导师组成员

王晨轩，研究员，博士生导师。

个人介绍：

461大魔王，脑回路清奇、好奇心旺盛的水瓶座。“n”“l”不分的安徽+湖北+陕西+山东人后代，内核是个十足的安徽+湖北人。社恐，工作所迫，从i人心理扭曲成e人。二次元浓度高，bilibili常驻，喜欢日常番、治愈番。爱祖国，爱子弟兵。热爱生活，养过十几只仓鼠。热衷于吃各种虫子、脑子、内脏等黑暗料理，并安利（强迫）给大家。对感兴趣的事情很投入、很专注。曾经在实验室里100小时连续工作，不眠不休。也曾经几天几夜不合眼完成了7541片积木的乐高模型。喜欢捣鼓奇怪的发明，比如自制果蝇陷阱。会在实验室轰隆轰隆地磨咖啡、泡大壶茶（也打呼噜）。换日历会把各种纪念日和生日都标注好。重度恐高，不敢走过街天桥，进了环球影城什么项目都不敢坐。不会用支付宝。稻香村与义利的骨灰级粉丝。退役文青，最近热衷于教大家学中文。461唯一的兰大校友，自参加工作以来从没有兰大学生报考。在渤海、黄海、南海、波罗的海、地中海、五大湖里游过泳，下个目标是恒河。461毒王，各种流感和新冠病毒的策源地，凭一己之力团灭自己的课题组。擅长画小动物，擅长p图搞创作，留下许多经典作品（师弟瑟瑟发抖）。爱发微博，曾被集体围观。玩狼人杀总当暴民或者不救人的女巫。喜欢在实验室里和大家一起死宅，孩子王。没事儿就和大家聊课题、聊人生、聊未来。爱闭关，更爱出关。不爱运动，不爱出差，461常住人口，大年初一也来上班。

于兰兰，副研究员，硕士生导师。

教育及工作经历：

2009-2013年，南京理工大学高分子材料与工程专业，本科。

2013-2018年，中国科学院国家纳米科学中心与清华大学化学系联合培养研究生，物理化学专业。导师王琛研究员、杨延莲研究员、李艳梅教授。研究方向：在单分子水平研究蛋白折叠与组装结构及多肽-多肽/糖相互作用。2017年7月，以色列巴伊兰大学访学。2018年获清华大学理学博士学位。

2018至今，中国医学科学院基础医学研究所/北京协和医学院基础学院，历任博士后、助理研究员、副研究员。

研究方向：

围绕蛋白质的折叠与组装这一科学问题，重点研究与疾病相关蛋白质的组装与调控，在单分子水平解析组装结构中的构象多态性与动态演变规律，进一步研究其调控规律；基于脑库样本，研究病理性蛋白的组装构象与相关疾病表型之间的关联规律；基于对蛋白质组装过程中分子间相互作用的理解，研究蛋白质发生液-液相转变以及固化成熟的过程，解析与疾病之间的关联性，进一步实现对这一过程的有效调控；关注蛋白质寡聚化与药物分子的选择性寡聚化，研究寡聚化与生物功能的关联性；靶向药物分子的设计与筛选研究。

个人介绍：

461萌兰，刚刚晋升宝妈。反差感代表人物。山东人，但是在江苏和上海居住的时间更长。热爱山东大煎饼，但不吃大葱大蒜。一方水土养一方人（王老师说的）。实验室4i之一，骑起摩托来超帅。家里养过马。爱爬山，练过武术，但是体力不好。夏天不怕热，长袖。冬天不出门，很丧。461纳米中心分室大总管，贴心负责。比王老师还社恐。狼人杀上帝专业户。夜精灵一只，晚上效率高。照片上过《科技日报》。曾经在实验室里睡过一星期行军床。爱吃肉，烤肉火锅。爱吃炒土豆丝、芹菜馅儿饺子。辣椒的重度爱好者，肠胃是铜墙铁壁。爱吃榴莲，开发过各种榴莲吃法。因为研发出榴莲配饭扫光拌饭酱这种丧心病狂的吃法，被饭扫光公司赠送了一箱拌饭酱。喜欢给王老师投喂山东的各种虫子料理，炸豆虫、炸知了猴、炸蝎子...... 平时是舒适风穿搭，优衣库的白金会员，但喜欢买项链首饰，还爱买小电器（积灰中）。用双脚丈量世界，去过国内外大大小小的城市：在死海里漂浮，在地中海里溺水，在耶路撒冷遇到过枪战。不会迷路，人型GPS。小邓师兄不着调学术脑洞的倾听者，时不时会收到他50+条60s+的语音。

张文博，副研究员，硕士生导师。

教育及工作经历：

2009-2013年，中国农业大学生物学院，生物科学专业，本科。

2013-2019年，北京大学，北京核磁共振中心，生物化学与分子生物学专业。导师金长文教授，理学博士。研究方向：核磁共振技术研究蛋白质的结构、动态特性与功能关系。

