主持承担了国家“863”、“973”、“重大传染病防治科技重大专项”、“国家自然科学基金”和“科技部国际合作项目”等一些国家科研项目

PUBLICATIONS:

1.    Quinoline and Quinazoline DerivativesInhibit Viral RNA Synthesis by SARS-CoV-2 RdRp. Zhao J, Zhang Y, Wang M, Liu Q,Lei X, Wu M, Guo S, Yi D, Li Q, Ma L, Liu Z, Guo F, Wang J, Li X, Wang Y,Cen S. ACS Infect Dis. 2021 May 26. doi: 10.1021/acsinfecdis.1c00083. Onlineahead of print.

2.    A cell-based assay to discover inhibitors ofSARS-CoV-2 RNA dependent RNA polymerase. Zhao J, Guo S, Yi D, Li Q, Ma L, ZhangY, Wang J, Li X, Guo F, Lin R, Liang C, Liu Z, Cen S. Antiviral Res.2021 Apr 21;190:105078. doi: 10.1016/j.antiviral.2021.105078. Online ahead ofprint.PMID: 33894278

3.    The CREB Regulated Transcription Coactivator2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1LTR.TMa L, Chen S, Wang Z, Guo S, Zhao J, Yi D, Li Q, Liu Z, Guo F, Li X,Jia P, Ding J, Liang C, Cen S. Virol Sin. 2021 Mar 15. doi:10.1007/s12250-021-00363-1. 

4.    The engineered MARCH8-resistant VSVglycoprotein enhances lentiviral vector transduction. Xu F, Liu X,Zhang D, Zhao F, Fan Z, Hu S, Mei S, Huang Y, Sun H, Wei L, Guo L, Wang J, CenS, Liang C, Guo F. Hum Gene Ther. 2021 Mar 7. doi: 10.1089/hum.2020.292.

5.    Corilagin inhibits SARS-CoV-2replication by targeting viral RNA-dependent RNA polymerase. Li Q,Yi D, Lei X, Zhao J, Zhang Y, Cui X, Xiao X, Jiao T, Dong X, Zhao X, Zeng H,Liang C, Ren L, Guo F, Li X, Wang J, Cen S. Acta Pharm Sin B. 2021 Feb 15.doi: 10.1016/j.apsb.2021.02.011. 

6.    A Nuclear Export Signal Is Requiredfor cGAS to Sense Cytosolic DNA. Sun H, Huang Y, Mei S, Xu F, Liu X,Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, HuS, Guo F. Cell Rep. 2021 Jan 5;34(1):108586. doi: 10.1016/j.celrep.2020.108586.PMID: 33406424

7.    HIV-1 resists MxB inhibition of viral Revprotein. Wang Z, Chai K, Liu Q, Yi DR, Pan Q, Huang Y, Tan J, Qiao W, Guo F,Cen S, Liang C. Emerg Microbes Infect. 2020 Sep 1:1-44. doi:10.1080/22221751.2020.1818633. Online ahead of print. PMID: 32873191

8.    Activation and evasion of type Iinterferon responses by SARS-CoV-2.  Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z,Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J. Nat Commun.2020 Jul 30;11(1):3810. doi: 10.1038/s41467-020-17665-9.

9.     Chemokine (C-X-C motif) Ligand 4 is aRestrictor of Respiratory Syncytial Virus Infection and an Indicator ofClinical Severity. Han Z, Rao J, Xie Z, Wang C, Xu B, Qian S, Wang Y, Zhu J,Yang B, Xu F, Lei X, Guo F, Zhao Z, Ren L, Wang J. Am J Respir Crit Care Med.2020 Jun 16. doi: 10.1164/rccm.201908-1567OC.

10.  CRISPR-Cas13a Inhibits HIV-1 Infection. YinL, Zhao F, Sun H, Wang Z, Huang Y, Zhu W, Xu F, Mei S, Liu X, Zhang D, Wei L,Cen S, Hu S, Liang C, Guo F. Mol Ther Nucleic Acids. 2020 Jun 1;21:147-155.doi: 10.1016/j.omtn.2020.05.030.

