抗肿瘤药物分子的设计、合成及活性研究

抗糖尿病药物分子的设计、合成及活性研究

靶向钾离子通道阻断剂的设计、合成及生物功能研究

发表论文：

1.   Jie Zhou, Jianbo Bie, Xiaoyu Wang, Quan Liu, Rongrui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu, Zhufang Shen, Bailing Xu,Discovery of N‑Arylsulfonyl-Indole-2-CarboxamideDerivatives as Potent, Selective, and Orally BioavailableFructose-1,6-Bisphosphatase Inhibitors Design, Synthesis, In Vivo GlucoseLowering Effects, and X‑ray Crystal Complex Analysis .  J. Med. Chem. 2020, 63, 10307-10329

2. Jie Zhou, Ming Ji, Haiping Yao, Ran Cao, Hailong Zhao, Xiaoyu Wang,Xiaoguang Chen, Bailing Xu. Discovery of quinazoline-2,4(1H,3H)-dione derivatives asnovel PARP-1/2 inhibitors: design, synthesis and their antitumor activity, Organic& Biomolecular Chemistry, 2018, 16, 3189-3220

3. JieZhou, Ming Ji, Zhixiang Zhu, Ran Cao, Xiaoguang Chen, Bailing Xu,Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives asnovel poly(ADP-ribose) polymerase-1 inhibitors with in vivo anti-tumor activity, EuropeanJournal of Medicinal Chemistry, 2017, 132, 26-41. 

4. 周洁，朱枝祥，季鸣，曹冉，陈晓光，徐柏玲，3-氨基苯甲酰胺衍生物PARP-1抑制剂的设计、合成及活性评价，中国药物化学杂志，2016, 26, 165-174.

5. JieZhou, Mingyu Ba, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao,Bailing Xu, Ying Guo. Synthesis and biological evaluation of novelquinoxalinone-based HIV-1 reverse transcriptase inhibitors. MedChemComm,2014, 5, 441-444. 

6. JieZhou, Jing Jin, Yi Zhang, Yuwen, Yin, Xiaoguang Chen, Bailing Xu.Synthesis and antiproliferative evaluation of novel benzoimidazole-containedoxazole-bridged analogs of combretastatin A-4. European Journal of Medicinal Chemistry,2013, 68, 222-232. 

7. 周 洁, 朱枝祥, 陈晓光, 徐柏玲. 氮杂吲哚类PARP-1抑制剂的合成及活性评价，药学学报，2013, 48, 1792-1799.

8. JieZhou, Yi Zhang, Yiwen Cui, Zhanmei Li, Hongrui Song, Jinhua Dong,Xiaoguang Chen, Bailing Xu. Synthesis and cytotoxic evaluation of N-(4-methoxy-1H benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d] imidazol)- 7-sulfonamide analogs of combretastatin A-4. Journal of AsianNatural Products Research,2011, 3, 330-340.

9. Hailong Zhao, Ming Ji, Guonan Cui, Jie Zhou, Fangfang Lai, XiaoguangChen, Bailing Xu, Discovery of novel quinazoline-2,4(1H,3H)-dione derivativesas potent PARP-2 selective inhibitors, Bioorganic & Medicinal Chemistry. 2017,25 , 4045-4054.

10. QinZhou, Ming Ji, Jie zhou, JingJin, Nina Xue, Ju Chen, Bailing xu, Xiaoguang chen , Poly (ADP-ribose) polymerases inhibitor, Zj6413, as apotential therapeuticagent against breast cancer, Biochemical Pharmacology,2016, 107, 29-40.

11. Hai-Long Zhao, Hua-Long Chen, Jie zhou, Bailing xu, Structureidentification of 4-amino -2-(arylamino)thiazole-5-carboxylic esters, Chinese ChemicalLetters, 2016, 27,302-304.

12. Haiping Yao, Ming Ji, Zhixiang Zhu, Jie Zhou, Ran Cao, Xiaoguang Chen,Bailing Xu. Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dionederivatives as novel poly (ADP-ribose) polymerase-1 inhibitors. Bioorganic &Medicinal Chemistry. 2015,23, 681–693.

授权专利

1. 徐柏玲、陈晓光、周洁、季鸣、姚海平、周秦；含有哌嗪酮的喹唑啉酮类PARP-1/2抑制剂及其制备方法、药物组合物和用途；专利号：ZL201610108263.3, 专利授权日：2020-5-7.

2. 徐柏玲、申竹芳、别建波、穆永钊、刘率男、周洁、李彩娜、曹冉、环弈、孙淑娟, N-酰基磺酰胺类FBPase抑制剂、其制备方法、药物组合物及用途; 专利号：ZL 2016 10105864.9, 专利授权日：2020-10-9.