共培养研究生16名，目前在读博士研究生2名。

现已主持国家自然科学基金两项，国家自然科学基金⻘年科学基金项目一项，中国医学科院临床与转化医学研究基金项目一项，中央高水平医院临床科研业项目一项，参加国家级课题四项。

课题名称：先心病患儿线粒体ALDH2活化对深低温停循环期间突触可塑性的影响及机制研究

来源：国家自然科学基金

课题名称：mic-200c调控UBC9表达诱导深低温停循环下脑缺血耐受的机制研究

来源：国家自然科学基金

课题名称：一种新选择性脑灌注策略对深低温停循环术中未成熟脑的保护及作用机制

来源：国家自然科学基金青年科学基金项目

课题名称：优化低体重（≤10kg）先心病患儿围体外循环期目标导向灌注的研究 

来源：中国医学科院临床与转化医学研究基金项目

课题名称： 新生儿先心病手术围体外循环期最适抗凝策略的探索研究

来源：阜外医院高水平临床科研项目

【近5年发表论文】

1.       Zhang P, Bai L, Tong Y, Guo S, Lu W, Yuan Y, Wang W, Jin Y, Gao P, Liu J. CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways. Mol Med. 2023 May 1;29(1):61.

2.       Zhang P, Tong Y, Yuan D, Li Y, Jin Y, Bai L, Gao P, Wang W, Hu J, Duan X, Liu J. Association of high-sensitivity C-reactive protein and anemia with acute kidney injury in neonates. Front Pediatr. 2022 Nov 2;10:882739.

3.       Jin Y, Zhang Y, Liu J. Ischemic stroke and intracranial hemorrhage in extracorporeal membrane oxygenation for COVID-19: A systematic review and meta-analysis. Perfusion. 2022.

4.       Jin Y, Zhang Y, Liu J, Zhou Z. Thrombosis and bleeding in patients with COVID-19 requiring extracorporeal membrane oxygenation: a systematic review and meta-analysis. Res Pract Thromb Haemost. 2023;7(2):100103. 

5.       Gao P, Zhang Y, Jin Y, Zhang P, Wang W, Liu J. Development and Validation of a Nomogram for Predicting Heparin Resistance in Neonates and Young Infants Undergoing Cardiac Surgery: A Retrospective Study [published online ahead of print, 2023 May 22]. Anesth Analg. 2023.

6.       Gao P, Wang X, Zhang P, et al. Preoperative Iron Deficiency Is Associated With Increased Blood Transfusion in Infants Undergoing Cardiac Surgery. Front Cardiovasc Med. 2022;9:887535. Published 2022 Jun 2. 

7.       Jin Y, et al. Hemostatic complications and systemic heparinization in pediatric post-cardiotomy veno-arterial extracorporeal membrane oxygenation failed to wean from cardiopulmonary bypass. Translational Pediatrics. 2022.

8.       Jin Y, Gao P, Zhang P, et al. Mortality prediction in pediatric postcardiotomy veno-arterial extracorporeal membrane oxygenation: A comparison of scoring systems. Front Med (Lausanne). 2022;9:967872.

9.       Gao P, Wang X, Zhang P, et al. Preoperative Iron Deficiency Is Associated With Increased Blood Transfusion in Infants Undergoing Cardiac Surgery. Front Cardiovasc Med. 2022;9:887535. 

10.    Zhang P, Tong Y, Liu J, et al. The lower threshold of hypothermic oxygen delivery to prevent neonatal acute kidney injury. Pediatr Res. 2022;91(7):1741-1747. 

11.    Wang W, Tan JS, Hua L, et al. Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy. Front Cardiovasc Med. 2022;9:888982.

12.    Gao P, Liu J, Zhang P, Bai L, Jin Y, Li Y. Goal-directed perfusion for reducing acute kidney injury in cardiac surgery: A systematic review and meta-analysis. Perfusion. 2022;2676591211073783.

13.    Zhang P, Liu J, Tong Y, et al. Investigation of myocardial protection during pediatric CPB: Practical experience in 100 Chinese hospitals. Perfusion. 2022;37(1):5-13. 

14.    Gao P, Liu J, Wang X, et al. The association between neutrophil-lymphocyte ratio and poor outcomes following infant cardiac surgery. BMC Cardiovasc Disord. 2021;21(1):529. 

15.    Bai LT, Tong YY, Liu JP, et al. Comparable prognosis in different neonatal histidine-tryptophan-ketoglutarate dosage management. Chin Med J (Engl). 2021;134(24):2968-2975.

