主持有“中医药现代化研究”重点专项(课题负责人)、国家自然科学基金2项、北京协和医学院青年基金、所青年基金；参与中国医学科学院医学与健康科技创新工程课题、国家自然科学基金面上项目、北京市自然基金面上项目等

1. 化橘红功能因子确定及大健康产品开发，国家重点研发计划课题，主持

2. 以脂溶性药物为亲酯链段的两亲性聚合物前药的制备与给药系统的建立，国家自然科学基金，主持

3. 高载药量羟基喜树碱纳米粒对肿瘤治疗的增效减毒研究，北京协和医学院青年基金，主持

4.  基于树枝状大分子的新型单分子胶束的合成与表征，国家自然科学基金，主持

5. 中药安全风险预警及防控，中国医学科学院医学与健康科技创新工程，参与

[1] Zhengqi Dong, Yiping Shen, Shuang Zhao, XiangtaoWang, Meihua Han, Ning Zhao, Hui Ao, and Yifei Guo*, Influence of hydrophobicchains in nanocarriers on antitumor efficacy of docetaxel nanoparticles, MolecularPharmaceutics, 2020, 17(4), 1205.

[2] Zhengqi Dong, Xiangtao Wang, ShuangZhao, Hanhong Qiu, Meihua Han, Jingguo Li, Ning Zhao, Rui Wang, Yifei Guo*,The influence of nanocarrierarchitectures on antitumor efficacy of docetaxel nanoparticles, RSC Advances, 2020, 10, 11074.

[3] Xuejie Zhang, Xiangtao Wang, Hanhong Qiu, XueqingSun, Meihua Han, Yifei Guo*, Nanoadsorbents preparing fromoligoethylene glycol dendron and citric acid: Enhanced adsorption effect forthe removal of heavy metal ions, Colloids and Surfaces B: Biointerfaces, 2020, 189,110876.

[4] Xuejie Zhang, Xiangtao Wang, Hanhong Qiu, DandanKong, Meihua Han, Yifei Guo*, Poly(methacrylate citric acid) withgood biosafety as nanoadsorbents of heavy metal ions, Colloids and Surfaces B:Biointerfaces, 2020, 187, 110656.

[5] Haowen Li,Biao Liu, Hui Ao, Jingxin Fu, Yian Wang, Yue Feng, Yifei Guo* and XiangtaoWang*, Soybean lecithin stabilizes disulfiram nanosuspensions with ahigh drug-loading content: Remarkably improved antitumor efficacy, Journalof Nanobiotechnology, 2020, 18:4.

[6] Yifei Guo, Ting Wang, Hanhong Qiu, Meihua Han,Zhengqi Dong, Xiangtao Wang, Yanhong Wang, Hydroxycamptothecin nanoparticlesbased on poly/oligo (ethylene glycol): Architecture effects of nanocarriers onantitumor efficacy, European Journal of Pharmaceutics and Biopharmaceutics,2019, 134, 178.

[7] Yifei Guo*, Ting Wang, Shuang Zhao,Meihua Han, Zhengqi Dong, Xiangtao Wang*, and Yanhong Wang.Amphiphilic hybrid dendritic-linear molecules as nanocarriers forshape-dependent antitumor drug delivery, Molecular Pharmaceutics, 2018, 15,2665.

[8] Yifei Guo, Shuang Zhao, Hanhong Qiu, Ting Wang, YannaZhao, Meihua Han, Zhengqi Dong, and Xiangtao Wang*. Shape ofnanoparticles as a design parameter to improve docetaxel antitumor efficacy,Bioconjugate Chemistry, 2018, 29, 1302.

[9] Yifei Guo, Ting Wang, Shuang Zhao, Hanhong Qiu,Meihua Han, Zhengqi Dong*, Xiangtao Wang*. Effect ofalkyl chain on cellular uptake and antitumor activity of hydroxycamptothecinnanoparticles based on amphiphilic linear molecules, European Jourmal ofPharmaceutical Sciences, 2018, 124, 266.