11.  Pro-515 of the Dynamin-Like GTPase MxBContributes to HIV-1 Inhibition by Regulating MxB Oligomerization and Bindingto HIV-1 Capsid. Xu F, Zhao F, Zhao X, Zhang D, Liu X, Hu S, Mei S, Fan Z,Huang Y, Sun H, Wei L, Wu C, Li Q, Wang J, Cen S, Liang C, Guo F. J Biol Chem.2020 May 8;295(19):6447-6456. doi: 10.1074/jbc.RA119.012439. Epub 2020 Mar 26.

12.  PKR-dependent cytosolic cGAS foci arenecessary for intracellular DNA sensing. Hu S, Sun H, Yin L, Li J,Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, LiangC, Guo F. Sci Signal. 2019 Nov 26;12(609). pii: eaav7934. doi:10.1126/scisignal.aav7934.

13.  Influenza Virus Exploits anInterferon-Independent lncRNA to Preserve Viral RNA Synthesis throughStabilizing Viral RNA Polymerase PB1. Wang J, Zhang Y, Li Q, Zhao J,Yi D, Ding J, Zhao F, Hu S, Zhou J, Deng T, Li X, Guo F, Liang C, Cen S.  Cell Rep. 2019 Jun 11;27(11):3295-3304.e4.doi: 10.1016/j.celrep.2019.05.036

14.  MOV10 sequesters the RNP of influenzaA virus in the cytoplasm and is antagonized by viral NS1 protein. LiJ, Hu S, Xu F, Mei S, Liu X, Yin L, Zhao F, Zhao X, Sun H, Xiong Z, Zhang D,Cen S, Wang J, Liang C, Guo F. Biochem J. 2019 Feb 5;476(3):467-481. doi:10.1042/BCJ20180754.

15.  Human MxB inhibits the replication ofHCV. Yi DR, An N, Liu ZL, Xu FW, Raniga K, Li QJ, Zhou R, Wang J,Zhang YX, Zhou JM, Zhang LL, An J, Qin CF, Guo F, Li XY, Liang C, Cen S. JVirol. 2018 Oct 17. pii: JVI.01285-18. doi: 10.1128/JVI.01285-18.

16.  HIV-1 employs multiple mechanisms toresist Cas9/sgRNA targeting the viral primer binding site. Wang Z,Wang W, Cui YC, Pan Q, Zhu W, Gendron P, Guo F, Cen S, Witcher M, Liang C. JVirol. 2018 Aug 1. pii: JVI.01135-18. doi: 10.1128/JVI.01135-18.

17.  Host Long Noncoding RNA lncRNA-PAANRegulates the Replication of Influenza A Virus. Wang J, Wang Y, ZhouR, Zhao J, Zhang Y, Yi D, Li Q, Zhou J, Guo F, Liang C, Li X, Cen S. Viruses.2018 Jun 16;10(6). pii: E330. doi: 10.3390/v10060330

18.  Identification of small moleculecompounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtualscreening and biological evaluation. Ma L, Zhang Z, Liu Z, Pan Q,Wang J, Li X, Guo F, Liang C, Hu L, Zhou J, Cen S. Sci Rep. 2018 May23;8(1):8067. doi: 10.1038/s41598-018-26318-3

19.  CRISPR/Cas9 Inhibits Multiple Stepsof HIV-1 Infection. Yin L, Hu S, Mei S, Sun H, Xu F, Li J, Zhu W,Liu X, Zhao F, Zhang D, Cen S, Liang C, Guo F. Hum Gene Ther. 2018Nov;29(11):1264-1276

20.  A highly conserved amino acid in VP1regulates maturation of enterovirus 71. Zhang YX, Huang YM, Li QJ,Li XY, Zhou YD, Guo F, Zhou JM, Cen S. PLoS Pathog. 2017 Sep 22;13(9):e1006625.

