实验室骨干

蛋白质的正确折叠与组装是维持人体生理机能的必需。肽链通过精密地调控分子间相互作用自组装形成有序三维分子结构，进一步组装、聚集、相分离，形成执行生理功能的分子机器与无膜细胞器。蛋白质组装稳态失衡是一系列退行性疾病共同的病理生理基础。研究蛋白质组装过程与结构，认识自组装过程中的分子间相互作用的本质与规律，实现对自组装过程与功能的有效调控对蛋白质组装相关疾病的预防和治疗有重要意义，从经典药物治疗到相关新型药物治疗的兴起，从微观层面对发病分子机理的阐述到宏观层面治疗模式的创新，新的认识将在未来改变相关疾病的诊治模式，为患者改善预后带来新的机遇。

课题组遵循“认识组装-调控组装-利用组装”的研究思路，发展扫描隧道显微术、原子力探针显微术、核磁共振波谱技术、X-射线单晶衍射、光散射等新颖的物理、物理化学方法用于生物大分子的结构测定，在单分子水平理解与重大疾病发生、发展密切相关的蛋白、多肽的折叠、组装结构和过程，认识蛋白、多肽折叠组装过程中的相互作用本质与调控规律。

       课题组开展的研究课题包括：

（1）药物的选择性寡聚化识别淀粉样蛋白组装体的分子机制以及生物学功能（Science Advances, 2020, 6, eabc1449.）

（2）蛋白质折叠、组装与分子识别的物理化学机制（Nature, 2015, 517, 347-350; Journal of the American Chemical Society, 2017, 139, 18536–18544; Nano Letters, 2023, 23, 2370-2378）。

（3）蛋白质折叠与组装调控的生物学与医学应用：围绕与嗜酸性粒细胞型炎症发生发展密切相关的夏科-莱登蛋白质晶体，解析蛋白质折叠、组装产生晶体的分子机制，寻找逆转其组装趋势的小分子抑制剂，为临床治疗嗜酸性粒细胞型炎症相关疾病提供可行的化学干预方法。 (Nano Letters, 2022, 22, 2350-2357)。

北京市自然科学基金委员会，面上项目，2222039，药物与淀粉样蛋白聚集体相互作用的结构多态性研究，2022.01至2024.12，20万元，在研，主持

国家自然科学基金委员会，青年项目，31901007，碳基纳米材料表面多肽折叠结构与调控的单分子水平研究，2020.01至2022.12，21万元，在研，主持

中国医学科学院医学与健康创新工程，2018-I2M-3-006，离子通道相关疾病的发病机制及转化研究，2018.01-2020.12，70万元/年，已结题，主持

中国科学院纳米生物效应与安全性重点实验室开放课题，NSKF201812，纳米颗粒-多肽组装结构的抗 MRSA应用，2018.11-2019.10，5万元，已结题，主持

中国医学科学院中央级公益性科研院所基本科研业务费，2018PT31028，纳米颗粒表面调控多肽折叠组装结构的单分子水平研究，2018.01-2018.12，50万元，已结题，主持

国家自然科学基金委，面上项目，21273051，基于特异性识别多肽的循环肿瘤细胞检测新方法研究，2013.01-2016.12，81万元，已结题，主要参与

国家自然科学基金委，重大研究计划，91127043，疾病相关多肽组装结构及其调控的 分子水平研究，2012.01-2015.12，300万元，已结题，主要参与

2022 Publications

57. Yan Zhao#, Shanshan Mo#, Lanlan Yu#, Xiaolu Li, Yun Hao, Wenbo Zhang, Qi Zhang, Ping Wang, Xiangdong Wang*, Chenxuan Wang*, and Luo Zhang*, Crystalline state determines the potency of galectin-10 protein assembly to induce inflammation, Nano Letters, 2022, 22, 2350-2357, DOI: 10.1021/acs.nanolett.1c04817.