2019至今，中国医学科学院基础医学研究所/北京协和医学院基础学院生物物理与结构生物学系，王晨轩研究员课题组。历任助理研究员、副研究员、硕士生导师。

研究方向：

蛋白质的正确折叠与错误折叠与人体生理病理过程密切相关。针对多种疾病相关蛋白，包括：炎症相关蛋白、皮肤病相关蛋白、眼部疾病相关蛋白、脑疾病相关蛋白等，主要利用多种生物物理技术包括：液体核磁共振、多种显微术、光散射等，研究疾病相关蛋白质的折叠结构、组装结构及其与生理功能之间的关联，开发多种小分子、多肽类靶向药物，并阐述其与蛋白质相互作用的分子机制，包括相互作用方式及相互作用位点，深入理解靶向性药物调控疾病相关蛋白质/多肽折叠组装结构的规律，为干预相关病症的发生与发展提供科学依据与潜在的新方法。

个人介绍：

461手艺人，钩织技术高超。东北吉林人，非常淘，非常皮。经典语录：“看，王老师一副指点江山的样子。” 巨能唠，461迷茫学生的加油站，情报业务水平一流。刀子嘴豆腐心，王老师说她像一品芝麻狐里的老姑（躺枪）。核磁专家，认真靠谱，贤助飞速养成中。每次王老师放飞自我时，果断将王老师镇压。社牛，461教师团队中唯一的社交担当。王老师的小红书启蒙导师。爱吃大米饭，也给仓鼠喂大米饭。做事儿的时候喜欢吃棒棒糖。海淀辣妈，家有糖宝一只，茁壮成长中。曾经的461红娘月老，现在知难而退了（摊手）。461北大校友会总舵主。会打麻将，会打王者荣耀，吃鸡游戏。重度路痴。爱花草，工位上常插束花，家里的多肉能长到楼下去。喜欢粉色，bulingbuling的东西。爱逛街。爱追剧看剧，嗑cp上头且长情（博君一肖）。修仙玄幻文学爱好者。纳豆发烧友，广式小吃、韩国料理爱好者。爱吃米线，但是吃米线时因为坐在王老师对面留下了心理阴影。特能跑步。各种乐器无敌。一手好字，睡前会写写毛笔字（十天半个月吧）。各种颜色的大毛袜子。常在半夜收到某师弟的实时电话实验技术求助。

蛋白质的正确折叠与组装是维持人体生理机能的必需。肽链通过精密地调控分子间相互作用自组装形成有序三维分子结构，进一步组装、聚集、相分离，形成执行生理功能的分子机器与无膜细胞器。蛋白质组装稳态失衡是一系列退行性疾病共同的病理生理基础。研究蛋白质组装过程与结构，认识自组装过程中的分子间相互作用的本质与规律，实现对自组装过程与功能的有效调控对蛋白质组装相关疾病的预防和治疗有重要意义，从经典药物治疗到相关新型药物治疗的兴起，从微观层面对发病分子机理的阐述到宏观层面治疗模式的创新，新的认识将在未来改变相关疾病的诊治模式，为患者改善预后带来新的机遇。

课题组遵循“认识组装-调控组装-利用组装”的研究思路，发展扫描隧道显微术、原子力探针显微术、核磁共振波谱技术、X-射线单晶衍射、光散射等新颖的物理、物理化学方法用于生物大分子的结构测定，在单分子水平理解与重大疾病发生、发展密切相关的蛋白、多肽的折叠、组装结构和过程，认识蛋白、多肽折叠组装过程中的相互作用本质与调控规律。

       课题组开展的研究课题包括：

（1）蛋白质折叠、组装与分子识别的物理化学机制（Sci Adv, 2023; ACS Cent Sci, 2023; Nano Lett, 2023; Mater Today Phys, 2024; J Am Chem Soc, 2017; Nature, 2015）

（2）蛋白质折叠与组装调控的生物学与医学应用：靶向夏科-莱登晶体的药物干预及其在慢性鼻鼻窦炎治疗中的应用（Nano Lett, 2022）

（3）药物的选择性寡聚化识别淀粉样蛋白组装体的分子机制以及生物学功能（Sci Adv, 2020）

国家自然科学基金委员会，重大研究计划集成项目，92353302，神经退行性疾病相关蛋白质的翻译后修饰异质化效应和动态结构研究，2024年1月至2025年12月，360万元，在研，子任务负责人

中国医学科学院医学健康前沿交叉研究专项，2023-I2M-QJ-009，解析人脑内源Aβ 纤维结构的单分子学研究方法，2023 年10月至2025 年9月，40万元，在研，主持

