主持多项国家自然科学基金委项目，先后主持国家十五、十一五心血管外科学相关支撑计划，北京市科委重大科研项目，国家高技术研究发展计划（863计划）项目，国家重点基础研究发展计划（973计划）项目。

主要学术贡献：

        一、建立了冠状动脉搭桥微创系列技术“三步曲”：在国内最早开展以“避免体外循环，减少心肌缺血再灌注损伤”为目的的正中切口、非体外循环、心脏跳动下的冠脉搭桥术；在国内率先建立了以“避免完全劈开胸骨、缩小手术切口”为目的的胸腔镜辅助下小切口冠脉搭桥术；完成国际上首例胸腔镜辅助下小切口冠脉搭桥与冠脉介入支架植入相结合的术式，开创了我国“复合技术（Hybrid）”治疗冠心病的新领域。引领并推动了中国冠状动脉搭桥微创技术的发展和普及，使冠状动脉搭桥手术成功率达到世界一流水平。

        二、创建了我国首个心血管再生医学实验室，开展从心肌再生到心脏移植、人工心脏的系列研究；在国际上首次建立致心律失常型右室心肌病的精准分型。领导的心脏移植团队将阜外医院打造成了世界上最大的心脏移植中心之一；主持研制了具有自主知识产权的FWI—FWIII轴流泵，并与国内苏州同心公司合作将全植入磁悬浮人工心脏成功应用于临床。

        三、主持了我国首个有关先天性心脏病的国家重点基础研究发展计划（973计划）项目，完成了各类复杂先天性心脏病，及先天性心脏病合并肺动脉高压的外科治疗。在国际上首创了“一站式”复合技术治疗肺动脉闭锁、房间隔缺损合并动、静脉畸形的新技术。创立主动脉-肺动脉“双根部调转手术（DRT）”，解决了复杂先心病外科治疗领域的一个难点问题，连续3年在美国胸外科协会年会（87-89届）就该术式进行报告；2009年应邀将该术式发表在OperTech Thorac Cardiovasc Surg，作为首个中国人创立的心脏手术列入美国心脏外科医师继续教育课程。

        四、先后主持国家十五、十一五心血管外科学相关支撑计划，北京市科委重大科研项目，国家高技术研究发展计划（863计划）项目，国家重点基础研究发展计划（973计划）项目。相关研究结果在国际心血管疾病主流SCI杂志如Circulation、JACC、EuropeanHeart Journal、StemCells、JThoracic Cardiovascular Surgery、AnnThoracic Surgery等杂志。主编《冠心病外科治疗学》、《临床微创心脏外科技术》、《心脏外科手术集》和《今日心脏血管外科学》等专著4部。

近五年来在高水平期刊所发表的代表性论著：

1.     Chen, L., Song, J., Chen, X., Chen, K., Ren, J., Zhang, N., Rao, M., Hu, Z., Zhang, Y., Gu, M., Zhao, H., Tang, H., Yang, Z., & Hu, S. (2019). A novel genotype-based clinicopathology classification of arrhythmogenic cardiomyopathy provides novel insights into disease progression. Eur Heart J, 40(21), 1690-1703. doi:10.1093/eurheartj/ehz172

2.     Chu, Q., Jiang, H., Zhang, L., Zhu, D., Yin, Q., Zhang, H., Zhou, B., Zhou, W., Yue, Z., Lian, H., Liu, L., Nie, Y., & Hu, S. (2020). CACCT: An Automated Tool of Detecting Complicated Cardiac Malformations in Mouse Models. Adv Sci (Weinh), 7(8), 1903592. doi:10.1002/advs.201903592

3.     Han, C., Nie, Y., Lian, H., Liu, R., He, F., Huang, H., & Hu, S. (2015). Acute inflammation stimulates a regenerative response in the neonatal mouse heart. Cell Res, 25(10), 1137-1151. doi:10.1038/cr.2015.110