16.    Bai L, Feng Z, Zhao J, et al. Risk Factors and Long-Term Prognosis for Chylothorax After Total Cavopulmonary Connection in Children: A Retrospective Study From a Single Center. Front Pediatr. 2021;9:744019. 

17.    Zhang P, Liu J, Hu J: Some Perplexities About The Comparison Of Two Cardiopulmonary Bypass Strategies. Ann Thorac Surg2021.

18.    Jin Y, Liu J: Blood Products During Extracorporeal Membrane Oxygenation: Why and How to Use? Anesth Analg 2021, 132:e85.

19.    Jin Y, Feng Z, Zhao J, Hu J, Tong Y, Guo S, Zhang P, Bai L, Li Y, Liu J: Outcomes and factors associated with early mortality in pediatric postcardiotomy  veno-arterial extracorporeal membrane oxygenation. Artif Organs 2021, 45:6-14.

20.    Gao P, Liu J: Pediatric Goal Directed Perfusion: Is There a General Target？. Ann Thorac Surg 2021.

21.    Guo S, Bai L, Tong Y, Yu J, Zhang P, Duan X, Liu J: Contrast media exposure in the perioperative period confers no additional risk of  acute kidney injury in infants and young children undergoing cardiac surgery with  cardiopulmonary bypass. Pediatr Nephrol 2021.

22.    Guo S, Tong Y, Bai L, Zhang P, Duan X, Liu J. Incidence, Risk Factors, and Outcomes of Hyperferritinemia after PediatricCardiac Surgery with Cardiopulmonary Bypass: A Retrospective Study. CONGENIT HEART DIS 2020; 15 (5): 275-85.

23.    Tong Y, Zhang P, Li S, Yan J, Feng Z, Zhao J, Guo S, Jin Y, Liu J. Perioperative blood product transfusion of two different perfusion strategies on pediatric patients undergoing aortic arch surgery. Artif Organs. 2019 Jul 17. doi: 10.1111/aor.13539.

24.    Zhou C, Tong Y, Feng Z, Cui Y, Zhao M, Hu J, Liu K, Zhao J, Liu J.Artif Organs.  Effect of two different colloid priming strategies in infants weighing less than 5 kg undergoing on-pump cardiac surgeries. 2019 Sep 8. 

25.    Yuanyuan Tong, Jinping Liu, Lihua Zou, et al. Perioperative Outcomes of Using Different Temperature Management Strategies on Pediatric Patients Undergoing Aortic Arch Surgery: A Single-Center, 8-Year Study. Front Pediatr. 2018 Nov 27;6:356.

26.    Tian Wang, Xiangyu Wang, Jinping Liu, et al. Substitution of artificial colloids for fresh frozen plasma in pediatric cardiopulmonary bypass surgery. Pediatric Anesthesia. 2018;1–10.

27.    刘晋萍等。WS/T 795—2022，儿科输血指南[S].北京：中华人民共和国国家卫生健康委员会，2022.

28.    刘晋萍。浅谈新时代先天性心脏病外科格局变化下的儿科体外循环应对与挑战，中国体外循环杂志，2022，20（04），193-195。

29.    刘晋萍。浅谈婴幼儿围体外循环期重要脏器保护研究进展。中国体外循环杂志, 2018, (06), 321-323

30.     张沛瑶,童媛媛,李艺萱,柏利婷,靳雨,高鹏,王文婷,胡金晓,刘晋萍.血清NT-proBNP浓度对新生儿心脏手术后AKI的预测价值：基于pROCK标准.中华麻醉学杂志,2022,42(04):389-393.

31.      李艺萱,童媛媛,张沛瑶,柏利婷,靳雨,国胜文,高鹏,刘晋萍.新生儿先天性心脏病体外循环术后长时间机械通气的影响因素分析.中西医结合心脑血管病杂志,2022,20(05):826-830.

32.     李艺萱,刘晋萍.体外循环术中水通道蛋白改变对机体重要脏器的影响.中国体外循环杂志,2021,19(06):372-375.

33.     高鹏,靳雨,张沛瑶,柏利婷,童媛媛,国胜文,李艺萱,刘晋萍.氧供指数与体外循环后急性肾损伤的研究进展.中国体外循环杂志,2021,19(06):376-380.

34.     李艺萱,靳雨,胡金晓,童媛媛,国胜文,柏利婷,张沛瑶,高鹏,刘晋萍.小儿体外膜氧合期间重度血小板减少与不良预后相关.中国体外循环杂志,2021,19(05):261-264+293

35.     靳雨,崔勇丽,刘晋萍,冯正义,赵举,赵明霞,胡金晓.小儿心脏术后难治性出血行体外膜氧合的临床经验.中国体外循环杂志,2021,19(04):201-204.