北京市自然科学基金委员会，面上项目，2222039，药物与淀粉样蛋白聚集体相互作用的结构多态性研究，2022.01至2024.12，20万元，在研，主持

国家自然科学基金委员会，青年项目，31901007，碳基纳米材料表面多肽折叠结构与调控的单分子水平研究，2020.01至2022.12，21万元，已结题，主持

中国医学科学院医学与健康创新工程，2018-I2M-3-006，离子通道相关疾病的发病机制及转化研究，2018.01-2020.12，70万元/年，已结题，主持

中国科学院纳米生物效应与安全性重点实验室开放课题，NSKF201812，纳米颗粒-多肽组装结构的抗 MRSA应用，2018.11-2019.10，5万元，已结题，主持

中国医学科学院中央级公益性科研院所基本科研业务费，2018PT31028，纳米颗粒表面调控多肽折叠组装结构的单分子水平研究，2018.01-2018.12，50万元，已结题，主持

国家自然科学基金委，面上项目，21273051，基于特异性识别多肽的循环肿瘤细胞检测新方法研究，2013.01-2016.12，81万元，已结题，主要参与

国家自然科学基金委，重大研究计划，91127043，疾病相关多肽组装结构及其调控的 分子水平研究，2012.01-2015.12，300万元，已结题，主要参与

课题组历年发表论文

2024 Publications

64. Zhongyi Jian#, Ruonan Wang#, Shanshan Mo, Zhun Deng, Shuyuan Li, Zhenyan Li, Mingzhan Wang, Yanlian Yang, Chen Wang, Wenbo Zhang, Lanlan Yu*, Chenxuan Wang*, Structural evolution of the conformational ensembles in peptide fibrillar aggregates, Materials Today Physics, 2024, 44, 101437, DOI: 10.1016/j.mtphys.2024.101437.

2023 Publications

63. Wenbo Zhang#, Ruonan Wang#, Mingwei Liu#, Shucong Li, Asher E. Vokoun, Weichen Deng, Robert L. Dupont, Feiyi Zhang, Shuyuan Li, Yang Wang, Zhenyu Liu, Yongfang Zheng, Shuli Liu, Yanlian Yang, Chen Wang, Lanlan Yu*, Yuxing Yao, Xiaoguang Wang*, Chenxuan Wang*, Single-molecule visualization determines conformational sub-state ensembles in β-sheet-rich peptide fibrils, Science Advances, 2023, 9(27), eadg794, DOI: 10.1126/sciadv.adg7943.

62. LanlanYu#, Ruonan Wang#, Shucong Li, Ufuoma I. Kara, Eric C. Boerner, Boyuan Chen, Feiyi Zhang, Zhongyi Jian, Shuyuan Li, Mingwei Liu, Yang Wang, Shuli Liu, Yanlian Yang, Chen Wang, Wenbo Zhang*, Yuxing Yao, Xiaoguang Wang*, Chenxuan Wang*, Experimental insights into conformational ensembles of assembled sheet peptides, ACS Central Science, 2023, 9(7), 1480–1487, DOI: 10.1021/acscentsci.3c00230.

61. Wenbo Zhang#, Mingwei Liu#, Yang Wang#, Xin Wang, Ruonan Wang, Shuyuan Li, Lanlan Yu, Feiyi Zhang, Chenxuan Wang*, β-Sheet assembly translates conservative single-site mutation into a perturbation in macroscopic structure, Nano Letters, 2023, 23(6), 2370-2378, DOI: 10.1021/acs.nanolett.3c00311.

60. Chenxuan Wang*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical organization of supramolecular systems: from fundamentals to biomedical applications, volume II, Frontiers in Bioengineering and Biotechnology, 2023,11, 1177799, DOI: 10.3389/fbioe.2023.1177799.

2022 Publications

59. Meichen Zhang#, Yangyang Ge#, Shilin Xu, Xiaocui Fang, Jie Meng, Lanlan Yu, Chenxuan Wang, Jian Liu, Tao Wen, Yanlian Yang, Chen Wang*, Haiyan Xu*, Nanomicelles co-loading CXCR4 antagonist and doxorubicin combat the refractory acute myeloid leukemia, Pharmacological Research, 2022, 185,106503, DOI: 10.1016/j.phrs.2022.106503.

58. Lanlan Yu#, Ruonan Wang#, Tao Wen#, Lei Liu, Tao Wang, Shuli Liu, Haiyan Xu*, Chenxuan Wang*, Peptide binder with high-affinity for the SARS-CoV-2 spike receptor-binding domain, ACS Applied Materials & Interfaces, 2022, 14(25),28527–28536, DOI: 10.1021/acsami.2c03707.

57. Yan Zhao#, Shanshan Mo#, Lanlan Yu#, Xiaolu Li, Yun Hao, Wenbo Zhang, Qi Zhang, Ping Wang, Xiangdong Wang*, Chenxuan Wang*, Luo Zhang*, Crystalline state determines the potency of galectin-10 protein assembly to induce inflammation, Nano Letters, 2022, 22(6), 2350-2357, DOI: 10.1021/acs.nanolett.1c04817.