56. Feiyi Zhang#,Lanlan Yu#, Zhun Deng, Shuli Liu, Chenxuan Wang*, Lei Liu*, Composition-dependent wettability of nature-inspired homo poly(amino acid) coating and its influences on bacterial adhesion, European Polymer Journal, 2022, 168, 111127,DOI: 10.1016/j.eurpolymj.2022.111127.

55. Wenbo Zhang#, Mingwei Liu#, Lanlan Yu#, Shanshan Mo, Zhun Deng, Shuli Liu, Yanlian Yang, Chen Wang, Chenxuan Wang*, Perturbation effect of single polar group substitution on the self-association of amphiphilic peptide helices, Journal of Colloid and Interface Science, 2022, 610, 1005-1014, DOI: 10.1016/j.jcis.2021.11.154.

54. Zhichao Lou#, Qiuyi Wang, Xiaodi Zhou, Ufuoma I. Kara, Rajdeep S. Mamtani, Hualiang Lv*, Meng Zhang, Zhihong Yang, Yanjun Li, Chenxuan Wang*, Solomon Adera*, Xiaoguang Wang*, An angle-insensitive electromagnetic absorber enabling a wideband absorption, Journal of Materials Science & Technology, 2022, 113, 33-39, DOI: 10.1016/j.jmst.2021.11.007.

2021 Publications

53. Wenbo Zhang#, Mingwei Liu#, Robert L. Dupont, Kai Huang, Lanlan Yu, Shuli Liu, Xiaoguang Wang*, Chenxuan Wang*, Conservation and identity selection of cationic residues flanking the hydrophobic regions in intermediate filament superfamily, Frontiers in Chemistry, 2021, 9,752630, doi: 10.3389/fchem.2021.752630.

52. Feiyi Zhang#, Lanlan Yu#, Wenbo Zhang#, Lei Liu*, Chenxuan Wang*, A minireview on the perturbation effects of polar groups to direct nanoscale hydrophobic interaction and amphiphilic peptide assembly, RSC Advances, 2021, 11, 28667-28673, doi: 10.1039/d1ra05463e.

51. Chenxuan Wang#*, Lei Liu*, Xiaoguang Wang*,Editorial: the hierarchical organization of supramolecular systems: from fundamentals to biomedical applications, Frontiers in Bioengineering and Biotechnology, 2021, 9, 754980, doi: 10.3389/fbioe.2021.754980.

50. Lanlan Yu#, Zhun Deng#, Wenbo Zhang, Shuli Liu, Feiyi Zhang, Jianjian Zhou, Chunhua Ma, Chenxuan Wang*, Opposite Regulatory Effects of immobilized cations on the folding versus assembly of melittin, Frontiers in Chemistry, 2021, 9,685947, doi: 10.3389/fchem.2021.685947.

49. Yan Zhao#, Xiaolu Li#, Wenbo Zhang#, LanlanYu#, Yang Wang, Zhun Deng, Mingwei Liu, Shanshan Mo, Ruonan Wang, Jinming Zhao, Shuli Liu, Yun Hao, Xiangdong Wang, Tianjiao Ji*, Luo Zhang*, Chenxuan Wang*, Trends in the biological functions and medical applications of extracellular vesicles and analogues, Acta Pharmaceutica Sinica B, 2021, 11(8),2114e2135, doi: 10.1016/j.apsb.2021.03.012.

48. Lanlan Yu#, Yongfang Zheng, Xiaocui Fang, Yimin Zou, Chenxuan Wang*, Yanlian Yang*, Chen Wang*, Composition-dependent multivalency of peptide-peptide interactions revealed by tryptophan-scanning mutagenesis, Journal of Peptide Science,2021, 27, e3310, doi: 10.1002/psc.3310.