21.  Identification and characterizationof loop7 motif and its role in regulating biological function of human APOBEC3Gthrough molecular modeling and biological assay. Zhai C, Ma L, ZhangZ, Ding J, Wang J, Zhang Y, Li X, Guo F, Yu L, Zhou J, Cen S. Acta Pharm Sin B.2017 Sep;7(5):571-582. doi: 10.1016/j.apsb.2017.05.002. Epub 2017 Jun 2.

22.  BST-2 restricts IAV release and iscountered by the viral M2 protein. Hu S, Yin L, Mei S, Li J, Xu F,Sun H, Liu X, Cen S, Liang C, Li A, Guo F. Biochem J. 2017 Feb20;474(5):715-730. doi: 10.1042/BCJ20160861.

23.  Distribution and characteristics ofrodent picornaviruses in China. Du J, Lu L, Liu F, Su H, Dong J, SunL, Zhu Y, Ren X, Yang F, Guo F, Liu Q, Wu Z, Jin Q. Sci Rep. 2016 Sep29;6:34381. doi: 10.1038/srep34381.

24.  Amphotericin B Inhibits Enterovirus71 Replication by Impeding Viral Entry. Xu F, Zhao X, Hu S, Li J,Yin L, Mei S, Liu T, Wang Y, Ren L, Cen S, Zhao Z, Wang J, Jin Q, Liang C,Ai B, Guo F. Sci Rep. 2016 Sep 9;6:33150.

25.  CRISPR/Cas9-derived mutations both inhibitHIV-1 replication and accelerate viral escape. Zhen Wang, Qinghua Pan, PatrickGendron, Weijun Zhu, Fei Guo, Shan Cen, Mark A Wainberg, and Chen Liang. Cell reports2016：15, 1–9.

26.  2-thio-6-azauridine inhibits Vpumediated BST-2 degradation. Zhang Q, Mi Z, Huang Y, Ma L, Ding J,Wang J, Zhang Y, Chen Y, Zhou J, Guo F, Li X, Cen S. Retrovirology.2016 Mar 2;13(1):13. doi: 10.1186/s12977-016-0247-z.

27.  Stress out the LINEs. HuS, Liang C, Guo F. Mob Genet Elements. 2015 Dec 29;6(1):e1133267.

28.  A small molecule compound IMB-LAinhibits HIV-1 infection by preventing viral Vpu from antagonizing the hostrestriction factor BST-2. Mi Z, Ding J, Zhang Q, Zhao J, Ma L, Yu H,Liu Z, Shan G, Li X, Zhou J, Wei T, Zhang L, Guo F, Liang C, Cen S. Sci Rep. 2015 Dec 16;5:18499. doi:10.1038/srep18499.

29.  SAMHD1 Inhibits LINE-1 Retrotransposition byPromoting Stress Granule Formation.  Hu S, Li J, Xu F, Mei S, LeDuff Y, Yin L, Pang X, Cen S, Jin Q, Liang C and Guo F. PLoS Genet. 2015 Jul 2;11(7):e1005367. doi:10.1371/ journal.pgen.1005367. eCollection 2015 Jul.

30.  The CRISPR/Cas9 system inactivateslatent HIV-1 proviral DNA.Zhu W, Lei R, Le Duff Y, Li J, Guo F, Wainberg MA, Liang C. Retrovirology.2015 Feb 27;12(1):22. doi: 10.1186/s12977-015-0150-z。

31.  Characterization of the interactionsbetween SIVrcm Vpx and red-capped mangabey SAMHD1. Li J, Xu F, Hu S,Zhou J, Mei S, Zhao X, Cen S, Jin Q, Liang C, Guo F. Biochem J. 2015 Jun 1;468(2):303-13. doi:10.1042

32. Human APOBEC3F incorporation intohuman immunodeficiency virus type 1 particles.Wang X, Li X, Ma J,Zhang L, Ma L, Mi Z, Zhou J, Guo F, Kleiman L, Cen S. Virus Res. 2014 Oct 13;191:30-8.

