团队及合作单位研究人员：

1. 郑可 北京协和医院 肾内科  副教授

代表性研究成果

(1) Qian Y#, Zheng K*, Wang H, You H, Han F, Ni J, Hou B, Chen L, Zhu Y, Feng F, Li X*. Cerebral microbleeds and their influence on cognitive impairment in Dialysis patients. Brain Imaging Behav. 2020 Jan 2. doi: 10.1007/s11682-019-00235-z.

(2) Chen RX#, Zhang L, Ye W, Wen YB, Si N, Li H, Li MX, Li XM, Zheng K*. The renal manifestations of type 4 familial partial lipodystrophy: a case report and review of literature. BMC Nephrol. 2018 May 10;19(1):111.

(3) Ke Zheng#, Haiyun Wang, Bo Hou, Hui You, Jing Yuan, Kai Luo, Limeng Chen, Mingxi Li, Qun Xu, Yicheng Zhu, Liying Cui, Sagar Uday Nigwekar, Feng Feng*, Xuemei Li1*.Malnutrition-inflammation is a risk factor for cerebral small vessel diseases and cognitive decline in peritoneal dialysis patients: a cross-sectional observational study. BMC Nephrol. 2017 Dec 20;18(1):366.

(4) Si N#, Zheng K#, Ma J, Meng XL, Li XM*, Zhang X*. Genetic Testing of the mucin 1 gene-Variable Number Tandem Repeat Single Cytosine Insertion Mutation in a Chinese Family with Medullary Cystic Kidney Disease. Chin Med J (Engl). 2017 Oct 20;130(20):2459-2464.

(5) Zheng K#, Teng F, Li XM*. Immunoglobulin G4-related kidney disease: Pathogenesis, diagnosis, and treatment. Chronic Dis Transl Med. 2017 Jul 8;3(3):138-147.

2. 乐偲 北京协和医院，肾内科，主治医师

代表性研究成果

(1) Yue Cai(#), Su Jian, Gao Ruitong, Wen Yubing, Li Chao, Chen Gang, Zhang Xuan(*), Li Xuemei(*). Characteristics and Outcomes of Patients with Systemic Lupus Erythematosus-associated Thrombotic Microangiopathy, and Their Acquired ADAMTS13 Inhibitor Profiles. J Rheumatol. 2018 Nov;45(11):1549-1556.

(2) Yue Cai(#), Li Guanhong, Wen Yubing, Li Xuemei, Gao Ruitong(*). Early Renin-angiotensin System Blockade Improved Short-term and Longterm Renal Outcomes in Systemic Lupus Erythematosus Patients with Antiphospholipid-associated Nephropathy. J Rheumatol. 2018 May;45(5):655-662.

3. 张泽建 中国医学科学院北京协和医院  医学科学研究中心  研究实习员

代表性研究成果

(1) Ren Shifang#; Zhang Zejian#; Xu Congjian; Guo Lin; Lu Renquan; Sun Yihong; Guo Jianming; Qin Ruihuan; Qin Wenjun; Gu Jianxin*; Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types, Cell Research, 2016, 26(8): 963-966.
(2) Qin Ruihuan#; Zhao Junjie#; Qin Wenjun; Zhang Zejian; Zhao Ran; Han Jing; Yang Yupeng; Li Lixiao; Wang Xuefei*; Ren Shifang*; Sun yihong; Gu jianxin; Discovery of non-invasive glycan biomarkers for detection and surveillance of gastric
cancer, Journal of Cancer, 2017, 8(10): 1908-1916.
(3) Zhang Zejian; Wuhrer Manfred; Holst Stephanie*; Serum sialylation changes in cancer, Glycoconjugate Journal, 2018, 35(2): 139-160.
(4) Qin Wenjun; Zhang Zejian; Qin Ruihuan; Han Jing; Zhao Ran; Gu Yong; Pan Yiqing; Gu Jianxin*; Ren Shifang*; Providing Bionic Glycome as internal standards by glycan reducing and isotope labeling for reliable and simple quantitation of N-glycome based on MALDI- MS, Analytica Chimica Acta, 2019, 1081(2019):112-119.
(5) Zhang Zejian; Westhrin Marita; Bondt Albert; Wuhrer Manfred; Standal Therese; Holst Stephanie*; Serum protein N-glycosylation changes in multiple myeloma, BBA - general subjects, 2019, 1863(5): 960-970.

4. 孙伟 中国医学科学院 北京协和医学院 基础医学研究所 中心仪器室 研究员

5. 彭丽盈 博士后 北京协和医院，目前主要从事SGLT2抑制剂对糖尿病肾病患者发挥肾脏保护作用的机制研究。

代表性研究成果

(1) Peng L, Wang Z, Li M, et al. Flares in Chinese systemic lupus erythematosus patients: a 6-year follow-up study. Clinical rheumatology. 2017;36:2727-2732.

