我们这里有优秀的指导教师、良好的工作科研环境和成熟的科研平台。

1.  国家自然科学基金面上项，C1QL3敲除与定点转基因大鼠模型建立及该基因对胶质细胞吞噬调节机制的研究， 31970508，2020.01-2023.12，在研

2.  中国医学与健康科技创新工程项目，神经科学与重大神经退行性疾病防治研究， 2016-I2M-1-004, 2016.01-2020.12，在研

3.  艾滋病和病毒性肝炎等重大传染病防治专项，重大及突发传染病动物模型研制及关键技术研究， 2017ZX10304402, 2017.01-2020.12，在研

4.  三种不同病因肌萎缩侧索硬化症基因修饰大鼠模型建立与对比分析，国家自然科学基金疾病实验动物模型专项，81571222,2016.01-2019.12，已结题；

1.  国家自然科学基金面上项，C1QL3敲除与定点转基因大鼠模型建立及该基因对胶质细胞吞噬调节机制的研究，31970508，2020.01-2023.12，在研

2.  中国医学与健康科技创新工程项目，神经科学与重大神经退行性疾病防治研究，2016-I2M-1-004, 2016.01-2020.12，在研

3.  艾滋病和病毒性肝炎等重大传染病防治专项，重大及突发传染病动物模型研制及关键技术研究， 2017ZX10304402, 2017.01-2020.12，在研

4.  三种不同病因肌萎缩侧索硬化症基因修饰大鼠模型建立与对比分析，国家自然科学基金疾病实验动物模型专项，81571222,2016.01-2019.12，已结题

1．    Lu D, Wang J, Li J, Guan F, Zhang X, DongW, Liu N, Gao S, Zhang L.Meox1accelerates myocardial hypertrophic decompensation through Gata4. Cardiovasc Res. 2017 Nov 16. doi: 10.1093/cvr/cvx222. [Epubahead of print]

2．    Liang Z, Zhang L, Su H, Luan R, Na N, SunL, Zhao Y, Zhang X, Zhang Q, Li J, Zhang L, Zhao Y.MTOR signaling is essentialfor the development of thymic epithelial cells and the induction of centralimmune tolerance. Autophagy. 2017 Nov 3:0. 10. 1080/15548627.2017.1376161

3．    Zhang L, Sun C, Jin Y, Gao K, Shi X, QiuW, Ma C, Zhang L. Dickkopf3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and CerebralGlucose Metabolism in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2017;60(2):733-746. doi: 10.3233/JAD-161254

4．    Ma Y, Zhang L, Huang X. Building Cre Knockin RatLines Using CRISPR/Cas9. Methods Mol Biol.2017;1642:37-52. doi: 10.1007/978-1-4939-7169-5_3.

5．    Ma Y, Yu L, Pan S, Gao S, Chen W, Zhang X,Dong W, Li J, Zhou R, Huang L, Han Y, Bai L, Zhang L. CRISPR/Cas9-mediated targetingof the Rosa26 locus produces Cre reporter rat strains for monitoringCre-loxP-mediated lineage tracing. FEBS J. 2017Oct;284(19):3262-3277.

6．    Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H,Hu Y, Wu J, Cao X. Nuclearcarbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12expression in innate response. Proc Natl Acad Sci U S A.2017 Aug 8;114(32):8620-8625.

7．    Wang P, Su H, Zhang L, Chen H, Hu X, YangF, Lv J, Zhang L, Zhao Y. Phosphatasewild-type p53-induced phosphatase 1 controls the development of TH9cells and allergic airway inflammation. J Allergy ClinImmunol. 2017 Jul 19. pii: S0091-6749(17)31106-5.

8．    Li Y, Zhu L, Chu Z, Yang T, Sun HX, YangF, Wang W, Hou Y, Wang P, Zhao Q, Tao Y, Zhang L, Zhang X, Zhao Y. Characterization andbiological significance of IL-23-induced neutrophil polarization. Cell Mol Immunol. 2017 Jul 10.

9．    Wang Y, Shi J, Yan J, Xiao Z, Hou X, Lu P,Hou S, Mao T, Liu W, Ma Y, Zhang L, Yang X, Qi H. Germinal-center developmentof memory B cells driven by IL-9 from follicular helper T cells. Nat Immunol. 2017 Aug;18(8):921-930.

10．             Liu W, Li J, Zheng W, Shang Y, Zhao Z,Wang S, Bi Y, Zhang S, Xu C, Duan Z, Zhang L, Wang YL, Jiang Z, Liu W, Sun L. Cyclophilin A-regulatedubiquitination is critical for RIG-I-mediated antiviral immune responses. Elife. 2017 Jun 8;6. pii: e24425.

11．             Xu J, Feng L, Han Z, Li Y, Wu A, Shao T,Ding N, Li L, Deng W, Di X, Wang J, Zhang L, Li X, Zhang K, Cheng S.Extensive ceRNA-ceRNAinteraction networks mediated by miRNAs regulate development in multiple rhesustissues.Nucleic Acids Res. 2016 Nov2;44(19):9438-9451.