47. Shan He#, Xinyue He, Lei Liu, Wenbo Zhang, Lanlan Yu, Zhun Deng, Zhang Feiyi, Shanshan Mo, Yue Fan, Xinyue Zhao, Lun Wang, Chenxuan Wang*, Shuyang Zhang*, The structural understanding of transthyretin misfolding and the inspired drug approaches for the treatment of heart failure associated with transthyretin amyloidosis, Frontiers in Pharmacology, 2021, 12, 628184, doi: 10.3389/fphar.2021.628184.

46. Chenxuan Wang#, Naomi A. Biok, Karthik Nayani, Xiaoguang Wang, Hongseung Yeon, Chi-Kuen Derek Ma, Samuel H. Gellman*, Nicholas L. Abbott*, Cationic side chain identity directs the hydrophobically driven self-assembly of amphiphilic β-peptides in aqueous solution, Langmuir, 2021, 37, 3288-3298,doi: 10.1021/acs.langmuir.0c03255.

2020 Publications

45. Lanlan Yu#, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang*, Yanlian Yang, Chen Wang, Chenxuan Wang*, Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, Science Advances, 2020, 6(32),eabc1449, doi: 10.1126/sciadv.abc1449.

44. Wenbo Zhang#, Shanshan Mo#, Mingwei Liu#, Lei Liu, Lanlan Yu*, Chenxuan Wang*, Rationally designed protein building blocks for programmable hierarchical architectures, Frontiers in Chemistry, 2020, 8, 587975, doi: 10.3389/fchem.2020.587975.

43. Lanlan Yu#, Zhun Deng#, Lei Liu, Wenbo Zhang*and Chenxuan Wang*, Plant-derived nanovesicles: a novel form of nanomedicine, Frontiers in Bioengineering and Biotechnology, 2020, 8,584391, doi: 10.3389/fbioe.2020.584391.

42. Wenbo Zhang#, Lanlan Yu, Tianjiao Ji*, Chenxuan Wang*, Tumor microenvironment-responsive peptide based supramolecular drug delivery system, Frontiers in Chemistry, 2020, 8, 549, doi: 10.3389/fchem.2020.00549.

41. Hongseung Yeon#, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Influence of immobilized cations on the thermodynamic signature of hydrophobic interactions at chemically heterogeneous surfaces, Molecular Systems Design and Engineering, 2020, 5(4),835-846, doi: 10.1039/d0me00016g.

40. Qize Xuan#, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang*, Yibing Wang*, Ping Wang, Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity, Chemical Communications, 2020, 56(11), 1633-1636, doi: 10.1039/c9cc08671d.

2019 Publications

39. Naomi A. Biok#, Alexander D. Passow, Chenxuan Wang, Craig A. Bingman, Nicholas L. Abbott*, Samuel H. Gellman*, Retention of coiled-coil dimer formation in the absence of ion pairing at positions flanking the hydrophobic core, Biochemistry, 2019, 58(48),4821-4826, doi: 10.1021/acs.biochem.9b00668.

38. Chenxuan Wang#, Travis Nelson, Dayue Chen, Joseph Christopher Ellis, Nicholas L. Abbott*, Understanding Lipopolysaccharide Aggregation and its Influence on Activation of Factor C, Journal of Colloid and Interface Science, 2019, 552,540-553, doi: 10.1016/j.jcis.2019.05.013.

37. Xiaoyun Li#, Zhu Liang#, Jianchao Du#, Zhiqing Wang, Song Mei, Zhiqing Li, Yan Zhao, Dandan Zhao, Yiming Ma, Jun Ye, Jiantao Xu, Yu Zhao, Jiahui Chang, Yuhao Qin, Lanlan Yu, Chenxuan Wang*, Chengyu Jiang*, Herbal decoctosome is a novel form of medicine, Science China-Life Sciences, 2019, 62(3),333-348, doi: 10.1007/s11427-018-9508-0.