[10] Yifei Guo, Yanna Zhao, Ting Wang, Ran Li, MeihuaHan, Zhengqi Dong, Chunyan Zhu*, and Xiangtao Wang*, Hydroxycamptothecinnanorods prepared by fluorescently labeled oligoethylene glycols (OEG)codendrimer: Antitumor efficacy in vitro and in vivo, Bioconjugate Chemistry,2017, 28(2), 390.

[11] Yifei Guo, Chunying Hao, Xiangkang Wang, YannaZhao, Meihua Han, Mincan Wang, and Xiangtao Wang*, Well-definedpodophyllotoxin polyprodrug brushes: Preparation via RAFT polymerization andevaluation as drug carriers, Polymer Chemistry, 2017, 8, 901.

[12] Yifei Guo, Yanna Zhao, Ting Wang, Shuang Zhao,Hanhong Qiu, Meihua Han, and Xiangtao Wang*, Honokiol nanoparticlesstabilized by oligoethylene glycols codendrimer: In vitro and in vivoinvestigations, Journal of Materials Chemistry B, 2017, 5, 697.

[13] Yanna Zhao, Jing Zhao, Chunying Hao, Meihua Han,Mincan Wang, Yifei Guo* and Xiangtao Wang*,Self-assembled thermosensitive nanoparticles based on oligoethylene glycol Dendronconjugated doxorubicin: Preparation, and efficient delivery of freedoxorubicin, RSC Advances, 2016, 6, 2602.

[14] Yanna Zhao, Yifei Guo*, Ran Li, TingWang, Meihua Han, Chunyan Zhu, Xiangtao Wang*, Methotrexate nanoparticlesprepared with codendrimer from polyamidoamine (PAMAM) and oligoethylene glycols(OEG) dendrons: Antitumor efficacy in vitro and in vivo, Scientific Reports,2016, 6, 28983.

[15] Yanna Zhao, Jing Zhao, Ran Li, Meihua Han,Chunyan Zhu, Mincan Wang, Yifei Guo* and Xiangtao Wang*,A series of codendrimers from polyamidoamine (PAMAM) and oligoethylene glycols(OEG) dendrons as drug carriers: The effect of OEG Dendron decoration degree, RSCAdvances, 2015, 5, 85547.

[16] Yifei Guo, Yanna Zhao, Jing Zhao, Meihua Han,Afang Zhang*, Xiangtao Wang*, Codendrimer frompolyamidoamine (PAMAM) and oligoethylene dendron as a thermosensitive drugcarrier, Bioconjugate Chemistry, 2014, 25, 24.

[17] Yifei Guo, Yanna Zhao, Meihua Han, Chunying Haoand Xiangtao Wang*, Codendrimer (PAG) from polyamidoamine (PAMAM)and oligoethylene glycols (OEG) dendron: Evaluation as drug carrier, Journal ofMaterials Chemistry B, 2013, 1, 6078.

[18] Yifei Guo, Yanna Zhao, Meihua Han, Jing Zhao,Chunying Hao, Xiangkang Wang, Xiangtao Wang*, A codendrimer of PAMAMdecorated with oligoethylene glycol dendrons: Synthesis, self-assembly, andapplication as a drug carrier, Soft Matter, 2013, 9, 10306.

[19] Yifei Guo, Jacco D. van Beek, Baozhong Zhang,Martin Colussi, Peter Walde, Afang Zhang, * Martin Kroger, Avraham Halperin*,and A. Dieter Schluter*. Tuning polymer thickness: Synthesis andscaling theory of homologous series of dendronized polymers, Journal of theAmerican Chemical Society, 2009, 131, 11841.

1. 一种含有柠檬酸甲基丙烯酸酯单体单元的聚合物及其在去除重金属离子中的应用，申请，专利号201811443699.3

2. 一种喜树碱类药物的纳米晶及其制备方法，授权，专利号ZL201610195547.0

3. 一种含有柠檬酸甲基丙烯酸酯单体单元的聚合物及其在去除重金属离子中的应用，授权，专利号ZL201610886783.0

《中药质量控制与分析》，中国协和医科大学出版社，2020年出版，副主编

2017年药用植物研究所青年人员科研产出第一名