肿瘤病因学教研室介绍

       目前由林东昕院士担任主任，谭文教授担任副主任。研究生招生专业为肿瘤学（基础）。本教研室的主要研究方向和目标是探讨肿瘤发生和发展的分子机制，从中甄别出可应用于肿瘤早期诊断、个体化治疗、预后判断、以及预防或干预的分子标志物或分子靶点。开展肿瘤基因异常表达的分子机制研究：运用新一代测序等技术平台，在全基因组水平研究特定肿瘤组织中表达失调基因的遗传和表遗传改变，阐明肿瘤发生发展中基因表达异常的机制，为预防、个体化治疗和发现药物和治疗靶点提供新思路。本研究室建于1971年，2001年成为“癌发生及预防分子机理”北京市重点实验室。截至2020年6月，肿瘤病因学教研室有教学和科研人员8人，其中博士生导师5人：林东昕、吴晨、谭文、张开泰、姜伟。硕士生导师2人：肖汀、冯林。教学秘书1人：余茜颖。其中有中国工程院院士1人，国家青年千人和杰出青年基金获得者1人。

        肿瘤病因学教研室教学团队负责并参加了多项国家及省部级课题，包括：国家973计划项目，国家863项目，国家支撑计划，国家科技重大专项，国家重大科学仪器开发专项，国家新药创制重大专项，国家自然科学基金创新团队、重点项目、重点国际合作项目、重大研究计划、面上项目、青年基金等，北京市自然科学基金，教育部新世纪优秀人才支持计划，教育部高校博士点学科基金，北京市教育共建实验室，北京市科技计划重大项目等 。2012年至2019年期间，累计发表学术论文152篇，其中SCI收录学术论文121篇，包括Nature Genetics，Nature Medicine，Nature Communications，Gut，Gastroenterology，Cancer Research等顶级学术期刊，总影响因子约为1023分。

       肿瘤学（基础）专业研究生培养取得突出成绩，林东昕院士课题组培养的于春媛、张雪梅、孙瞳和吴晨的博士学位论文被评为全国优秀博士学位论文，杨明、赵丹、翟侃的博士学位论文入选北京市优秀博士学位论文，常江、郑健、黄旭东、程欣欣和赵艳洁的博士学位论文入选北京协和医学院优秀博士学位论文。

林东昕2016年以来第一负责人承担在研科研项目

       研究成果获2002年中华医学科技奖三等奖、2003年北京市科学技术奖二等奖、2005年中华医学科技奖二等奖和北京市科学技术奖一等奖、2006年和2013年国家自然科学奖二等奖、2008年国家科学技术进步奖二等奖、2013年国家科学技术进步奖一等奖。2011年教育部自然科学奖一等奖和北京市科学技术奖二等奖。2019年国家科学技术进步奖二等奖。

林东昕2016年以来发表通讯作者12篇文章目录

1. Jiahui Chu#, Xiangjie Niu#, JiangChang, Mingming Shao, Linna Peng, Yiyi Xi, Ai Lin, Chengcheng Wang, QionghuaCui, Yingying Luo, Wenyi Fan, Yamei Chen, Yanxia Sun, Wenjia Guo, Wen Tan, Dongxin Lin*, Chen Wu*. Metabolic remodeling by TIGAR overexpression is atherapeutic target in esophageal squamous-cell carcinoma. Theranostics. 2020;10(8): 3488-3502. doi: 10.7150/thno.41427 IF: 8.579