36. Zhihui Yao#, Brian P. Cary, Craig A. Bingman, Chenxuan Wang, Dale F. Kreitler, Kenneth A. Satyshur, Katrina T. Forest, Samuel H. Gellman*, Use of a stereochemical strategy to probe the mechanism of phenol-soluble modulin alpha3 toxicity, Journal of the American Chemical Society, 2019, 141(19), 7660-7664, doi: 10.1021/jacs.9b00349.

35. Qunxing Huang#, Qiong Zhao, Jiaxi Peng, Ooolalla Yu, Chenxuan Wang, Yimin Zou, Yanlei Su, Ling Zhu*, Chen Wang*, Yanlian Yang*, Peptide-polyphenol(KLVFF/EGCG) binary modulators for inhibiting aggregation and neurotoxicity of amyloid-beta peptide, ACS Omega, 2019, 4(2),4233-4242, doi: 10.1021/acsomega.8b02797.

2018 Publications

34. Reza Abbasi#, Chenxuan Wang, Yiqun Bai, Nicholas L. Abbott*,Phosphorylation status of peptide monolayers modulates hydrogen bonding and orientations of nematic liquid crystals, Liquid Crystal, 2018, 45 (13-15), 2253-2268, doi: 10.1080/02678292.2018.1509389.

2017 Publications

33. Chenxuan Wang#, C. Derek Ma, Hongseung Yeon, Xiaoguang Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Nonadditive interactions mediated by water at chemically heterogeneous surfaces: nonionic polar groups and hydrophobic interactions, Journal of the American Chemical Society, 2017, 139(51), 18536-18544,doi: 10.1021/jacs.7b08367.

32. Hongseung Yeon#, Chenxuan Wang, Reid C. Van Lehn, Nicholas L. Abbott*, Influence of order within nonpolar monolayers on hydrophobic interactions, Langmuir, 2017, 33(19), 4628-4637, doi: 10.1021/acs.langmuir.7b00226.

31. Timothy J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Redox-triggered mixing and demixing of surfactants within assemblies formed in solution and at surfaces, Journal of Colloid and Interface Science, 2017, 502, 122-133, doi: 10.1016/j.jcis.2017.04.052.

30. Aihua Yang#, Chenxuan Wang, Baomin Song, Wendi Zhang, Yuanyuan Guo, Rong Yang, Guangjun Nie, Yanlian Yang*, Chen Wang*, Attenuation of beta-amyloid toxicity in vitro and in vivo by accelerated aggregation, Neuroscience Bulletin, 2017, 33(4), 405-412, doi: 10.1007/s12264-017-0144-z.

2016 Publications

29. C. Derek Ma#, Claribel Acevedo-Vélez, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Interaction of the hydrophobic tip of an atomic force microscope with oligopeptides immobilized using short and long tethers, Langmuir, 2016, 32(12),2985-2995, doi: 10.1021/acs.langmuir.5b04618.

28. Juan Liu#, Tuo Wei, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowei Ma, Xingjie Liang*, Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance, Biomaterials, 2016, 91, 44-56, doi: 10.1016/j.biomaterials.2016.03.013.

2015 Publications

27. C. Derek Ma#, Chenxuan Wang, Claribel Acevedo-Vélez, Samuel H. Gellman*, Nicholas L. Abbott*, Modulation of hydrophobic interactions by proximally immobilized ions, Nature, 2015, 517(7534), 347-U443 doi: 10.1038/nature14018.

26. Yanmei Wang#, Chenxuan Wang#, Zhiqiang Cheng, Dongdong Zhang, Shaopeng Li, Lusheng Song, Wenfei Zhou, Mo Yang, Zhiyou Wang, Zheng Zheng, Baohang Han, Chen Wang*, Yanlian Yang*, Jinsong Zhu*, SPRi determination of inter-peptide interaction by using 3D supramolecular co-assembly polyrotaxane film, Biosensors and Bioelectronics,2015, 66, 38-44, doi: 10.1016/j.bios.2014.11.025.