(2) 彭丽盈, 等. 抗磷脂抗体综合征抗凝过程中反复脑卒中 1 例。中华临床免疫和变态反应杂志。

6. 张淑宇 博士研究生 北京协和医院，目前主要从事利用蛋白质组学技术建立IgAN诊断及预测模型相关研究工作。

(1) Xueying Yuan , Xingzhi Wang , Yushu Li , Xin Li, Shuyu Zhang, Lirong Hao. Aldosterone promotes renal interstitial fibrosis via the AIF‑1/AKT/mTOR signaling pathway. Mol Med Rep. 2019, 20(5):4033-4044.

(2) 张淑宇，等. 《mTORC1/2在肾脏病中作用机制的研究进展》，国际泌尿系统杂志。

在研课题

1.科技部重点研发计划：罕见病临床队列研究   肾小球疾病负责人     罕见结节样肾小球硬化注册队列研究 2016-2021 10万 

2.北京市科委：IgA肾病尿液新型标志物的筛选及应用评价    分课题负责人 2018-2022  20万.    利用蛋白质组学技术筛选出IgA肾病患者尿液中蛋白质标志物并在独立样本人群中进行验证，以期协助IgA肾病临床诊断和预测预后。 

3.白求恩公益基金：卡格列净通过调节糖尿病肾病患者线粒体功能发挥肾脏保护作用    负责人    2020-2022 20万

一、在研课题

1.科技部重点研发计划：罕见病临床队列研究 肾小球病负责人 罕见结节样肾小球硬化注册队列研究 2016-2021 10万 

2.北京市科委：IgA肾病尿液新型标志物的筛选及应用评价 分课题负责人 2018-2022  20万

3.白求恩公益基金会：卡格列净通过调节糖尿病肾病患者线粒体功能发挥肾脏保护作用 负责人 2020-2022 20万 

二、结题项目

1.一二、五国家科技支撑计划子课题（参加）：糖尿病等代谢性疾病肾损害的早期诊断与治疗 负责人 郑法雷教授 2012-2015 

2.国家自然科学基金（参加）： 糖尿病肾病的尿液糖基化蛋白质组学研究 负责人 孙伟研究员 2009-2012 

3.卫生公益性行业科研专项课题（参加）：代谢综合征肾脏损害的早期诊断和干预 负责人 李学旺教授 2007-2010

一、代表性研究成果和学术奖励：

(1)  Zixuan Zhu#, Cai Yue, Ying Sun, Xuemei Li,Mingxi Li* Light-chainamyloidosis with renal involvement: renal outcomes andvalidation of two renal staging systems in the Chinese population, Amyloid,2019 DOI: 10.1080/13506129.2019.16391491. (IF 4.919)

(2)ZGGuo#, XJ Liu#, ML Li, C Sao, JLTao, W Sun, MX Li*. Differential UrinaryGlycoproteomeanalysis of  Type 2 DiabeticNephropathyUsing 2D-LC-MS/MS and iTRAQ quantification. J of Translational Med，2015,13:371-388( IF 4.12)

(3)Jia LL#, Liu XJ#, Liu L, Li MX*, Gao YH*. Urimem, a membrane that can storeurinary proteins simply and economically, makes the large-scale storage ofclinical samples possible. Sci China Life Sci, 2014, 57(1):1-4 (IF 3.583)

(4)  Wenli Xia #, Bixia Gao, Lin Duan1, Yan Li1,Yubing Wen, Limeng Chen1, Xuemei Li1, Falei Zheng, Mingxi Li1* Clinicalsignificance of C4d deposition in renal tissues from patients with primarySjögren’s syndrome—a preliminary study, BMC Nephrology, 2019, 20(189):1-10 (IF2.53)

(5)ZiWang#, Mingxi Li*. Evolution of the Urinary Proteome During Human RenalDevelopment and Maturation.  Advances inexperimental Medicine and Biology, 2015, 845:95-101 (IF 2.45)

(6)LiuL#, Liu X, Sun W, Li M*，GaoY*.Unrestrictive identification of post-translational modifications in theurine proteome without enrichment. Proteome Science, 2013, 11:1-9 (IF 2.5)

(7)XJLiu#, C Shao, LL Wei, JD Duan, SZ Wu, XW Li，MXLi*,W Sun*. An individual urinary proteome analysis in normal  human beings to define the minimal samplenumber to represent the normal urinary proteome. Proteome Science 2012,10:70-82. (IF 2.5)

(8)Bixia Gao, Mingxi Li*, Wenli Xia, Yubin Wen, Zhen Qu. Rapidly progressiveglomerulonephritis due to anti-glomerular basement membrane disease accompaniedby IgA nephropathy: a case report. Clin Nephrol. 2014, 81(2):138-41.