12．             Zhang W, Bao L, Yang S, Qian Z, Dong M,Yin L, Zhao Q, Ge K, Deng Z, Zhang J, Qi F, An Z, Yu Y, Wang Q, Wu R, Fan F,Zhang L, Chen X, Na Y, Feng L, Liu L, Zhu Y, Qin T, Zhang S, Zhang Y, Zhang X,Wang J, Yi X, Zou L, Xin HW, Ditzel HJ, Gao H, Zhang K, Liu B, Cheng S. Tumor-selective replication herpessimplex virus-based technology significantly improves clinical detection andprognostication of viable circulating tumor cells. Oncotarget. 2016Jun 28;7(26):39768-39783.

13．             Yang T, Zhu L, Zhai Y, Zhao Q, Peng J,Zhang H, Yang Z, Zhang L, Ding W, Zhao Y. TSC1 controls IL-1β expression inmacrophages via mTORC1-dependent C/EBPβ pathway. Cell Mol Immunol.2016 Sep;13(5):640-50.

14．             Chen S, Yang M, Du J, Li D, Li Z, Cai C,Ma Y, Zhang L, Tian Z, Dong Z. The Self-Specific Activation ReceptorSLAM Family Is Critical for NK Cell Education. Immunity. 2016 Aug16;45(2):292-304.

15．             Wang W, Jiang M, Liu S, Zhang S, Liu W, MaY, Zhang L, Zhang J, Cao X. RNF122 suppresses antiviral type Iinterferon production by targeting RIG-I CARDs to mediate RIG-I degradation.Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9581-6

16．             Xu J, Feng L, Han Z, Li Y, Wu A, Shao T,Ding N, Li L, Deng W, Di X, Wang J, Zhang L, Li X, Zhang K, Cheng S.Extensive ceRNA-ceRNA interactionnetworks mediated by miRNAs regulate development in multiple rhesus tissues.Nucleic Acids Res. 2016 Jun 30. pii: gkw587. [Epub ahead of print]

17．             Ma Y, Chen W, Zhang X, Yu L, Dong W, PanS, Gao S, Huang X, Zhang L. Increasing the efficiency ofCRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ andusing Cas9 protein. RNA Biol. 2016 Jul 2;13(7):605-12.

18．             Zhang L, Li X, Dong W, Sun C, Guo D, ZhangL. Mmu-miR-1894-3pInhibits Cell Proliferation and Migration of Breast Cancer Cells by TargetingTrim46. Int J Mol Sci. 2016 Apr 22;17(4).

19．             Lu D, Bao D, Dong W, Liu N, Zhang X, GaoS, Ge W, Gao X, Zhang L.Dkk3 preventsfamilial dilated cardiomyopathy development through Wnt pathway. LabInvest. 2016 Feb;96(2):239-48.

20．             Bao D, Ma Y, Zhang X, Guan F, Chen W, GaoK, Qin C, Zhang L.PreliminaryCharacterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9System.Sci Rep. 2015 Nov 5;5:15942.

21．             Liu Y, Snedecor ER, Choi YJ, Yang N, ZhangX, Xu Y, Han Y, Jones EC, Shroyer KR, Clark RA, Zhang L, Qin C, Chen J.Gorab Is Required for DermalCondensate Cells to Respond to Hedgehog Signals during Hair FollicleMorphogenesis. J Invest Dermatol. 2016 Feb;136(2):378-86.

22．             Hu X, Wang P, Du J, Yang F, Tian Y, ShenX, Yang T, Zhang L, Zhao Y.PhosphataseWip1 Masters IL-17-producing Neutrophil-mediated Colitis in Mice.Inflamm Bowel Dis. 2016 Mar 4. [Epub ahead of print]

23．             Yang F, Li Y, Wu T, Na N, Zhao Y, Li W,Han C, Zhang L, Lu J, Zhao Y.TNFα-induced M-MDSCs promotetransplant immune tolerance via nitric oxide.J Mol Med (Berl). 2016Mar 2. [Epub ahead of print]

24．             Yang N, Ren Z, Zheng J, Feng L, Li D, GaoK, Zhang L, Liu Y, Zuo P. 5-(4-hydroxy-3-dimethoxybenzylidene)-rhodanine(RD-1)-improved mitochondrial function prevents anxiety- and depressive-likestates induced by chronic corticosterone injections in mice.Neuropharmacology. 2016 Feb 27;105:587-593. doi: 1

25．             Yu X, Feng L, Han Z, Wu B, Wang S, Xiao Y,Li F, Zhang L, Cao B, Di X, Lu D, Li X, Jiang W, Zhang K, Cheng S.Crosstalk of dynamic functionalmodules in lung development of rhesus macaques.Mol Biosyst. 2016 Feb29. [Epub ahead of print]

26．             Yu X, Feng L, Liu D, Zhang L, Wu B, JiangW, Han Z, Cheng S.Quantitativeproteomics reveals the novel co-expression signatures in early braindevelopment for prognosis of glioblastoma multiforme.Oncotarget.2016 Feb 15. doi: 10.18632/oncotarget.7416.