56. Feiyi Zhang#, Lanlan Yu#, Zhun Deng, Shuli Liu, Chenxuan Wang*, Lei Liu*, Composition-dependent wettability of nature-inspired homo poly(amino acid) coating and its influences on bacterial adhesion, European Polymer Journal, 2022, 168, 111127, DOI: 10.1016/j.eurpolymj.2022.111127.

55. Wenbo Zhang#, Mingwei Liu#, Lanlan Yu#, Shanshan Mo, Zhun Deng, Shuli Liu, Yanlian Yang, Chen Wang, Chenxuan Wang*, Perturbation effect of single polargroup substitution on the self-association of amphiphilic peptide helices, Journalof Colloid and Interface Science, 2022, 610, 1005-1014, DOI: 10.1016/j.jcis.2021.11.154.

54. Zhichao Lou#, Qiuyi Wang, Xiaodi Zhou, Ufuoma I. Kara, Rajdeep S. Mamtani, Hualiang Lv*, Meng Zhang, Zhihong Yang, Yanjun Li, Chenxuan Wang*, Solomon Adera*, Xiaoguang Wang*, An angle-insensitive electromagnetic absorber enablinga wide band absorption, Journal of Materials Science & Technology, 2022, 113, 33-39, DOI: 10.1016/j.jmst.2021.11.007.

2021 Publications

53. Wenbo Zhang#, Mingwei Liu#, Robert L. Dupont, Kai Huang, LanlanYu, Shuli Liu, Xiaoguang Wang*, Chenxuan Wang*, Conservation and identity selection of cationic residues flanking the hydrophobic regions in intermediate filament superfamily, Frontiers in Chemistry, 2021, 9,752630, doi: 10.3389/fchem.2021.752630.

52. Feiyi Zhang#, Lanlan Yu#, Wenbo Zhang#, Lei Liu*, Chenxuan Wang*, A minireview on the perturbation effects of polar groups to direct nanoscale hydrophobic interaction and amphiphilic peptide assembly, RSC Advances, 2021, 11,28667-28673, doi: 10.1039/d1ra05463e.

51. Chenxuan Wang#*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical organization of supramolecular systems: from fundamentals to biomedical applications, Frontiers in Bioengineering and Biotechnology, 2021, 9, 754980, doi: 10.3389/fbioe.2021.754980.

50. Lanlan Yu#, Zhun Deng#, Wenbo Zhang, Shuli Liu, Feiyi Zhang, Jianjian Zhou, Chunhua Ma, Chenxuan Wang*, Opposite regulatory effects of immobilized cations on the folding versus assembly of melittin, Frontiers in Chemistry, 2021, 9, 685947, doi: 10.3389/fchem.2021.685947.

49. Yan Zhao#, Xiaolu Li#, Wenbo Zhang#, LanlanYu#, Yang Wang, Zhun Deng, Mingwei Liu, Shanshan Mo, Ruonan Wang, Jinming Zhao, Shuli Liu, Yun Hao, Xiangdong Wang, Tianjiao Ji*, Luo Zhang*, Chenxuan Wang*, Trends in the biological functions and medical applications of extracellular vesicles and analogues, Acta Pharmaceutica Sinica B, 2021, 11(8), 2114-2135, doi: 10.1016/j.apsb.2021.03.012.

48. Lanlan Yu#, Yongfang Zheng, Xiaocui Fang, Yimin Zou, Chenxuan Wang*, YanlianYang*, Chen Wang*, Composition-dependent multivalency of peptide-peptide interactions revealed by tryptophan-scanning mutagenesis, Journal of Peptide Science, 2021, 27, e3310, doi: 10.1002/psc.3310.

47. Shan He#, Xinyue He, Lei Liu, Wenbo Zhang, Lanlan Yu, Zhun Deng, Feiyi Zhang, Shanshan Mo, Yue Fan, Xinyue Zhao, Lun Wang, Chenxuan Wang*, Shuyang Zhang*, The structural understanding of transthyretin misfolding and the inspired drug approaches for the treatment of heart failure associated with transthyretin amyloidosis, Frontiers in Pharmacology, 2021, 12, 628184, doi: 10.3389/fphar.2021.628184.

46. Chenxuan Wang#, Naomi A. Biok, Karthik Nayani, Xiaoguang Wang, Hongseung Yeon, Chi-Kuen Derek Ma, Samuel H. Gellman*, Nicholas L. Abbott*, Cationic side chain identity directs the hydrophobically driven self-assembly of amphiphilic β-peptides in aqueous solution, Langmuir, 2021, 37, 3288-3298, doi: 10.1021/acs.langmuir.0c03255.

2020 Publications

45. Lanlan Yu#, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang*, Yanlian Yang, Chen Wang, Chenxuan Wang*, Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, Science Advances, 2020, 6(32), eabc1449, doi: 10.1126/sciadv.abc1449.

44. Wenbo Zhang#, Shanshan Mo#, Mingwei Liu#, Lei Liu, Lanlan Yu*, Chenxuan Wang*, Rationally designed protein building blocks for programmable hierarchical architectures, Frontiers in Chemistry, 2020, 8, 587975, doi: 10.3389/fchem.2020.587975.