4.     Hao, H., Hu, S., Chen, H., Bu, D., Zhu, L., Xu, C., Chu, F., Huo, X., Tang, Y., Sun, X., Ding, B. S., Liu, D. P., Hu, S., & Wang, M. (2017). Loss of Endothelial CXCR7 Impairs Vascular Homeostasis and Cardiac Remodeling After Myocardial Infarction: Implications for Cardiovascular Drug Discovery. Circulation, 135(13), 1253-1264. doi:10.1161/circulationaha.116.023027

5.     He, L., Huang, X., Kanisicak, O., Li, Y., Wang, Y., Li, Y., Pu, W., Liu, Q., Zhang, H., Tian, X., Zhao, H., Liu, X., Zhang, S., Nie, Y., Hu, S., Miao, X., Wang, Q. D., Wang, F., Chen, T., Xu, Q., Lui, K. O., Molkentin, J. D., & Zhou, B. (2017). Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest, 127(8), 2968-2981. doi:10.1172/jci93868

6.     He, L., Li, Y., Li, Y., Pu, W., Huang, X., Tian, X., Wang, Y., Zhang, H., Liu, Q., Zhang, L., Zhao, H., Tang, J., Ji, H., Cai, D., Han, Z., Han, Z., Nie, Y., Hu, S., Wang, Q. D., Sun, R., Fei, J., Wang, F., Chen, T., Yan, Y., Huang, H., Pu, W. T., & Zhou, B. (2017). Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med, 23(12), 1488-1498. doi:10.1038/nm.4437

7.     Jiang, L., Krumholz, H. M., Li, X., Li, J., & Hu, S. (2015). Achieving best outcomes for patients with cardiovascular disease in China by enhancing the quality of medical care and establishing a learning health-care system. Lancet, 386(10002), 1493-1505. doi:10.1016/s0140-6736(15)00343-8

8.     Jiang, Q., Xiang, B., Wang, H., Huang, K., Kong, H., & Hu, S. (2019). Remote ischaemic preconditioning ameliorates sinus rhythm restoration rate through Cox maze radiofrequency procedure associated with inflammation reaction reduction. Basic Res Cardiol, 114(3), 14. doi:10.1007/s00395-019-0723-4

9.     Lamy, A., Devereaux, P. J., Prabhakaran, D., Taggart, D. P., Hu, S., Straka, Z., Piegas, L. S., Avezum, A., Akar, A. R., Lanas Zanetti, F., Jain, A. R., Noiseux, N., Padmanabhan, C., Bahamondes, J. C., Novick, R. J., Tao, L., Olavegogeascoechea, P. A., Airan, B., Sulling, T. A., Whitlock, R. P., Ou, Y., Gao, P., Pettit, S., & Yusuf, S. (2016). Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting. N Engl J Med, 375(24), 2359-2368. doi:10.1056/NEJMoa1601564

10.  Li, X., Krumholz, H. M., Yip, W., Cheng, K. K., De Maeseneer, J., Meng, Q., Mossialos, E., Li, C., Lu, J., Su, M., Zhang, Q., Xu, D. R., Li, L., Normand, S. T., Peto, R., Li, J., Wang, Z., Yan, H., Gao, R., Chunharas, S., Gao, X., Guerra, R., Ji, H., Ke, Y., Pan, Z., Wu, X., Xiao, S., Xie, X., Zhang, Y., Zhu, J., Zhu, S., & Hu, S. (2020). Quality of primary health care in China: challenges and recommendations. Lancet, 395(10239), 1802-1812. doi:10.1016/s0140-6736(20)30122-7

11.  Li, X., Lu, J., Hu, S., Cheng, K. K., De Maeseneer, J., Meng, Q., Mossialos, E., Xu, D. R., Yip, W., Zhang, H., Krumholz, H. M., Jiang, L., & Hu, S. (2017). The primary health-care system in China. Lancet, 390(10112), 2584-2594. doi:10.1016/s0140-6736(17)33109-4

12.  Li, Y., Feng, J., Song, S., Li, H., Yang, H., Zhou, B., Li, Y., Yue, Z., Lian, H., Liu, L., Hu, S., & Nie, Y. (2020). Gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration. Circulation. doi:10.1161/circulationaha.119.044484