27．             Wei H, Wang S, Chen Q, Chen Y, Chi X,Zhang L, Huang S, Gao GF, Chen JL.Correction: Suppression of InterferonLambda Signaling by SOCS-1 Results in Their Excessive Production duringInfluenza Virus Infection.PLoS Pathog. 2016 Jan 14;12(1):

28．             Liu Y, Snedecor ER, Zhang X, Xu Y, HuangL, Jones EC, Zhang L, Clark RA, Roop DR, Qin C, Chen J.Correction of Hair Shaft Defectsthrough Allele-Specific Silencing of Mutant Krt75. J InvestDermatol. 2016 Jan;136(1):45-51.

29．             Li F, Xiao Y, Huang F, Deng W, Zhao H, ShiX, Wang S, Yu X, Zhang L, Han Z, Luo L, Zhu Q, Jiang W, Cheng S, Li X, Zhang K.Spatiotemporal-specific lncRNAs inthe brain, colon, liver and lung of macaque during development. MolBiosyst. 2015 Dec;11(12):3253-63.

30．             Yang Y, Guan F, Bai L, Zhang L, Liu J, PanX, Zhang L. Quinolizidinealkaloids reduced mortality in EV71-infected mice by compensating for thelevels of T cells. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3526-8.

31．             Yi W, Hu X, Chen Z, Liu L, Tian Y, Chen H,Cong YS, Yang F, Zhang L, Rudolph KL, Zhang Z, Zhao Y, Ju Z. Phosphatase Wip1 controlsantigen-independent B-cell development in a p53-dependent manner.Blood. 2015 Jul 30;126(5):620-8.

32．             Ma N, Cheng H, Lu M, Liu Q, Chen X, Yin G,Zhu H, Zhang L, Meng X, Tang Y, Zhao S.Magnetic resonance imaging withsuperparamagnetic iron oxide fails to track the long-term fate of mesenchymalstem cells transplanted into heart.Sci Rep. 2015 Mar 12;5:9058.

33．             Zhang L, Liu L, He Z, Li G, Liu J, Song Z,Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z. Inhibition of Wild-type p53-inducedphosphatase 1 promotes liver regeneration in mice by direct activation of mTOR.Hepatology. 2015 Feb 23.

34．             XiYang YB, Wang YC, Zhao Y, Ru J, Lu BT,Zhang YN, Wang NC, Hu WY, Liu J, Yang JW, Wang ZJ, Hao CG, Feng ZT, Xiao ZC,Dong W, Quan XZ, Zhang LF, Wang TH

35．             Sodium Channel Voltage-Gated Beta 2Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity andExpression of COX5A and FGF-2. Mol Neurobiol. 2015 Jan 10

36．              

37．             Lian H, Wang X, Wang J, Liu N, Zhang L, LuY, Yang Y, Zhang L. Heart-specificoverexpression of (pro)renin receptor induces atrial fibrillation in mice.Int J Cardiol. 2015 Jan 29;184C:28-35.

38．             Ouyang J1, Zhu X2, Chen Y1, Wei H1, Chen Q3, Chi X4, Qi B4, Zhang L5, Zhao Y6, Gao GF1, Wang G7, Chen JL.NRAV, a long noncoding RNA, modulates antiviral responses through suppressionof interferon-stimulated gene transcription. Cell HostMicrobe. 2014 Nov 12;16(5):616-26.

39．             Zhu L, Yang T, Li L, Sun L, Hou Y, Hu X,Zhang L, Tian H, Zhao Q, Peng J, Zhang H, Wang R, Yang Z, Zhang L, Zhao Y. TSC1 controls macrophage polarizationto prevent inflammatory disease. Nat Commun. 2014 Sep 1;5:4696.

40．             Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W,Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. SAP-regulated T Cell-APC adhesion andligation-dependent and -independent Ly108-CD3ζ interactions. JImmunol. 2014 Oct 15;193(8):3860-71.

41．             Lu D, Zhang L, Bao D, Lu Y, Zhang X, LiuN, Ge W, Gao X, Li H, Zhang L.Calponin1 inhibits dilatedcardiomyopathy development in mice through the εPKC pathway. Int JCardiol. 2014 Feb 25. pii: S0167-5273(14)00385-4.

42．             Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J,Yang T, Shi X, Guo H, Tan X, Zhang L, Wang Q, Li Z, Zhao Y. The Inhibitory Effect of IFN-γ onProtease HTRA1 Expression in Rheumatoid Arthritis. J Immunol. 2014Jun 6. pii: 1302700. [Epub ahead of print

43．              BaiL, Shi G, Zhang L, Guan F, Ma Y, Li Q, Cong YS, Zhang L Cav-1 deletion impaired hematopoieticstem cell function. Cell Death Dis. 2014 Mar 27;5:e1140. doi:10.1038/cddis.2014.105

44．             Ma Y, Shen B, Zhang X, Lu Y, Chen W, Ma J,Huang X, Zhang L. Heritable Multiplex Genetic Engineering in Rats UsingCRISPR/Cas9。PLoSOne. 2014 Mar 5;9(3):e89413. doi: 10.1371/journal.pone.0089413.