43. Lanlan Yu#, Zhun Deng#, Lei Liu, Wenbo Zhang*, Chenxuan Wang*, Plant-derived nanovesicles: a novel form of nanomedicine, Frontiers in Bioengineering and Biotechnology, 2020, 8, 584391, doi: 10.3389/fbioe.2020.584391.

42. Wenbo Zhang#, Lanlan Yu, Tianjiao Ji*, Chenxuan Wang*, Tumor microenvironment-responsive peptide based supramolecular drug delivery system, Frontiers in Chemistry, 2020, 8, 549, doi: 10.3389/fchem.2020.00549.

41. Hongseung Yeon#, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Influence of immobilized cations on the thermodynamic signature of hydrophobic interactions at chemically heterogeneous surfaces, Molecular Systems Design and Engineering, 2020, 5(4),835-846, doi: 10.1039/d0me00016g.

40. Qize Xuan#, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang*, Yibing Wang*, Ping Wang, Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity, Chemical Communications, 2020, 56(11), 1633-1636, doi: 10.1039/c9cc08671d.

2019 Publications

39. Naomi A. Biok#, Alexander D. Passow, Chenxuan Wang, Craig A. Bingman, Nicholas L. Abbott*, Samuel H. Gellman*, Retention of coiled-coil dimer formation in the absence of ion pairing at positions flanking the hydrophobic core, Biochemistry, 2019, 58(48), 4821-4826, doi: 10.1021/acs.biochem.9b00668.

38. Chenxuan Wang#, Travis Nelson, Dayue Chen, Joseph Christopher Ellis, Nicholas L. Abbott*, Understanding Lipopolysaccharide Aggregation and its Influence on Activation of Factor C, Journal of Colloid and Interface Science, 2019, 552,540-553, doi: 10.1016/j.jcis.2019.05.013.

37. Xiaoyun Li#, Zhu Liang#, Jianchao Du#, Zhiqing Wang, Song Mei, Zhiqing Li, Yan Zhao, Dandan Zhao, Yiming Ma, Jun Ye, JiantaoXu, Yu Zhao, Jiahui Chang, Yuhao Qin, Lanlan Yu, Chenxuan Wang*, Chengyu Jiang*, Herbal decoctosome is a novel form of medicine, Science China-Life Sciences, 2019, 62(3),333-348, doi: 10.1007/s11427-018-9508-0.

36. Zhihui Yao#, Brian P. Cary, Craig A. Bingman, Chenxuan Wang, Dale F. Kreitler, Kenneth A. Satyshur, Katrina T. Forest, Samuel H. Gellman*, Use of a stereochemical strategy to probe the mechanism of phenol-soluble modulin alpha3 toxicity, Journal of the American Chemical Society, 2019, 141(19), 7660-7664, doi: 10.1021/jacs.9b00349.

35. Qunxing Huang#, Qiong Zhao, Jiaxi Peng, Ooolalla Yu, Chenxuan Wang, Yimin Zou, Yanlei Su, Ling Zhu*, Chen Wang*, Yanlian Yang*, Peptide-polyphenol(KLVFF/EGCG) binary modulators for inhibiting aggregation and neurotoxicity of amyloid-beta peptide, ACS Omega, 2019, 4(2), 4233-4242, doi: 10.1021/acsomega.8b02797.

2018 Publications

34. Reza Abbasi#, Chenxuan Wang, Yiqun Bai, Nicholas L. Abbott*, Phosphorylation status of peptide monolayers modulates hydrogen bonding and orientations of nematic liquid crystals, Liquid Crystal, 2018, 45 (13-15), 2253-2268, doi: 10.1080/02678292.2018.1509389.

2017 Publications

33. Chenxuan Wang#, C. Derek Ma, Hongseung Yeon, Xiaoguang Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Nonadditive interactions mediated by water at chemically heterogeneous surfaces: nonionic polar groups and hydrophobic interactions, Journal of the American Chemical Society, 2017, 139(51), 18536-18544,doi: 10.1021/jacs.7b08367.

32. Hongseung Yeon#, Chenxuan Wang, Reid C. Van Lehn, Nicholas L. Abbott*, Influence of order within nonpolar monolayers on hydrophobic interactions, Langmuir, 2017, 33(19), 4628-4637, doi: 10.1021/acs.langmuir.7b00226.

31. Timothy J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Redox-triggered mixing and demixing of surfactants within assemblies formed in solution and at surfaces, Journal of Colloid and Interface Science, 2017, 502,122-133, doi: 10.1016/j.jcis.2017.04.052.

30. Aihua Yang#, Chenxuan Wang, Baomin Song, Wendi Zhang, Yuanyuan Guo, Rong Yang, Guangjun Nie, Yanlian Yang*, Chen Wang*, Attenuation of beta-amyloidtoxicity in vitro and in vivo by accelerated aggregation, Neuroscience Bulletin, 2017, 33(4), 405-412, doi: 10.1007/s12264-017-0144-z.