25. TimothyJ. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Influence of self-assembling redox mediators on charge transfer at hydrophobic electrodes, Langmuir, 2015, 31(39), 10638-10648, doi: 10.1021/acs.langmuir.5b02212.

24. Yang Sun#, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo, Dangsheng Li, Bo Li, Qihan Li, Nanshan Zhong, Chen Wang, Josef M. Penninger, Chengyu Jiang*, Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice, Particle and Fibre Toxicology, 2015, 12, 4, doi: 10.1186/s12989-015-0080-x.

2014 Publications

23. YiqunBai#, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott*, Liquid crystals anchored on mixed monolayers of chiral versus achiral molecules: continuous change in orientation as a function of enantiomeric excess, Angewandte Chemie International Edition, 2014, 53 (31), 8079-8083, doi: 10.1002/anie.201402770.

22. Huiwen Du#, Denghua Li, Yibin Wang, Chenxuan Wang, Ping Li, Yanlian Yang*, Chen Wang*, Peptide-assisted directional adsorption of purple membrane at the liquid-solid interface, Journal of Physical Chemistry C, 2014, 118 (51), 29770-29776, doi: 10.1021/jp5077017.

2013 Publications

21. Min Zhang#, Xiaobo Mao, Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang*,Wei Liang*, Chen Wang*, The effect of graphene oxide onconformation change, aggregation and cytotoxicity of HIV-1 regulatory protein(Vpr), Biomaterials, 2013, 34 (4), 1383-1390, doi: 10.1016/j.biomaterials.2012.10.067.

20. Min Zhang#, Xiaobo Mao, Yue Yu, Chenxuan Wang, Yanlian Yang*, Chen Wang*, Nanomaterials for reducing amyloid cytotoxicity, Advanced Materials, 2013, 25(28),3780-3801, doi: 10.1002/adma.201301210.

19. Huiwen Du#, Denghua Li, Yibing Wang, Chenxuan Wang, Dongdong Zhang, YanlianY ang*, Chen Wang*, Determination of the surface charge density and temperature dependence of purple membrane by electric force microscopy, Journal of Physical Chemistry B, 2013, 117(34), 9895-9899, doi: 10.1021/jp403075w.

18. Ting Zhou#, Axel Llizo, Ping Li, Chenxuan Wang, Yuanyuan Guo, Mingqi Ao, Linling Bai, Chen Wang*, Yanlian Yang*, Guiying Xu*, High transfection efficiency of homogeneous DNA nanoparticles induced by imidazolium gemini surfactant as nonviral vector, Journal of Physical Chemistry C, 2013, 117(50), 26573-26581, doi: 10.1021/jp4061363.

2012 Publications

17. Chenxuan Wang#, Aihua Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang*, Chen Wang*, Observationof molecular inhibition and binding structures of amyloid peptides, Nanoscale, 2012, 4(6), 1895-1909, doi: 10.1039/c2nr11508e.

16. Yuanyuan Guo#, Chenxuan Wang, Jingfei Hou, Aihua Yang, Xuemei Zhang, Yibing Wang, Min Zhang, Yanlian Yang*, Chen Wang*, Odd-even sequence effect of surface-mediated peptide assemblies observed by scanning tunneling microscopy, Chinese Journal of Chemistry, 2012, 30 (9),1987-1991, doi: 10.1002/cjoc.201200656.

15. Jie Song#, Menglin Chen, Viduthalai Regina, Chenxuan Wang, Rikke Meyer, Erqing Xie, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Safe and effective Ag nanoparticles immobilized antimicrobial nanowovens, Advanced Engineering Materials, 2012, 14(5),B240-B246, doi: 10.1002/adem.201180085.

14. Peng Liu#, Shuai Zhang, Meisha Chen, Qian Liu, Chenxuan Wang, Chen Wang, Yanmei Li*, Flemming Besenbacher, Mingdong Dong*, Co-assembly of human islet amyloid polypeptide (hIAPP)/insulin, Chemical Communications, 2012, 48(2),191-193, doi: 10.1039/c1cc14285b.