45．             Metabolizable Bi2Se3 Nanoplates:Biodistribution, Toxicity, and Uses for Cancer Radiation Therapy and Imaging， advancedFunctional materials 2013, DOI: 10.1002/adfm.201302312

46．             Guo G1,Kang Q1,Zhu X2,Chen Q3,Wang X1,Chen Y1,Ouyang J1,Zhang L4,Tan H5,Chen R6,Huang S7,Chen JLA long noncoding RNA critically regulates Bcr-Abl-mediated cellulartransformation by acting as a competitive endogenous RNA. Oncogene. 2014 May 19. doi: 10.1038/onc.2014.131.

47．             Deng J, Liu X, Rong L, Ni C, Li X, Yang W,Lu Y, Yan X, Qin C, Zhang L, Qin Z. IFNγ-Responsiveness of EndothelialCells Leads to Efficient Angiostasis in Tumors involving down-regulation ofDll4. J Pathol. 2014 Feb 24. doi: 10.1002/path.4340.

48．             Chen K, Fu C, Chen C, Liu L, Ren H, Han Y,Yang J, He D, Zhou L, Yang Z, Zhang L, Jose PA, Zeng C. Role of GRK4 in the regulation ofarterial AT1 receptor in hypertension. Hypertension. 2014Feb;63(2):289-96.

49．             Wang S, Yu Y, Geng S, Wang D, Zhang L, XieX, Wu B, Li C, Xu H, Li X, Hu Y, Zhang L, Kaether C, Wang B. A coimmunization vaccine of Aβ42ameliorates cognitive deficits without brain inflammation in an Alzheimer'sdisease model. Alzheimers Res Ther. 2014 May 12;6(3):26.

50．             Yan-Bin XiYang, Bing-Tuan Lu, Ya-Zhao,Yuan-Zhang, Qin-Jie Xia, Yu Zou, Wei Zhang, Xiong-Zhi Quan, Lian-Feng Zhang andTing-Hua Wang Expressional difference, distributions of TGF-b1 in TGF-b1 knockdown transgenic mouse, possible roles in injured spinal cord. Exp Biol Med(Maywood) 2014 239: 320 originally published online 17 February 2， 2014-7-17

51．             Yang Y, Ma J, Xiu J, Bai L, Guan F, ZhangL, Liu J, Zhang L. Deferoxaminecompensates for decreases in B cell counts and reduces mortality in enterovirus71-infected mice. Mar Drugs. 2014 Jul 7;12(7):4086-95.

52．              XuL, Bao L, Deng W, Dong L, Zhu H, Chen T, Lv Q, Li F, Yuan J, Xiang Z, Gao K, XuY, Huang L, Li Y, Liu J, Yao Y, Yu P, Li X, Huang W, Zhao X, Lan Y, Guo J, YongW, Wei Q, Chen H, Zhang L, Qin C. Novel Avian-Origin Human InfluenzaA(H7N9) Can Be Transmitted Between Ferrets via Respiratory Droplets.J Infect Dis. 2014

53．             Ma Y, Zhang X, Shen B, Lu Y, Chen W, Ma J,Bai L, Huang X, Zhang L. Generatingrats with conditional alleles using CRISPR/Cas9. Cell Res. 2014Jan;24(1):122-5.

54．             Wei H, Wang S, Chen Q, Chen Y, Chi X,Zhang L, Huang S, Gao GF, Chen JL. Suppression of interferon lambdasignaling by SOCS-1 results in their excessive production during influenzavirus infection. PLoS Pathog. 2014 Jan;10(1):

55．             Sun B, Hu X, Liu G, Ma B, Xu Y, Yang T,Shi J, Yang F, Li H, Zhang L, Zhao Y. Phosphatase wip1 negatively regulatesneutrophil migration and inflammation. J Immunol. 2014 Feb1;192(3):1184-95.

56．             Xu L, Bao L, Deng W, Zhu H, Chen T, Lv Q,Li F, Yuan J, Xiang Z, Gao K, Xu Y, Huang L, Li Y, Liu J, Yao Y, Yu P, Yong W,Wei Q, Zhang L, Qin C.The mouse andferret models for studying the novel avian-origin human influenza A (H7N9)virus. Virol J. 2013 Aug 8;10:253. doi: 10.1186/1743-422X-10-253.

57．             Zhang X, Chen X, Hou S, Peng L, Xu C, LiuW, Zhang L, Qi H. FollicularT-helper cell recruitment governed by bystander B cells and ICOS-drivenmotility. Nature. 2013 Apr 25; 496(7446):523-7.