2. Guo-WangLin#, Caigang Xu#, Kexin Chen#, Hui-QiangHuang#, Jieping Chen#, Bao Song#, JohnK.C. Chan#, Wenyu Li#, Weiping Liu, Lee-Yung Shih,Wen-Yu Chuang, Won Seog Kim, Wen Tan, Rou-Jun Peng, Yurike Laurensia,Daryl Ming Zhe Cheah, DaChuan Huang, Chee Leong Cheng, Yi-JiunSu, Soo-Yong Tan, Siok-Bian Ng, Tiffany Pooi Ling Tang, Kyudong Han, VivienYa-Fan WANG, Wei-Hua Jia, Zhong Pei, Ya-Jun Li, Song Gao, Yongyong Shi,Zhibin Hu, Furen Zhang, Ben Zhang, Yi-Xin Zeng, Hongbing Shen, Lin He,Choon Kiat Ong, Soon Thye Lim, Stephen Chanock, Yok-Lam Kwong*, Dongxin Lin*, Nathaniel Rothman*, Chiea Chuen Khor*, Qing Lan*, Jin-XinBei*, Wing-Yan Au, Brian Chiu, Lei Fan, Zheng Li,Tai Hing LAM, Raymond Liang, Su-Peng Yeh, Jun Xu, Dennis Kai Ming Ip,Gandi Li, Gang Xu, Xiaodong Wang, Ou Bai, Qing-Qing Cai, Yi Xia, Jie-RongChen, Chun-Ling Luo, Xiang-Yu Xiong, Yanni Zeng, Pan-Pan Wei, Chu-JunLiu, Yu-Xiang Liu, Yu-Lu Cao, Shuai He, Yang Liu, Jeslin Chian Hung Ha,Lay Poh Khoo, Rebecca Xiangpin Kee, Jing Tan, Yanhui Liu, FenZhang, Yanfen Feng, Huilan Rao, Wee Joo Chng, Jason Yong Sheng Chan,Nagavalli D/O Somasundaram, Miriam Tao, Mohamad Farid Bin Harunal Ras,Kheng-Wei Yeoh, Yeow Tee Goh, Shin Yeu Ong, NicholasFrancis Grigoropoulos, Esther Kam Yin Wong, Jane Wan Lu Pang, Jing QuanLim, Burton Kuan Hui Chia, Seok Jin Kim, Sang Eun Yoon, Seungkyu Choi,Ching-Yuan Kuo, Tsai-Yun Chen, Yu-Chieh Su, Wen-Tsung Huang,Ming-Yang Lee, Wenxiu Yao, Kai-Cheong Ngan, Herman Liu, Harold Lee,Sze-Fai Yip, Jie Liu, Jianyong Li, Charles S. Rabkin, Sonja Berndt,Bryan Bassig, Wei Hu, Mingfeng Zhao, Yuming Li, Qiongli Zhai, ZonghongShao, Lugui Qiu, Jianxiang Wang, Fu-Ping Xu, Ling Chen, Yu Hou, ShuangnianXu, Zhen Huang, Mingling Xie, Ming Li, Shilong Zhong, Yan Zhang,Dongqing Gu, Xin Wang, Jia Nee Foo, Zhiqiang Li, Juncheng Dai,Liangdan Sun, Zhenzhen Wang, Hong Liu, Hui Zhou, Yonghu Sun, Woon-PuayKoh, Chew-Kiat Heng, Chew Soo Hong, Jeeyun Ahn, Kyu Hyung Park, Aung Tin,Jieruo Gu, Xiaojun Xia, Bo Li, Xueqing Yu. Genetic risk of extranodal natural killer T-celllymphoma: a genome-wide association study in multiple populations. Lancet Oncol. 2020; 21(2): 306-316.Doi:10.1016/S1470-2045(19)30799-5IF: 33.752

3. Yang J#, Lin Y#, Huang Y, Jin J, Zou S,Zhang X, Li H, Feng T, Chen J, Zuo Z, Zheng J, Li Y, Gao G, Wu C, Tan W*, Lin D*. Genome landscapes of rectal cancer before and afterpreoperative chemoradiotherapy. Theranostics. 2019; 9(23): 6856-6866.doi:10.7150/thno.37794. IF: 8.579