2011 Publications

13. XiaoboMao#, Chenxuan Wang#, Xingkui Wu, Lei Liu, Lan Zhang, Lin Niu, YanlianYang*, Chen Wang*, Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies, Proceedings of the National Academy of Sciences of the USA, 2011, 108(49),19605-19610, doi: 10.1073/pnas.1102971108.

12. Chenxuan Wang#, Xiaobo Mao#, Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibin Wang, Yanlian Yang*, Chen Wang*, Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy, Chemical Communications, 2011, 47(38), 10638-10640, doi: 10.1039/c1cc12380g.

11. Xiaobo Mao#, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Molecular level studies on binding modes of labeling molecules with polyalanine peptides, Nanoscale, 2011, 3(4), 1592-1599, doi: 10.1039/c0nr00782j.

10. Xiaobo Mao#, Yuanyuan Guo, Chenxuan Wang, Min Zhang, Xiaojing Ma, Lei Liu, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy, ACS Chemical Neuroscience, 2011, 2(6),281-287, doi: 10.1021/cn200006h.

9. Zengguang Cheng#, Qiaoyu Zhou, Chenxuan Wang, Qiang Li, Chen Wang,Ying Fang*, Toward intrinsic graphene surfaces: a systematic study on thermal annealing and wet-chemical treatment of SiO2-supported graphene devices, Nano Letters, 2011, 11(2), 767-771, doi: 10.1021/nl103977d.

8. Jie Song#, Menglin Chen, Mikkel Buster Olesen, Chenxuan Wang, Rasmus Havelund, QiangLi, Erqing Xie, Rong Yang, Peter Boggild, Chen Wang, Flemming Besenbacher, Mingdong Dong*, Direct electrospinning of Ag/polyvinylpyrrolidone nanocables, Nanoscale,2011, 3(12), 4966-4971, doi: 10.1039/c1nr10512d.

7. Weiwei He#, Shuai Hou, Xiaobo Mao, Xiaochun Wu*, Yinglu Jin, Jianbo Liu, Xiaona Hu, Ke Zhang, Chenxuan Wang, Yanlian Yang, Qi Wang, Peptide-tailored assembling of Au nanorods, Chemical Communications, 2011, 47(19), 5482-5484, doi: 10.1039/c1cc10394f.

2010 Publications

6. Xiaobo Mao#, Chenxuan Wang, Lei Liu, Xiaojing Ma, Lin Niu, Yanlian Yang*, Chen Wang*, Study on the fine structure of polypeptides at solid-liquid interfaces by scanning tunneling microscopy, Acta Physico-Chimica Sinica,2010, 26(4), 850-861, doi: 10.3866/PKU.WHXB20100440.

5. Xuemei Zhou#, Hongchao Yang, Chenxuan Wang, Yinfang Cui, Xiaobo Mao, Cong Wang, Yinshu Wang, Gang Liu*, Visible light induced photocatalytic degradation rhodamine B on one-dimensional iron oxide particles, Journal of Physical Chemistry C, 2010, 114(40), 17051-17061, doi: 10.1021/jp103816e.

4. Xiaobo Mao#, Hongchao Yang, Xuemei Zhou, Chenxuan Wang, Yinshu Wang, Yanlian Yang, Chen Wang, Gang Liu*, Straight and Branched Goethite Topology by Oriented Attachment at High pH, Crystal Growth & Design, 2010, 10(2), 504-509, doi: 10.1021/cg900392m.

3.Tao Zhang#, Zengguang Cheng, Yibing Wang, Zhongjun Li, Chenxuan Wang, Yibao Li, Ying Fang*, Self-assembled1-octadecanethiol monolayers on graphene for mercury detection, Nano Letters, 2010, 10(11), 4738-4741, doi: 10.1021/nl1032556.

