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本人长期致力于代谢性疾病药物药理学研究工作,特别是基于肠道菌群微生态和功能调节揭示药物发挥功效的新机制。目前作为通讯作者或第一作者在Nanoscale, Part Fibre Toxicol, Acta Pharm Sin B等期刊发表SCI论文50余篇,被引用1600余次,担任Mol Med Rep(SCI)等三家国际期刊的编委,并担任Nanomedicine, Phytomedicine, J Agr Food Chem等50余种SCI期刊的资深审稿人。
肠道菌群与人类健康以及药物功效的内在关系是当前生物和医学领域发展最迅猛、最活跃的前沿热点。本人成功建立了肠道菌群测序新技术,能够以和16S测序接近的成本实现精准的宏基因组测序,同时建立了包含6万余株肠道活菌的人类肠道菌库,并在菌株层面对肠道菌的基因组、代谢组、以及药理活性进行了精准解析和研究,期望突破本领域的瓶颈,取得原始创新的成果。
2020-2023 |
精准肠道菌研究在菌株水平解析肠道菌群促进胰高血糖素样肽-1(GLP-1)分泌的功能及活性分子发现 |
国家自然基金(面上) |
2017-2020 |
基于特征性肠道菌种及其功能基因和活性代谢产物探究小檗碱降血脂功效的肠道机制 |
国家自然基金(面上) |
2018-2019 |
人类肠道菌群500种单一菌种的调血脂功效及作用机制研究 |
青年医学人才奖励项目 |
2016-2020 |
创新中药发现与研发协同创新团队 |
医学科学院创新团队 |
2015-2017 |
虫草素上调促脂肪褐化关键因子irisin表达的分子机制研究 |
国家自然基金(青年) |
2012-2012 |
FSP27调节脂滴融合的分子机制研究 |
中国博士后基金 |
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg(1)国家自然科学基金青年资助项目:虫草素上调促脂肪褐化关键因子irisin表达的分子机制研究,编号81402983,金额24万元
(2)国家自然科学基金面上资助项目:基于特征性肠道菌种及其功能基因和活性代谢产物探究小檗碱降血脂功效的肠道机制,编号81673663,金额57万元
(3)国家自然科学基金面上资助项目:精准肠道菌研究在菌株水平解析肠道菌群促进胰岛血糖素样肽-1(GLP-1)分泌的功能及活性分子发现,编号81973217,金额55万元。
2021年
[1] Qiao J, et al. Perturbation of gut microbiota playsan important role in micro/nanoplastics-induced gut barrier dysfunction. Nanoscale 2021. 13(19):8806-8816 (2021即时IF:7.56,中科院1区)(封面论文)
[2] DongC, et al. Berberine, a potentialprebiotic to indirectly promote Akkermansia growth through stimulating gut mucinsecretion. Biomed Pharmacother. 2021; 139:111595. (2021即时IF:6.3)
[3] Zhang X, et al. The Traditional Chinese Medicinesdifferentially modulate the gut microbiota on the base of their natures(Yao-Xing). Phytomedicine 2021; 85:153496 (2021即时IF:5.09,中科院1区)
[4] SunL, et al. The triterpenoids ofthe bitter gourd (Momordica Charantia) and their pharmacological activities: Areview. J Food Compo Anal. 96 (2021) 103726. (2021即时IF:4.36)
[5] YuY, et al. Akkermansiamuciniphila: A potential novel mechanism of nuciferine to improvehyperlipidemia. Biomed Pharmacother. 2021;133:111014. (2021即时IF:6.3)
[6] 于佳琪, 等. 加氏乳杆菌的降脂活性研究. 中国食品学报. 2021. (已接收)
[7] Wu, et al. Shallow whole-metagenome shotgunsequencing (S-WMS): a low-cost and high accurate alternative method of 16S rRNAgene amplicon sequencing to characterize gut microbiota. Front Microbiol 2021, In press
[8] Wu,et al. The maintenance ofmicrobial community in human fecal samples by a self-made cost-effectivepreservation buffer. Sci Rep 2021, In press
2020年
[1] ZhangF, et al. The gut microbiotaconfers the lipid-lowering effect of bitter melon (Momordica charantia L.) inhigh-fat diet (HFD)-induced hyperlipidemic mice. Biomed Pharmacother. 2020;131:110667.(IF:4.545)
[2] LiY, et al. The GutMicrobiota-Produced Indole-3-Propionic Acid Confers the AntihyperlipidemicEffect of Mulberry-Derived 1-Deoxynojirimycin. mSystems.2020;5(5):e00313-20. (5-year IF: 7.389)
[3] 陈天达, 等. DNA提取过程中的实验室空气微生物DNA定量. 生物工程学报,2020, 36(12):2541-47.