4. Jialiang Zhang#, Ruihong Bai#, MeiLi#, Huilin Ye, Chen Wu, Chengfeng Wang, Shengping Li, Liping Tan,Dongmei Mai, Guolin Li, Ling Pan, Yanfen Zheng, Jiachun Su, Ying Ye, ZhiqiangFu, Shangyou Zheng, Zhixiang Zuo, Zexian Liu, Qi Zhao, Xu Che, Dan Xie, WeihuaJia, Mu-Sheng Zeng, Wen Tan, Rufu Chen*,Rui-Hua Xu*, Jian Zheng*, Dongxin Lin*.Excessive miR-25-3p maturation via N6-methyladenosinestimulated by cigarette smoke promotespancreatic cancer progression. Nature Communications. 2019; 10(1858):1-15. doi: 10.1038/s41467-019-09712-x IF: 12.121

5. Chang J#, Tian J#, Zhu Y#,Zhong R#, Zhai K, Li J, Ke J, Han Q, Lou J, Chen W, Zhu B, Shen N,Zhang Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Yang M, WangL, Wu C*, Lin D*, Miao X*. Exome-wideanalysis identifies three low-frequency missensevariants associated with pancreatic cancer risk in Chinese populations. Nat Commun. 2018; 9(3688):1-8. doi: 10.1038/s41467-018-06136-x IF: 12.124

6. Cui Q, Wu C, Lin D*.Genomic alterations and precise medicine of esophageal squamous cell carcinoma.Journalof Bio-X Research. 2018; 1: 7-11.

7. HuangX#, Zheng J#, Li J#, Che X#, Tan W,Tan W, Shao M, Cheng X, Du Z, Zhao Y, WangC*, Wu C*, Lin D*. Functional role of BTB and CNC Homology 1 gene inpancreatic cancer and its association with survival in patients treated withgemcitabine. Theranostics. 2018; 8(12):3366-3379. doi: 10.7150/thno.23978. IF: 8.712

8. Li J, Tan W, PengL, Zhang J, Huang X, Cui Q, Zheng J, Tan W, Wu C, Lin D*. Integrative analysis of geneexpression profiles reveals specific signaling pathways associated withpancreatic duct adenocarcinoma. Cancer Commun (Lond). 2018; 38(1):13. doi: org/10.1186/s40880-018-0289-9IF: 4.111

9. Wei L,Shao M, Zhao Y, Zheng J, Chu J, Chang J, Cheng X, Cui Q, Peng L, Luo Y, Tan W,Tan W, Lin D*, Wu C*. Functional role of PLCE1 intronic insertion variantassociated with susceptibility to esophageal squamous-cell carcinoma. Carcinogenesis.2018; 39(2):191-201. doi: 10.1093/carcin/bgx123. IF:5.073

10. Zhao Y#, Wei L#, Shao M,Huang X, Chang J, Zheng J, Chu J, Cui Q, Peng L, Luo Y, Tan W, Tan W, Lin D*, Wu C*. BRCA1-associated protein increases invasiveness of esophagealsquamous cell carcinoma. Gastroenterology. 2017; 153(5):1304-1319.e5. IF: 20.773

11. Cheng X, Wei L, Huang X, Zheng J, Shao M,Feng T, Li J, Han Y, Tan W, Tan W*, Lin D*, Wu C*. Solute carrier family 39 member 6 gene promotesaggressiveness of esophageal carcinoma cells by increasing intracellular levelsof Zinc, activating phosphatidylinositol 3-Kinase signaling, and up-regulating genesthat regulate metastasis. Gastroenterology. 2017; 152(8):1985-1997.e12.IF: 20.773

12. Zheng J#, Huang X#,Tan W, Yu D, Du Z, Chang J, Wei L, Han Y, Wang C, Che X, Zhou Y, Miao X, JiangG, Yu X, Yang X, Cao G, Zuo C, Li Z, Wang C, Cheung ST, Jia Y, Zheng X, Shen H,Wu C*, Lin D*. Pancreatic cancer risk variant in LINC00673 creates amiR-1231 binding site and interferes with PTPN11 degradation. Nat Genet. 2016; 48(7):747-757. IF: 27.959