2016 Publications

29. C. Derek Ma#, Claribel Acevedo-Vélez, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Interaction of the hydrophobic tip of an atomic force microscope with oligopeptides immobilized using short andlong tethers, Langmuir, 2016, 32(12), 2985-2995, doi: 10.1021/acs.langmuir.5b04618.

28. Juan Liu#, Tuo Wei, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowei Ma, Xingjie Liang*, Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance, Biomaterials, 2016, 91, 44-56, doi: 10.1016/j.biomaterials.2016.03.013.

2015 Publications

27. C. Derek Ma#, Chenxuan Wang, Claribel Acevedo-Vélez, Samuel H. Gellman*, Nicholas L. Abbott*, Modulation of hydrophobic interactions by proximally immobilized ions, Nature, 2015, 517(7534), 347-U443 doi: 10.1038/nature14018.

26. Yanmei Wang#, Chenxuan Wang#, Zhiqiang Cheng, Dongdong Zhang, Shaopeng Li, Lusheng Song, Wenfei Zhou, Mo Yang, Zhiyou Wang, Zheng Zheng, Baohang Han, Chen Wang*, Yanlian Yang*, Jinsong Zhu*, SPRi determination of inter-peptide interaction by using 3D supramolecular co-assembly polyrotaxane film, Biosensors and Bioelectronics, 2015, 66, 38-44, doi: 10.1016/j.bios.2014.11.025.

25. Timothy J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Influence of self-assembling redox mediators on charge transfer at hydrophobic electrodes, Langmuir, 2015, 31(39), 10638-10648, doi: 10.1021/acs.langmuir.5b02212.

24. Yang Sun#, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo, Dangsheng Li, Bo Li, Qihan Li, Nanshan Zhong, Chen Wang, Josef M. Penninger, Chengyu Jiang*, Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice, Particle and Fibre Toxicology,2015, 12, 4, doi: 10.1186/s12989-015-0080-x.

2014 Publications

23. Yiqun Bai#, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott*, Liquid crystals anchored on mixed monolayers of chiral versus achiral molecules: continuous change in orientationas a function of enantiomeric excess, Angewandte Chemie International Edition, 2014, 53 (31), 8079-8083, doi: 10.1002/anie.201402770.

22. Huiwen Du#, Denghua Li, Yibin Wang, Chenxuan Wang, Ping Li, Yanlian Yang*, Chen Wang*, Peptide-assisted directional adsorption of purple membrane at the liquid-solid interface, Journal of Physical Chemistry C, 2014, 118 (51), 29770-29776, doi: 10.1021/jp5077017.

2013 Publications

21. Min Zhang#, Xiaobo Mao, Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang*, Wei Liang*, Chen Wang*, The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein(Vpr), Biomaterials, 2013, 34 (4), 1383-1390, doi: 10.1016/j.biomaterials.2012.10.067.

20. Min Zhang#, Xiaobo Mao, Yue Yu, Chenxuan Wang, Yanlian Yang*, Chen Wang*, Nanomaterials for reducing amyloid cytotoxicity, Advanced Materials, 2013, 25(28),3780-3801, doi: 10.1002/adma.201301210.

19. Huiwen Du#, Denghua Li, Yibing Wang, Chenxuan Wang, Dongdong Zhang, Yanlian Yang*, Chen Wang*, Determination of the surface charge density and temperature dependence of purple membrane by electric force microscopy, Journal of Physical Chemistry B, 2013, 117(34), 9895-9899, doi: 10.1021/jp403075w.

18. Ting Zhou#, Axel Llizo, Ping Li, Chenxuan Wang, Yuanyuan Guo, Mingqi Ao, Linling Bai, Chen Wang*, Yanlian Yang*, Guiying Xu*, High transfection efficiency of homogeneous DNA nanoparticles induced by imidazolium gemini surfactant asnonviral vector, Journal of Physical Chemistry C, 2013, 117(50), 26573-26581, doi: 10.1021/jp4061363.

2012 Publications

17. Chenxuan Wang#, Aihua Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang*, Chen Wang*, Observation of molecular inhibition and binding structures of amyloid peptides, Nanoscale, 2012, 4(6), 1895-1909, doi: 10.1039/c2nr11508e.

16. Yuanyuan Guo#, Chenxuan Wang, Jingfei Hou, Aihua Yang, Xuemei Zhang, Yibing Wang, Min Zhang, Yanlian Yang*, Chen Wang*, Odd-even sequence effect of surface-mediated peptide assemblies observed by scanning tunneling microscopy, Chinese Journal of Chemistry, 2012, 30 (9),1987-1991, doi: 10.1002/cjoc.201200656.

