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王增蕾,山东人,博士。毕业于中国人民解放军第二军医大学,其后于美国宾夕法尼亚州立大学进行博士后研究,现就职于中国医学科学院病原生物学研究所,副研究员。主要从事疟疾的流行及种群分析、输入性传播、青蒿素类药物的抗性机制、新药筛选及药物作用机制,以及包虫病和滴虫性阴道炎等重要寄生虫病的流行、耐药性分布、耐药机制、新药筛选平台建立及新型检测方法等相关研究。以第一作者或通讯作者在Infectious Diseases of Poverty (IF=10.485)、Antimicrobial Agents and Chemotherapy(IF=5.938)、Food Chemistry(IF=9.231)、Journal ofAntimicrobial Chemotherapy(IF=5.758)、Marine Drugs(IF=6.085)等杂志发表SCI论文十余篇,具有交叉学科研究背景。担任中国动物学会寄生虫学专业委员会常务理事、《中国寄生虫学与寄生虫病杂志》编委。
1. 中国医学科学院创新工程协同创新项目“疟疾和日本血吸虫病防治技术研究”(项目编号:2017-I2M-3-016),首席专家;
2. 国家卫生健康委包虫病防治研究重点实验室开放课题项目“外泌体在包虫病中的诊断价值研究”(项目编号2020WZK2009),项目负责人;
3. 国家十三五重大新药创制专项“青蒿素及其衍生物创新药物研究”之子任务“新型抗疟药物的潜在抗药性及药效体外评价技术平台”(2017ZX09101002-001-001-03),子任务负责人;
4. 国家十三五“艾滋病和病毒性肝炎等重大传染病防治”专项子任务“湄公河流域疟疾的抗药株传播监测及抗药性研究”(2018ZX10101001-004-005),子任务负责人。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1. 中国医学科学院创新工程协同创新项目“疟疾和日本血吸虫病防治技术研究”(项目编号:2017-I2M-3-016),首席专家;
2. 国家卫生健康委包虫病防治研究重点实验室开放课题项目“外泌体在包虫病中的诊断价值研究”(项目编号2020WZK2009),项目负责人;
3. 国家十三五重大新药创制专项“青蒿素及其衍生物创新药物研究”之子任务“新型抗疟药物的潜在抗药性及药效体外评价技术平台”(2017ZX09101002-001-001-03),子任务负责人;
4. 国家十三五“艾滋病和病毒性肝炎等重大传染病防治”专项子任务“湄公河流域疟疾的抗药株传播监测及抗药性研究”(2018ZX10101001-004-005),子任务负责人。
发表论文 (IF 基于论文发表年;分区基于“中科院 SCI 论文分区”)
1) Xin Ji, Zhensheng Wang, Qianqian Chen, Jingzhong Li, Heng Wang, ZengleiWang*, Lan Yang*. In Silico and In Vitro AntimalarialScreening and Validation Targeting Plasmodium falciparum Plasmepsin V.Molecules. 2022, 27(9):2670.
2) Zhensheng Wang, Chunyan Wei,Yunchun Pan, Zhihua Wang, Xin Ji, Qianqian Chen, Lianhui Zhang, Zenglei Wang*,Heng Wang*. Polymorphisms of potential drug resistant molecular markers in Plasmodiumvivax from China-Myanmar border during 2008‒2017. InfectiousDiseases of Poverty. 2022, 11(1):43.
3)Zhen-Sheng Wang, Hong-ChangZhou, Chun-Yan Wei, Zhi-Hua Wang, Xiao Hao, Lian-Hui Zhang, Jing-Zhong Li, Zeng-LeiWang*, Heng Wang*. Global survey of miRNAs and tRNA-derived small RNAs fromhuman parasitic protist Trichomonas vaginalis. Parasites & Vectors. 2021,14: 87.
4) Wang ZS, Wei CY, Hao X, Deng WW, Zhang LH, Wang ZL*,Wang H*. Genome-wide Identification and Characterization of TransferRNA-derived Small RNAs in Plasmodium Falciparum. Parasites & Vectors. 2019,12(1):36.
5) Wang ZL, Cabrera M., Yang J.Y., Yuan L.L., Gupta B., Liang X.Y.,Kemirembe K., Brashear A., Shrestha S., Liu M., Li X.L., Miao J., Parker D.M.,Yang Z.Q., Su X.Z. & Cui L.W.. Genome-wide association studies ofPlasmodium falciparum susceptibility to multiple antimalarial drugs inChina-Myanmar border. Scientific Reports. 2016, 6: 33891. doi:10.1038/srep33891.