33. The role of A-kinase anchoringprotein 95-like protein in annealing of tRNALys3 to HIV-1 RNA.XingL, Zhao X, Guo F, Kleiman L.Retrovirology. 2014 Jul 17;11:58. doi:10.1186/1742-4690-11-58.

34.Identification of an endocytic signalessential for the antiviral action of IFITM3. Jia R, Xu F, Qian J,Yao Y, Miao C, Zheng YM, Liu SL, Guo F,Geng Y, Qiao W, Liang C. Cell Microbiol. 2014 Jul;16(7):1080-93. doi:10.1111/cmi.12262. Epub 2014 Feb 13.

35. The interferon-inducible MxB proteininhibits HIV-1 infection. Liu Z, Pan Q, Ding S, Qian J, Xu F, ZhouJ, Cen S, Guo F, Liang C. Cell Host Microbe. 2013 Oct 16;14(4):398-410. doi:10.1016/j.chom.2013.08.015.

36. The roles of APOBEC3G complexes inthe incorporation of APOBEC3G into HIV-1. Ma J, Li X, Xu J, Zhang Q,Liu Z, Jia P, Zhou J, Guo F, You X, Yu L, Zhao L, Jiang J, Cen S. PLoSOne. 2013 Oct 2;8(10):e74892. doi: 10.1371/journal.pone.0074892.

37. Identification of novel key aminoacids at the interface of the transmembrane domains of human BST-2 and HIV-1Vpu. Pang X, Hu S, Jian Li, Xu F, Mei S, Zhou J, Cen S, Jin Q, and Guo F. Retrovirology.2013 Aug 6;10:84. doi: 10.1186/1742-4690-10-84..

38.The MOV10 helicase inhibits LINE-1mobility. Li X, Zhang J, Jia R, Cheng V, Xu X, Qiao W, Guo F, Liang C, Cen S.J Biol Chem. 2013 Jul 19;288(29):21148-60. doi:10.1074/jbc.M113.465856.

39.The role of the structuraldomains of human BST-2 ininhibiting the release of xenotropic murine leukemia virus-related virus. Hu S,Pang X, Li J, Cen S, Jin Q, Guo F. BiochemBiophys Res Commun. 2012 Nov 9;428(1):17-23. doi:10.1016/j.bbrc.2012.10.001. Epub 2012 Oct 6

40.From promoting to inhibiting: diverse roles of helicases in HIV-1Replication. Lorgeoux RP, Guo F, Liang C. Retrovirology. 2012 Sep 28;9:79.doi: 10.1186/1742-4690-9-79.

41.Transmembrane interactions ofHIV-1 Vpu and tetherin. Guo F, Liang C. Curr HIV Res.2012 Jun;10(4):292-7. Review

42.High-throughput assay to identify inhibitors of Vpu-mediateddown-regulation of cell surface BST-2. Zhang Q, Liu Z, Mi Z, Li X, JiaP, Zhou J, Yin X, You X, Yu L, Guo F, Ma J, Liang C, Cen S.Antiviral Res. 2011 Sep;91(3):321-9.

43.Functional analysis of the twocytidine deaminase domains in APOBEC3G. Li X, Ma J,Zhang Q, Zhou J, Yin X, Zhai C, You X, Yu L, Guo F, Zhao L, Li Z, Zeng Y, Cen S.  Virology. 2011 Jun 5;414(2):130-6. doi: 10.1016/j.virol.2011.03.014. Epub 2011Apr 13.

44.Thecontribution of the primer activation signal to differences between Gag- andNCp7-facilitated tRNA(Lys3) annealing in HIV-1. Saadatmand J, Niu M, Kleiman L, Guo F. Virology. 2009 Sep1;391(2):334-41.

45.ROLES OF GAG AND NCp7 IN FACILITATING tRNALys3 ANNEALING TO VIRAL RNA INHIV-1. Guo F, Saadatmand J, Niu M,Kleiman L. J Virol. 2009Aug;83(16):8099-107.