15. Jie Song#, Menglin Chen, Viduthalai Regina, Chenxuan Wang, Rikke Meyer, Erqing Xie, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Safe and effective Ag nanoparticles immobilized antimicrobial nanononwovens, Advanced Engineering Materials, 2012, 14(5), B240-B246, doi: 10.1002/adem.201180085.

14. Peng Liu#, Shuai Zhang, Meisha Chen, Qian Liu, Chenxuan Wang, Chen Wang, Yanmei Li*, Flemming Besenbacher, Mingdong Dong*, Co-assembly of human islet amyloid polypeptide (hIAPP)/insulin, Chemical Communications, 2012, 48(2),191-193, doi: 10.1039/c1cc14285b.

2011 Publications

13. Xiaobo Mao#, Chenxuan Wang#, Xingkui Wu, Lei Liu, Lan Zhang, Lin Niu, Yanlian Yang*, Chen Wang*, Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies, Proceedings of the National Academy of Sciences of the USA, 2011, 108(49),19605-19610, doi: 10.1073/pnas.1102971108.

12. Chenxuan Wang#, Xiaobo Mao#, Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibin Wang, Yanlian Yang*, Chen Wang*, Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy, Chemical Communications, 2011, 47(38), 10638-10640, doi: 10.1039/c1cc12380g.

11. Xiaobo Mao#, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Liu,Qingdao Zeng, Yanlian Yang*, Chen Wang*, Molecular level studies on binding modes of labeling molecules with polyalanine peptides, Nanoscale,2011, 3(4), 1592-1599, doi: 10.1039/c0nr00782j.

10. Xiaobo Mao#, Yuanyuan Guo, Chenxuan Wang, Min Zhang, Xiaojing Ma, Lei Liu, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy, ACS Chemical Neuroscience, 2011, 2(6),281-287, doi: 10.1021/cn200006h.

9. Zengguang Cheng#, Qiaoyu Zhou, Chenxuan Wang, Qiang Li, Chen Wang, Ying Fang*, Toward intrinsic graphene surfaces: a systematic study on thermal annealing and wet-chemical treatment of SiO2-supported graphene devices, Nano Letter, 2011, 11(2), 767-771, doi: 10.1021/nl103977d.

8. Jie Song#, Menglin Chen, Mikkel Buster Olesen, Chenxuan Wang, Rasmus Havelund, QiangLi, Erqing Xie, Rong Yang, Peter Boggild, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Direct electrospinning of Ag/polyvinylpyrrolidone nanocables, Nanoscale, 2011, 3(12), 4966-4971, doi: 10.1039/c1nr10512d.

7. Weiwei He#, Shuai Hou, Xiaobo Mao, Xiaochun Wu*, Yinglu Jin, Jianbo Liu, Xiaona Hu, Ke Zhang, Chenxuan Wang, Yanlian Yang, Qi Wang, Peptide-tailored assembling of Au nanorods, Chemical Communications, 2011, 47(19), 5482-5484, doi: 10.1039/c1cc10394f.

2010 Publications

6. Xiaobo Mao#, Chenxuan Wang, Lei Liu, Xiaojing Ma, Lin Niu, Yanlian Yang*, Chen Wang*, Study on the fine structure of polypeptides at solid-liquid interfaces by scanning tunneling microscopy, Acta Physico-Chimica Sinica, 2010, 26(4), 850-861, doi: 10.3866/PKU.WHXB20100440.

5. Xuemei Zhou#, Hongchao Yang, Chenxuan Wang, Yinfang Cui, Xiaobo Mao,Cong Wang, Yinshu Wang, Gang Liu*, Visible light induced photocatalytic degradation rhodamine B on one-dimensional iron oxide particles, Journal of Physical Chemistry C, 2010, 114(40), 17051-17061, doi: 10.1021/jp103816e.

4. Xiaobo Mao#, Hongchao Yang, Xuemei Zhou, Chenxuan Wang, Yinshu Wang, Yanlian Yang, Chen Wang, Gang Liu*, Straight and Branched Goethite Topology by Oriented Attachment at High pH, Crystal Growth & Design, 2010, 10(2), 504-509, doi: 10.1021/cg900392m.

3.Tao Zhang#, Zengguang Cheng, Yibing Wang, Zhongjun Li, Chenxuan Wang, Yibao Li, Ying Fang*, Self-assembled 1-octadecanethiol monolayers on graphene for mercury detection, Nano Letters, 2010, 10(11), 4738-4741, doi: 10.1021/nl1032556.

2. Hongchao Yang#, Xuemei Zhou, Tengteng Tang, Xiaoying Qi, Chenxuan Wang, Jinyao Lan, Yinshu Wang, Yanlian Yang, Gang Liu*, Anisotropic growth of multi-twinned goethite particles by oriented aggregation, CrystEngComm, 2010, 12(12), 4007-4009, doi: 10.1039/c0ce00437e.