6) Wang ZL, Wang YN, Cabrera M, Zhang YM, Gupta B, Wu YR, KemirembeK, Hu Y, Liang XY, Brashear A, Shrestha S, Li XL, Miao J, Sun XZ, Yang ZQ, CuiLW. Artemisinin resistance at the China-Myanmar border and association withmutations in the K13 propeller gene. Antimicrobial Agents and Chemotherapy.2015, 59(11): 6952-9.
7) Wang ZL, Shrestha S, Li XL, Miao J, Yuan LL, Cabrera M, Gube C,Yang ZQ, Cui LW. Prevalence of K13-propeller polymorphisms in Plasmodiumfalciparum from China-Myanmar border in 2007-2012. Malaria Journal. 2015,14(1):168.
8) Wang ZL, Liu M, Liang XY, Siriwat S, Li XL, Chen XG, Parker DM,Miao J, Cui LW. A flow cytometry-based quantitative drug sensitivity assay forall Plasmodium falciparum gametocyte stages. PLoS One. 2014, 9(4): e93825.
9) Gupta B#, Xu SH#, Wang ZL#, SunL, Miao J, Cui LW, Yang ZQ. Plasmodium falciparum multidrug resistance protein1 (pfmrp1) gene and its association with in vitro drug susceptibility ofparasite isolates from north-east Myanmar. Journal of AntimicrobialChemotherapy. 2014, 69(8), 2110-7.
10) Wang ZL, Parker D, Meng H, Wu LO, Li J, Zhao Z, Zhang RP, Fan Q,Wang HY, Cui LW, Yang ZQ. In Vitro Sensitivity of Plasmodium falciparum fromChina-Myanmar Border Area to Major ACT Drugs and Polymorphisms in PotentialTarget Genes. PLoS One. 2012, 7(5), e30927.
11) Wang ZL, Tang H, Wang P, Gong W, Xue M, Zhang HW, Liu TF, Liu BS,Yi YH, Zhang W. Bioactive polyoxygenated steroids from the south china sea softcoral Sarcophyton sp.. Marine Drugs. 2013, 11(3), 775-787.
12) Wang ZL, Zhang HW, Yuan WH, Gong W, Tang H, Liu BS, Krohn K, LiL, Yi YH, Zhang W. Antifungal nortriterpene and triterpene glycosides from thesea cucumber Apostichopus japonicus Selenka. Food Chemistry. 2012, 132(1),295-300.
13) Wang ZL, Gong W, Sun GQ, Tang H, Liu BS, Li L, Yi YH, Zhang W.New Holostan-type Triterpene Glycosides from the Sea Cucumber Apostichopusjaponicus. Natural Product Communications. 2012, 7(11), 1431-1434.
14) Miao J, Wang ZL, Liu M, Parker D, Li XL, Chen XG, Cui LW.Plasmodium falciparum: Generation of pure gametocyte culture by heparintreatment. Experimental Parasitology. 2013, 135(3), 541-545.
15) Miao M, Wang ZL, Yang .Q, Yuan LL, Parker DM, Putaporntip C,Jongwutiwes S, Xangsayarath P, Pongvongsa T, Moji H et al. Genetic Diversityand Lack of Artemisinin Selection Signature on the Plasmodium falciparum ATP6in the Greater Mekong Subregion. PLoS One. 2013, doi 10.1371.
16) Cui L, Wang ZL, Miao J, Miao M, Chandra R, Jiang HY , Su XZ, CuiLW. Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodiumfalciparum. Molecular Microbiology. 2012, 86, 111-128.
17) Cui L, Wang ZL, Jiang HY , Parker D, Wang HY, Su XZ, Cui LW.Lack of Association of the S769N Mutation in Plasmodium falciparum SERCA(PfATP6) with Resistance to Artemisinins. Antimicrobial Agents andChemotherapy. 2012, 56, 2546-2552.
18) Lin HW, Wang ZL, Wu JH, Shi N, Zhang HJ, Chen WS,Morris-Natschke SL, Lin AS. Stellettins L and M, cytotoxic isomalabaricane-typetriterpenes, and sterols from the marine sponge Stelletta tenuis. Journal ofNatural Products. 2007, 70, 1114-1117.
参编专著
《高等药理学(第二版)》,科学出版社,2019年7月。
《现代海洋药物学》,科学出版社,2006 年5 月第一版。
北京协和医学院研究生院招生办公室
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