46.The Transmembrane Domain of BST-2 Determines Its Sensitivity toDown-Modulation by HIV-1 Vpu. Rong L, Zhang J, Lu J, Pan Q, LorgeouxRP, Aloysius C, Guo F, LiuSL, Wainberg MA, Liang C. J Virol. 2009 Aug;83(15):7536-46.

47.Methods for analysis of incorporation and annealing methods for analysisof tRNA(Lys) in HIV-1. Cen S, GuoF, Kleiman L.  MethodsMol Biol. 2009;485:223-32.

48.Interactions of reversetranscriptase sequences in Pol with Gag and LysRS in the HIV-1 tRNALyspackaging/annealing complex. Saadatmand J, Guo F，Niu M,Kleiman L. Virology, 2008 Oct 10;380(1):109-17.

49.Function analysis of sequence inhuman APOBEC3G involved in Vif-mediated degradation. ZhangL, Saadatmand J, Li XY, Guo F,Niu M, Lawrence K, Cen S. Virology, 2008 Jan 5;370(1):113-21.

50.APOBEC3Ginhibits DNA strand transfer during HIV-1 reverse transcription. Li XY, Guo F, Zhang L, Kleiman L, CenS. J Biol Chem. 2007 Nov 2;282(44):32065-74.)

51.The interaction of APOBEC3G with HIV-1 nucleocapsid inhibitstRNALys3 annealing to viral RNA. GuoF, Cen S, Niu M, Yang Y, Gorelick RJ, Kleiman L. J Virol. 2007Oct;81(20):11322-31.

52.Inhibition of initiation of reversetranscription in HIV-1 by human APOBEC3F.Yang Y, GuoF, Cen S, Kleiman L. Virology. 2007 Aug 15;365(1):92-100.

53.Inhibition of formula-primed reversetranscription by human APOBEC3Gduring human immunodeficiency virus type 1 replication. Guo F, Cen S, Niu M, Saadatmand J, Kleiman L. J Virol. 2006Dec;80(23):11710-22.

54. Association of RNA helicase A with humanimmunodeficiency virus type 1 particles. Roy BB, Hu J, Guo X, Russell RS, Guo F,Kleiman L, Liang C. J Biol Chem. 2006 May 5;281(18):12625-35.

55. Defective replication in HIV-1 usingnon-tRNALys3 primers for reverse transcription.  Wei, M.,Cen, S., Niu, M., Guo, F.,Kleiman, L.  JVirol. 2005 Jul;79(14):9081-7.

56.  Inhibition of cellular HIV-1 protease activity by LYSYL-tRNAsynthetase. Guo, F,Gabor J, Cen S, Hu K, Mouland A, Kleiman L. J Biol Chem. 2005Jul 15;280(28):26018-23.

57. The interaction between HIV-1Gag and APOBEC3G. CenS, Guo, F, Niu M, SaadatmandJ, Deflassieux J, Kleiman L. J Biol Chem. 2004 Aug 6;279(32):33177-84

58. Galpha protein selectivitydeterminant specified by a viral chemokine receptor-conserved region in the Ctail of the human herpesvirus 8 g-protein-coupledreceptor. Liu C, Sandford G, FeiGuo, Nicholas J.  J Virol. 2004: 78(5):2460-71

59. Incorporation of pol into HIV-1 Gag VLPsOccurs independently of Upstream Gag Domain in Gagpol. Cen S, Niu M, SaadatmandJ, Guo, F, Huang Y, Nabel GJand L. Kleiman. J Virol 2004 Jan;78(2):1042-9 .

60. Specific Inhibition of the Synthesis ofHuman LysRS Result in Decreases in tRNAlys Incorporation, tRNAlys Annealing toViral RNA, and Viral infectivity in Human immunodeficiency Virus-1. Guo, F, Cen S, Niu M,Javanbakht, J., and L. Kleiman..J Virol 2003Sep;77(18):9817-22.