(9)XuejiaoLiu , Chen Shao , Lilong Wei , Mingxi Li *, Wei Sun*,et al. An individualurinary proteome analysis in normal human beings to define the minimal samplenumber to represent the normal urinary proteome. Proteome Sci. 2012,21;10(1):70.

(10)YingSun, Mingxi Li, et al.  A comparison ofimmunohistochemistry and mass spectrometry for determining light chain amyloidfibril protein from formalin-fixed renal biopsy tissue in a single Chinese centerResearch Square 2019 DOI: 10.21203/rs.2.13027/v1

(11)WenliXia, Mingxi Li*  Impairment of renalfunction in a patient with IgA deficiency-associated MePGN.  Clinical Nephrology. 2010; 73(4): 331-332.

(12)MingxiLi, Kathy M.Nicholls, Gavin J.Becker. Glomerular size and globalglomerulosclerosis in normal Caucasian donor kidneys. J NEPHROL. 2002; 15(6):614-619.

(13)Mingxi Li, Kathy M.Nicholls, Gavin J.Becker. Risk factors for late renalallograft dysfunction. J NEPHROL. 2002; 15(6): 620-625.

(14)Li Xuewang, Li Mingxi, et al. Hemofiltration or hemodiafiltrationwith on-lineproduction of substitution fluid: clinical observation of safety andeffectiveness. Chinese Medical Journal 1997; 110(7): 520-525

(15)孙颖#，孙健，蔡建芳，文煜冰，郭正光，孙伟，李明喜*，李雪梅,显微切割联合质谱分析继发淀粉样变性患者肾组织SAA蛋白, 基础医学与临床，2017,37(8):1-88-1093

(16)孙颖#, 李明喜*, 文煜冰, 李雪梅, 孙健 激光显微切割/质谱联用技术在肾脏疾病诊断中的应用进展，生物工程学报，2014，30(7):1134-1140

(17)王明铭#、刘雪姣#,孙颖,高友鹤,李明喜* 尿蛋白膜保存法与直接冻存法的成本效益分析，生物工程学报，2014，7(30):1128-11339

(18)李思倩 朱子璇 文煜冰 庄俊玲 陈丽萌 李雪梅 李明喜∗多发性骨髓瘤管型肾病和肾淀粉样变性的临床特征及预后分析, 基础医学与临床,2019,39(10):1483-87

(19)李丹妮 文煜冰 李太生 李明喜HIV感染伴微小病变肾病一例并文献复习, 中华肾脏病杂志,2018,18（34）：785-786

(20)朱子璇  李明喜 特发性结节样肾小球硬化的 诊断与治疗进展, 中华肾病研究电子杂志,2017,6(1):6-8

(21)赵旭冉 李明喜  尿铜蓝蛋白在糖尿病肾病早期诊断中的 研究进展, 国际移植与血液净化杂志,2017,15(2):5-7

(22)刘雪姣 李明喜 高碧霞 樊小红 蔡建芳 高友鹤 李雪梅 李学旺 代谢综合征患者尿蛋白质组的建立及差异蛋白功能分析 中华临床营养杂志2012；20(3):74-79

(23)高碧霞 李明喜 刘雪娇 蔡建芳 樊晓红 杨啸林 李雪梅 李学旺 磁珠分离结合生物质谱分析代谢综合征早期肾损害尿液蛋白谱 中国医学科学院学报33（5）：513-518（2011）

(24)刘雪娇 李明喜* 孙伟 王小蓉 高友鹤 李雪梅 李学旺 丙酮沉淀法富集尿液蛋白的影响因素分析 中华肾脏病杂志2011；27（1）：51-53

(25)高碧霞 李明喜 文煜冰 李雪梅 李学旺  Churg-Strauss 综合征肾脏损害的临床特征 基础医学与临床2011；31(7): 834-838

二、其它英文论著

(1)H-TWu#, Y-B Wen, W Ye, B-Y Liu, K-N Shen, R-To Gao*, Ming-Xi Li1. Underlying IgMheavy chain amyloidosis in treatment-refractory IgA nephropathy: a case report.World J Clin Cases. 2019,7(18):1-6

(2)Yan W#, Yong C, Yang Z, Shuzhen W, Sucan M, Siqi H, Ling Z, Chen S, Mingxi L,Youhe G*. Differential ConA-enriched Urinary Proteome in Rat ExperimentalGlomerular Diseases. Biochem Biophys Res Commun 2008, 371 (3):385-90

(3)Ru-Xuan Chen, Lei Zhang , Wei Ye  ,Yu-Bing Wen , Nuo Si , Hang Li  , Ming-XiLi , Xue-Mei Li , Ke Zheng. The renal manifestations of type 4 familial partiallipodystrophy: a case report and review of literature.BMC Nephrol,2018,19(1):111.