1.     Jie Jiang#, Xiaoliang Tang, Wei Dou, Huihui Zhang, Weisheng Liu*, Chenxuan Wang, Jiangrong Zheng, Synthesis and characterization of the ligand based on benzoxazole and its transition metal complexes: DNA-binding and antitumoractivity, Journal of Inorganic Biochemistry, 2010, 104(5), 583-591, doi: 10.1016/j.jinorgbio.2010.01.011.

著作

Books and Chapters

3. Lanlan Yu#, Yanlian Yang, Chen Wang, Chenxuan Wang*. Peptide Assemblies on Surfaces: A Study Using Scanning Tunneling Microscopy. In: Xuehai Yan (eds) Peptide Self-Assembly and Engineering, 2 Volumes: Fundamentals, Structures, and Applications. 2024, Wiley-VCH, Weinheim, Germany.

2. Wenbo Zhang#, Lanlan Yu, Chenxuan Wang*. Intermolecular interactions and self-assembly of peptide-based nanomaterials against human pathogenic bacteria. In: Haiyan Xu, Ning Gu. (eds) Nanotechnology in regenerative medicine and drug delivery therapy. 2020, Springer, Singapore

1. 王晨轩#，杨延莲*，王琛*. 《纳米生物医学光电子学前沿》第七章《淀粉样蛋白的结构分析研究进展》科学出版社，2013年，北京

发明专利

Patents

16. 王晨轩，张文博，王洋，李淑媛. 二甲双胍及其它含胍化合物在逆转Gal-10结晶趋势并缓解相关疾病中应用。国家发明专利. 授权公告日2024-03-19, 专利号 ZL202210534642.4

15. 王晨轩，张罗，莫珊珊，王向东，于兰兰，赵妍，李小璐，张文博，郝蕴. 多肽在制备治疗2型免疫疾病的药物中的应用。国家发明专利. 授权公告日2022-08-19, 专利号 ZL202111008545.3

14. 王晨轩，莫珊珊，于兰兰，张罗，赵妍，王向东，李小璐，张文博，郝蕴. 用于治疗2型免疫疾病的多肽。国家发明专利. 授权公告日2022-08-19, 专利号 ZL202111008519.0

13. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种亲和肽在制备抗冠状病毒药物中的应用。国家发明专利. 授权公告日2022-07-15, 专利号 ZL202110178816.3

12. 王晨轩，莫珊珊，张罗，赵妍，于兰兰，王向东，李小璐，张文博，郝蕴. 靶向夏科-莱登结晶蛋白的多肽及其应用。国家发明专利. 授权公告日2022-05-03, 专利号 ZL202111008517.1

11. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种亲和肽M5稳定的纳米金颗粒及其制备方法和用途。国家发明专利. 授权公告日2022-04-01, 专利号 ZL202110529881.6

10. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种新型冠状病毒主蛋白酶的亲和肽M1及其应用。国家发明专利. 授权公告日2022-02-08, 专利号 ZL202110231722.8

9. 王晨轩，于兰兰，王琛，杨延莲. 一种研究蛋白质及药物-蛋白质复合体构象多态性的方法。国家发明专利. 授权公告日2021-03-05,专利号 ZL202010070997.3

8. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种低溶血活性的蜂毒肽及其应用。国家发明专利. 授权公告日2020-04-28,专利号 ZL201910854177.0

7. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种蜂毒肽变体及其应用。国家发明专利. 授权公告日2020-05-12,专利号 ZL201910854956.0

6. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp41蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-03-01,专利号 ZL201310298420.8

5. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp120蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-06-27,专利号 ZL201310298450.9

4. 张敏，李平，王晨轩，杨延莲，王琛. 抑制b淀粉样蛋白聚集和毒性的多肽抑制剂及其应用。国家发明专利. 授权公告日2017-12-12,专利号 ZL201310294070.8

3. 王琛，杨爱华，王晨轩，杨延莲. 调节beta淀粉样蛋白生理毒性的多肽。国家发明专利. 授权公告日2017-12-26,专利号 ZL201310421560.X

2. 王琛，张敏，王晨轩，杨延莲. 一种抑制人胰淀素聚集或毒性的多肽、试剂及其应用。国家发明专利. 授权公告日2015-11-25,专利号 ZL201210410206.2

1. 王琛，杨延莲，许海燕，李潇瑾，张卫奇，孟洁，王晨轩. 一种增强肿瘤细胞对抗肿瘤药物敏感性的多肽及其应用。国家发明专利.授权公告日2018-5-4,专利号 ZL201310298419.5

      课题组开展多学科交叉研究，欢迎生物学、生物技术、药学、基础医学、生物工程、生物信息学及相关专业的学生

      要求：（1）本科专业主干课成绩优秀，有读博意愿；（2）热爱科学研究与基础研究，对未知领域有强烈好奇心、献身精神；（3）有团队合作精神；（4）中文表达与写作能力优异，优异的普通话书面语沟通、交流与演讲能力，有一定的中国文学与文化修养；（5）英文读写能力合格，全国大学英语六级考试成绩及格。