58．             Sun L, Li H, Luo H, Zhang L, Hu X, Yang T,Sun C, Chen H, Zhang L, Zhao Y. Phosphatase Wip1 Is Essential for theMaturation and Homeostasis of Medullary Thymic Epithelial Cells in Mice.J Immunol. 2013 Aug 21.

59．             Xu L, Bao L, Deng W, Zhu H, Chen T, Lv Q,Li F, Yuan J, Xiang Z, Gao K, Xu Y, Huang L, Li Y, Liu J, Yao Y, Yu P, Yong W,Wei Q, Zhang L, Qin C. The mouse andferret models for studying the novel avian-origin human influenza A (H7N9)virus. Virol J. 2013 Aug 8;10:253. /1743-422X-10-253.

60．             Lu D, Dong W, Zhang X, Quan X, Bao D, LuY, Zhang L. WIF1 causesdysfunction of heart in transgenic mice. Transgenic Res. 2013 Aug 7.

61．             Bai L, Shi G, Zhang X, Dong W, Zhang L. Transgenic expression of BRCA1disturbs hematopoietic stem and progenitor cells quiescence and function.Exp Cell Res. 2013 Jul 10.  (13)00275-9.

62．              XiuJH, Zhu H, Xu YF, Liu JN, Xia XZ, Zhang LF. Necrotizing myositis causesrestrictive hypoventilation in a mouse model for human enterovirus 71infection. Virol J. 2013 Jun 28;10(1):215.

63．             Yang J, Wang J, Chen K, Guo G, Xi R,Rothman PB, Whitten D, Zhang L, Huang S, Chen JL. eIF4B phosphorylation by Pim kinasesplays a critical role in cellular transformation by Abl oncogenes.Cancer Res. 2013 Jun 7.

64．             Wang X,Wang J,Su M,Wang C,Chen J,Wang H,Song L,Zou Y,Zhang L,Zhang Y,Hui R.TNNI3K, a cardiac-specific kinase, promotes physiological cardiac hypertrophyin transgenic mice. PLoS One. 2013;8(3):e58570. doi:10.1371/journal.pone.0058570.

65．             Gao K, Li X, Zhang L, Bai L, Dong W, GaoK, Shi G, Xia X, Wu L, Zhang L. Transgenic expression of IL-33activates CD8+ T cells and NK cells and inhibits tumor growth and metastasis inmice. Cancer Lett. 2013 Mar 14. S0304-3835(13)00225-5.

66．             Yajun Yang, , Jiangning Liu, Li Zhang, Xiaoying Li, Yanfeng Xu, Chuan Qin and LianfengZhang，Chebulagic Acid, a Hydrolyzable Tannin, ExhibitedAntiviral Activity in Vitro and in Vivo against Human Enterovirus 71.  Int. J. Mol. Sci. 2013, 14(5), 9618-9627;

67．             Memo M, Leung MC, Ward DG, Dos Remedios C,Morimoto S, Zhang L, Ravenscroft G, McNamara E, Nowak KJ, Marston SB, MesserAE. FamilialDilated Cardiomyopathy mutations uncouple Troponin I Phosphorylation FromChanges In Myofibrillar Ca2+-Sensitivity. Cardiovasc Res. 2013 Mar27.

68．             Dong-Mei Wang, Ya-Jun Yang , Li Zhang , XuZhang , Fei-Fei Guan and Lian-Feng Zhang, Naringin Enhances CaMKII Activity and Improves Long-Term Memory in aMouse Model of Alzheimer’s Disease. Int. J. Mol. Sci. 2013, 14, 5576-5586

69．             Zhigang Luo, Jiuming He, Yi Chen, JingjingHe, Tao Gong, Fei Tang, Xiaohao Wang, Ruiping Zhang, Lan Huang, Lianfeng Zhang,Haining Lv, Shuanggang Ma, Zhaodi Fu, Xiaoguang Chen,  Shishan Yu, and Zeper Abliz, AirFlow-Assisted Ionization Imaging Mass Spectrometry Method for Easy Whole-BodyMolecular Imaging under Ambient Conditions. Anal. Chem. 2013, 85, 2977−2982

70．             Xiaojian Wang, Jizheng Wang, Ming Su,Changxin Wang, Jingzhou Chen, Hu Wang, Lei Song, Yubao Zou, Lianfeng Zhang,Youyi Zhang, Rutai Hui, TNNI3K, a Cardiac-Specific Kinase, PromotesPhysiological Cardiac Hypertrophy in Transgenic Mice. PLos, March 2013 | Volume8 | Issue 3 | e58570

71．             Liu G,Hu X,Sun B,Yang T,Shi J,Zhang L,Zhao Y.Phosphatase Wip1 negatively regulates neutrophil development through p38MAPK-STAT1. Blood. 2013 Jan 17;121(3):519-29.

72．             Zhang L, Lu D, Zhang W, Quan X, Dong W, XuY, Zhang L. Cardioprotectionby Hepc1 in cTnT (R141W) transgenic mice.Transgenic Res. 2012 Aug;21(4):867-78.

