1.        国家自然科学基金面上项目，31871310，C/EBPa的精氨酸甲基化修饰在乳腺癌中的作用及机制研究，2019/01-2022/12，60万元、在研、主持。
2.        国家自然科学基金面上项目，31671359，p53蛋白精氨酸脱氨化及其功能调节研究，2017/1-2020/12，62万元、今年年底结题，主持。
3.        国家自然科学基金重大研究计划集成项目，91519301，Klf4的精氨酸甲基化修饰在细胞重编程中的作用,2016/01-2016/12，75万元，已结题，主持。
4.        国家自然科学基金面上项目，31371305，JAK2介导的磷酸化促进组蛋白甲基转移酶EZH2降解的分子机制研究，2014/01-2017/12，80万元、已结题、主持。
5.        国家重点基础研究发展计划，2013CB531301，MDD分子遗传学与表观遗传学机制，2013/01-2017/12，150万元，已结题，参加。
6.        国家自然科学基金面上项目，31171239、组蛋白去甲基酶KDM3A的磷酸化修饰调控基因差异表达的分子机制，2012/01-2015/12，60万元，已结题，主持。
7.        国家重大科学研究计划，2011CB964902，干细胞分化调控网络机制研究，2011/01-2015/12，100万元，已结题，参加。
8.        北京协和医学院协和特聘教授，2011/10-2014/09，100万元，已结题，主持
9.        国家自然科学基金重大研究计划培育项目，90919048，PRMT对肌肉细胞分化中myogenin基因的染色质调控机制，2010/01-2012/12，60万元，已结题，主持。
10.    国家自然科学基金面上项目，30871382，真核基因协调表达的染色质重塑机制研究，2009/01-2011/12，33万元，已结题，主持。
11.    国家自然科学基金面上项目，30471376，趋化因子RANTES激活神经胶质细胞的信号转导网络研究，2005/01-2007/12，22万元，已结题，主持。
12.    国家重点基础研究发展计划，2005CB522405，神经元分化、再生的表观遗传学机制，2005/01-2010/12，98万元，已结题，参加。
13.    教育部新世纪优秀人才支持计划，组蛋白修饰与基因转录调控的研究，2005/01-2007/12，50万元，已结题，主持。
14.    国家重点基础研究发展计划，2004CB518605，分子生物学技术平台的建立、完善及计算机系统生物学研究，2004/09-2009/08，123万元，已结题，参加。

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2.          Q. Liu, X. L. Zhang, M. B. Cheng, Y.Zhang, PRMT1 activates myogenin transcription via MyoD arginine methylation atR121. Biochim Biophys Acta Gene RegulMech, 194442 (2019).

3.          L. M. Liu et al., Methylation of C/EBPalpha by PRMT1 Inhibits ItsTumor-Suppressive Function in Breast Cancer. Cancer research 79,2865-2877 (2019).

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9.          Y. Zhang et al., The impact of R213 mutation on p53-mediated p21 activity. Biochimie 99, 215-218 (2014).

10.        L. X. Wang, J. Wang, T. T. Qu, Y. Zhang,Y. F. Shen, Reversible acetylation of Lin28 mediated by PCAF and SIRT1. Biochimica et biophysica acta 1843, 1188-1195 (2014).

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12.        J. C. Zhao, L. X. Zhang, Y. Zhang, Y. F.Shen, The differential regulation of Gap43 gene in the neuronal differentiationof P19 cells. Journal of cellularphysiology 227, 2645-2653(2012).

13.        N. Zhai et al., Human PIH1 associates with histone H4 to mediate theglucose-dependent enhancement of pre-rRNA synthesis. Journal of molecular cell biology 4, 231-241 (2012).

14.        L. Yan, H. Y. Zhao, Y. Zhang, Y. F.Shen, Differential effects of AdOx on gene expression in P19 embryonalcarcinoma cells. BMC neuroscience 13, 6 (2012).

15.        H. Y. Zhao, Y. J. Zhang, H. Dai, Y. Zhang,Y. F. Shen, CARM1 mediates modulation of Sox2. PloS one 6, e27026(2011).

16.        Y. Mi, Y. Zhang, Y. F. Shen, Mechanismof JmjC-containing protein Hairless in the regulation of vitamin D receptorfunction. Biochimica et biophysica acta1812, 1675-1680 (2011).