2. Hongchao Yang#, Xuemei Zhou, Tengteng Tang, Xiaoying Qi, Chenxuan Wang, JinyaoLan, Yinshu Wang, Yanlian Yang, Gang Liu*, Anisotropic growth of multi-twinned goethite particles by oriented aggregation, CrystEngComm, 2010, 12(12), 4007-4009, doi: 10.1039/c0ce00437e.

1. Jie Jiang#,Xiaoliang Tang, Wei Dou, Huihui Zhang, Weisheng Liu*, Chenxuan Wang, Jiangrong Zheng, Synthesis and characterization of the ligand based on benzoxazole and its transition metal complexes: DNA-binding and antitumor activity, Journal of Inorganic Biochemistry, 2010, 104(5), 583-591, doi: 10.1016/j.jinorgbio.2010.01.011.

著作

Books and Chapters

2. Wenbo Zhang#, Lanlan Yu, Chenxuan Wang*. Intermolecular interactions and self-assembly of peptide-based nanomaterials against human pathogenic bacteria. In: Haiyan Xu, Ning Gu. (eds) Nanotechnology in regenerative medicine and drug delivery therapy. 2020, Springer, Singapore

1. 王晨轩#，杨延莲*，王琛*. 《纳米生物医学光电子学前沿》第七章《淀粉样蛋白的结构分析研究进展》科学出版社，2013年，北京

发明专利

Patents

12. 王晨轩，莫珊珊，张罗，赵妍，于兰兰，王向东，李小璐，张文博，郝蕴. 靶向夏科-莱登结晶蛋白的多肽及其应用。国家发明专利. 授权公告日2022-5-3, 专利号 ZL202111008517.1

11. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种亲和肽M5稳定的纳米金颗粒及其制备方法和用途。国家发明专利. 授权公告日2022-4-1, 专利号 ZL202110529881.6

10. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种新型冠状病毒主蛋白酶的亲和肽M1及其应用。国家发明专利. 授权公告日2022-2-8, 专利号 ZL202110231722.8

9. 王晨轩，于兰兰，王琛，杨延莲. 一种研究蛋白质及药物-蛋白质复合体构象多态性的方法。国家发明专利. 授权公告日2021-03-05,专利号 ZL202010070997.3

8. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种低溶血活性的蜂毒肽及其应用。国家发明专利. 授权公告日2020-04-28,专利号 ZL201910854177.0

7. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种蜂毒肽变体及其应用。国家发明专利. 授权公告日2020-05-12,专利号 ZL201910854956.0

6. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp41蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-03-01,专利号 ZL201310298420.8

5. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp120蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-06-27,专利号 ZL201310298450.9

4. 张敏，李平，王晨轩，杨延莲，王琛. 抑制b淀粉样蛋白聚集和毒性的多肽抑制剂及其应用。国家发明专利. 授权公告日2017-12-12,专利号 ZL201310294070.8

3. 王琛，杨爱华，王晨轩，杨延莲. 调节beta淀粉样蛋白生理毒性的多肽。国家发明专利. 授权公告日2017-12-26,专利号 ZL201310421560.X

2. 王琛，张敏，王晨轩，杨延莲. 一种抑制人胰淀素聚集或毒性的多肽、试剂及其应用。国家发明专利. 授权公告日2015-11-25,专利号 ZL201210410206.2

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      课题组开展多学科交叉研究，目前实验室成员的教育背景涵盖了生物学、化学、药学、物理、基础医学、检验医学、生物信息学、化学工程、材料科学、法医。欢迎生物学、生物技术、药学、基础医学、生物工程、生物信息学及相关专业的学生报考。

      要求：（1）本科专业主干课成绩优秀；（2）热爱科学研究与基础研究，对未知领域有强烈好奇心、献身精神；（3）有团队合作精神；（4）中文表达与写作能力优异，良好的普通话书面语沟通、交流与演讲能力；（5）英文读写能力合格，全国大学英语六级考试成绩及格。