73．             Liu J,Li X,Fan X,Ma C,Qin C,Zhang L.Adoptive transfer of macrophages from adult mice reduces mortality in miceinfected with human enterovirus 71. Arch Virol. 2012  Oct 11.

74．             Gu YL,Yin LW,Zhang Z,Liu J,Liu SJ,Zhang LF,Wang TH.Neurotrophin expressions in neural stem cells grafted acutely to transectedspinal cord of adult rats linked to functional improvement. Cell Mol Neurobiol. 2012Oct; 32(7):1089-97.

75．             Lian H, Ma Y, Feng J, Dong W, Yang Q,Zhang L. (2012) Heparin-Binding EGF-Like Growth Factor Induces HeartInterstitial Fibrosis via an Akt/mTor/p70s6kPathway. PLoS ONE 7(9): e44946.doi:10.1371

76．             Wang D, Gao K, Li X, Shen X, Zhang X, MaC, Qin C, Zhang L. Long-termnaringin consumption reverses a glucose uptake defect and improves cognitivedeficits in a mouse model of Alzheimer's disease.  Pharmacol Biochem Behav. 2012Jul;102(1):13-20.

77．             Yang Y,Xiu J,Zhang X,Zhang L,Yan K,Qin C,Liu J.Antiviral Effect of Matrine against Human Enterovirus 71.  Molecules. 2012 Aug 29; 17(9):10370-6.

78．             Yang Y,Xiu J,Zhang X,Zhang L,Yan K,Qin C,Liu J.Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo，Bioorg Med ChemLett 2012 Mar 15;22(6):2209-11

79．             Yang Y,Xiu J,Zhang X,Zhang L,Yan K,Qin C,Liu J.Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo. Phytomedicine 20(2012) 67–70.

80．             Lu D, Ma Y, Zhang W, Bao D, Dong W, LianH, Huang L, Zhang L. Knockdown ofcytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W)dilated cardiomyopathy transgenic mice. Hypertension. 2012 Jul; 60(1):81-9.

81．             Lu, Dan，Shao, Hai-Tao，Ge,Wen-Ping，Liu,Ning，Zhang,Xu，Ma,Chun-Mei，Qin,Chuan， Zhang,Lian-Feng， Ginsenoside-Rb1and Tetramethylpyrazine Phosphate Act Synergistically to Prevent DilatedCardiomyopathy in cTnTR141W Transgenic Mice. Journal of Cardiovascular Pharmacology: May 2012 - Volume 59 - Issue 5 -p 426–433

82．             Liu J, Dong W, Quan X, Ma C, Qin C, ZhangL. Transgenicexpression of human P-selectin glycoprotein ligand-1 is not sufficient forenterovirus 71 infection in mice. Arch Virol. 2012 Mar; 157(3):539-43.

83．             Liu X,Zhao Z,Xu C,Sun L,Chen J,Zhang L,Liu W.Cyclophilin A restricts influenza A virus replication through degradation ofthe M1 protein. PLoS One. 2012; 7(2):e31063.

84．             Yang Y, Zhang L, Fan X, Qin C, Liu J. Antiviral effect of geraniin on humanenterovirus 71 in vitro and in vivo. Bioorg Med Chem Lett. 2012 Mar15; 22(6):2209-11.

85．             Tao Tang, Lianfeng Zhang, Ran Gao,YunpingDai ,Fanchao Meng , Ying Li. Fluorescence imaging and targeted distribution ofbacterial magnetic particles in nude mice. Appl Microbiol Biotechnol (2012)94:495–503

86．              Bian ZY, Wei X, Deng S, Tang QZ, Feng J, ZhangY, Liu C, Jiang DS, Yan L, Zhang LF, Chen M, Fassett J, Chen Y, He YW, Yang Q,Liu PP, Li H. Disruption ofmindin exacerbates cardiac hypertrophy and fibrosis. J Mol Med(Berl). 2012 Aug;90(8):895-910.

87．             Wenjun Zhang,Wei Zhang, Ni Mao, JiantingMiao, Lianfeng Zhang S14G-Humaninimprovescognitivedeficitsandreducesamyloidpathologyinthemiddle-agedAPPswe/PS1dE9micePharmacology, Biocheistry and Behavior (2012)361–369

88．             Liu J,Chen SS,Dan QQ,Rong R,Zhou X,Zhang LF,Wang TH.Crucial roles of NGF in dorsal horn plasticity in partially deafferentatedcats. Growth Factors. 2011Apr;29(2-3):49-56.