36.     柏利婷,童媛媛,国胜文,靳雨,张沛瑶,李艺萱,刘晋萍.体外生命支持技术在儿童心脏移植术的应用.中国体外循环杂志,2021,19(03):183-187.

37.     李艺萱,刘晋萍.急性肺损伤过程中水通道蛋白的作用研究进展.中国药物与临床,2021,21(04):590-592.

38.       国胜文, 童媛媛, 柏利婷, 靳雨, 张沛瑶, 李艺宣, et al.. 铁死亡及其在器官缺血再灌注损伤中作用研究进展. 中国体外循环杂志2020; 18 (04): 248-50.

39.    王会颖，冯正义，赵明霞等， 改良扩大Morrow手术治疗儿童肥厚型梗阻性心肌病的体外循环管理. 中国体外循环杂志，2020， 18（01）： 8-11.

40.    国胜文，童媛媛，柏利婷，等. 术后铁蛋白与儿童心内直视手术预后的相关性分析[J]. 中国体外循环杂志,2020,18(3):141-145.

41.    张沛瑶，刘晋萍， 复杂先天性心脏病术后患者的妊娠结局及围妊娠期管理. 中国体外循环杂志， 2019， 17（04）： 252-256.

42.    邹丽华，刘晋萍，张浩等， 兔心肺转流模型中乙醛脱氢酶2活化的心肌保护研究. 中国体外循环杂志， 2019， 17（05）：293-298.

43.    周纯，冯正义，赵举等， 体外循环中人工胶体预充对体重低于5 kg先天性心脏病患儿术后凝血功能影响的研究. 中国胸心血管外科临床杂志， 2019， 26（08）： 766-771.

44.    童媛媛，刘晋萍。婴幼儿主动脉弓部手术中心脑灌注策略的研究进展。中国胸心血管外科临床杂志, 2018, 25(09), 809-813

45.    周纯，冯正义，童媛媛，崔勇丽，赵明霞，胡金晓，刘凯，赵举，刘晋萍。不同胶体预充策略对体重低于5公斤的先天性心脏病患儿手术预后影响的临床研究。中国体外循环杂志, 2018, (06), 324-329

46.    童媛媛，刘晋萍。血栓弹力图检测在体外循环心脏手术中的应用。中国体外循环杂志, 2018, 16(05), 314-317

47.    吕若宁，童媛媛，刘晋萍。不同温度糖氧剥夺对人神经母细胞瘤细胞表达小泛素样修饰蛋白化相关蛋白的影响。中国体外循环杂志, 2018, 16(01), 41-47

48.    童媛媛，刘晋萍。体外循环对小儿内分泌系统的影响。中国体外循环杂志, 2018, 16(01), 48-52

【近5年参加国际学术会议及报告】

1.  参加欧洲心脏病学会2019年年会暨世界心血管病学大会-大会发言并获得优秀青年研究者称号

Shengwen Guo MD, JinpingLiu MD, Xin Duan MD. Effect of intraoperative hybrid surgery on incidenceof CPB-AKI in childrenCongenital heart disease patients: apropensity score matched study. ESC Congress 2019 together with World Congress of Cardiology

2.  参加第十五届婴幼儿体外循环及辅助循环会议-大会发言

Yuanyuan Tong MD, PeiyaoZhang MD, Jinping Liu MD PhD. Perioperative blood product transfusion of twodifferent perfusion strategies on pediatric patients undergoing aortic archsurgery. The 15th International Conference on Pediatric Mechanical CirculatorySupport Systems and Pediatric Cardiopulmonary Perfusion

3.  参加第十五届婴幼儿体外循环及辅助循环会议-大会发言

Shengwen Guo MD, Jinping Liu MD,Xin Duan MD. Contrast exposure beforecardiopulmonary bypass: a new challenge for kidney protection in young childrenundergoing cardiac surgery. The 15thInternational Conference on Pediatric Mechanical Circulatory Support Systemsand Pediatric Cardiopulmonary Perfusion

【获奖情况】

1、2015年 北京市科学技术奖 二等奖

2、2014年北京市科学技术奖 三等奖

2、2013年 中华医学会胸心血管外科青年医师论坛奖中华医学会胸心血管外科分会 二等奖

3、2010年 中华医学科技奖 三等奖

4、2006年 院所技术创新奖

【专利】

实用新型专利证书 《用于体外循环三联三通的可拆卸固定架》

实用新型专利证书 《小儿体外循环术用超滤装置》

实用新型专利证书 《婴幼儿变径节血套包》