product library. Antiviral Res. 2021 Dec;196:105210.

5.Chi X, Liu X, Wang C, ZhangX, Li X, Hou J, Ren L, Jin Q, Wang J, Yang W. Humanized single domainantibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain. Nat Commun. 2020Sep 10;11(1):4528.

6.Ci Y, Liu ZY, Zhang NN, NiuY, Yang Y, Xu C, Yang W, Qin CF, Shi L. Zika NS1-induced ER remodeling is essential for viralreplication. J Cell Biol. 2020 Feb 3;219(2). pii:e201903062.

7.Zhou J, Chi X, Cheng M, Huang X,Liu X, Fan J, Xu H, Lin T, Shi L, Qin C, Yang W. Zika virus degrades the ω-3fatty acidtransporter Mfsd2a in brain microvascular endothelial cells and impairs lipidhomeostasis. Sci Adv. 2019 Oct 23;5(10):eaax7142.

8.Xu H, Cheng M, Chi X, LiuX, Zhou J, Lin T, Yang W. High-Throughput Screening Identifies Mixed-Lineage Kinase 3 as a Key HostRegulatory Factor in Zika Virus Infection. J Virol. 2019Aug 28;93(18). pii: e00758-19.

9.Fan J, Cheng M, Chi X, Liu X, Yang W. A HumanLong Non-coding RNA LncATV Promotes Virus Replication Through RestrictingRIG-I-Mediated Innate Immunity. Front Immunol. 2019 Jul 19;10:1711.

10. Cheng M, Niu Y, Fan J, ChiX, Liu X, Yang W. Interferon down-regulation of miR-1225-3p as an antiviral mechanismthrough modulating Grb2-associated binding protein 3 expression. J Biol Chem. 2018Apr 20;293(16):5975-5986.

11.Li D, Cheng M, Niu Y, Chi X, Liu X, Fan J, Fan H, Chang Y, Yang W. Identification of a novel human long non-coding RNA that regulates hepatic lipidmetabolism by inhibiting SREBP-1c. Int J Biol Sci. 2017 Feb 25;13(3):349-357.

12.Chi X, Niu Y, Cheng M, Liu X, Feng Y, Zheng F, Fan J, Li X, Jin Q,Zhong J, Li YP, Yang W. Identification of a Potent and Broad-Spectrum Hepatitis C Virus FusionInhibitory Peptide from the E2 Stem Domain. Sci Rep. 2016 Apr 28;6:25224.

13.Li X, Niu Y, Cheng M, Chi X, Liu X, Yang W. AP1S3 is required for hepatitis C virusinfection by stabilizingE2 protein. Antiviral Res. 2016 Jul;131:26-34.

14.Yang W, Zhang M, Chi X, Liu X, Qin B, Cui S. An intramolecular bond at cluster of differentiation 81ectodomain isimportant for hepatitis C virus entry. FASEB J. 2015Oct;29(10):4214-26.

15.Niu Y, Si Y, Li Y, Chi X, Li X, Liu X, Li D, Cheng M, Fan J, Si S, Yang W. A novelsmall-molecule inhibitor of hepatitis C virus replication acts by suppressingsignal transducer and activator of transcription 3. J Antimicrob Chemother. 2015Jul;70(7):2013-23.

16.Cheng M, Si Y, Niu Y, Liu X, Li X, Zhao J, Jin Q, Yang W. High-throughput profiling of alpha interferon- andinterleukin-28B-regulatedmicroRNAs and identification of let-7s with anti-hepatitis C virus activity bytargeting IGF2BP1. J Virol. 2013Sep;87(17):9707-18.

17.Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, LiX, Chen Y, Yang W. Screening and rational design of hepatitis C virus entry inhibitorypeptides derived from GB virus ANS5A. J Virol. 2013 Feb;87(3):1649-57.

18.Si Y, Liu S, Liu X, Jacobs JL, Cheng M, Niu Y, Jin Q, Wang T, Yang W. A humanclaudin-1-derived peptide inhibits hepatitis C virus entry. Hepatology. 2012Aug;56(2):507-15.

19.Cheng M, Si Y, Yang Y, Liu X, Gong Q, Zhao J, Niu Y, Li X, Jin Q, Yang W. Recombinanthuman interleukin 28B:anti-HCV potency, receptor usage and restricted cell-typeresponsiveness. J Antimicrob Chemother. 2012 May;67(5):1080-7.

20.Liu X, Wang T, Wakita T, Yang W. Systematic identification of microRNA andmessenger RNA profiles in hepatitis C virus-infected human hepatoma cells. Virology. 2010Mar1;398(1):57-67.

21.Liu S#, Yang W#, Shen L, Turner JR, Coyne CB, Wang T. Tight junction proteins claudin-1and occludin control hepatitis C virus entry and are downregulated duringinfection to prevent superinfection. J Virol. 2009 Feb;83(4):2011-4.

22.Yang W, Hood BL, Chadwick SL, Liu S,Watkins SC, Luo G, Conrads TP, Wang T. Fatty acid synthase is up-regulatedduring hepatitis C virus infection and regulates hepatitis C virus entry andproduction. Hepatology.2008 Nov;48(5):1396-403.

23.Yang W, Qiu C, Biswas N, Jin J, WatkinsSC, Montelaro RC, Coyne CB, Wang T. Correlation of the tight junction-likedistribution of Claudin-1 to the cellular tropism of hepatitis C virus. J Biol Chem. 2008Mar 28;283(13):8643-53.

24.Yang W, Zhang Y, Li Y, Wu Z, Zhu D. Myostatin induces cyclin D1 degradation to cause cell cycle arrest through aphosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonizedby insulin-like growth factor 1. J Biol Chem. 2007 Feb 9;282(6):3799-808.

25.Yang W, Chen Y, Zhang Y, Wang X, Yang N, Zhu D. Extracellular signal-regulated kinase 1/2 mitogen-activated proteinkinase pathway is involved in myostatin-regulated differentiation repression. Cancer Res. 2006Feb 1;66(3):1320-6.