89．             Jiangning Liu，YajunYang，ChunmeiMa，Chuan Qin，LianfengZhang，Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virusreplication，Virology Journal 2011, 8:483

90．             Sheng-hua Zhang, Hao Zhang, Hong-wei He,YiLia, Xiao-yingLib, Lian-feng Zhang, Rong-guang Shao，In vivoreal-time imagingofgemcitabine-leaded growth inhibition in the orthotopictrans plantation model of human pancreatic tumor，Acta PharmaceuticaSinica B 2011;1(4):220–225

91．             Yan L,Wei X,Tang QZ,Feng J,Zhang Y,Liu C,Bian ZY,Zhang LF,Chen M,Bai X,Wang AB,Fassett J,Chen Y,He YW,Yang Q,Liu PP,Li H.Cardiac-specific mindin overexpression attenuates cardiac hypertrophy viablocking AKT/GSK3β and TGF-β1-Smad signalling. Cardiovasc Res. 2011 Oct 1;92(1):85-94.doi: 10.1093/cvr/cvr159. Epub 2011 Jun

92．             Jiangning Liu, Yajun Yang, Yanfeng Xu,Chunmei Ma, Chuan Qin and Lianfeng Zhang , Lycorine reduces mortality of humanenterovirus 71-infected mice by inhibiting virus replication. Virology Journal,2011 Oct 27; 8:483.

93．             Miyoshi-Akiyama T, Ishida I, Fukushi M,Yamaguchi K, Matsuoka Y, Ishihara T, Tsukahara M, Hatakeyama S, Itoh N,Morisawa A, Yoshinaka Y, Yamamoto N, Lianfeng Z, Chuan Q, Kirikae T, Sasazuki TFully human monoclonal antibodydirected to proteolytic cleavage site in severe acute respiratory syndrome(SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARSmodel. J Infect Dis. 2011 Jun 1; 203(11):1574-81.

94．             Dan Lu, Hong Lian, Xiaojuan Zhang, HaitaoShao, Lan Huang, Chuan Qin, Lianfeng Zhang* LMNA E82K Mutation Activates FASand Mitochondrial Pathways of Apoptosis in Heart Tissue Specific TransgenicMice PLoS ONE. 2010 Dec 6;5(12):e15167.

95．             Jiang ning liu, wei wang, jian ying duo,yihao, chun mei ma, wan bo li, Shu zhu lin, xue zhong gao, xiao lin liu, yan fengxu, wen-bo xu, chuan qin , Lian feng zhang. Combined peptides of humanenterovirus 71 protect against virus infection in mice, Vaccine,28(2010)7444-7451.

96．             Wei Zhang, Dan Lu, Wei Dong M and LianfengZhang, Expression of CYP2E1 increases oxidative stress and induces apoptosis ofcardiomyocytes in transgenic mice FEBS J. 2011 May; 278(9):1484-92.

97．             Shu-min Yuan1, Kai Gao1, Dong-mei Wang1,Xiong-zhi Quan1, and Lian-feng Zhang, Evodiamine improves congnitive abilitiesin SAMP8 and APPswe/PS1ΔE9 transgenic mouse models of Alzheimer's disease. ActaPharmacologica Sinica (2011) 32; 31 Jan 2011.

98．             Liu J,Wang H,Zhang L,Xu Y,Deng W,Zhu H,Qin C.S100B transgenic mice develop features of Parkinson's disease. Arch Med Res. 2011 Jan; 42(1):1-7.

99．             Chun Shi Jia, JiangNing Liu,WanBo Li, LianFengZhang, Chuan Qin, The cross-reactivity of the enterovirus71 to human brain tissueand identification of the cross-reactivity related fragments Virology Journal 2010,7:47.

100．        Zhao H, Lv D, Zhang W, Dong W, Feng J,Xiang Z, Huang L, Qin C, Zhang L.Ginsenoside-Rb1 attenuates dilatedcardiomyopathy in cTnT(R141W) transgenic mouse. J Pharmacol Sci.2010;112(2):214-22

101．        Lu Y,Yang W,Qin C,Zhang L,Deng J,Liu S,Qin ZResponsiveness of stromal fibroblasts to IFN-gamma blocks tumor growth viaangiostasis. J Immunol. 2009 Nov15;183(10):6413-21. Epub 2009 Oct 19.

102．        Li YN,Li GL,Zhang LF.Construction of cholecystokinin transgenic mouse and its effects on foodintake. Chin Med J (Engl). 2009 Sep 5;122(17): 2022-6.

103．        Zhiguang X, Wei C, Steven R, Wei D, Wei Z,Rong M, Zhanguo L, Lianfeng Z. Over-expression of IL-33 leads tospontaneous pulmonary inflammation in mIL-33 transgenic mice.Immunol Lett. Immunol Lett. 2010 Jul 8;131(2):159-65. Epub 2010 Apr 20.

104．        Hai-ping Zhao, Dan Lü, Wei Zhang, LiZhang, Shu-mei Wang1, Chun-mei Ma, Chuan Qin2 and Lian-feng Zhang. Protectiveaction of tetramethylpyrazine phosphate against dilated cardiomyopathy incTnTR141W transgenic mice. Acta Pharmacologica Sinica 2010. (2010)31:281-288.