(4)Mindi Zhao , Yehong Yang , Zhengguang Guo , Chen Shao , Haidan Sun , Yang Zhang, Ying Sun , Yaoran Liu , Yijun Song, Liwei Zhang, Qian Li  , Juntao Liu , Mingxi Li , Youhe Gao , WeiSun . A Comparative Proteomics Analysis of Five Body Fluids: Plasma, Urine,Cerebrospinal Fluid, Amniotic Fluid, and Saliva.Proteomics Clin Appl. 2018,12(6):e1800008.

(5)Ying Wang, Yan Qin, Xiaohong Fan, Jianfang Cai, Wei Ye, Jinghua Xia, Mingxi Li,Xuemei Li, Xuewang Li, Limeng Chen. Variability in Predialysis Systolic BloodPressure and Long-Term Outcomes in Hemodialysis Patients. Kidney Blood PressRes. 2018;43(1):115-124.

(6)Mindi Zhao , Menglin Li , Yehong Yang , Zhengguang Guo , Ying Sun  , Chen Shao , Mingxi Li , Wei Sun , YouheGao. A comprehensive analysis and annotation of human normal urinary proteome.Sci Rep. 2017, 7(1):3024.

(7)Jing Wang, Yubing Wen , Mengyu Zhou , Xiaoxiao Shi , Lanping Jiang , Mingxi Li, Yang Yu , Xuemei Li , Xuewang Li, Wen Zhang , Andrew L Lundquist , LimengChen. Ectopic germinal center and megalin defect in primary Sjogren syndromewith renal Fanconi syndrome. Arthritis Res Ther. 2017, 2;19(1):120.

(8)Ke Zheng , Haiyun Wang , Bo Hou , Hui You , Jing Yuan , Kai Luo , Limeng Chen ,Mingxi Li , Qun Xu , Yicheng Zhu , Liying Cui , Sagar Uday Nigwekar , Feng Feng, Xuemei Li. Malnutrition-inflammation is a risk factor for cerebral smallvessel diseases and cognitive decline in peritoneal dialysis patients: across-sectional observational study.BMC Nephrol . 2017, 18(1):366.

(9)Dong-Hong Ma , Fa-Lei Zheng , Ying Su , Ming-Xi Li , Ming-Hong Guo. Influenceand analysis of low-dosage steroid therapy in severe aristolochic acidnephropathy patients. Nephrology (Carlton) . 2016, 21(10):835-40.

(10)Jianling Tao , Wei Zhang, Yubing Wen, Ying Sun, Limeng Chen, Hang Li, MingxiLi, Xuewang Li, Richard A Lafayette, Xuemei Li. Endoplasmic Reticulum StressPredicts Clinical Response to Cyclosporine Treatment in Primary MembranousNephropathy

Evolutionof the urinary proteome during human renal development and maturation. Am JNephrol. 2016;43(5):348-56 

(11)Jian-Ling Tao , Li-Li Liu, Yu-Bing Wen, Rui-Tong Gao, Hang Li, Ming-Xi Li,Xue-Mei Li, Xue-Wang Li. Cyclosporine treatment in idiopathic membranousnephropathy nephrotic syndrome in adults: a retrospective study spanning 15years. Chin Med J (Engl) . 2011, 124(21):3490-4.

(12)Li-Li Liu , Yan Qin, Jian-Fang Cai, Hai-Yun Wang, Jian-Ling Tao, Hang Li,Li-Meng Chen, Ming-Xi Li, Xue-Mei Li, Xue-Wang Li. Th17/Treg imbalance in adultpatients with minimal change nephrotic syndrome. Clin Immunol. 2011,139(3):314-20.

(13)Lulu Jia , Ling Zhang, Chen Shao, Eli Song, Wei Sun, Mingxi Li, Youhe Gao. Anattempt to understand kidney's protein handling function by comparing plasmaand urine proteomes. PLoS One. 2009, 4(4):e5146.

三、授权发明专利：刘雪娇 贾露露 高友鹤 李明喜 李雪梅 李学旺；硝酸纤维素（NC）膜富集体液蛋白质组蛋白的用途，2016-8-15，中国，ZL201210012275.8