1)       中国医学科学院医学与健康科技创新工程，广谱抗RNA病毒药物

2)        十三五传染病科技重大专项基金，“胞内固有免疫网络在病毒性传染病防控中的应用”

3)       国家自然科学基金委，HIV-1宿主限制因子SAMHD1的dNTPase非依赖抗病毒机制的研究

4)       中国医学科学院、北京协和医科大学协和学者与创新团队基金，新型抗病毒药物

5)       国家自然科学基金委，阻断Vpu下调Tetherin的抗HIV-1小分子的作用机理研究

6)       国家重大科学研究计划，宿主因子在艾滋病易感性、病程进展及耐药性发生中的作用

7)       十二五“新药创制”科技重大专项基金，发展抗艾滋病病毒（HIV-1)创新药物的新策略

8)       中国医学科学院、北京协和医科大学协和学者基金

9)       国家基金委-加拿大国立卫生研究院研究基金课题(CIHR)合作基金,SAMHD1在艾滋病病毒（HIV-1）传播中的作用

10)    十二五传染病科技重大专项基金，“病毒性疾病的感染组学关键技术平台建立与应用”

11)    十一五“新药创制”科技重大专项基金，发展抗艾滋病病毒（HIV-1)创新药物的新策略

12)    科技部/ISTP Canada重大国际合作项目，新型HIV-1整合酶抑制剂的研究

13)    加拿大国立卫生研究院(CIHR)，Thepotential of APOBEC3G in the development of a novel anti-HIV-1 therapeutic

14)     国家自然科学基金委海外青年学者合作研究基金，以生物发光共振能转移为技术手段的新型抗HIV药物高通量筛选模型的建立

15)     加拿大国立卫生研究院 (CIHR)，Study on the mechanism of humanAPOBEC3G encapsidation into HIV-1

16)     美国艾滋病研究基金课题(AMFAR)，The interaction between HIV-1 Gagand human APOBEC3G

17)     加拿大艾滋病研究基金课题(CANFAR)，Study on the non-deaminatingantiviral function of human APOBEC3G.

发表文章(近三年,节选)

1)       Yi D, Li Q, PangL, Wang Y, Zhang Y, Duan Z, Liang C, CenS*.. Identification of a broad-spectrum inhibitor of Dengue virus andNorovirus that targets a novel allosteric site of RdRps. Front Microbiol 2020 Jun25;11:1440.

2)       Wang J* and Cen S*. Roles of lncRNAs ininfluenza virus infection. Emerg Microbes Infect. 2020 Dec;9(1):1407-1414.

3)       Wang M, Zhang G,Wang Y, Wang J, Zhu M, Cen S*,Wang Y*. Design, synthesis and anti-influenza A virus activity of novel2,4-disubstituted quinazoline derivatives. Bioorg Med Chem Lett. 2020 Jun1;30(11):127143. doi: 10.1016/j.bmcl.2020.127143.

4)       Wang Y, Zhou R,Quan Y, Chen S, Shi X, Li Y*, Cen S*.Design, synthesis and evaluation of novel 2-(benzyl piperazin-substituted) methylbenzonitrileanalogs as Zika inhibitors. Bioorg Med Chem Lett. 2020 Feb15;30(4):126906.

5)       Zhu M#, Ma L#, WenJ, Dong B, Wang Y, Wang Z, Zhou J, Zhang G, Wang J, Guo Y, Liang C, Cen S*, Wang Y*. Rational designand Structure-Activity relationship of coumarin derivatives effective on HIV-1protease and partially on HIV-1 reverse transcriptase. Eur J Med Chem. 2020 Jan15;186:111900.

6)       Zhang GN, Li Q,Zhao J, Zhang X, Xu Z, Wang Y, Fu Y, Shan Q, Zheng Y, Wang J, Zhu M, Li Z, Cen S*, He J*, Wang Y*. Designand synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dualinhibitors of respiratory syncytial virus and influenza virus A. Eur J Med Chem. 2020 Jan 15;186:111861.

7)       Zhu M, Ma L, ZhouH, Dong B, Wang Y, Wang Z, Zhou J, Zhang G, Wang J, Liang C, Cen S*, Wang Y*. Preliminary SAR and biologicalevaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novelP2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur JMed Chem. 2020 Jan 1;185:111866

8)       Liu T, Sun Q, LiuY, Cen S*, Zhang Q*. TheMOV10 helicase restricts hepatitis B virus replication by inhibiting viralreverse transcription" J Biol Chem. 2019 Dec20;294(51):19804-19813.