105．        Lu Y,Yang W,Qin C,Zhang L,Deng J,Liu S,Qin Z.Responsiveness of stromal fibroblasts to IFN-gamma blocks tumor growth viaangiostasis. J Immunol. 2009 Nov 15; 183(10):6413-21.Epub 2009 Oct 19.

106．        Bao L,Xu L,Zhan L,Deng W,Zhu H,Gao H,Sun H,Ma C,Lv Q,Li F,Chen H,Zhang L,Qin C..Challengeand polymorphism analysis of the novel A (H1N1) influenza virus to normalanimals. Virus Res. 2010 Jul;151(1):60-5.

107．        Juan Q Wang, Jun-ying Zhou , lianfengZhang, Wu GS. Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells. CellCycle. 2009 Oct 7;8(19)

108．        Z. G. Xiang1, 2, D. D. Jiang1, Y. Liu1, L.F. Zhang2 and L. P. Zhu1 hMan2c1transgene promotes tumor progress in mice Transgenic Research, Volume 19,Number 1(2010)P 67-75

109．        Wang H, Liu J, Zong Y, Xu Y, Deng W, ZhuH, Liu Y, Ma C, Huang L, Zhang L, Qin C.miR-106b aberrantly expressed in adouble transgenic mouse model for Al zheimer's disease targets TGF-β type IIreceptor.Brain Res. 2010 Oct 21;1357:166-74. Epub 2010 Aug 13.

110．         Xiaoying Wang1, Peng Liu1, , Hua Zhu1, ,Yanfeng Xu1, Chunmei Ma1, , Xiaowei Dai1, , Lan Huang1, , Yali Liu1, , LianfengZhang2, and Chuan Qin miR-34a,a microRNA up-regulated in a double transgenic mouse model of Alzheimer'sdisease, inhibits bcl2 translation Brain Res Bull. 2009 Aug 14.

111．        Zhang JM, Yang ZW, Chen RY, Gao P, ZhangYR, Zhang LF. Two new mutations in the keratin 4 gene causing oral white spongenevus in Chinese family. Oral Diseases 2009 Jan;15(1):100-5

112．        Lingjun Zhan, Lei Yang, Lei Zhou, YingliLi, He Gao, Zhaobiao Guo, Lianfeng Zhang, Chuan Dongsheng Zhou, Direct and negativeregulation of the sycO-ypkA-ypoJ operon by cyclic AMP receptor protein (CRP) inYersinia pestis BMC Microbiology 2009, 9:178

113．         Yang, L；Zhou, DS；Liu, XM；Han, HH；Zhan,LJ；Guo, ZB；Zhang,LF；Qin, C；Wong,HC；Yang,RF Cold-induced gene expression profiles of Vibrio parahaemolyticus: atime-course analysis FEMS Microbiology Letters 2009vol.291(no.1)

114．        Min Zhuanga, b, Hong Jiangc, YasuhiroSuzukia, Xiaoguang Lia, Peng Xiaoa, Takashi Tanakad, Hong Lingb, Baofeng Yange,Hiroki Saitoha, Lianfeng Zhangc, Chuan Qinc, Kazuo Sugamuraf and ToshioHattoria. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoVinfection. Antiviral Research Procyanidins and butanol extract of CinnamomiCortex inhibit SARS-CoV infection Volume 82, Issue 1, April 2009, Pages 73-81

115．        Yang XH, Deng W, Tong Z, Liu YX, Zhang LF,Zhu H, Gao H, Huang L, Liu YL, Ma CM, Xu YF, Ding MX, Deng HK, Qin C. Micetransgenic for human angiotensin-converting enzyme 2 provide a model for SARScoronavirus infection. Comp Med. 2007 Oct,57(5):450-9.

116．        Tsybouleva N, Zhang L, Chen S, Patel R,Lutucuta S, Nemoto S, DeFreitas G, Entman M, Carabello BA, Roberts R, MarianAJ.Aldosterone, through novel signaling proteins, is a fundamental molecularbridge between the genetic defect and the cardiac phenotype of hypertrophiccardiomyopathy. Circulation. 2004, 109(10):1284-91.

117．        Bewick M, Conlon M, Lee H, Parissenti AM,Zhang L, Gluck S, Lafrenie RM  Evaluationof sICAM-1, sVCAM-1, and sE-Selectin Levels in Patients with Metastatic BreastCancer Receiving High-Dose Chemotherapy. Stem Cells Dev. 2004, 13(3): 281-94.

118．        Zhang L, Bewick M and Lafrenie RM.  EGFR and ErbB2 differentially regulate Raf-1translocation and activation Lab Invest. 2002, 82(1): 71-8.

119．        Zhang L, Bewick M, Lafrenie RM. Role of Raf-1 and FAK in celldensity-dependent regulation of integrin-dependent activation of MAP kinase.Carcinogenesis. 2002 Jul;23(7):1251-8.

中国实验动物学报副主编；

中国分子心脏病杂志编委；

中国药学会毒性病理专业委员会委员;

中国实验动物学会理事；

北京实验动物学会理事；

北京老年协会理事。