17.        Y. Zhang et al., A switch from hBrm to Brg1 at IFNgamma-activated sequencesmediates the activation of human genes. Cellresearch 20, 1345-1360 (2010).

18.        L. Zhang, L. Yan, Y. Zhang, N. H. Wu, Y.F. Shen, Role of acetylated p53 in regulating the expression of map2 inretinoic acid-induced P19 cells. Chinesemedical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 25, 71-75 (2010).

19.        X. Gao et al., CARM1 activates myogenin gene via PCAF in the earlydifferentiation of TPA-induced rhabdomyosarcoma-derived cells. Journal of cellular biochemistry 110, 162-170 (2010).

20.        H. B. Fang, Y. Mi, Y. Zhang, N. H. Wu,Y. F. Shen, HDAC3 augments the autoregulation of neuroD gene in P19 cells. Neuroreport 21, 19-23 (2010).

21.        J. P. Dai, J. Y. Lu, Y. Zhang, Y. F.Shen, Jmjd3 activates Mash1 gene in RA-induced neuronal differentiation of P19cells. Journal of cellular biochemistry110, 1457-1463 (2010).

22.        M. B. Cheng et al., Stat1 mediates an auto-regulation of hsp90beta gene inheat shock response. Cellular signalling22, 1206-1213 (2010).

23.        J. C. Zhao, Y. J. Chen, Y. Zhang, Y. F.Shen, [Regulatory effect of GAGA element-related protein on the DrosophilaGAGA-dependent promoter activity in Jurkat Cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae31, 765-769 (2009).

24.        Y. Zhang et al., TGFBI deficiency predisposes mice to spontaneous tumordevelopment. Cancer research 69, 37-44 (2009).

25.        N. Zhai, Y. Zhang, Y. F. Shen, [Effectof PIH1D1 on the degradation of its binding protein SNF5]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae31, 756-759 (2009).

26.        M. Wu, Y. Zhang, N. H. Wu, Y. F. Shen,Histone marks and chromatin remodelers on the regulation of neurogenin1 gene inRA induced neuronal differentiation of P19 cells. Journal of cellular biochemistry 107, 264-271 (2009).

27.        Z. Guo et al., An inhibitory role of p53 via NF-kappaB element on thecyclin D1 gene under heat shock. Biochimicaet biophysica acta 1789, 758-762(2009).

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29.        J. P. Dai, Y. Zhang, Y. F. Shen,[Histone lysine methyltransferase Setd7 enhances Ngn 1 gene expression]. Zhongguo yi xue ke xue yuan xue bao. ActaAcademiae Medicinae Sinicae 31,692-695 (2009).

30.        Y. Di, S. Li, L. Wang, Y. Zhang, M. E.Dorf, Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaBsignaling. Cellular signalling 20, 705-713 (2008).

31.        J. H. Shen, Y. Zhang, N. H. Wu, Y. F.Shen, Resistance to geldanamycin-induced apoptosis in differentiatedneuroblastoma SH-SY5Y cells. Neuroscienceletters 414, 110-114 (2007).

32.        Z. Y. Li et al., Sequential recruitment of PCAF and BRG1 contributes tomyogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced earlydifferentiation of rhabdomyosarcoma-derived cells. The Journal of biological chemistry 282, 18872-18878 (2007).

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35.        Y. Zhang, J. Yang, N. H. Wu, Y. F. Shen,[Screening, cloning, and analyzing for hSNF5 binding proteins in human fetalbrain]. Zhongguo yi xue ke xue yuan xuebao. Acta Academiae Medicinae Sinicae 26,529-532 (2004).

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37.        Y. Zhang, K. Griffin, N. Mondal, J. D.Parvin, Phosphorylation of histone H2A inhibits transcription on chromatintemplates. The Journal of biologicalchemistry 279, 21866-21872(2004).

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44.        Y. Zhang, Q. Zhai, Y. Luo, M. E. Dorf,RANTES-mediated chemokine transcription in astrocytes involves activation andtranslocation of p90 ribosomal S6 protein kinase (RSK). The Journal of biological chemistry 277, 19042-19048 (2002).

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