主持国家自然科学基金项目《难溶性药物纳米混悬剂的制备和稳定化相关基础研究》；北京市自然科学基金项目《借鉴"相似相容"假说设计高效稳定剂及在纳米混悬剂中的应用》2项；参与国家及重大项目10多项。

发表论文40余篇，其中SCI收录25篇。

近5年代表性论文：
1. Mengying Zhang,Yuan Zou, Cuiling Zuo, Hui Ao, Yifei Guo, Xiangtao Wang, Meihua Han. Targeted antitumor comparison study between dopamine self- polymerization and traditional synthesis for nanoparticle surface modification in drug delivery.Nanotechnology, 2021, DOI: 10.1088/1361-6528/abf8dd.
2.Yuan Zou, Xiangtao Wang, Dongdong Bi, Jingxin Fu, Jianwei Han, Yifei Guo, Li Feng, Meihua Han.Pterostilbene nanoparticles with small particle size show excellent anti-breast cancer activity in vitro and in vivo. Nanotechnology, 2021,DOI:10.1088/1361-6528/abfdec.
3.Lei Zhao, Dongdong Bi, Xiaoyu Qi, Yifei Guo, Xiangtao Wang, Meihua Han. Polydopamine-based surface modification of paclitaxel nanoparticles for osteosarcoma targeted therapy.Nanotechnology. 2019, 30 (25): 255101.
4.Run Qi Yu, Yuan Zou, Biao Liu, Yifei Guo, Xiangtao Wang, Meihua Han. Surface modification of pH-sensitive honokiol nanoparticles based on dopamine coating for targeted therapy of breast cancer. Colloids Surf B Biointerfaces. 2019,177: 1-10.
5.Dongdong Bi, Lei Zhao, Haowen Li, Yifei Guo, Xiangtao Wang, Meihua Han. A comparative study of polydopamine modified and conventional chemical synthesis method in doxorubicin liposomes form the aspect of tumor targeted therapy. International Journal of Pharmaceutics. 2019, 559: 76-85. 
6.XiaoYu Qi, Hao Liu,DongDong Bi, Xiangtao Wang, Yifei Guo, Ting Hao, Baoxin Zhang, Xing Guo Wang,Meihua Han. Combined administration on You-Gui Yin and low-dose Raloxifene partially attenuates the bone loss in ovariectomized mice through the proliferation and osteogenic differentiation of bone marrow stromal cells.Phytomedicine, 2019, 53: 286-293.
7.Lei Zhao, Mengying Zhang, Yifei Guo, Xiangtao Wang, Meihua Han. Alendronate-Modified Polydopamine-Coated Paclitaxel Nanoparticles for Osteosarcoma-Targeted Therapy.Journal of Drug Delivery Science and Technology, 2019, 53, 101133.
8.Dongdong Bi, Lei Zhao, Runqi Yu, Haowen Li, Yifei Guo, Xiangtao Wang, Meihua Han. Surface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy. Drug Delivery. 2018, 25(1):564-575. 
9.Meihua Han, Xiaoyu Qi, Dongdong Bi, Yijing Li, Yifei Guo, Xiangtao Wang, Li Feng. Administration of raloxifene hydrochloride nanosuspensions partially attenuates bone loss in ovariectomized mice. RSC Advances, 2018, 8, 23748-23756.
10.Meihua Han, Liqiang Ma, Xin Yu, Zhitao Li, Yifei Guo, Haixue Kuang, Xiangtao Wang. A nanoparticulate drug-delivery system for 20 (S)- protopanaxadiol: formulation,characterization, increased oral bioavailability and antitumor efficacy. Drug delivery, 2016，23(7): 2410-2418.
11.Meihua Han,Zhitao Li,Yifei Guo,Jian Zhang,and Xiangtao Wang.A nanoparticulate drug-delivery system for glaucocalyxin A: formulation,characterization, increased in vitro, and vivo antitumor activity. Drug delivery, 2016，23(7): 2457-2463. 
12.M. H.Han, H. Zheng, Y. F. Guo, Y. H. Wang, X. Y. Qi and X. T. Wang. Novel folate-targeted paclitaxel nanoparticles for tumor targeting: preparation,characterization, and efficacy. RSC Adv., 2016, 6, 45664–45672.
13.M. H. Han, Z. T. Li, D. D.Bi, Y. F. Guo, H. X. Kuang and X. T. Wang. Novel folate - targeted docetaxel-loaded nanoparticles as tumour targeting: in vitro and vivo evaluation. RSC Adv., 2016, 6, 64306–64314.

授权专利5项。

1. 韩美华，王向涛，于鑫，一种和厚朴酚纳米粒及其制备方法，专利号ZL201410001498.3 (授权公告日2016年1月20日)

2. 韩美华，王向涛，一种20（S）-原人参二醇纳米粒及其制备方法，专利号ZL201410009584.9 (授权公告日2015年12月9日)

3. 王向涛，杨晓凤，韩美华，郭一飞. 一种喜树碱类药物的纳米晶及其制备方法。专利号ZL201610195547.0 （授权公告日，2019年9月24日，CN106466296B）

4. 王向涛，张明珠，韩美华，郭一飞. 一种雷公藤红素纳米混悬剂及其制备方法，专利号ZL201610886793.0   （授权公告日，2019年9月24日，CN106309364B）

5. 王向涛，李怡静，王一安，敖惠，李好文，韩美华，郭一飞. 一种水合淫羊藿素纳米粒及其制备方法和应用. 专利号（CN201811338149.5（授权公告日，2019年1月29日）

获得省部级奖1项。

硕士研究论文《接骨木根皮用于治疗骨折的基础及应用研究》获黑龙江省二等奖。