9)       Fu YH, Xu ZX,Jiang N, Zheng YP, Rameix-Welti MA, Jiao YY, Peng XL, Wang Y, Eleouet JF*, Cen S*, He JS*. High-throughput screening of activecompounds against human respiratory syncytial virus. Virology. 2019 Jul3;535:171-178.

10)   Wang J, Zhang Y,Li Q, Zhao J, Yi D, Ding J, Zhao F, Hu S, Zhou J, Deng T, Li X*, Guo F, LiangC, Cen S*.. Influenza virus exploits an interferon-independent lncRNA towarrant viral RNA synthesis by suppression of RIG-I mediated immune response.Cellreports. 2019 Jun 11;27(11):3295-3304.

11)   Zhu M, Dong B,Zhang GN, Wang JX, Cen S*,Wang YC*. Preliminary SAR and biological evaluation of potent HIV-1 proteaseinhibitors with bases of nucleic acids as P2-ligands. Bioorg Med Chem Lett. 2019Jun 15;29(12):1541-1545.

12)   Wu M, Xie Y, CuiX, Huang C, Zhang R, He Y, Li X, Liu M, CenS*, Zhou J*. Rational drug design for androgen receptor andglucocorticoids receptor dual antagonist. EUR J MED CHEM 2019 Mar15;166:232-242.

13)   Ding J#, Ma L#,Zhao J, Xie Y, Zhou J, Li X*, Cen S*.An integrative genomic analysis of transcriptional profiles identifiedcharacteristic genes and patterns in HIV-infected long- term non- progressorsand elite controllers, J Transl Med. 2019 Jan 21;17(1):35. doi:10.1186/s12967-019-1777-7.

14)   Liu Y, Wu M, WangT, Xie Y, Cui X, He L, He Y, Li X, Liu M, Hu L*, Cen S*, Zhou J*. Structural based screening of antiandrogentargeting 2 activation function-2 binding site. Front Pharmacol. 2018 Nov30;9:1419. doi: 10.3389/ fphar.2018.01419.

15)   Yi DR#, An N#, LiuZL#, Xu FW, Raniga K, Li QJ, Zhou R, Wang J, Zhang YX, Zhou JM, Zhang LL, An J,Qin CF, Guo F, Li XY, Liang C*, Cen S*. Human MxB inhibits the replication ofHCV.J Virol. 2018 Dec 10;93(1). pii: e01285-18. doi: 10.1128/JVI.01285-18

16)   Wang J, Wang Y,Zhou R, Zhao J, Zhang Y, Yi D, Li Q, Zhou J, Guo F, Liang C, Li X, Cen S.*. Host Long Noncoding RNAlncRNA-PAAN Regulates the Replication of Influenza A Virus. Viruses.2018 Jun 16;10(6). pii: E330. doi: 10.3390/v10060330.

17)   Ma L, Zhang Z, LiuZ, Pan Q, Wang J, Li X*, Guo F, Liang C, Hu L, Zhou J*, Cen S*. Identification of small molecule compounds targetingthe interaction of HIV-1 Vif and human APOBEC3G by virtual screening andbiological evaluation. Sci. Rep. 2018 May 23;8(1):8067.

18)   Li Q, Ma L, Yi D,Wang H, Wang J, Zhang Y, Guo Y, Li X, Zhou J, Shi Y*, Gao GF, Cen S*. Novel cyclo-peptidesinhibit Ebola pseudotyped virus entry by targeting primed GP protein. AntiviralRes. 2018 Jul;155:1-11.

19)   Zhang Y, Huang Y,Li Q, Li X, Zhou Y, Guo F, Zhou J*, CenS*. A highlyconserved amino acid in VP1regulatesmaturation of enterovirus 71. PlosPathogens.2017 Sep 22;13(9):e1006625. doi: 10.1371

20)   Ding J, Zhao J,Yang Z, Ma L, Mi Z, Wu Y, Guo J, Zhou J, Li X, Guo Y, Peng Z, Wei T, Yu H,Zhang L, Ge M, Cen S*. Microbialnatural product alternariol 5-O-methyl ether inhibits HIV-1 integration byblocking nuclear import of the pre-integration complex. Viruses. 2017 May10;9(5). pii: E105.

21)   Zhai C, Ma L,Zhang Z, Ding J, Wang J, Zhang Y, Li X, Guo F, Yu L, Zhou J, Cen S*. Identification and characterization of the loop7 motif of as animportant role in regulating human APOBEC3G biological function throughmolecular modeling and biological assay. Acta Pharmaceutica Sinica B. 2017Sep;7(5):571-582. doi: 10.1016.