13.  Liu, Q., Liu, K., Cui, G., Huang, X., Yao, S., Guo, W., Qin, Z., Li, Y., Yang, R., Pu, W., Zhang, L., He, L., Zhao, H., Yu, W., Tang, M., Tian, X., Cai, D., Nie, Y., Hu, S., Ren, T., Qiao, Z., Huang, H., Zeng, Y. A., Jing, N., Peng, G., Ji, H., & Zhou, B. (2019). Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet, 51(4), 728-738. doi:10.1038/s41588-019-0346-6

14.  Liu, Q., Yang, R., Huang, X., Zhang, H., He, L., Zhang, L., Tian, X., Nie, Y., Hu, S., Yan, Y., Zhang, L., Qiao, Z., Wang, Q. D., Lui, K. O., & Zhou, B. (2016). Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res, 26(1), 119-130. doi:10.1038/cr.2015.143

15.  Liu, X., Chen, W., Li, W., Priest, J. R., Fu, Y., Pang, K., Ma, B., Han, B., Liu, X., Hu, S., & Zhou, Z. (2020). Exome-Based Case-Control Analysis Highlights the Pathogenic Role of Ciliary Genes in Transposition of the Great Arteries. Circ Res, 126(7), 811-821. doi:10.1161/circresaha.119.315821

16.  Song, J. P., Chen, L., Chen, X., Ren, J., Zhang, N. N., Tirasawasdichai, T., Hu, Z. L., Hua, W., Hu, Y. R., Tang, H. R., Chen, H. V., & Hu, S. S. (2020). Elevated plasma β-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy. Sci Transl Med, 12(530). doi:10.1126/scitranslmed.aay8329

17.  Tang, B., Song, Y., Cui, H., Ji, K., Zhu, C., Zhao, S., Huang, X., Yu, Q., Hu, S., & Wang, S. (2017). Prediction of Mid-Term Outcomes in Adult Obstructive Hypertrophic Cardiomyopathy After Surgical Ventricular Septum Myectomy. J Am Coll Cardiol, 70(16), 2092-2094. doi:10.1016/j.jacc.2017.08.032

18.  Tang, J., Li, Y., Huang, X., He, L., Zhang, L., Wang, H., Yu, W., Pu, W., Tian, X., Nie, Y., Hu, S., Wang, Q. D., Lui, K. O., & Zhou, B. (2018). Fate Mapping of Sca1(+) Cardiac Progenitor Cells in the Adult Mouse Heart. Circulation, 138(25), 2967-2969. doi:10.1161/circulationaha.118.036210

19.  Tian, X., Li, Y., He, L., Zhang, H., Huang, X., Liu, Q., Pu, W., Zhang, L., Li, Y., Zhao, H., Wang, Z., Zhu, J., Nie, Y., Hu, S., Sedmera, D., Zhong, T. P., Yu, Y., Zhang, L., Yan, Y., Qiao, Z., Wang, Q. D., Wu, S. M., Pu, W. T., Anderson, R. H., & Zhou, B. (2017). Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun, 8(1), 87. doi:10.1038/s41467-017-00118-1

20.  Wang, L., Yu, P., Zhou, B., Song, J., Li, Z., Zhang, M., Guo, G., Wang, Y., Chen, X., Han, L., & Hu, S. (2020). Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function. Nat Cell Biol, 22(1), 108-119. doi:10.1038/s41556-019-0446-7

21.  Xu, B., Tu, S., Qiao, S., Qu, X., Chen, Y., Yang, J., Guo, L., Sun, Z., Li, Z., Tian, F., Fang, W., Chen, J., Li, W., Guan, C., Holm, N. R., Wijns, W., & Hu, S. (2017). Diagnostic Accuracy of Angiography-Based Quantitative Flow Ratio Measurements for Online Assessment of Coronary Stenosis. J Am Coll Cardiol, 70(25), 3077-3087. doi:10.1016/j.jacc.2017.10.035

22.  Zhang, H., Pu, W., Liu, Q., He, L., Huang, X., Tian, X., Zhang, L., Nie, Y., Hu, S., Lui, K. O., & Zhou, B. (2016). Endocardium Contributes to Cardiac Fat. Circ Res, 118(2), 254-265. doi:10.1161/circresaha.115.307202