承担国家科研项目情况：

1. 国家重点研发计划项目，2018-2022，单细胞组学重建多能干细胞向肝脏命运决定关键机制，首席科学家。

2. 国家自然科学基金优秀青年科学基金项目，2022-2024，癌症功能基因组学，课题负责人。

3. 国家自然科学基金面上项目，2021-2024，基于基因组单碱基编辑的肿瘤基因功能突变的高通量鉴定，课题负责人。

4. 国家自然科学基金面上项目，2015-2018，通过系统检测基因间相互作用探索癌症基因功能，课题负责人。

        课题组致力于功能基因组学新技术的转化医学应用，通过开发功能基因组学新方法和生物信息学算法，解析疾病的发生机制并寻找可能的新疗法。课题组开发了一系列原创的功能基因组学方法，包括可通用于各类变异功能解析的单碱基编辑筛选（Genome Biol 2021），鉴定非编码区变异调控活性的系统方法（Genome Biol 2017），以及基因间相互作用图谱法（Nat Commun 2014），并运用创建的方法结合临床数据鉴定了与癌症风险、精确诊疗相关的重要变异位点及组合（Theranostics 2021），揭示了脑癌治疗的新靶点（Cancer Res 2020）。目前正在开展的研究项目是在类器官模型中结合单细胞多组学和基因编辑技术，高通量筛选与疾病相关的重要因子和变异，以助力精准治疗和再生医学。 

近期发表论文：

[1] Jianqing Liang#, Jun Qian#, Li Yang, Xiaojun Chen , Xiaoning Wang, Xinhua Lin*, Xiaoyue Wang* , Bing Zhao*. Modeling Human Thyroid Development by Fetal Tissue-Derived Organoid Culture. Advanced Science (Weinh). 2022, 9(9) : e2105568.

[2] Xuechun Li#, Zhao Sun#, Gongxin Peng#, Yi Xiao, Junchao Guo, Bin Wu, Xiaoyi Li, Weixun Zhou, Jiarui Li, Zhe Li, Chunmei Bai, Lin Zhao*, Qin Han*, Robert Chunhua Zhao*, Xiaoyue Wang*. Theranostics, 2022, 12(2):620-638. (2022 ESI highly cited paper)

[3] Jianzhen Lin#, Yinghao Cao#, Xu Yang# , Guangyu Li#, Yang Shi, Dongxu Wang, Junyu Long , Yang Song , Jinzhu Mao , Fucun Xie, Yi Bai, Lei Zhang, Xiaobo Yang, Xueshuai Wan , Anqiang Wang  Lei Guan, Lin Zhao , Ke Hu, Jie Pan, Li Huo , Xin Lu, Yilei Mao , Xinting Sang, Henghui Zhang , Kai Wang*, Xiaoyue Wang*, Haitao Zhao*. Mutational spectrum and precision oncology for biliary tract carcinoma. Theranostics. 2021, 11(10):4585-4598.

[4] Changcai Huang#, Guangyu Li#, Jiayu Wu, Junbo Liang*, Xiaoyue Wang*. Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Genome Biology, 2021, 22:80 

[5] Hongchao Liu, Huihui Yin, Guangyu Li, Junling Li*, Xiaoyue Wang*. Aperture: Alignment-free detection of structural variations and viral integrations in circulating tumor DNA. Briefings in Bioinformatics, 2021: bbab290.  

[6] Junbo Liang#, Hong Zhao#, Bill H. Diplas#, Song Liu#, Jianmei Liu, Dingding Wang, Yan Lu, Qing Zhu, Jiayu Wu, Wenjia Wang, Hai Yan, Yi-Xin Zeng, Xiaoyue Wang*, Yuchen Jiao*. Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX -Mutant Cancers to WEE1 Inhibition. Cancer research, 2020, 80(3):510-523.

[7] Bing Zhao#*, Chao Ni#, Ran Gao#, Yuyan Wang, Li Yang, Jinsong Wei, Ting Lv, Jianqing Liang, Qisheng Zhang, Wei Xu, Youhua Xie, Xiaoyue Wang, Zhenghong Yuan, Junbo Liang*, Rong Zhang*, and Xinhua Lin*. Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell, 2020. 

[8] Yinghao Cao, Xiaoyue Wang*, Gongxin Peng*. SCSA: A cell type annotation tool for single-cell RNA-seq Data. Frontiers in Genetics. 2020.11:490.

[9] Song Liu#, Yuwen Liu#, Qin Zhang, Jiayu Wu, Junbo Liang, Shan Yu, Gong-Hong Wei, Kevin P. White*, Xiaoyue Wang*. Systematic identification of regulatory variants associated with cancer risk. Genome Biology, 2017, 18(1):194.

[10] Xiaoyue Wang#, Audrey Q. Fu#, Megan E. McNerney, Kevin P. White*. Widespread genetic epistasis among cancer genes. Nature communications, 2014, 5:4828.

#co-first authors, *co-corresponding authors