[4] 孙乐, 等. 铁皮石斛多糖药理活性研究进展. 药学学报. 2020; 55(10):2322-2339.
[5]Huo J, et al. Whole-genomesequence of Phellinus gilvus (mulberry Sanghuang) reveals its unique medicinalvalues. J Adv Res. 2020; 24: 325-335. (IF:6.992)
2019年
[1] Qi G, et al. Cordycepin promotes browning ofwhite adipose tissue through an AMP-activated protein kinase (AMPK)-dependentpathway. Acta Pharm Sin B. 2019 Jan;9(1):135-143. (IF:6.014,中科院1区)
[2] Wu C, et al. Asperlin Stimulates EnergyExpenditure and Modulates Gut Microbiota in HFD-Fed Mice. Mar Drugs. 2019 Jan9;17(1). (IF:4.446)
[3] Wu C, et al. The pandanus tectorius fruitextract (PTF) modulates the gut microbiota and exerts anti-hyperlipidaemiceffects. Phytomedicine. 2019;58: 152863. (IF:4.18,中科院1区)
[4] Li Y, et al. The mulberry-derived 1-deoxynojirimycin (DNJ)inhibits high-fat diet (HFD)-induced hypercholesteremia and modulates the gutmicrobiota in a gender-specific manner. J Funct Foods. 2019; 52: 63-72.(IF:3.47,中科院1区)
[5] Wang R, et al. Four-week administration ofnicotine moderately impacts blood metabolic profile and gut microbiota in adiet-dependent manner. Biomed Pharmacother. 2019;115:108945 (IF:3.743)
[6] 于佳琪, 等. 肠道菌群对动脉粥样硬化发病的影响及机制. 国际药学研究杂志. 2019; 4.
2018年
[1] Sun Y, et al. The aqueous extract ofPhellinus igniarius (SH) ameliorates dextran sodium sulfate-induced colitis inC57BL/6 mice. PLoS One. 2018 Oct 5;13(10):e0205007. (IF:3.352)
[2] Zhong S, et al. Butylene fipronil inducesapoptosis in PC12 murine nervous cells via activation of p16-CDK4/6-cyclin D1and mitochondrial apoptotic pathway. J Biochem Mol Toxicol. 2018 Dec31:e22264. doi: 10.1002/jbt.22264. (IF:1.837)
[3] Li J, et al. Lipid- and gutmicrobiota-modulating effects of graphene oxide nanoparticles in high-fatdietinduced hyperlipidemic mice. RSC Adv., 2018, 8, 31366. (IF:3.168)
[4] Cao L, et al. Ameliorating Effect andPotential Mechanism of Camellia Oil on Constipated Mice. J Beijing Inst Technol.2018, 27(2):312-318. (EI indexed)
[5] Wang S, et al. Phenylpropanoid glucosides fromTadehagi triquetrum inhibit oxLDL-evoked foam cell formation through modulatingcholesterol homeostasis in RAW264.7 macrophages. Nat Prod Res. 2018,1-4.(IF:1.999)
[6] Li J, et al. The Antihyperlipidemic Effectsof Fullerenol Nanoparticles via Adjusting the Gut Microbiota in vivo. PartFibre Toxicol 2018, 15(1):5. (5-year IF:9.628,中科院1区)
[7] Li J, et al. Oral administration of rutileand anatase TiO2 nanoparticles shifts mouse gut microbiota structure. Nanoscale.2018;10(16):7736-7745. (IF:7.736,中科院1区)
[8] 曹良顺,等. 山茶油对乙醇和消炎痛致小鼠胃溃疡的影响. 海南医学. 2018; 29(7): 895-897.
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